{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:05:07Z","timestamp":1784379907860,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.metabol.2018.01.010","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T08:25:07Z","timestamp":1517559907000},"page":"128-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis"],"prefix":"10.1016","volume":"83","author":[{"given":"Yui","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaho","family":"Watanabe-Kominato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remina","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2018.01.010_bb0005","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/ATVBAHA.115.305380","article-title":"Atherosclerosis","volume":"35","author":"Lu","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/cvr\/cvv147","article-title":"Monocyte trafficking across the vessel wall","volume":"107","author":"Gerhardt","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.metabol.2018.01.010_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cca.2013.06.006","article-title":"Foam cells in atherosclerosis","volume":"424","author":"Yu","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.metabol.2018.01.010_bb0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.115.306256","article-title":"Macrophage phenotype and function in different stages of atherosclerosis","volume":"118","author":"Tabas","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.metabol.2018.01.010_bb0025","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.atherosclerosis.2010.05.029","article-title":"Effect of endothelial cell proliferation on atherogenesis: a role of p21(Sdi\/Cip\/Waf1) in monocyte adhesion to endothelial cells","volume":"212","author":"Obikane","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2018.01.010_bb0030","first-page":"86","article-title":"The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis","volume":"39","author":"Rudijanto","year":"2007","journal-title":"Acta Med Indones"},{"key":"10.1016\/j.metabol.2018.01.010_bb0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fpls.2015.00163","article-title":"Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin","volume":"6","author":"Anil Kumar","year":"2015","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molcel.2004.11.050","article-title":"Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor","volume":"17","author":"Narasimhan","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2018.01.010_bb0045","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2174\/138920312804142129","article-title":"Osmotin, a pathogenesis-related protein","volume":"13","author":"Viktorova","year":"2012","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0050","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/oxfordjournals.jbchem.a021483","article-title":"Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma","volume":"120","author":"Nakano","year":"1996","journal-title":"J Biochem"},{"key":"10.1016\/j.metabol.2018.01.010_bb0055","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/prot.10571","article-title":"Crystal structure of osmotin, a plant antifungal protein","volume":"54","author":"Min","year":"2004","journal-title":"Proteins"},{"key":"10.1016\/j.metabol.2018.01.010_bb0060","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00425-013-1956-3","article-title":"Pepper osmotin-like protein 1 (CaOSM1) is an essential component for defense response, cell death, and oxidative burst in plants","volume":"238","author":"Choi","year":"2013","journal-title":"Planta"},{"key":"10.1016\/j.metabol.2018.01.010_bb0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/BF00014974","article-title":"Fine structure and function of the osmotin gene promoter","volume":"29","author":"Liu","year":"1995","journal-title":"Plant Mol Biol"},{"key":"10.1016\/j.metabol.2018.01.010_bb8070","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1097-2765(00)80080-5","article-title":"Osmotin, a plant antifungal protein, subverts signal transduction to enhance fungal cell susceptibility","volume":"1","author":"Yun","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2018.01.010_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/69357261-7e31-40e0-96ff-13cdc783c768","article-title":"Structural and functional similarities between osmotin from Nicotiana tabacum seeds and human adiponectin","volume":"6","author":"Miele","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.01.010_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065454","article-title":"A Saccharomyces cerevisiae assay system to investigate ligand\/AdipoR1 interactions that lead to cellular signaling","volume":"8","author":"Aouida","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.01.010_bb0080","doi-asserted-by":"crossref","first-page":"24493","DOI":"10.1038\/srep24493","article-title":"Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4\/NF\u03baB signaling pathway","volume":"6","author":"Badshah","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2018.01.010_bb0085","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3389\/fphys.2017.00611","article-title":"Osmotin protects H9c2 cells from simulated ischemia-reperfusion injury through AdipoR1\/PI3K\/AKT signaling pathway","volume":"8","author":"Liu","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0090","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1007\/s10620-011-1692-0","article-title":"Adiponectin and plant-derived mammalian adiponectin homolog exert a protective effect in murine colitis","volume":"56","author":"Arsenescu","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0095","first-page":"70","article-title":"Osmotin: a new adiponectin agonist, in type-II diabetes and obesity","volume":"16","author":"Trivedi","year":"2012","journal-title":"Int J Pharm Sci Rev Res"},{"key":"10.1016\/j.metabol.2018.01.010_bb0100","first-page":"196","article-title":"Antiatherosclerotic activity of osmotin, an adiponectin agonist in atherogenic diet induced hypertriglyceridemia and hypercholesterolemia in Wister rats","volume":"2","author":"Trivedi","year":"2012","journal-title":"Adv Res Pharm Biol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0105","series-title":"Genetic factors in coronary heart disease","first-page":"179","article-title":"Rat models for atherosclerosis","volume":"vol. 156","author":"Yamori","year":"1994"},{"key":"10.1016\/j.metabol.2018.01.010_bb0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.peptides.2016.06.009","article-title":"Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration","volume":"82","author":"Yamamoto","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.metabol.2018.01.010_bb0115","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jacbts.2016.07.008","article-title":"Atheroprotective effects of tumor necrosis factor-stimulated gene-6","volume":"6","author":"Watanabe","year":"2016","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005790","article-title":"Potent vasoconstrictor kisspeptin-10 induces atherosclerotic plaque progression and instability: reversal by its receptor GPR54 antagonist","volume":"6","author":"Sato","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.metabol.2018.01.010_bb0125","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1160\/TH17-05-0349","article-title":"Catestatin prevents macrophage-driven atherosclerosis but not arterial injury-induced neointimal hyperplasia","volume":"118","author":"Kojima","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.metabol.2018.01.010_bb0130","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.atherosclerosis.2016.01.037","article-title":"Facilitatory effects of fetuin-A on atherosclerosis","volume":"246","author":"Naito","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2018.01.010_bb0135","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/HYPERTENSIONAHA.113.01653","article-title":"Stimulatory effects of cardiotrophin 1 on atherosclerosis","volume":"62","author":"Konii","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.metabol.2018.01.010_bb0140","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/cvr\/cvw016","article-title":"Counteractive effects of omentin-1 against atherogenesis","volume":"110","author":"Watanabe","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.metabol.2018.01.010_bb0145","doi-asserted-by":"crossref","first-page":"11708","DOI":"10.1038\/srep11708","article-title":"Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus","volume":"5","author":"Ali","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2018.01.010_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100045","article-title":"Inflammatory biomarkers in atherosclerosis: pentraxin 3 can become a novel marker of plaque vulnerability","volume":"9","author":"Shindo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.01.010_bb0155","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.metabol.2013.07.007","article-title":"Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice","volume":"62","author":"Saraswathi","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2018.01.010_bb0160","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/CS20070347","article-title":"Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention","volume":"114","author":"Zhu","year":"2008","journal-title":"Clin Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0165","first-page":"107","article-title":"AdipoRon may be benefit for atherosclerosis prevention","volume":"20","author":"Esfahani","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.metabol.2018.01.010_bb0170","first-page":"296","article-title":"Adiponectin up-regulates the expression of T-cadherin in cardiomyocytes injured by hypoxia\/reoxygenation","volume":"64","author":"Wang","year":"2012","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.metabol.2018.01.010_bb0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1210\/en.2014-1618","article-title":"Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice","volume":"156","author":"Matsuda","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2018.01.010_bb0180","first-page":"725","article-title":"Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats","volume":"20","author":"Asada","year":"2007","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.metabol.2018.01.010_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.53","article-title":"Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain","volume":"5","author":"Naseer","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.metabol.2018.01.010_bb0190","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/mp.2016.23","article-title":"Novel osmotin inhibits SREBP2 via the AdipoR1\/AMPK\/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits","volume":"22","author":"Shah","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.metabol.2018.01.010_bb0195","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1158\/1078-0432.CCR-12-0930","article-title":"Molecular pathways: adiponectin and leptin signaling in cancer","volume":"19","author":"VanSaun","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"Suppl. A","key":"10.1016\/j.metabol.2018.01.010_bb0200","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.1016\/j.jvs.2007.02.061","article-title":"Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons","volume":"45","author":"Muto","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.metabol.2018.01.010_bb0205","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1253\/circj.CJ-14-0621","article-title":"Macrophage phenotypes and their modulation in atherosclerosis","volume":"78","author":"De Paoli","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.metabol.2018.01.010_bb0210","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000363025","article-title":"GLP-2 suppresses LPS-induced inflammation in macrophages by inhibiting ERK phosphorylation and NF-\u03baB activation","volume":"34","author":"Xie","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.metabol.2018.01.010_bb0215","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.HYP.0000184226.99196.b5","article-title":"Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages","volume":"46","author":"Watanabe","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.metabol.2018.01.010_bb0220","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/978-1-4419-0901-5_7","article-title":"Pattern recognition by pentraxins","volume":"653","author":"Agrawal","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fimmu.2012.00378","article-title":"Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps","volume":"3","author":"Daigo","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0230","first-page":"830421","article-title":"Pathogen recognition by the long pentraxin PTX3","volume":"2011","author":"Moalli","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0235","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pep.2016.09.008","article-title":"New findings in potential applications of tobacco osmotin","volume":"129","author":"Viktorova","year":"2017","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.metabol.2018.01.010_bb0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/cei.12442","article-title":"Immunotherapy with B cell epitopes ameliorates inflammatory responses in Balb\/c mice","volume":"179","author":"Sharma","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.metabol.2018.01.010_bb0245","first-page":"10619","article-title":"Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease","volume":"9","author":"Amin","year":"2017","journal-title":"Nano"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518300167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518300167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:17:08Z","timestamp":1758428228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049518300167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":50,"alternative-id":["S0026049518300167"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2018.01.010","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2018.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}