{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:44:02Z","timestamp":1791459842494,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.metabol.2019.07.008","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T08:04:35Z","timestamp":1570781075000},"page":"153944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"S","title":["Fine particle environmental pollution and cardiovascular diseases"],"prefix":"10.1016","volume":"100","author":[{"given":"Alain","family":"Combes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Franchineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2019.07.008_bb0005","unstructured":"WHO air quality guidelines - global update 2018, last accessed Nov 30th 2018."},{"key":"10.1016\/j.metabol.2019.07.008_bb0010","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.008_bb0015","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(17)30505-6","article-title":"Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015","volume":"389","author":"Cohen","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0025","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0030","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1001\/jama.2012.3488","article-title":"Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults","volume":"307","author":"Rich","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2019.07.008_bb0035","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1093\/eurheartj\/ehn464","article-title":"Diesel exhaust inhalation increases thrombus formation in man","volume":"29","author":"Lucking","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.metabol.2019.07.008_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-8977-10-7","article-title":"A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans","volume":"10","author":"Krishnan","year":"2013","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0045","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1056\/NEJMoa066314","article-title":"Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease","volume":"357","author":"Mills","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2019.07.008_bb0050","doi-asserted-by":"crossref","first-page":"32916","DOI":"10.1038\/srep32916","article-title":"Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract","volume":"6","author":"Lakey","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2019.07.008_bb0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/ATVBAHA.117.309971","article-title":"Inhalation of fine particulate matter impairs endothelial progenitor cell function via pulmonary oxidative stress","volume":"38","author":"Haberzettl","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0060","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1289\/EHP212","article-title":"Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress","volume":"124","author":"Haberzettl","year":"2016","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0065","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1289\/ehp.11027","article-title":"Diesel exhaust inhalation elicits acute vasoconstriction in vivo","volume":"116","author":"Peretz","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCRESAHA.110.222679","article-title":"Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells","volume":"107","author":"O'Toole","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.metabol.2019.07.008_bb0075","doi-asserted-by":"crossref","unstructured":"Cai Y, Zhang B, Ke W, Feng B, Lin H, Xiao J, et al. Associations of short-term and long-term exposure to ambient air pollutants with hypertension: a systematic review and meta-analysis. Hypertension. 2016;68:62\u201370.","DOI":"10.1161\/HYPERTENSIONAHA.116.07218"},{"key":"10.1016\/j.metabol.2019.07.008_bb0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCULATIONAHA.113.003532","article-title":"Spatial association between ambient fine particulate matter and incident hypertension","volume":"129","author":"Chen","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.008_bb0085","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.envpol.2018.01.001","article-title":"Global association between ambient air pollution and blood pressure: a systematic review and meta-analysis","volume":"235","author":"Yang","year":"2018","journal-title":"Environ pollution (Barking, Essex: 1987)"},{"key":"10.1016\/j.metabol.2019.07.008_bb0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12012-014-9272-0","article-title":"Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure","volume":"15","author":"Perez","year":"2015","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.1307151","article-title":"Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation","volume":"122","author":"Ying","year":"2014","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1513\/pats.200909-097RM","article-title":"Gene by environment interaction and ambient air pollution","volume":"7","author":"Romieu","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.metabol.2019.07.008_bb0105","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/all.12298","article-title":"GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma","volume":"68","author":"Su","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.metabol.2019.07.008_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099043","article-title":"Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study","volume":"9","author":"Levinsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2019.07.008_bb0115","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/thx.2009.119636","article-title":"Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma","volume":"65","author":"Kerkhof","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.metabol.2019.07.008_bb0120","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(16)31679-8","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0125","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1056\/NEJMoa1702747","article-title":"Air pollution and mortality in the Medicare population","volume":"376","author":"Di","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2019.07.008_bb0130","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1289\/ehp.1104049","article-title":"Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study","volume":"120","author":"Crouse","year":"2012","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0135","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1001\/jama.2017.17923","article-title":"Association of short-term exposure to air pollution with mortality in older adults","volume":"318","author":"Di","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2019.07.008_bb0140","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1289\/ehp.11345","article-title":"Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study","volume":"116","author":"Samoli","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/jama.2012.126","article-title":"Main air pollutants and myocardial infarction: a systematic review and meta-analysis","volume":"307","author":"Mustafic","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2019.07.008_bb0150","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0140-6736(10)62296-9","article-title":"Public health importance of triggers of myocardial infarction: a comparative risk assessment","volume":"377","author":"Nawrot","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0155","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/eurheartj\/ehs480","article-title":"Long-term exposure to air pollution is associated with survival following acute coronary syndrome","volume":"34","author":"Tonne","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.metabol.2019.07.008_bb0160","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002506","article-title":"Short-term exposure to fine particulate matter air pollution is preferentially associated with the risk of ST-segment elevation acute coronary events","volume":"4","author":"Pope","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.metabol.2019.07.008_bb0165","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMoa054409","article-title":"Long-term exposure to air pollution and incidence of cardiovascular events in women","volume":"356","author":"Miller","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2019.07.008_bb0170","doi-asserted-by":"crossref","first-page":"f7412","DOI":"10.1136\/bmj.f7412","article-title":"Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE project","volume":"348","author":"Cesaroni","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2019.07.008_bb0175","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(16)00378-0","article-title":"Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study","volume":"388","author":"Kaufman","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0180","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1161\/CIRCULATIONAHA.114.011489","article-title":"Roadway proximity and risk of sudden cardiac death in women","volume":"130","author":"Hart","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.008_bb0185","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.hrtlng.2016.08.001","article-title":"Association between air pollution and development of atrial fibrillation: a meta-analysis of observational studies","volume":"45","author":"Shao","year":"2016","journal-title":"Heart Lung"},{"key":"10.1016\/j.metabol.2019.07.008_bb0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/eurheartj\/ehu458","article-title":"Expert position paper on air pollution and cardiovascular disease","volume":"36","author":"Newby","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.metabol.2019.07.008_bb0195","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/EDE.0b013e3181d61600","article-title":"Air pollution and activation of implantable cardioverter defibrillators in London","volume":"21","author":"Anderson","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.metabol.2019.07.008_bb0200","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.amjcard.2009.04.046","article-title":"T-wave alternans, air pollution and traffic in high-risk subjects","volume":"104","author":"Zanobetti","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0205","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(13)60898-3","article-title":"Global association of air pollution and heart failure: a systematic review and meta-analysis","volume":"382","author":"Shah","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2019.07.008_bb0210","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.amjcard.2017.11.039","article-title":"Effect of ambient air pollution on hospitalization for heart failure in 26 of China's largest cities","volume":"121","author":"Liu","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0215","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1164\/rccm.201312-2298OC","article-title":"Traffic-related air pollution and the right ventricle. The multi-ethnic study of atherosclerosis","volume":"189","author":"Leary","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.metabol.2019.07.008_bb0220","doi-asserted-by":"crossref","first-page":"h1295","DOI":"10.1136\/bmj.h1295","article-title":"Short term exposure to air pollution and stroke: systematic review and meta-analysis","volume":"350","author":"Shah","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2019.07.008_bb0225","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/STROKEAHA.117.019580","article-title":"Residential proximity to major roadways and risk of incident ischemic stroke in NOMAS (The Northern Manhattan Study)","volume":"49","author":"Kulick","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.metabol.2019.07.008_bb0230","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1161\/STROKEAHA.117.018816","article-title":"Synergism of short-term air pollution exposures and neighborhood disadvantage on initial stroke severity","volume":"48","author":"Wing","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.metabol.2019.07.008_bb0235","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1289\/ehp.1307301","article-title":"Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project","volume":"122","author":"Stafoggia","year":"2014","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0240","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/EJE-14-0365","article-title":"Effect of long-term exposure to air pollution on type 2 diabetes mellitus risk: a systemic review and meta-analysis of cohort studies","volume":"171","author":"Wang","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2019.07.008_bb0245","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1289\/ehp.1307823","article-title":"Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis","volume":"123","author":"Eze","year":"2015","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.metabol.2019.07.008_bb0250","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1164\/rccm.201205-0850OC","article-title":"Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics","volume":"186","author":"Huang","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.metabol.2019.07.008_bb0255","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/CIRCULATIONAHA.117.030377","article-title":"Developing a clinical approach to air pollution and cardiovascular health","volume":"137","author":"Hadley","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2019.07.008_bb0260","first-page":"2891","article-title":"Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity","volume":"2016","author":"Tong","year":"1860","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.metabol.2019.07.008_bb0265","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJMms1615242","article-title":"The Trump administration and the environment - heed the science","volume":"376","author":"Samet","year":"2017","journal-title":"N Engl J Med"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519301416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049519301416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:20:41Z","timestamp":1758428441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049519301416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":53,"alternative-id":["S0026049519301416"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2019.07.008","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fine particle environmental pollution and cardiovascular diseases","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2019.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153944"}}