{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:11:20Z","timestamp":1778505080279,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.metabol.2020.154354","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T02:48:53Z","timestamp":1599619733000},"page":"154354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Urinary GC\u2013MS steroid metabotyping in treated children with congenital adrenal hyperplasia."],"prefix":"10.1016","volume":"112","author":[{"given":"Clemens","family":"Kamrath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela F.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Pons-K\u00fchnemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan A.","family":"Wudy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.metabol.2020.154354_bb0005","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"103","author":"Speiser","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Part B","key":"10.1016\/j.metabol.2020.154354_bb0010","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jsbmb.2016.08.006","article-title":"The urinary steroidome of treated children with CAH","volume":"165","author":"Kamrath","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"8","key":"10.1016\/j.metabol.2020.154354_bb0015","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1373\/clinchem.2010.146035","article-title":"Monitoring of therapy in congenital adrenal hyperplasia","volume":"56","author":"Dauber","year":"2010","journal-title":"Clin. Chem."},{"issue":"9","key":"10.1016\/j.metabol.2020.154354_bb0020","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1210\/jc.2019-00438","article-title":"Height velocity defined metabolic control in children with congenital adrenal hyperplasia using urinary steroid GC-MS analysis","volume":"104","author":"Kamrath","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.metabol.2020.154354_bb0025","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1210\/jcem.86.10.7972","article-title":"Serum cortisol and 17-hydroxyprogesterone interrelation in classic 21-hydroxylase deficiency: is current replacement therapy satisfactory?","volume":"86","author":"Charmandari","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.metabol.2020.154354_bb0030","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/cen.12653","article-title":"Variation in absorption and half-life of hydrocortisone influence plasma cortisol concentrations","volume":"82","author":"Hindmarsh","year":"2015","journal-title":"Clin. Endocrinol."},{"issue":"4","key":"10.1016\/j.metabol.2020.154354_bb0035","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1542\/peds.2013-1451","article-title":"Medication adherence and health care utilization in pediatric chronic illness: a systematic review","volume":"132","author":"McGrady","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.metabol.2020.154354_bb0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jsbmb.2017.09.003","article-title":"The art of measuring steroids: principles and practice of current hormonal steroid analysis","volume":"179","author":"Wudy","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.metabol.2020.154354_bb0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jsbmb.2017.12.016","article-title":"Androgen excess in treated children with congenital adrenal hyperplasia is due to elevated 11-oxygenated androgens","volume":"178","author":"Kamrath","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.metabol.2020.154354_bb0050","doi-asserted-by":"crossref","first-page":"108426","DOI":"10.1016\/j.steroids.2019.108426","article-title":"Quantitative targeted GC-MS-based urinary steroid metabolome analysis for treatment monitoring of adolescents and young adults with autoimmune primary adrenal insufficiency","volume":"150","author":"Kamrath","year":"2019","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.metabol.2020.154354_bb0055","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1677\/joe.0.1650679","article-title":"Hormonal diagnosis of 21-hydroxylase deficiency in plasma and urine of neonates using bench top gas chromatography-mass spectrometry","volume":"165","author":"Wudy","year":"2000","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.metabol.2020.154354_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jsbmb.2015.10.013","article-title":"Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: reference values for neonates and infants","volume":"156","author":"Kamrath","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.metabol.2020.154354_bb0065","series-title":"Referenzperzentile f\u00fcr anthropometrische Ma\u00dfzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS). Beitr\u00e4ge zur Gesundheitsberichterstattung des Bundes","year":"2013"},{"issue":"6","key":"10.1016\/j.metabol.2020.154354_bb0070","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1055\/s-2008-1033752","article-title":"Growth velocity for supine length\/height of Normal children from birth to 16 years: longitudinal study Bonn \u2013 Dortmund","volume":"200","author":"Brandt","year":"1988","journal-title":"Klin. Padiatr."},{"issue":"4","key":"10.1016\/j.metabol.2020.154354_bb0075","doi-asserted-by":"crossref","first-page":"E970","DOI":"10.1152\/ajpendo.00495.2006","article-title":"Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinary cortisol metabolite excretion rates during growth","volume":"293","author":"Wudy","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.metabol.2020.154354_bb0080","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1210\/jc.2004-1571","article-title":"Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 years","volume":"90","author":"Remer","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"17","key":"10.1016\/j.metabol.2020.154354_bb0085","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N. Engl. J. Med."},{"issue":"W1","key":"10.1016\/j.metabol.2020.154354_bb0090","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.metabol.2020.154354_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1467-9868.2009.00723.x","article-title":"Sparse partial least squares regression for simultaneous dimension reduction and variable selection","volume":"72","author":"Chun","year":"2010","journal-title":"J. R. Stat. Soc. Ser. B Stat Methodol."},{"issue":"7","key":"10.1016\/j.metabol.2020.154354_bb0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/metabo9070143","article-title":"Statistical workflow for feature selection in human metabolomics data","volume":"9","author":"Antonelli","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.metabol.2020.154354_bb0105","series-title":"Williams Textbook of Endocrinology","first-page":"517","article-title":"The adrenal cortex","author":"Orth","year":"1998"},{"issue":"3","key":"10.1016\/j.metabol.2020.154354_bb0110","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/jcem-48-3-467","article-title":"6 beta-Hydroxycortisol excretion in hypercortisolemic states","volume":"48","author":"Voccia","year":"1979","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.metabol.2020.154354_bb0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/clinchem\/29.2.385","article-title":"Increased urinary excretion of free 20 alpha- and 20 beta-dihydrocortisol in a hypercortisolemic but hypocortisoluric patient with Cushing\u2019s disease","volume":"29","author":"Sch\u00f6nesh\u00f6fer","year":"1983","journal-title":"Clin. Chem."},{"issue":"32","key":"10.1016\/j.metabol.2020.154354_bb0120","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1200\/JCO.2009.22.2802","article-title":"Review of adherence-related issues in adolescents and young adults with cancer","volume":"28","author":"Butow","year":"2010","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.metabol.2020.154354_bb0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1542\/peds.113.4.825","article-title":"Medication adherence in pediatric and adolescent liver transplant recipients","volume":"113","author":"Shemesh","year":"2004","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.metabol.2020.154354_bb0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1203\/00006450-199701000-00005","article-title":"Growth of patients with 21-hydroxylase deficiency: an analysis of the factors influencing adult height","volume":"41","author":"Jaaskelainen","year":"1997","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.metabol.2020.154354_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/mpd.2001.110527","article-title":"Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis","volume":"138","author":"Eugster","year":"2001","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.metabol.2020.154354_bb0140","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2265.2002.01645.x","article-title":"Early growth, pubertal development, body mass index and final height of patients with congenital adrenal hyperplasia: factors influencing the outcome","volume":"57","author":"Manoli","year":"2002","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"10.1016\/j.metabol.2020.154354_bb0145","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1067\/mpd.2002.126601","article-title":"Indicators of adult height outcome in classical 21-hydroxylase deficiency congenital adrenal hyperplasia","volume":"141","author":"Muirhead","year":"2002","journal-title":"J. Pediatr."}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049520302183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049520302183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:24:22Z","timestamp":1758428662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049520302183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":29,"alternative-id":["S0026049520302183"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2020.154354","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary GC\u2013MS steroid metabotyping in treated children with congenital adrenal hyperplasia.","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2020.154354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154354"}}