{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:52:21Z","timestamp":1793055141919,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2013M3A9D5072550"],"award-info":[{"award-number":["2013M3A9D5072550"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1135"],"award-info":[{"award-number":["HI14C1135"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF- 2016R1A2B4015866"],"award-info":[{"award-number":["NRF- 2016R1A2B4015866"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK083567"],"award-info":[{"award-number":["R01DK083567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.metabol.2018.04.006","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T01:33:12Z","timestamp":1523755992000},"page":"286-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome"],"prefix":"10.1016","volume":"85","author":[{"given":"Ah-Reum","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyong","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Taek","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Baik","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2018.04.006_bb0005","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/76.5.911","article-title":"Fructose, weight gain, and the insulin resistance syndrome","volume":"76","author":"Elliott","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2018.04.006_bb0010","doi-asserted-by":"crossref","first-page":"31646","DOI":"10.1074\/jbc.M200544200","volume":"277","author":"Haidari","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.04.006_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev-med-042010-113026","article-title":"Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome","volume":"63","author":"Stanhope","year":"2012","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.metabol.2018.04.006_bb0020","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3945\/ajcn.2008.27336","article-title":"Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes","volume":"89","author":"Le","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2018.04.006_bb0025","doi-asserted-by":"crossref","first-page":"G202","DOI":"10.1152\/ajpgi.00457.2010","article-title":"Intestinal fructose transport and malabsorption in humans","volume":"300","author":"Jones","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0030","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jada.2009.04.012","article-title":"The role of diet in symptoms of irritable bowel syndrome in adults: a narrative review","volume":"109","author":"Heizer","year":"2009","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.metabol.2018.04.006_bb0035","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1572-0241.2003.07476.x","article-title":"Fructose intolerance: an under-recognized problem","volume":"98","author":"Choi","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0040","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0300-5089(21)00577-0","article-title":"Carbohydrate absorption and malabsorption","volume":"12","author":"Ravich","year":"1983","journal-title":"Clin Gastroenterol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0045","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1152\/ajpendo.00712.2009","article-title":"Glucose transporters in the 21st Century","volume":"298","author":"Thorens","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2018.04.006_bb0050","doi-asserted-by":"crossref","first-page":"14523","DOI":"10.1016\/S0021-9258(18)42067-4","article-title":"Fructose transporter in human spermatozoa and small intestine is GLUT5","volume":"267","author":"Burant","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.04.006_bb0055","first-page":"364","article-title":"Intestinal fructose absorption: clinical and molecular aspects","volume":"28","author":"Corpe","year":"1999","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.metabol.2018.04.006_bb0060","doi-asserted-by":"crossref","first-page":"G666","DOI":"10.1152\/ajpgi.2001.281.3.G666","article-title":"GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation","volume":"281","author":"Jiang","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0065","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1074\/jbc.M808128200","article-title":"Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension","volume":"284","author":"Barone","year":"2009","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"10.1016\/j.metabol.2018.04.006_bb0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj3090271","article-title":"Regulation of GLUT5 gene expression in rat intestinal mucosa: regional distribution, circadian rhythm, perinatal development and effect of diabetes","volume":"309","author":"Castello","year":"1995","journal-title":"Biochem J"},{"key":"10.1016\/j.metabol.2018.04.006_bb0075","first-page":"G446","article-title":"Dietary fructose enhances intestinal fructose transport and GLUT5 expression in weaning rats","volume":"272","author":"Shu","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20101987","article-title":"Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine","volume":"435","author":"Suzuki","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.metabol.2018.04.006_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2008.03.036","article-title":"De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells","volume":"475","author":"Takabe","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.metabol.2018.04.006_bb0090","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2008.04.075","article-title":"Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44\/42 MAPK inhibitor and glucocorticoid hormone","volume":"371","author":"Mochizuki","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2018.04.006_bb0095","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0401516101","article-title":"Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis","volume":"101","author":"Iizuka","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2018.04.006_bb0100","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1073\/pnas.161284298","article-title":"A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver","volume":"98","author":"Yamashita","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2018.04.006_bb0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tem.2013.01.003","article-title":"Novel insights into ChREBP regulation and function","volume":"24","author":"Filhoulaud","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.metabol.2018.04.006_bb0110","doi-asserted-by":"crossref","first-page":"12019","DOI":"10.1074\/jbc.M413063200","article-title":"Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes","volume":"280","author":"Ma","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.04.006_bb0115","doi-asserted-by":"crossref","first-page":"15662","DOI":"10.1074\/jbc.M311301200","article-title":"Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes","volume":"279","author":"Stoeckman","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.04.006_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047948","article-title":"Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver","volume":"7","author":"Lanaspa","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.04.006_bb0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2009.09.109","article-title":"Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus","volume":"390","author":"Koo","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2018.04.006_bb0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.metabol.2016.10.002","article-title":"Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice","volume":"66","author":"Bae","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2018.04.006_bb0135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.metabol.2018.04.006_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022544","article-title":"Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression","volume":"6","author":"Jeong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.04.006_bb0145","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1074\/jbc.M605023200","article-title":"The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR","volume":"282","author":"Cha","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.04.006_bb0150","first-page":"1","article-title":"Irritable bowel syndrome: clinical manifestations, dietary influences, and management","volume":"5","author":"Ikechi","year":"2017","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.metabol.2018.04.006_bb0155","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/MCG.0b013e31802cbc2f","article-title":"Fructose intolerance in IBS and utility of fructose-restricted diet","volume":"42","author":"Choi","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0160","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1113\/jphysiol.1976.sp011307","article-title":"The utilization of glucose and production of lactate by in vitro preparations of rat small intestine: effects of vascular perfusion","volume":"255","author":"Hanson","year":"1976","journal-title":"J Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj2220057","article-title":"Absorption and metabolism of fructose by rat jejunum","volume":"222","author":"Holloway","year":"1984","journal-title":"Biochem J"},{"key":"10.1016\/j.metabol.2018.04.006_bb0170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cmet.2017.12.016","article-title":"The small intestine converts dietary fructose into glucose and organic acids","volume":"27","author":"Jang","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2018.04.006_bb0175","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1152\/physiolgenomics.00056.2004","article-title":"Fructose-responsive genes in the small intestine of neonatal rats","volume":"18","author":"Cui","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.metabol.2018.04.006_bb0180","doi-asserted-by":"crossref","first-page":"R1186","DOI":"10.1152\/ajpregu.00372.2016","article-title":"Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3","volume":"311","author":"Dominguez Rieg","year":"2016","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0167-4889(97)00155-9","article-title":"The small intestinal fructose transporters: site of dietary perception and evidence for diurnal and fructose sensitive control elements","volume":"1402","author":"Corpe","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.metabol.2018.04.006_bb0190","doi-asserted-by":"crossref","first-page":"G779","DOI":"10.1152\/ajpgi.00188.2015","article-title":"Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK\u2212 and GLUT5\u2212 mice","volume":"309","author":"Patel","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0195","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jada.2006.07.010","article-title":"Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management","volume":"106","author":"Shepherd","year":"2006","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.metabol.2018.04.006_bb0200","first-page":"G29","article-title":"NHE2 and NHE3 are human and rabbit intestinal brush-border proteins","volume":"270","author":"Hoogerwerf","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2018.04.006_bb0205","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 Na+\/H+ exchanger","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2018.04.006_bb0210","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1172\/JCI81993","article-title":"ChREBP regulates fructose-induced glucose production independently of insulin signaling","volume":"126","author":"Kim","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2018.04.006_bb0215","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1172\/JCI89934","article-title":"Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity","volume":"127","author":"Zhang","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2018.04.006_bb0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/2050640613505279","article-title":"Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance","volume":"2","author":"Wilder-Smith","year":"2014","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.metabol.2018.04.006_bb0225","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1172\/JCI119053","article-title":"Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption","volume":"98","author":"Wasserman","year":"1996","journal-title":"J Clin Invest"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518301069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518301069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:20:05Z","timestamp":1758428405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049518301069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":45,"alternative-id":["S0026049518301069"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2018.04.006","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2018.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}