{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:44:17Z","timestamp":1792424657458,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"am","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.metabol.2019.01.006","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T01:41:13Z","timestamp":1547862073000},"page":"153865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"S","title":["Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting"],"prefix":"10.1016","volume":"103","author":[{"given":"Justine","family":"Bacchetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bardet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Pri\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0005","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1365-2044.1998.00463.x","article-title":"Hypophosphataemia. Pathophysiology, effects and management on the intensive care unit","volume":"53","author":"Bugg","year":"1998","journal-title":"Anaesthesia"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0010","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.ajkd.2011.08.035","article-title":"Evaluation of hypophosphatemia: lessons from patients with genetic disorders","volume":"59","author":"Bacchetta","year":"2012","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"issue":"Suppl. 1","key":"10.1016\/j.metabol.2019.01.006_bb0015","first-page":"584","article-title":"Evaluation of bone and mineral disorders","volume":"5","author":"Ardeshirpour","year":"2007","journal-title":"Pediatr Endocrinol Rev"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0020","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/EC-13-0103","article-title":"Therapeutic management of hypophosphatemic rickets from infancy to adulthood","volume":"3","author":"Linglart","year":"2014","journal-title":"Endocr Connect"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","author":"ADHR Consortium","year":"2000","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.metabol.2019.01.006_bb0030","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0035","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bone.2006.12.062","article-title":"FGF23 is a hormone-regulating phosphate metabolism\u2014unique biological characteristics of FGF23","volume":"40","author":"Fukumoto","year":"2007","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1744-9987.2005.00288.x","article-title":"Structural and biochemical properties of fibroblast growth factor 23","volume":"9","author":"Yamashita","year":"2005","journal-title":"Ther Apher Dial"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2169\/internalmedicine.47.0730","article-title":"Physiological regulation and disorders of phosphate metabolism\u2014pivotal role of fibroblast growth factor 23","volume":"47","author":"Fukumoto","year":"2008","journal-title":"Intern Med"},{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0050","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ki.2008.643","article-title":"Latest findings in phosphate homeostasis","volume":"75","author":"Pri\u00e9","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.metabol.2019.01.006_bb0055","article-title":"The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases","author":"Hannan","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"10.1016\/j.metabol.2019.01.006_bb0060","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.bone.2007.01.017","article-title":"Mineralized tissue cells are a principal source of FGF23","volume":"40","author":"Yoshiko","year":"2007","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0065","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1359\/jbmr.080417","article-title":"Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23","volume":"23","author":"Yamazaki","year":"2008","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"12","key":"10.1016\/j.metabol.2019.01.006_bb0070","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Ben-Dov","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0075","first-page":"229","article-title":"FGF23 promotes renal calcium reabsorption through the TRPV5 channel","volume":"33","author":"Andrukhova","year":"2014","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mce.2008.10.052","article-title":"The Klotho gene family as a regulator of endocrine fibroblast growth factors","volume":"299","author":"Kurosu","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0085","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1681\/ASN.2008070783","article-title":"Initial FGF23-mediated signaling occurs in the distal convoluted tubule","volume":"20","author":"Farrow","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0090","first-page":"3438","article-title":"Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"5747","key":"10.1016\/j.metabol.2019.01.006_bb0095","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1114245","article-title":"The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel","volume":"310","author":"Chang","year":"2005","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.metabol.2019.01.006_bb0100","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.metabol.2019.01.006_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003975","article-title":"Parathyroid-specific deletion of klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion","volume":"9","author":"Olauson","year":"2013","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbmr.1740","article-title":"Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes","volume":"28","author":"Bacchetta","year":"2013","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1681\/ASN.2014101009","article-title":"Low vitamin D and high fibroblast growth factor 23 serum levels associate with infectious and cardiac deaths in the HEMO study","volume":"27","author":"Chonchol","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.metabol.2019.01.006_bb0120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/emmm.201303716","article-title":"FGF23 regulates renal sodium handling and blood pressure","volume":"6","author":"Andrukhova","year":"2014","journal-title":"EMBO Mol Med"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0125","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/jnc.13585","article-title":"Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density","volume":"137","author":"Hensel","year":"2016","journal-title":"J Neurochem"},{"issue":"9\u201310","key":"10.1016\/j.metabol.2019.01.006_bb0130","first-page":"645","article-title":"Changes in plasma FGF23 in growth hormone deficient children during rhGH therapy","volume":"24","author":"Gardner","year":"2011","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0135","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.kint.2016.09.016","article-title":"Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression","volume":"91","author":"Rutkowski","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.metabol.2019.01.006_bb0140","article-title":"Circulating adiponectin modifies the FGF23 response to vitamin D receptor activation: a post hoc analysis of a double-blind, randomized clinical trial","author":"Spoto","year":"2018","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.kint.2016.11.009","article-title":"And the fat lady sings about phosphate and calcium","volume":"91","author":"Wagner","year":"2017","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0150","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int"},{"issue":"11","key":"10.1016\/j.metabol.2019.01.006_bb0155","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1210\/jc.2011-1239","article-title":"Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans","volume":"96","author":"Imel","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.metabol.2019.01.006_bb0160","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1681\/ASN.2016121350","article-title":"C-terminal fibroblast growth factor 23, Iron deficiency, and mortality in renal transplant recipients","volume":"28","author":"Eisenga","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.metabol.2019.01.006_bb0165","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.1923","article-title":"Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women","volume":"28","author":"Wolf","year":"2013","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"key":"10.1016\/j.metabol.2019.01.006_bb0170","doi-asserted-by":"crossref","first-page":"16011","DOI":"10.1038\/boneres.2016.11","article-title":"The hypoxia-inducible factor-1\u03b1 activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia","volume":"4","author":"Zhang","year":"2016","journal-title":"Bone Res"},{"issue":"11","key":"10.1016\/j.metabol.2019.01.006_bb0175","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.3324\/haematol.2017.167882","article-title":"Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow","volume":"102","author":"Clinkenbeard","year":"2017","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0180","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.3324\/haematol.2016.150987","article-title":"Carboxy-terminal fragment of fibroblast growth factor 23 induces heart hypertrophy in sickle cell disease","volume":"102","author":"Courbebaisse","year":"2017","journal-title":"Haematologica"},{"issue":"46","key":"10.1016\/j.metabol.2019.01.006_bb0185","doi-asserted-by":"crossref","first-page":"E1146","DOI":"10.1073\/pnas.1110905108","article-title":"Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice","volume":"108","author":"Farrow","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.metabol.2019.01.006_bb0190","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1359\/jbmr.060507","article-title":"Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women","volume":"21","author":"Burnett","year":"2006","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"10","key":"10.1016\/j.metabol.2019.01.006_bb0195","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1093\/ndt\/gfq263","article-title":"Direct micropuncture evidence that matrix extracellular phosphoglycoprotein inhibits proximal tubular phosphate reabsorption","volume":"25","author":"Shirley","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0200","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3109\/03008207.2012.753879","article-title":"Fibroblast growth factor 23 and klotho are present in the growth plate","volume":"54","author":"Raimann","year":"2013","journal-title":"Connect Tissue Res"},{"issue":"6","key":"10.1016\/j.metabol.2019.01.006_bb0205","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1359\/jbmr.080220","article-title":"Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro","volume":"23","author":"Wang","year":"2008","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0210","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jbmr.2606","article-title":"FGF23 regulates bone mineralization in a 1,25(OH)2 D3 and Klotho-independent manner","volume":"31","author":"Murali","year":"2016","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"5","key":"10.1016\/j.metabol.2019.01.006_bb0215","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1096\/fj.201601036R","article-title":"Klotho expression in long bones regulates FGF23 production during renal failure","volume":"31","author":"Kaludjerovic","year":"2017","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00223-015-0013-6","article-title":"Biphasic effects of vitamin D and FGF23 on human osteoclast biology","volume":"97","author":"Allard","year":"2015","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0225","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1074\/jbc.M112.410043","article-title":"FGF23 suppresses chondrocyte proliferation in the presence of soluble \u03b1-Klotho both in vitro and in vivo","volume":"288","author":"Kawai","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.metabol.2019.01.006_bb0230","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/ar.21152","article-title":"Ablation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex","volume":"293","author":"Chu","year":"2010","journal-title":"Anat Rec (Hoboken)"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0235","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1210\/jc.2009-1671","article-title":"Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations","volume":"95","author":"Imel","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0240","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1681\/ASN.2009121293","article-title":"Forging forward with 10 burning questions on FGF23 in kidney disease","volume":"21","author":"Wolf","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0245","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/EJE-14-0457","article-title":"Soluble Klotho and intact fibroblast growth factor 23 in long-term kidney transplant patients","volume":"172","author":"Bleskestad","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0250","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.metabol.2019.01.006_bb0255","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1681\/ASN.2006121385","article-title":"Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice","volume":"18","author":"Stubbs","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0260","first-page":"827","article-title":"Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23","volume":"23","author":"Marsell","year":"2008","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0265","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng1095-130","volume":"11","year":"1995","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.metabol.2019.01.006_bb0270","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1210\/endo.142.9.8403","article-title":"Cloning and characterization of the proximal murine Phex promoter","volume":"142","author":"Liu","year":"2001","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.metabol.2019.01.006_bb0275","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1152\/ajpendo.00008.2006","article-title":"Pathogenic role of Fgf23 in Hyp mice","volume":"291","author":"Liu","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.metabol.2019.01.006_bb0280","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/154405910708600210","article-title":"Phex mutation causes the reduction of npt2b mRNA in teeth","volume":"86","author":"Onishi","year":"2007","journal-title":"J Dent Res"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0285","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jbmr.1766","article-title":"Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia","volume":"28","author":"Barros","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2019.01.006_bb0290","article-title":"Hormonal regulation of osteocyte perilacunar and canalicular remodeling in the Hyp mouse model of X-linked hypophosphatemia","author":"Tokarz","year":"2017","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00223-009-9270-6","article-title":"Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice","volume":"85","author":"Liang","year":"2009","journal-title":"Calcif Tissue Int"},{"issue":"10","key":"10.1016\/j.metabol.2019.01.006_bb0300","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/JC.2015-2199","article-title":"Conventional therapy in adults with X-linked hypophosphatemia: effects on enthesopathy and dental disease","volume":"100","author":"Connor","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.metabol.2019.01.006_bb0305","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1359\/jbmr.090509","article-title":"Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets\/osteomalacia","volume":"24","author":"Aono","year":"2009","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"4","key":"10.1016\/j.metabol.2019.01.006_bb0310","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1172\/JCI72829","article-title":"Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia","volume":"124","author":"Carpenter","year":"2014","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.metabol.2019.01.006_bb0315","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1172\/JCI61405","article-title":"FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality","volume":"122","author":"Shalhoub","year":"2012","journal-title":"J Clin Invest"},{"issue":"21","key":"10.1016\/j.metabol.2019.01.006_bb0320","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1056\/NEJMoa1714641","article-title":"Burosumab therapy in children with X-linked hypophosphatemia","volume":"378","author":"Carpenter","year":"2018","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.metabol.2019.01.006_bb0325","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1507\/endocrj.EJ16-0199","article-title":"Hypertension is a characteristic complication of X-linked hypophosphatemia","volume":"64","author":"Nakamura","year":"2017","journal-title":"Endocr J"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519300216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519300216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:22:35Z","timestamp":1758428555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049519300216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":65,"alternative-id":["S0026049519300216"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2019.01.006","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2019.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153865"}}