{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:57:36Z","timestamp":1790693856907,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.metabol.2014.10.025","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T18:51:34Z","timestamp":1414608694000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype"],"prefix":"10.1016","volume":"64","author":[{"given":"Daniela","family":"Omodei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pucino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Labruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Procaccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Galgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pirozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"De Caprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Marone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Contaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pasanisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Matarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Sacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.metabol.2014.10.025_bb0005","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1038\/sj.ejcn.1601819","article-title":"Changes in the immune system are conditioned by nutrition","volume":"57","author":"Marcos","year":"2003","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.metabol.2014.10.025_bb0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1586\/1744666X.2.3.433","article-title":"Immunocompetence to assess nutritional status in eating disorders","volume":"2","author":"Nova","year":"2006","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.metabol.2014.10.025_bb0015","doi-asserted-by":"crossref","first-page":"610950","DOI":"10.1155\/2013\/610950","article-title":"Nutritionally mediated oxidative stress and inflammation","volume":"2013","author":"Mu\u00f1oz","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.metabol.2014.10.025_bb0020","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1179\/1351000213Y.0000000044","article-title":"Redox regulation of the immune response","volume":"18","author":"Gostner","year":"2013","journal-title":"Redox Rep"},{"key":"10.1016\/j.metabol.2014.10.025_bb0025","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.cca.2011.06.007","article-title":"Adipocytokines, gut hormones and growth factors in anorexia nervosa","volume":"412","author":"Kowalska","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.metabol.2014.10.025_bb0030","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/oby.20097","article-title":"Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin","volume":"21","author":"Gustafsson","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.metabol.2014.10.025_bb0035","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.yexcr.2006.03.023","article-title":"Weight-dependent changes of immune system in adipose tissue: importance of leptin","volume":"312","author":"Caspar-Bauguil","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.metabol.2014.10.025_bb0040","first-page":"371","article-title":"The weight of leptin in immunity","volume":"4","author":"La Cava","year":"2004","journal-title":"Nat Rev"},{"key":"10.1016\/j.metabol.2014.10.025_bb0045","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.4049\/jimmunol.1001674","article-title":"Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient\/energy-sensing mammalian target of rapamycin signaling pathway","volume":"185","author":"Galgani","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.metabol.2014.10.025_bb0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/eat.20417","article-title":"Malnutrition induces dissociated changes in lymphocyte count and subset proportion in patients with anorexia nervosa","volume":"40","author":"Saito","year":"2007","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.metabol.2014.10.025_bb0055","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/sj.ejcn.1602651","article-title":"Investigation of regulatory T cells in anorexia nervosa","volume":"61","author":"P\u00e1szthy","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.metabol.2014.10.025_bb0060","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.metabol.2014.10.025_bb0065","doi-asserted-by":"crossref","first-page":"287457","DOI":"10.1155\/2012\/287457","article-title":"Leptin in anorexia and cachexia syndrome","volume":"2012","author":"Engineer","year":"2012","journal-title":"Int J Pept"},{"key":"10.1016\/j.metabol.2014.10.025_bb0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2007.01.011","article-title":"Key role of leptin in the control of regulatory T cells proliferation","volume":"26","author":"De Rosa","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.metabol.2014.10.025_bb0075","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.4049\/jimmunol.1200935","article-title":"Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses","volume":"189","author":"Procaccini","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.metabol.2014.10.025_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2010.11.024","article-title":"An oscillatory switch in mTOR Kinase activity sets regulatory T cell responsiveness","volume":"33","author":"Procaccini","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.metabol.2014.10.025_bb0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1586\/eci.10.48","article-title":"At the crossroad between immunity and metabolism: focus on leptin","volume":"6","author":"Conde","year":"2010","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.metabol.2014.10.025_bb0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1399-0039.2007.00886.x","article-title":"Leptin in autoimmunity: many questions, some answers","volume":"70","author":"Matarese","year":"2007","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.metabol.2014.10.025_bb0095","doi-asserted-by":"crossref","first-page":"E818","DOI":"10.1073\/pnas.1214554110","article-title":"Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia","volume":"110","author":"Matarese","year":"2013","journal-title":"PNAS"},{"key":"10.1016\/j.metabol.2014.10.025_bb0100","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/eat.22166","article-title":"Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration","volume":"46","author":"Terra","year":"2013","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.metabol.2014.10.025_bb0105","doi-asserted-by":"crossref","first-page":"587","DOI":"10.33549\/physiolres.931089","article-title":"Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines","volume":"56","author":"Dost\u00e1lov\u00e1","year":"2007","journal-title":"Physiol Res"},{"key":"10.1016\/j.metabol.2014.10.025_bb0110","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1210\/jc.2006-1683","article-title":"Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients","volume":"92","author":"Modan-Moses","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.10.025_bb0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.regpep.2011.02.005","article-title":"Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa","volume":"168","author":"Janas-Kozik","year":"2011","journal-title":"Regul Pept"},{"key":"10.1016\/j.metabol.2014.10.025_bb0120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00702-010-0551-z","article-title":"Screening for anorexia nervosa via measurement of serum leptin levels","volume":"118","author":"F\u00f6cker","year":"2011","journal-title":"J Neural Transm"},{"key":"10.1016\/j.metabol.2014.10.025_bb0125","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0196-9781(00)00349-1","article-title":"Activation of urocortin transport into brain by leptin","volume":"21","author":"Kastin","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.metabol.2014.10.025_bb0130","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/jc.2002-021215","article-title":"Anorexia nervosa is characterized by increased adiponectin plasma levels and reduced nonoxidative glucose metabolism","volume":"88","author":"Pannacciulli","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.10.025_bb0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2265.2003.01702.x","article-title":"Hyperadiponectinaemia in anorexia nervosa","volume":"58","author":"Delporte","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2014.10.025_bb0140","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1038\/oby.2010.309","article-title":"High leptin\/adiponectin ratio and serum triglycerides are associated with an \"at-risk\" phenotype in young severely obese patients","volume":"19","author":"Labruna","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.metabol.2014.10.025_bb0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.metabol.2014.10.025_bb0150","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1126\/science.1249077","article-title":"Cell biology. Ronning after the adiponectin receptors","volume":"342","author":"Holland","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.metabol.2014.10.025_bb0155","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ibd.20107","article-title":"Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients","volume":"13","author":"Spoettl","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.metabol.2014.10.025_bb0160","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.metabol.2014.10.025_bb0165","doi-asserted-by":"crossref","first-page":"599","DOI":"10.18632\/aging.100584","article-title":"Serum from humans on long-term calorie restriction enhances stress resistance in cell culture","volume":"5","author":"Omodei","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.metabol.2014.10.025_bb0170","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11357-009-9118-z","article-title":"Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production","volume":"32","author":"Fontana","year":"2010","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.metabol.2014.10.025_bb0175","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3132\/dvdr.2008.017","article-title":"Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins","volume":"5","author":"Plant","year":"2008","journal-title":"Diab Vasc Dis Res"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049514003345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049514003345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:05:20Z","timestamp":1758427520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049514003345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0026049514003345"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2014.10.025","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2014.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}