{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:12Z","timestamp":1790482032765,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.metabol.2016.09.005","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T07:31:22Z","timestamp":1474529482000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels"],"prefix":"10.1016","volume":"66","author":[{"given":"Brian","family":"Bostick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annayya R.","family":"Aroor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Durante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent G.","family":"DeMarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Garro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Sowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0005","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat Rev Endocrinol"},{"issue":"9","key":"10.1016\/j.metabol.2016.09.005_bb0010","doi-asserted-by":"crossref","first-page":"H1126","DOI":"10.1152\/ajpheart.00898.2014","article-title":"Mineralocorticoid receptor blockade prevents western diet-induced diastolic dysfunction in female mice","volume":"308","author":"Bostick","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0015","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jacc.2009.12.003","article-title":"The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study","volume":"55","author":"From","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2016.09.005_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/epirev\/mxm012","article-title":"The global epidemic of obesity: an overview","volume":"29","author":"Caballero","year":"2007","journal-title":"Epidemiol Rev"},{"issue":"10","key":"10.1016\/j.metabol.2016.09.005_bb0025","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/en.2013-1256","article-title":"Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a western diet","volume":"154","author":"Manrique","year":"2013","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.metabol.2016.09.005_bb0030","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/HYPERTENSIONAHA.115.06015","article-title":"Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females","volume":"66","author":"Jia","year":"2015","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0035","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.CIR.0000045671.62860.98","article-title":"Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study","volume":"107","author":"Rutter","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.metabol.2016.09.005_bb0040","doi-asserted-by":"crossref","first-page":"H628","DOI":"10.1152\/ajpheart.00859.2013","article-title":"Role of estrogen in diastolic dysfunction","volume":"306","author":"Zhao","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.whi.2016.03.001","article-title":"Advancing women's heart health through policy and science: highlights from the First National Policy and Science Summit on Women's Cardiovascular Health","volume":"26","author":"Wood","year":"2016","journal-title":"Womens Health Issues"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0050","first-page":"e29","article-title":"Heart disease and stroke statistics \u2013 2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"issue":"7500","key":"10.1016\/j.metabol.2016.09.005_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/509282a","article-title":"Policy: NIH to balance sex in cell and animal studies","volume":"509","author":"Clayton","year":"2014","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.metabol.2016.09.005_bb0060","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMra1109345","article-title":"Noncommunicable diseases","volume":"369","author":"Hunter","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.annepidem.2009.01.019","article-title":"Healthy hearts \u2013 and the universal benefits of being physically active: physical activity and health","volume":"19","author":"Blair","year":"2009","journal-title":"Ann Epidemiol"},{"issue":"5","key":"10.1016\/j.metabol.2016.09.005_bb0070","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1249\/MSS.0b013e31823cd16a","article-title":"Exercise training improves diastolic function in heart failure patients","volume":"44","author":"Alves","year":"2012","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.metabol.2016.09.005_bb0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1758-5996-3-37","article-title":"High fat diet enhances cardiac abnormalities in SHR rats: protective role of heme oxygenase-adiponectin axis","volume":"3","author":"Cao","year":"2011","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"10.1016\/j.metabol.2016.09.005_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tips.2015.09.003","article-title":"Translational significance of heme oxygenase in obesity and metabolic syndrome","volume":"37","author":"Abraham","year":"2016","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.metabol.2016.09.005_bb0085","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2174\/1389450111009011504","article-title":"Targeting heme oxygenase-1 in vascular disease","volume":"11","author":"Durante","year":"2010","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.metabol.2016.09.005_bb0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-61779-430-8_27","article-title":"A mouse model of diet-induced obesity and insulin resistance","volume":"821","author":"Wang","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"8","key":"10.1016\/j.metabol.2016.09.005_bb0095","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.metabol.2014.04.002","article-title":"Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of western diet induced obesity","volume":"63","author":"Bostick","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2016.09.005_bb0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2016.03.003","article-title":"Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction","volume":"94","author":"Liu","year":"2016","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.metabol.2016.09.005_bb0105","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/ijo.2010.25","article-title":"Western diet increases wheel running in mice selectively bred for high voluntary wheel running","volume":"34","author":"Meek","year":"2010","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0110","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/japplphysiol.00668.2011","article-title":"Effects of voluntary running on oxygen consumption, RQ, and energy expenditure during primary prevention of diet-induced obesity in C57BL\/6N mice","volume":"113","author":"Brown","year":"2012","journal-title":"J Appl Physiol (1985)"},{"issue":"5","key":"10.1016\/j.metabol.2016.09.005_bb0115","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/HYPERTENSIONAHA.116.07954","article-title":"Regular exercise reduces endothelial cortical stffness in western diet-fed mice","volume":"68","author":"Padilla","year":"2016","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/HYPERTENSIONAHA.114.04737","article-title":"Uric acid promotes left ventricular diastolic dysfunction in mice fed a western diet","volume":"65","author":"Jia","year":"2015","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.metabol.2016.09.005_bb0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCRESAHA.110.236687","article-title":"Estrogen signaling and cardiovascular disease","volume":"109","author":"Murphy","year":"2011","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.metabol.2016.09.005_bb0130","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jacc.2003.10.062","article-title":"Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging","volume":"43","author":"Peterson","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0135","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jcmg.2008.05.004","article-title":"Impact of gender on the myocardial metabolic response to obesity","volume":"1","author":"Peterson","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0140","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/oby.2011.208","article-title":"Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans","volume":"20","author":"Peterson","year":"2012","journal-title":"Obesity"},{"issue":"18","key":"10.1016\/j.metabol.2016.09.005_bb0145","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/01.CIR.0000127959.28627.F8","article-title":"Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women","volume":"109","author":"Peterson","year":"2004","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.metabol.2016.09.005_bb0150","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1210\/en.2014-1342","article-title":"Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice","volume":"155","author":"Litwak","year":"2014","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exger.2005.10.010","article-title":"Recent female mouse models displaying advanced reproductive aging","volume":"41","author":"Danilovich","year":"2006","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.metabol.2016.09.005_bb0160","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphys.2015.00124","article-title":"Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10","volume":"6","author":"Kesherwani","year":"2015","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0165","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1139\/h11-153","article-title":"Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl\/6J mice","volume":"37","author":"Louwe","year":"2012","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.metabol.2016.09.005_bb0170","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2015.06.136","article-title":"A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice","volume":"198","author":"Carbone","year":"2015","journal-title":"Int J Cardiol"},{"issue":"7","key":"10.1016\/j.metabol.2016.09.005_bb0175","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2337\/db12-1580","article-title":"High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity","volume":"62","author":"Hafstad","year":"2013","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.metabol.2016.09.005_bb0180","doi-asserted-by":"crossref","first-page":"H823","DOI":"10.1152\/ajpheart.00734.2014","article-title":"Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice","volume":"308","author":"Lund","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"10.1016\/j.metabol.2016.09.005_bb0185","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/heart.89.10.1152","article-title":"Effects of isolated obesity on systolic and diastolic left ventricular function","volume":"89","author":"Pascual","year":"2003","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0190","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1210\/en.2015-1681","article-title":"Endothelial estrogen receptor-alpha does not protect against vascular stiffness induced by western diet in female mice","volume":"157","author":"Manrique","year":"2016","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.metabol.2016.09.005_bb0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/HYPERTENSIONAHA.115.05674","article-title":"Low-dose mineralocorticoid receptor blockade prevents western diet-induced arterial stiffening in female mice","volume":"66","author":"DeMarco","year":"2015","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0200","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.metabol.2016.09.005_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003046","article-title":"Role of mitochondrial oxidative stress in glucose tolerance, insulin resistance, and cardiac diastolic dysfunction","volume":"5","author":"Jeong","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/FJC.0b013e318256ce10","article-title":"Autophagy, myocardial protection, and the metabolic syndrome","volume":"60","author":"Giricz","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1016\/j.metabol.2016.09.005_bb0215","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1139\/H09-028","article-title":"Mitochondrial function and dysfunction in exercise and insulin resistance","volume":"34","author":"Holloway","year":"2009","journal-title":"Appl Physiol Nutr Metab"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000335675","article-title":"Mitochondria and oxidative stress in the cardiorenal metabolic syndrome","volume":"2","author":"Aroor","year":"2012","journal-title":"Cardiorenal Med"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0225","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.hfc.2012.06.005","article-title":"Insulin resistance and heart failure: molecular mechanisms","volume":"8","author":"Aroor","year":"2012","journal-title":"Heart Fail Clin"},{"issue":"4","key":"10.1016\/j.metabol.2016.09.005_bb0230","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1139\/cjpp-2015-0122","article-title":"The effect of moderate-intensity exercise on the expression of HO-1 mRNA and activity of HO in cardiac and vascular smooth muscle of spontaneously hypertensive rats","volume":"94","author":"Ren","year":"2016","journal-title":"Can J Physiol Pharmacol"},{"issue":"6","key":"10.1016\/j.metabol.2016.09.005_bb0235","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00395-014-0450-9","article-title":"Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology","volume":"109","author":"Czibik","year":"2014","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0240","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2337\/db15-1003","article-title":"Gasotransmitters in vascular complications of diabetes","volume":"65","author":"van den Born","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.metabol.2016.09.005_bb0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85817","article-title":"Heme oxygenase-1 regulates mitochondrial quality control in the heart","volume":"1","author":"Hull","year":"2016","journal-title":"JCI insight"},{"issue":"49","key":"10.1016\/j.metabol.2016.09.005_bb0250","doi-asserted-by":"crossref","first-page":"34327","DOI":"10.1074\/jbc.M807036200","article-title":"Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1\/phosphoinositide 3-kinase\/Akt-2 pathway","volume":"283","author":"Geraldes","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2016.09.005_bb0255","doi-asserted-by":"crossref","first-page":"359732","DOI":"10.1155\/2010\/359732","article-title":"Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity","volume":"2010","author":"Ndisang","year":"2010","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.metabol.2016.09.005_bb0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/10715760400022327","article-title":"Exercise-induced expression of heme oxygenase-1 in human lymphocytes","volume":"39","author":"Thompson","year":"2005","journal-title":"Free Radic Res"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049516301111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049516301111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:11:45Z","timestamp":1758427905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049516301111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":52,"alternative-id":["S0026049516301111"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2016.09.005","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2016.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}