{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:18:49Z","timestamp":1790198329231,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.metabol.2019.07.001","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:08:52Z","timestamp":1562238532000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study"],"prefix":"10.1016","volume":"99","author":[{"given":"Ha-Na","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2019.07.001_bb0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0140-6736(09)61794-3","article-title":"The metabolic syndrome","volume":"375","author":"Eckel","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.001_bb0010","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.001_bb0015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/ATVBAHA.107.151092","article-title":"Metabolic syndrome pandemic","volume":"28","author":"Grundy","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-200512000-00006","article-title":"The key role of insulin resistance in the cardiometabolic syndrome","volume":"330","author":"Gill","year":"2005","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.metabol.2019.07.001_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2009.02.026","article-title":"Oxidative stress and metabolic syndrome","volume":"84","author":"Roberts","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.metabol.2019.07.001_bb0030","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1089\/met.2004.2.82","article-title":"The metabolic syndrome and inflammation","volume":"2","author":"Sutherland","year":"2004","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.metabol.2019.07.001_bb0035","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2019.07.001_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.15159","article-title":"Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study","volume":"33","author":"Fernandez-Armenteros","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.clindermatol.2017.09.005","article-title":"Psoriasis and the metabolic syndrome","volume":"36","author":"Gisondi","year":"2018","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2017.04.1133","article-title":"Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome","volume":"77","author":"Rodriguez-Zuniga","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/bjd.16885","article-title":"Metabolic syndrome and risk of incident psoriasis: prospective data from the HUNT study, Norway","volume":"180","author":"Snekvik","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0060","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4093\/dmj.2014.38.5.395","article-title":"Background and data configuration process of a nationwide population-based study using the Korean national health insurance system","volume":"38","author":"Song","year":"2014","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.metabol.2019.07.001_bb0065","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute scientific statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.001_bb0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.diabres.2006.04.013","article-title":"Appropriate waist circumference cutoff points for central obesity in Korean adults","volume":"75","author":"Lee","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.metabol.2019.07.001_bb0075","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S1368980008002802","article-title":"Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians","volume":"12","author":"Wen","year":"2009","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.metabol.2019.07.001_bb0080","article-title":"An update on psoriasis and metabolic syndrome: a meta-analysis of observational studies","volume":"12","author":"Singh","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2019.07.001_bb0085","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/jid.2011.365","article-title":"Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom","volume":"132","author":"Langan","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0090","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/jdv.12595","article-title":"The association of metabolic syndrome and psoriasis: a population- and hospital-based cross-sectional study","volume":"29","author":"Miller","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0095","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s40257-014-0074-8","article-title":"Metabolic syndrome prevalence in psoriasis: a cross-sectional study in the Italian population","volume":"15","author":"Parodi","year":"2014","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0100","doi-asserted-by":"crossref","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.metabol.2019.07.001_bb0105","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1038\/ncomms8687","article-title":"Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from gammadelta-T cells","volume":"6","author":"Shibata","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2019.07.001_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-016-9381-0","article-title":"Adipokines in psoriasis: an important link between skin inflammation and metabolic alterations","volume":"17","author":"Wolk","year":"2016","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.metabol.2019.07.001_bb0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2340\/00015555-2227","article-title":"Insulin resistance may contribute to upregulation of adhesion molecules on endothelial cells in psoriatic plaques","volume":"96","author":"Schluter","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/ijd.13699","article-title":"Adipokines, psoriasis, systemic inflammation, and endothelial dysfunction","volume":"56","author":"Lynch","year":"2017","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2019.07.001_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15071486","article-title":"Psoriasis severity-a risk factor of insulin resistance independent of metabolic syndrome","volume":"15","author":"Polic","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.metabol.2019.07.001_bb0135","doi-asserted-by":"crossref","DOI":"10.1001\/jamadermatol.2013.9957","article-title":"Hypertension, antihypertensive medication use, and risk of psoriasis","volume":"150","author":"Wu","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0140","article-title":"Hypertension and risk of psoriasis incidence: an 11-year nationwide population-based cohort study","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2019.07.001_bb0145","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41598-017-01983-y","article-title":"Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2019.07.001_bb0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bjd.17328","article-title":"The multifaceted association between psoriasis and obesity","volume":"180","author":"Gisondi","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002739","article-title":"Evidence of a causal relationship between body mass index and psoriasis: a Mendelian randomization study","volume":"16","author":"Budu-Aggrey","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.metabol.2019.07.001_bb0160","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.17741","article-title":"Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? A critically-appraised topic","author":"Mahil","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0165","article-title":"Prevalence of psoriasis in China: a population-based study in six cities","volume":"22","author":"Ding","year":"2012","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0170","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006450","article-title":"Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database","volume":"5","author":"Kubota","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.metabol.2019.07.001_bb0175","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-0642","article-title":"Epidemiological study of psoriasis in the national health insurance database in Taiwan","volume":"89","author":"Chang","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0180","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2340\/00015555-2877","article-title":"Epidemiology and medication trends in patients with psoriasis: a nationwide population-based cohort study from Korea","volume":"98","author":"Han","year":"2018","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2008.09.022","article-title":"The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004","volume":"60","author":"Kurd","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0195","doi-asserted-by":"crossref","DOI":"10.1001\/jamadermatol.2013.5015","article-title":"Psoriasis severity and the prevalence of major medical comorbidity: a population-based study","volume":"149","author":"Yeung","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.metabol.2019.07.001_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2016.07.065","article-title":"Psoriasis and comorbid diseases: epidemiology","volume":"76","author":"Takeshita","year":"2017","journal-title":"J Am Acad Dermatol"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519301349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519301349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:20:12Z","timestamp":1758428412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049519301349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":40,"alternative-id":["S0026049519301349"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2019.07.001","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2019.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}