{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:34:37Z","timestamp":1790278477858,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007176","name":"Sant'Anna School of Advanced Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.metabol.2022.155247","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T02:06:21Z","timestamp":1656036381000},"page":"155247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals"],"prefix":"10.1016","volume":"134","author":[{"given":"Domenico","family":"Tric\u00f2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Mengozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bizzotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladapo","family":"Olaniru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Toczyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Cai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Seghieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Frascerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta","family":"Persaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Natali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.metabol.2022.155247_bb0005","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00125-009-1647-6","article-title":"Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance","volume":"53","author":"Mari","year":"2010","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0010","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2337\/db11-0425","article-title":"Fatty acids, obesity, and insulin resistance: time for a reevaluation","volume":"60","author":"Karpe","year":"2011","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.metabol.2022.155247_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2337\/db19-0138","article-title":"Glucolipotoxicity, beta-cells, and diabetes: the emperor has no clothes","volume":"69","author":"Weir","year":"2020","journal-title":"Diabetes"},{"issue":"6979","key":"10.1016\/j.metabol.2022.155247_bb0020","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1136\/bmj.310.6979.560","article-title":"Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men","volume":"310","author":"Perry","year":"1995","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.metabol.2022.155247_bb0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1464-5491.2004.01189.x","article-title":"Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18-year follow-up of the BEDA study","volume":"21","author":"Dotevall","year":"2004","journal-title":"Diabet Med"},{"issue":"6","key":"10.1016\/j.metabol.2022.155247_bb0030","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2337\/diacare.25.6.989","article-title":"Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study","volume":"25","author":"Schaefer","year":"2002","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0035","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2337\/dc08-0825","article-title":"Changes in triglyceride levels over time and risk of type 2 diabetes in young men","volume":"31","author":"Tirosh","year":"2008","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2337\/dc20-1567","article-title":"Processes underlying glycemic deterioration in type 2 diabetes: an IMI DIRECT study","volume":"44","author":"Bizzotto","year":"2021","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.metabol.2022.155247_bb0045","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.2337\/db14-1710","article-title":"Using genetic variants to assess the relationship between circulating lipids and type 2 diabetes","volume":"64","author":"Fall","year":"2015","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.metabol.2022.155247_bb0050","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2337\/db11-1254","article-title":"Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts","volume":"61","author":"Qi","year":"2012","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.metabol.2022.155247_bb0055","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.diabet.2017.04.010","article-title":"The impact of triglycerides on glucose tolerance: lipotoxicity revisited","volume":"43","author":"Seghieri","year":"2017","journal-title":"Diabetes Metab"},{"issue":"5","key":"10.1016\/j.metabol.2022.155247_bb0060","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0026-0495(95)90122-1","article-title":"Respective role of plasma nonesterified fatty acid oxidation and total lipid oxidation in lipid-induced insulin resistance","volume":"44","author":"Laville","year":"1995","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.metabol.2022.155247_bb0065","first-page":"E641","article-title":"Mechanisms of glucose intolerance during triglyceride infusion","volume":"275","author":"Rigalleau","year":"1998","journal-title":"Am J Physiol"},{"issue":"8","key":"10.1016\/j.metabol.2022.155247_bb0070","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.2337\/db12-1664","article-title":"Beta-cell lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus Caucasian contrast","volume":"62","author":"Michaliszyn","year":"2013","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.metabol.2022.155247_bb0075","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/jc.2012-3492","article-title":"Beta-cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight\/obese adolescents","volume":"98","author":"Hughan","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.metabol.2022.155247_bb0080","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0026-0495(03)00102-1","article-title":"Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes","volume":"52","author":"Storgaard","year":"2003","journal-title":"Metabolism"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0085","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.2337\/diabetes.52.10.2461","article-title":"A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes","volume":"52","author":"Kashyap","year":"2003","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0090","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1210\/jcem.86.10.7958","article-title":"Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion","volume":"86","author":"Magnan","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2022.155247_bb0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2017.01.001","article-title":"Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjects","volume":"69","author":"Natali","year":"2017","journal-title":"Metabolism"},{"issue":"12","key":"10.1016\/j.metabol.2022.155247_bb0100","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1111\/dom.13467","article-title":"Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents","volume":"20","author":"Trico","year":"2018","journal-title":"Diabetes Obes Metab"},{"issue":"Suppl 1","key":"10.1016\/j.metabol.2022.155247_bb0105","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.2337\/dc21-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2021","volume":"44","author":"American Diabetes","year":"2021","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.metabol.2022.155247_bb0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0169-2607(02)00097-4","article-title":"A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models","volume":"71","author":"Mari","year":"2003","journal-title":"Comput Methods Programs Biomed"},{"issue":"3","key":"10.1016\/j.metabol.2022.155247_bb0115","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diabetes.41.3.368","article-title":"Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance","volume":"41","author":"Van Cauter","year":"1992","journal-title":"Diabetes"},{"issue":"Suppl 4","key":"10.1016\/j.metabol.2022.155247_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1463-1326.2008.00946.x","article-title":"Beta-cell function assessment from modelling of oral tests: an effective approach","volume":"10","author":"Mari","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.metabol.2022.155247_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154185","volume":"105","author":"Mengozzi","year":"2020","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.metabol.2022.155247_bb0130","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/dom.13640","article-title":"One-hour post-load plasma glucose predicts progression to prediabetes in a multi-ethnic cohort of obese youths","volume":"21","author":"Trico","year":"2019","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"10.1016\/j.metabol.2022.155247_bb0135","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1210\/jc.2018-02166","article-title":"Intestinal glucose absorption is a key determinant of 1-hour postload plasma glucose levels in nondiabetic subjects","volume":"104","author":"Trico","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.metabol.2022.155247_bb0140","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0145","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/bj2540397","article-title":"Protein phosphorylation in electrically permeabilized islets of Langerhans. Effects of Ca2+, cyclic AMP, a phorbol ester and noradrenaline","volume":"254","author":"Jones","year":"1988","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/emm.1999.10","article-title":"Change of plasma lipoproteins by heparin-released lipoprotein lipase","volume":"31","author":"Yang","year":"1999","journal-title":"Exp Mol Med"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0155","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2337\/diab.36.2.163","article-title":"Effects of heparin on insulin binding and biological activity","volume":"36","author":"Kriauciunas","year":"1987","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0160","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1210\/endo.138.10.5420","article-title":"Low density lipoprotein binding and uptake by human and rat islet beta cells","volume":"138","author":"Grupping","year":"1997","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.metabol.2022.155247_bb0165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)64724-4","article-title":"Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age","volume":"156","author":"Cnop","year":"2000","journal-title":"Am J Pathol"},{"issue":"20","key":"10.1016\/j.metabol.2022.155247_bb0170","doi-asserted-by":"crossref","first-page":"18368","DOI":"10.1074\/jbc.M300102200","article-title":"Insulin-secreting beta-cell dysfunction induced by human lipoproteins","volume":"278","author":"Roehrich","year":"2003","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0175","doi-asserted-by":"crossref","first-page":"E532","DOI":"10.1152\/ajpendo.00127.2009","article-title":"Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms","volume":"297","author":"Bonuccelli","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0180","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/hep.24072","article-title":"Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance","volume":"53","author":"Kozlitina","year":"2011","journal-title":"Hepatology"},{"issue":"28","key":"10.1016\/j.metabol.2022.155247_bb0185","doi-asserted-by":"crossref","first-page":"14695","DOI":"10.1074\/jbc.M115.707885","article-title":"Effect of hypertriglyceridemia on beta cell mass and function in ApoC3 transgenic mice","volume":"291","author":"Liu","year":"2016","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0190","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2362.2006.01597.x","article-title":"Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system","volume":"36","author":"Parini","year":"2006","journal-title":"Eur J Clin Invest"},{"issue":"10","key":"10.1016\/j.metabol.2022.155247_bb0195","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/BF00400466","article-title":"Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man","volume":"37","author":"Del Prato","year":"1994","journal-title":"Diabetologia"},{"issue":"9","key":"10.1016\/j.metabol.2022.155247_bb0200","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.2337\/dc20-0750","article-title":"The measurement of insulin clearance","volume":"43","author":"Piccinini","year":"2020","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.metabol.2022.155247_bb0205","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.2337\/dc21-0545","article-title":"New insights on the interactions between insulin clearance and the main glucose homeostasis mechanisms","volume":"44","author":"Bizzotto","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2022.155247_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.575789","article-title":"Mathematical modeling for the physiological and clinical investigation of glucose homeostasis and diabetes","volume":"11","author":"Mari","year":"2020","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.metabol.2022.155247_bb0215","first-page":"E517","article-title":"Splanchnic and renal metabolism of insulin in human subjects: a dose-response study","volume":"244","author":"Ferrannini","year":"1983","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0220","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/oby.21699","article-title":"Dissecting the relationship between obesity and hyperinsulinemia: role of insulin secretion and insulin clearance","volume":"25","author":"Kim","year":"2017","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"10.1016\/j.metabol.2022.155247_bb0225","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1172\/JCI136756","article-title":"Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics","volume":"130","author":"Smith","year":"2020","journal-title":"J Clin Invest"},{"issue":"24","key":"10.1016\/j.metabol.2022.155247_bb0230","first-page":"e124912","article-title":"Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents","volume":"3","author":"Trico","year":"2018","journal-title":"JCIInsight"},{"issue":"9","key":"10.1016\/j.metabol.2022.155247_bb0235","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2337\/db19-0098","article-title":"Hypothesis: role of reduced hepatic insulin clearance in the pathogenesis of type 2 diabetes","volume":"68","author":"Bergman","year":"2019","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.metabol.2022.155247_bb0240","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/db19-0120","article-title":"Lower insulin clearance parallels a reduced insulin sensitivity in obese youths and is associated with a decline in beta-cell function over time","volume":"68","author":"Galderisi","year":"2019","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.metabol.2022.155247_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrendo.2014.202","article-title":"Gastric emptying and glycaemia in health and diabetes mellitus","volume":"11","author":"Phillips","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"10.1016\/j.metabol.2022.155247_bb0250","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s00125-015-3710-9","article-title":"Mechanisms through which a small protein and lipid preload improves glucose tolerance","volume":"58","author":"Trico","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2022.155247_bb0255","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.genm.2009.02.002","article-title":"Gender differences in insulin resistance, body composition, and energy balance","volume":"6","author":"Geer","year":"2009","journal-title":"Gend Med"},{"key":"10.1016\/j.metabol.2022.155247_bb0260","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fendo.2019.00144","article-title":"Impact of nutrient type and sequence on glucose tolerance: physiological insights and therapeutic implications","volume":"10","author":"Nesti","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"21","key":"10.1016\/j.metabol.2022.155247_bb0265","doi-asserted-by":"crossref","first-page":"18383","DOI":"10.1074\/jbc.M111.241182","article-title":"Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets","volume":"286","author":"MacDonald","year":"2011","journal-title":"J Biol Chem"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049522001251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049522001251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:28:50Z","timestamp":1758428930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049522001251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":53,"alternative-id":["S0026049522001251"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2022.155247","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2022.155247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155247"}}