{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:50:06Z","timestamp":1790866206221,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.metabol.2017.01.019","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T16:37:24Z","timestamp":1484584644000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth"],"prefix":"10.1016","volume":"69","author":[{"given":"Sheryl L.","family":"Rifas-Shiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Fleisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Mantzoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Gillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2017.01.019_bb0005","series-title":"Weight gain during pregnancy: reexamining the guidelines","article-title":"The National Academies Collection: reports funded by National Institutes of Health","author":"Institute of Medicine National Research Council Committee to Reexamine I.O.M. Pregnancy Weight Guidelines","year":"2009"},{"key":"10.1016\/j.metabol.2017.01.019_bb0010","first-page":"168","article-title":"Point of diminishing returns: when does gestational weight gain cease benefiting birthweight and begin adding to maternal obesity?","volume":"5","author":"Luke","year":"1996","journal-title":"J Matern Fetal Med"},{"key":"10.1016\/j.metabol.2017.01.019_bb0015","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-3476(98)70302-6","article-title":"Role of the prenatal environment in the development of obesity","volume":"132","author":"Whitaker","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.metabol.2017.01.019_bb0020","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/oby.2003.69","article-title":"Fetal origins of obesity","volume":"11","author":"Oken","year":"2003","journal-title":"Obes Res"},{"issue":"322","key":"10.1016\/j.metabol.2017.01.019_bb0025","first-page":"e321","article-title":"Gestational weight gain and child adiposity at age 3years","volume":"196","author":"Oken","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.metabol.2017.01.019_bb0030","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1002\/oby.21511","article-title":"Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood","volume":"24","author":"Hivert","year":"2016","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"10.1016\/j.metabol.2017.01.019_bb0035","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10995-011-0846-1","article-title":"Trimester of maternal gestational weight gain and offspring body weight at birth and age five","volume":"16","author":"Margerison-Zilko","year":"2012","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.metabol.2017.01.019_bb0040","doi-asserted-by":"crossref","unstructured":"Karachaliou M, Georgiou V, Roumeliotaki T, Chalkiadaki G, Daraki V, Koinaki S, Dermitzaki E, Sarri K, Vassilaki M, Kogevinas M, Oken E, Chatzi L. Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood. Am J Obstet Gynecol, 212, 4, 502.e1\u2013502.e14","DOI":"10.1016\/j.ajog.2014.12.038"},{"key":"10.1016\/j.metabol.2017.01.019_bb0045","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jogc.2015.12.014","article-title":"Timing of excessive weight gain during pregnancy modulates newborn anthropometry","volume":"38","author":"Ruchat","year":"2016","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.metabol.2017.01.019_bb0050","doi-asserted-by":"crossref","first-page":"e0159500","DOI":"10.1371\/journal.pone.0159500","article-title":"Trimester-specific gestational weight gain and infant size for gestational age","volume":"11","author":"Sridhar","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2017.01.019_bb0055","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/1471-0528.13700","article-title":"Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: a prospective cohort study","volume":"123","author":"Gaillard","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.metabol.2017.01.019_bb0060","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1038\/oby.2005.248","article-title":"Associations of maternal prenatal smoking with child adiposity and blood pressure","volume":"13","author":"Oken","year":"2005","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2017.01.019_bb0065","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.2337\/diabetes.49.12.2208","article-title":"Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships","volume":"49","author":"Dabelea","year":"2000","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.metabol.2017.01.019_bb0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ije\/dyu008","article-title":"Cohort profile: project viva","volume":"44","author":"Oken","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"7","key":"10.1016\/j.metabol.2017.01.019_bb0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/jwh.2014.5016","article-title":"Associations of maternal material hardships during childhood and adulthood with prepregnancy weight, gestational weight gain, and postpartum weight retention","volume":"24","author":"Provenzano","year":"2015","journal-title":"J Womens Health (Larchmt)"},{"issue":"6","key":"10.1016\/j.metabol.2017.01.019_bb0080","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ije\/dym156","article-title":"How should gestational weight gain be assessed? A comparison of existing methods and a novel method, area under the weight gain curve","volume":"36","author":"Kleinman","year":"2007","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.metabol.2017.01.019_bb0085","article-title":"Associations of trimester-specific gestational weight gain with maternal adiposity and systolic blood pressure at 3 and 7years postpartum","volume":"13","author":"Walter","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.metabol.2017.01.019_bb0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jpeds.2010.07.052","article-title":"Gestational glucose tolerance and cord blood leptin levels predict slower weight gain in early infancy","volume":"158","author":"Parker","year":"2011","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.metabol.2017.01.019_bb0095","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1542\/peds.2008-0343","article-title":"Cord blood leptin and adiponectin as predictors of adiposity in children at 3years of age: a prospective cohort study","volume":"123","author":"Mantzoros","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.metabol.2017.01.019_bb0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2431-3-6","article-title":"A nearly continuous measure of birth weight for gestational age using a United States national reference","volume":"3","author":"Oken","year":"2003","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.metabol.2017.01.019_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/EDE.0b013e31823aca5d","article-title":"Conditioning on intermediates in perinatal epidemiology","volume":"23","author":"VanderWeele","year":"2012","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.metabol.2017.01.019_bb0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/aje\/kwi002","article-title":"Why evidence for the fetal origins of adult disease might be a statistical artifact: the \u201creversal paradox\u201d for the relation between birth weight and blood pressure in later life","volume":"161","author":"Tu","year":"2005","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.metabol.2017.01.019_bb0115","article-title":"Sex-specific associations of maternal gestational glycemia with hormones in umbilical cord blood at delivery","author":"Oken","year":"2016","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.metabol.2017.01.019_bb0120","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/ijo.2015.109","article-title":"Associations of maternal weight status prior and during pregnancy with neonatal cardiometabolic markers at birth: the Healthy Start study","volume":"39","author":"Lemas","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.metabol.2017.01.019_bb0125","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/ppe.12074","article-title":"Maternal weight status, cord blood leptin and fetal growth: a prospective mother\u2013child cohort study (Rhea study)","volume":"27","author":"Karakosta","year":"2013","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.metabol.2017.01.019_bb0130","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm1029","article-title":"Adiponectin acts in the brain to decrease body weight","volume":"10","author":"Qi","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2017.01.019_bb0135","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1464-5491.2012.03726.x","article-title":"Development of associations among central adiposity, adiponectin and insulin sensitivity from adolescence to young adulthood","volume":"29","author":"Rasmussen-Torvik","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.metabol.2017.01.019_bb0140","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.annepidem.2003.10.006","article-title":"Serum adiponectin in young adults\u2014interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study","volume":"14","author":"Steffes","year":"2004","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.metabol.2017.01.019_bb0145","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s00125-012-2598-x","article-title":"Adiponectin: mechanistic insights and clinical implications","volume":"55","author":"Turer","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2017.01.019_bb0150","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/jama.2014.1","article-title":"Preterm birth and random plasma insulin levels at birth and in early childhood","volume":"311","author":"Wang","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2017.01.019_bb0155","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/ijo.2014.179","article-title":"Gestational weight gain in normal weight women and offspring cardio-metabolic risk factors at 20years of age","volume":"39","author":"Hrolfsdottir","year":"2015","journal-title":"Int J Obes (Lond)"},{"issue":"11","key":"10.1016\/j.metabol.2017.01.019_bb0160","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.annepidem.2014.08.002","article-title":"A prospective study of maternal prenatal weight and offspring cardiometabolic health in mid-childhood","volume":"24","author":"Perng","year":"2014","journal-title":"Ann Epidemiol"},{"issue":"1","key":"10.1016\/j.metabol.2017.01.019_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(83)90028-2","article-title":"Growth and development of human adipose tissue during early gestation","volume":"8","author":"Poissonnet","year":"1983","journal-title":"Early Hum Dev"},{"issue":"2","key":"10.1016\/j.metabol.2017.01.019_bb0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cytogfr.2008.01.005","article-title":"IGF2: epigenetic regulation and role in development and disease","volume":"19","author":"Chao","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.metabol.2017.01.019_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2013.03.003","article-title":"Fetal growth factors and fetal nutrition","author":"Bloomfield","year":"2013","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.metabol.2017.01.019_bb0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ijpo.12038","article-title":"Cord IGF-I concentrations in Indian newborns: associations with neonatal body composition and maternal determinants","volume":"11","author":"Wiley","year":"2016","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.metabol.2017.01.019_bb0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12887-015-0499-0","article-title":"Fetal metabolic influences of neonatal anthropometry and adiposity","volume":"15","author":"Donnelly","year":"2015","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.metabol.2017.01.019_bb0190","first-page":"268","article-title":"High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth","volume":"70","author":"Inoue","year":"2008","journal-title":"Horm Res"},{"issue":"11","key":"10.1016\/j.metabol.2017.01.019_bb0195","first-page":"4266","volume":"85","author":"Ong","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.metabol.2017.01.019_bb0200","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00001703-200006000-00001","article-title":"Insulin-like growth factors in obstetrics","volume":"12","author":"Rutanen","year":"2000","journal-title":"Curr Opin Obstet Gynecol"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049517300239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049517300239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:12:52Z","timestamp":1758427972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049517300239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":40,"alternative-id":["S0026049517300239"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2017.01.019","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2017.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}