{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:40:42Z","timestamp":1774878042913,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1,110,864"],"award-info":[{"award-number":["1,110,864"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SOCHED","award":["2009-48 05"],"award-info":[{"award-number":["2009-48 05"]}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.metabol.2016.01.006","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T02:00:19Z","timestamp":1452909619000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Metabolic profile in women with polycystic ovary syndrome across adult life"],"prefix":"10.1016","volume":"65","author":[{"given":"B\u00e1rbara","family":"Echibur\u00fa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Crisosto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Maliqueo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"P\u00e9rez-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Ladron","family":"de Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Cavada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Clavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Sir-Petermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2016.01.006_bb0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.metabol.2016.01.006_bb0010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/des463","article-title":"Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp","volume":"28","author":"Stepto","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.metabol.2016.01.006_bb0015","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2016.01.006_bb0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.metabol.2016.01.006_bb0025","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.fertnstert.2014.02.020","article-title":"Metabolic profile of the different phenotypes of polycystic ovary syndrome in two Latin American populations","volume":"101","author":"Ladron de Guevara","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.metabol.2016.01.006_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/gme.0b013e318278e9b4","article-title":"Acceleration of cardiovascular risk during the late menopausal transition","volume":"20","author":"Pai","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.metabol.2016.01.006_bb0035","doi-asserted-by":"crossref","first-page":"757461","DOI":"10.1155\/2014\/757461","article-title":"Estrogen deficiency and the origin of obesity during menopause","volume":"2014","author":"Lizcano","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.metabol.2016.01.006_bb0040","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1530\/EJE-10-0205","article-title":"Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome","volume":"162","author":"Alemzadeh","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2016.01.006_bb0045","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1210\/jc.2011-0039","article-title":"Unfavorable hormonal, metabolic, and inflammatory alterations persist after menopause in women with PCOS","volume":"96","author":"Puurunen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2016.01.006_bb0050","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1210\/jc.2007-0425","volume":"93","author":"Shaw","year":"2008","journal-title":"J Clin Endocr Metab"},{"key":"10.1016\/j.metabol.2016.01.006_bb0055","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1210\/jc.2013-4170","article-title":"Hyperandrogenic oligomenorrhea and metabolic risks across menopausal transition","volume":"99","author":"Polotsky","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2016.01.006_bb0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejogrb.2013.06.013","article-title":"Evaluation of ovarian function in 35\u201340-year-old women with polycystic ovary syndrome","volume":"170","author":"de Guevara","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.metabol.2016.01.006_bb0065","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/1536867X0100100107","article-title":"Review of generalized linear models and extensions by Hardin and Hilbe","volume":"1","author":"Newson","year":"2001","journal-title":"Stata J"},{"key":"10.1016\/j.metabol.2016.01.006_bb0070","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3109\/09513590.2013.819079","article-title":"Age- and body mass index-related differences in the prevalence of metabolic syndrome in women with polycystic ovary syndrome","volume":"29","author":"Panidis","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.metabol.2016.01.006_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1530\/EJE-14-0094","article-title":"Comparison of various adiposity indexes in women with polycystic ovary syndrome and normo-ovulatory non-hirsute women: a population-based study","volume":"171","author":"Ramezani Tehrani","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2016.01.006_bb0080","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/humrep\/deg482","article-title":"Proinsulin serum concentrations in women with polycystic ovary syndrome: a marker of beta-cell dysfunction?","volume":"18","author":"Maliqueo","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.metabol.2016.01.006_bb0085","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/nu5020498","article-title":"Fat depots, free fatty acids, and dyslipidemia","volume":"5","author":"Ebbert","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.metabol.2016.01.006_bb0090","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1152\/ajpendo.00366.2002","article-title":"Aging and insulin secretion","volume":"284","author":"Chang","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2016.01.006_bb0095","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.metabol.2008.02.012","article-title":"Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women","volume":"57","author":"Maturana","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2016.01.006_bb0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/13697137.2013.828687","article-title":"Polycystic ovaries \u2014 beyond menopause","volume":"17","author":"Shah","year":"2014","journal-title":"Climacteric"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049516000135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049516000135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:12:26Z","timestamp":1758427946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049516000135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0026049516000135"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2016.01.006","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic profile in women with polycystic ovary syndrome across adult life","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2016.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}