{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:01:22Z","timestamp":1791853282311,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01"],"award-info":[{"award-number":["R01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD034568"],"award-info":[{"award-number":["HD034568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3OD023286"],"award-info":[{"award-number":["UG3OD023286"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54CA155626"],"award-info":[{"award-number":["1U54CA155626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.metabol.2017.06.008","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T17:01:07Z","timestamp":1498755667000},"page":"70-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-3432","authenticated-orcid":false,"given":"Olivia M.","family":"Farr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Rifas-Shiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsie M.","family":"Taveras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Supplement s1","key":"10.1016\/j.metabol.2017.06.008_bb0005","first-page":"12","article-title":"Health risks associated with overweight and obesity","volume":"8","author":"Kopelman","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.metabol.2017.06.008_bb0010","series-title":"Obesity and obesity statistics","author":"NIDDK NIoDaDaKD","year":"2013"},{"key":"10.1016\/j.metabol.2017.06.008_bb0015","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.2109080","article-title":"The epidemiology of obstructive sleep apnea: A population health perspective","volume":"165","author":"Young","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.metabol.2017.06.008_bb0020","first-page":"2","article-title":"Prevalence of obesity among adults and youth: United states, 2011\u20132014","volume":"219","author":"Ogden","year":"2015","journal-title":"NCHS Data Brief"},{"issue":"1","key":"10.1016\/j.metabol.2017.06.008_bb0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5665\/sleep.4318","article-title":"Remission and incidence of obstructive sleep apnea from middle childhood to late adolescence","volume":"38","author":"Spilsbury","year":"2015","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0030","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1183\/13993003.01771-2015","article-title":"Natural history of sleep disordered breathing in prepubertal children transitioning to adolescence","volume":"47","author":"Bixler","year":"2016","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.metabol.2017.06.008_bb0035","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11892-014-0507-z","article-title":"Metabolic consequences of sleep and circadian disorders","volume":"14","author":"Depner","year":"2014","journal-title":"Curr Diab Rep"},{"issue":"1","key":"10.1016\/j.metabol.2017.06.008_bb0040","first-page":"29","article-title":"Sleep disturbances, body fat distribution, food intake and\/or energy expenditure: Pathophysiological aspects","volume":"17","author":"St-Onge","year":"2014","journal-title":"Horm Mol Biol Clin Invest"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijcard.2013.08.088","article-title":"Obstructive sleep apnea and risk of cardiovascular disease and all-cause mortality: A meta-analysis of prospective cohort studies","volume":"169","author":"Wang","year":"2013","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0050","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2337\/dc06-2107","article-title":"Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes","volume":"30","author":"Williams","year":"2007","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.metabol.2017.06.008_bb0055","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2337\/dc13-0933","article-title":"Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: Therapeutic implications","volume":"37","author":"Grimaldi","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2017.06.008_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smrv.2015.10.002","article-title":"Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis","volume":"30","author":"Anothaisintawee","year":"2015","journal-title":"Sleep Med Rev"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0065","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1164\/rccm.200909-1423OC","article-title":"Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes","volume":"181","author":"Aronsohn","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.metabol.2017.06.008_bb0070","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1378\/chest.13-2403","article-title":"Diabetes mellitus prevalence and control in sleep-disordered breathing: The european sleep apnea cohort (esada) study","volume":"146","author":"Kent","year":"2014","journal-title":"Chest"},{"issue":"11-12","key":"10.1016\/j.metabol.2017.06.008_bb0075","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.nut.2015.05.017","article-title":"Obstructive sleep apnea is independently associated with inflammation and insulin resistance, but not with blood pressure, plasma catecholamines, and endothelial function in obese subjects","volume":"31","author":"Araujo Lda","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.metabol.2017.06.008_bb0080","article-title":"Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases","author":"Tobaldini","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0085","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5664\/jcsm.3690","article-title":"Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: A meta-regression analysis","volume":"10","author":"Nadeem","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"10.1016\/j.metabol.2017.06.008_bb0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.7326\/0003-4819-157-8-201210160-00005","article-title":"Impaired insulin signaling in human adipocytes after experimental sleep restriction: A randomized, crossover study","volume":"157","author":"Broussard","year":"2012","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0095","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1152\/japplphysiol.00660.2005","article-title":"Sleep loss: A novel risk factor for insulin resistance and type 2 diabetes","volume":"99","author":"Spiegel","year":"2005","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jpeds.2014.11.001","article-title":"Sleep-disordered breathing, sleep duration, and childhood overweight: A longitudinal cohort study","volume":"166","author":"Bonuck","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.metabol.2017.06.008_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2017.04.011","article-title":"Increased inflammation from childhood to adolescence predicts sleep apnea in boys: A preliminary study","author":"Gaines","year":"2017","journal-title":"Brain Behav Immun"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0110","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5664\/JCSM.1068","article-title":"Relationship between sleep apnea, fat distribution, and insulin resistance in obese children","volume":"7","author":"Canapari","year":"2011","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1378\/chest.09-2153","article-title":"Adipokines in children with obstructive sleep apnea and the effects of treatment","volume":"137","author":"Li","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.metabol.2017.06.008_bb0120","series-title":"Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice","author":"Khalyfa","year":"2017"},{"key":"10.1016\/j.metabol.2017.06.008_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2017.01.026","article-title":"Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring","author":"Trzepizur","year":"2017","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.metabol.2017.06.008_bb0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.psc.2015.07.004","article-title":"Genetics of sleep disorders","volume":"38","author":"Gehrman","year":"2015","journal-title":"Psychiatr Clin North Am"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0135","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1378\/chest.09-1926","article-title":"Prevalence and risk factors of habitual snoring in primary school children","volume":"138","author":"Li","year":"2010","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.metabol.2017.06.008_bb0140","first-page":"3","article-title":"Obstructive sleep apnea: Women's perspective","author":"Jehan","year":"2016","journal-title":"J Sleep Med Disord"},{"issue":"2","key":"10.1016\/j.metabol.2017.06.008_bb0145","first-page":"346","article-title":"Decline in fish consumption among pregnant women after a national mercury advisory","volume":"102","author":"Oken","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.metabol.2017.06.008_bb0150","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jpeds.2003.10.064","article-title":"Maternal age and other predictors of newborn blood pressure","volume":"144","author":"Gillman","year":"2004","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.metabol.2017.06.008_bb0155","first-page":"2030","article-title":"Methodological challenges in studying the causal determinants of child growth","volume":"45","author":"Kramer","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.metabol.2017.06.008_bb0160","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.12191","article-title":"Adherence to the mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood","author":"Chatzi","year":"2017","journal-title":"Pediatr Obes"},{"issue":"11","key":"10.1016\/j.metabol.2017.06.008_bb0165","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.annepidem.2014.08.002","article-title":"A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood","volume":"24","author":"Perng","year":"2014","journal-title":"Ann Epidemiol"},{"issue":"12","key":"10.1016\/j.metabol.2017.06.008_bb0170","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1002\/oby.20894","article-title":"Longitudinal associations of sleep curtailment with metabolic risk in mid-childhood","volume":"22","author":"Cespedes","year":"2014","journal-title":"Obesity (Silver Spring)"},{"issue":"Supplement 1","key":"10.1016\/j.metabol.2017.06.008_bb0175","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.2337\/diacare.27.2007.S88","article-title":"Gestational diabetes mellitus","volume":"27","author":"Association AD","year":"2004","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.metabol.2017.06.008_bb0180","doi-asserted-by":"crossref","first-page":"e1473","DOI":"10.1542\/peds.2013-1274","article-title":"Changes in children's sleep duration on food intake, weight, and leptin","volume":"132","author":"Hart","year":"2013","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0185","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/MPG.0000000000000868","article-title":"Short sleep duration is related to emerging cardiovascular risk factors in obese children","volume":"61","author":"Navarro-Solera","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0190","doi-asserted-by":"crossref","first-page":"613","DOI":"10.5665\/sleep.3510","article-title":"Childhood sleep duration and quality in relation to leptin concentration in two cohort studies","volume":"37","author":"Boeke","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.metabol.2017.06.008_bb0195","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.metabol.2017.01.028","article-title":"Sleep apnea in relation to metabolism: An urgent need to study underlying mechanisms and to develop novel treatments for this unmet clinical need","volume":"69","author":"Farr","year":"2017","journal-title":"Metabolism"},{"issue":"23","key":"10.1016\/j.metabol.2017.06.008_bb0200","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1001\/jama.284.23.3015","article-title":"Longitudinal study of moderate weight change and sleep-disordered breathing","volume":"284","author":"Peppard","year":"2000","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/j.metabol.2017.06.008_bb0205","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1001\/jama.289.17.2230","article-title":"Incidence of sleep-disordered breathing in an urban adult population: The relative importance of risk factors in the development of sleep-disordered breathing","volume":"289","author":"Tishler","year":"2003","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.metabol.2017.06.008_bb0210","doi-asserted-by":"crossref","first-page":"641","DOI":"10.5665\/sleep.2618","article-title":"Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes","volume":"36","author":"Kuna","year":"2013","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0215","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11325-013-0806-7","article-title":"The impact of diet and lifestyle management strategies for obstructive sleep apnoea in adults: A systematic review and meta-analysis of randomised controlled trials","volume":"17","author":"Thomasouli","year":"2013","journal-title":"Sleep Breath"},{"issue":"9","key":"10.1016\/j.metabol.2017.06.008_bb0220","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"issue":"6","key":"10.1016\/j.metabol.2017.06.008_bb0225","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MCP.0000000000000099","article-title":"The impact of sleep and hypoxia on the brain: Potential mechanisms for the effects of obstructive sleep apnea","volume":"20","author":"Rosenzweig","year":"2014","journal-title":"Curr Opin Pulm Med"},{"issue":"9","key":"10.1016\/j.metabol.2017.06.008_bb0230","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.5665\/sleep.2950","article-title":"Executive dysfunction in osa before and after treatment: A meta-analysis","volume":"36","author":"Olaithe","year":"2013","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.metabol.2017.06.008_bb0235","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3945\/ajcn.111.027383","article-title":"Sleep restriction leads to increased activation of brain regions sensitive to food stimuli","volume":"95","author":"St-Onge","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0240","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ijo.2013.114","article-title":"Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals","volume":"38","author":"St-Onge","year":"2014","journal-title":"Int J Obes"},{"issue":"6","key":"10.1016\/j.metabol.2017.06.008_bb0245","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1378\/chest.13-1333","article-title":"A 4-year prospective follow-up study of childhood osa and its association with bp","volume":"145","author":"Li","year":"2014","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.metabol.2017.06.008_bb0250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.sleep.2013.09.011","article-title":"Long-term changes in blood pressure control in elementary school-aged children with sleep-disordered breathing","volume":"15","author":"Vlahandonis","year":"2014","journal-title":"Sleep Med"},{"issue":"2","key":"10.1016\/j.metabol.2017.06.008_bb0255","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsw054","article-title":"Sleep duration and adiposity in early childhood: Evidence for bidirectional associations from the born in bradford study","volume":"40","author":"Collings","year":"2017","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.metabol.2017.06.008_bb0260","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/DBP.0000000000000369","article-title":"Relationship of sleep duration and regularity with dietary intake among preschool-aged children with obesity from low-income families","volume":"38","author":"Petrov","year":"2017","journal-title":"J Dev Behav Pediatr"},{"key":"10.1016\/j.metabol.2017.06.008_bb0265","article-title":"Continuous positive airway pressure and diabetes risk in sleep apnea patients: A systemic review and meta-analysis","author":"Chen","year":"2016","journal-title":"Eur J Intern Med"},{"issue":"12","key":"10.1016\/j.metabol.2017.06.008_bb0270","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/jhh.2015.15","article-title":"Obstructive sleep apnea, hypertension and cardiovascular diseases","volume":"29","author":"Gonzaga","year":"2015","journal-title":"J Hum Hypertens"},{"issue":"1","key":"10.1016\/j.metabol.2017.06.008_bb0275","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5665\/sleep.5312","article-title":"A randomized controlled trial of continuous positive airway pressure on glucose tolerance in obese patients with obstructive sleep apnea","volume":"39","author":"Salord","year":"2016","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.metabol.2017.06.008_bb0280","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/dom.12823","article-title":"Effect of one week of cpap treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes","volume":"19","author":"Mokhlesi","year":"2017","journal-title":"Diabetes Obes Metab"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049517301804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049517301804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:14:44Z","timestamp":1758428084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049517301804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":56,"alternative-id":["S0026049517301804"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2017.06.008","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2017.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}