{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:26:17Z","timestamp":1792801577620,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81270936"],"award-info":[{"award-number":["81270936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81570516"],"award-info":[{"award-number":["81570516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["16JC1404600"],"award-info":[{"award-number":["16JC1404600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support","award":["20152520"],"award-info":[{"award-number":["20152520"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.metabol.2018.05.004","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T12:26:15Z","timestamp":1525868775000},"page":"259-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype"],"prefix":"10.1016","volume":"85","author":[{"given":"Huan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2018.05.004_bb0005","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.tem.2016.08.006","article-title":"Sarcolipin: a key thermogenic and metabolic regulator in skeletal muscle","volume":"27","author":"Pant","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.metabol.2018.05.004_bb0010","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1242\/jcs.114041","article-title":"Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies","volume":"126","author":"Sandri","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.metabol.2018.05.004_bb0015","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35022604","article-title":"Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)","volume":"406","author":"Nishino","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2018.05.004_bb0020","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrm2745","article-title":"Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function","volume":"10","author":"Saftig","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.metabol.2018.05.004_bb0025","doi-asserted-by":"crossref","first-page":"21327","DOI":"10.1016\/S0021-9258(18)54636-6","article-title":"Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking","volume":"266","author":"Fukuda","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2018.05.004_bb0030","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbrc.2016.05.122","article-title":"Spontaneous nonalcoholic fatty liver disease and ER stress in Sidt2 deficiency mice","volume":"476","author":"Gao","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2018.05.004_bb0035","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.bbrc.2010.09.133","article-title":"SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal membrane protein","volume":"402","author":"Jialin","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2018.05.004_bb0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/1873-3468.12528","article-title":"Identification of Sidt2 as a lysosomal cation-conducting protein","volume":"591","author":"Beck","year":"2017","journal-title":"FEBS Lett"},{"key":"10.1016\/j.metabol.2018.05.004_bb0045","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/15548627.2016.1145325","article-title":"Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes","volume":"12","author":"Aizawa","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.metabol.2018.05.004_bb0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.immuni.2017.08.007","article-title":"SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition","volume":"47","author":"Nguyen","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.metabol.2018.05.004_bb0055","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddh077","article-title":"Alzheimer's disease: one disorder, too many genes?","volume":"13","author":"Bertram","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metabol.2018.05.004_bb0060","article-title":"Impaired glucose tolerance in a mouse model of sidt2 deficiency","volume":"8","author":"Gao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2018.05.004_bb0065","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1194\/jlr.M073817","article-title":"Sidt2 regulates hepatocellular lipid metabolism through autophagy","volume":"59","author":"Chen","year":"2018","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2018.05.004_bb0070","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.2337\/db11-0851","article-title":"A novel cellular defect in diabetes: membrane repair failure","volume":"60","author":"Howard","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2018.05.004_bb0075","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2337\/dc09-0264","article-title":"Excessive loss of skeletal muscle mass in older adults with type 2 diabetes","volume":"32","author":"Park","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2018.05.004_bb0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1097-2765(00)80155-0","article-title":"A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance","volume":"2","author":"Bruning","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2018.05.004_bb0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1530\/JME-15-0227","article-title":"SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules","volume":"56","author":"Chang","year":"2016","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.metabol.2018.05.004_bb0090","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jneumeth.2011.10.001","article-title":"Noninvasive in vivo assessment of muscle impairment in the mdx mouse model\u2014a comparison of two common wire hanging methods with two different results","volume":"203","author":"Klein","year":"2012","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.metabol.2018.05.004_bb0095","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2337\/db10-1540","article-title":"Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts","volume":"60","author":"Liu","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2018.05.004_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/684965","article-title":"Myostatin activates the ubiquitin-proteasome and autophagy-lysosome systems contributing to muscle wasting in chronic kidney disease","volume":"2015","author":"Wang","year":"2015","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.metabol.2018.05.004_bb0105","doi-asserted-by":"crossref","first-page":"10815","DOI":"10.1523\/JNEUROSCI.0987-13.2013","article-title":"Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease","volume":"33","author":"Micsenyi","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.metabol.2018.05.004_bb0110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10585-005-6244-6","article-title":"Metastasis predictive signature profiles pre-exist in normal tissues","volume":"22","author":"Yang","year":"2005","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.metabol.2018.05.004_bb0115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10974-013-9350-0","article-title":"Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy","volume":"34","author":"Schneider","year":"2013","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.metabol.2018.05.004_bb0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1083\/jcb.201212142","article-title":"The cell biology of disease: cellular and molecular mechanisms underlying muscular dystrophy","volume":"201","author":"Rahimov","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.metabol.2018.05.004_bb0125","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.3611","article-title":"The intracellular Ca(2)(+) channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy","volume":"20","author":"Cheng","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2018.05.004_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.metabol.2018.05.004_bb0135","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.metabol.2018.05.004_bb0140","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1021\/pr060407o","article-title":"Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins","volume":"6","author":"Zhang","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1016\/j.metabol.2018.05.004_bb0145","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2006.05.034","article-title":"DRAM, a p53-induced modulator of autophagy, is critical for apoptosis","volume":"126","author":"Crighton","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.metabol.2018.05.004_bb0150","doi-asserted-by":"crossref","first-page":"80909","DOI":"10.18632\/oncotarget.20757","article-title":"6-Phosphofructo-2-kinase\/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway","volume":"8","author":"Yan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.metabol.2018.05.004_bb0155","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41467-018-02950-5","article-title":"Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2018.05.004_bb0160","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.metabol.2016.03.005","article-title":"Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle","volume":"65","author":"Tsompanidis","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2018.05.004_bb0165","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/35022595","article-title":"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice","volume":"406","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2018.05.004_bb0170","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","article-title":"In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker","volume":"15","author":"Mizushima","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.metabol.2018.05.004_bb0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tibs.2013.12.001","article-title":"At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy","volume":"39","author":"Shen","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.metabol.2018.05.004_bb0180","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.biocel.2013.04.023","article-title":"Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome","volume":"45","author":"Sandri","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.metabol.2018.05.004_bb0185","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/emmm.201202057","article-title":"Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease","volume":"5","author":"Nemazanyy","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.metabol.2018.05.004_bb0190","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1093\/hmg\/ddn292","article-title":"Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease","volume":"17","author":"Raben","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metabol.2018.05.004_bb0195","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13238-016-0269-2","article-title":"Deacetylation of TFEB promotes fibrillar Abeta degradation by upregulating lysosomal biogenesis in microglia","volume":"7","author":"Bao","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.metabol.2018.05.004_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166080","article-title":"A one-step immunostaining method to visualize rodent muscle fiber type within a single specimen","volume":"11","author":"Sawano","year":"2016","journal-title":"PLoS One"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518301215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049518301215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:19:40Z","timestamp":1758428380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049518301215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":40,"alternative-id":["S0026049518301215"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2018.05.004","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2018.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}