{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:24:59Z","timestamp":1791897899617,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20210351"],"award-info":[{"award-number":["20210351"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2018-00123"],"award-info":[{"award-number":["2018-00123"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-00977"],"award-info":[{"award-number":["2019-00977"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021-00160"],"award-info":[{"award-number":["2021-00160"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017-00644"],"award-info":[{"award-number":["2017-00644"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017-06100"],"award-info":[{"award-number":["2017-06100"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004200","name":"Stiftelsen Olle Engkvist Byggm\u00e4stare","doi-asserted-by":"publisher","award":["SIMP2021005"],"award-info":[{"award-number":["SIMP2021005"]}],"id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.metabol.2022.155329","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T01:50:26Z","timestamp":1664934626000},"page":"155329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH"],"prefix":"10.1016","volume":"137","author":[{"given":"Susanna C.","family":"Larsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Micha\u00eblsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mola-Caminal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"H\u00f6ijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.metabol.2022.155329_bb0005","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2022.155329_bb0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s42255-021-00354-2","article-title":"Metabolic messengers: FGF21","volume":"3","author":"Flippo","year":"2021","journal-title":"Nat Metab"},{"issue":"5","key":"10.1016\/j.metabol.2022.155329_bb0020","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1210\/er.2017-00016","article-title":"Fibroblast growth factor 21-metabolic role in mice and men","volume":"38","author":"Staiger","year":"2017","journal-title":"Endocr Rev"},{"issue":"11","key":"10.1016\/j.metabol.2022.155329_bb0025","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0030","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2012.258","article-title":"The role of hepatokines in metabolism","volume":"9","author":"Stefan","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0035","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cmet.2016.02.001","article-title":"A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.celrep.2018.03.070","article-title":"A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure","volume":"23","author":"Frayling","year":"2018","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2013.08.005","article-title":"The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes","volume":"18","author":"Gaich","year":"2013","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.metabol.2022.155329_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/oby.22344","article-title":"Pegbelfermin (BMS-986036), PEGylated FGF21, in patients with obesity and type 2 diabetes: results from a randomized phase 2 study","volume":"27","author":"Charles","year":"2019","journal-title":"Obesity"},{"issue":"10165","key":"10.1016\/j.metabol.2022.155329_bb0055","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/S0140-6736(18)31785-9","article-title":"Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial","volume":"392","author":"Sanyal","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.metabol.2022.155329_bb0060","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41591-021-01425-3","article-title":"Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial","volume":"27","author":"Harrison","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.metabol.2022.155329_bb0065","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1210\/clinem\/dgab624","article-title":"LLF580, an FGF21 analog, reduces triglycerides and hepatic fat in obese adults with modest hypertriglyceridemia","volume":"107","author":"Rader","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0070","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa019","article-title":"FGF21 and the physiological regulation of macronutrient preference","volume":"161","author":"Hill","year":"2020","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cmet.2015.12.003","article-title":"FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver","volume":"23","author":"von Holstein-Rathlou","year":"2016","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0080","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cmet.2015.12.008","article-title":"FGF21 regulates sweet and alcohol preference","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cmet.2021.12.024","article-title":"FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit","volume":"34","author":"Flippo","year":"2022","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.metabol.2022.155329_bb0090","doi-asserted-by":"crossref","first-page":"14578","DOI":"10.1038\/s41598-020-71569-8","article-title":"Genome-wide association study for circulating fibroblast growth factor 21 and 23","volume":"10","author":"Chuang","year":"2020","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.metabol.2022.155329_bb0095","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/hmg\/ddt032","article-title":"Novel locus including FGF21 is associated with dietary macronutrient intake","volume":"22","author":"Chu","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.metabol.2022.155329_bb0100","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3945\/ajcn.112.052183","article-title":"Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake","volume":"97","author":"Tanaka","year":"2013","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.metabol.2022.155329_bb0105","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/ije\/dyx207","article-title":"Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities","volume":"46","author":"Walker","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"7","key":"10.1016\/j.metabol.2022.155329_bb0110","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrg2796","article-title":"Genotype imputation for genome-wide association studies","volume":"11","author":"Marchini","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.metabol.2022.155329_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41588-018-0307-5","article-title":"Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use","volume":"51","author":"Liu","year":"2019","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003062","article-title":"Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: a multivariable mendelian randomisation analysis","volume":"17","author":"Richardson","year":"2020","journal-title":"PLoS Med"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0130","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/CIRCRESAHA.117.312086","article-title":"Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease","volume":"122","author":"van der Harst","year":"2018","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.metabol.2022.155329_bb0135","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41588-018-0171-3","article-title":"Biobank-driven genomic discovery yields new insight into atrial fibrillation biology","volume":"50","author":"Nielsen","year":"2018","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.metabol.2022.155329_bb0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41467-019-13690-5","article-title":"Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure","volume":"11","author":"Shah","year":"2020","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.metabol.2022.155329_bb0145","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41588-018-0058-3","article-title":"Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes","volume":"50","author":"Malik","year":"2018","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.metabol.2022.155329_bb0150","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41588-021-00852-9","article-title":"The trans-ancestral genomic architecture of glycemic traits","volume":"53","author":"Chen","year":"2021","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.metabol.2022.155329_bb0155","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s42255-020-00287-2","article-title":"Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals","volume":"2","author":"Folkersen","year":"2020","journal-title":"Nat Metab"},{"issue":"11","key":"10.1016\/j.metabol.2022.155329_bb0160","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0165","article-title":"Machine learning enables new insights into genetic contributions to liver fat accumulation","volume":"1","author":"Haas","year":"2021","journal-title":"Cell Genom"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort\u2606","volume":"73","author":"Anstee","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.metabol.2022.155329_bb0175","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.metabol.2018.10.010","article-title":"Pharmacotherapy of obesity: available medications and drugs under investigation","volume":"92","author":"Pilitsi","year":"2019","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0180","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/joim.13078","article-title":"Fat mass and fat-free mass in relation to cardiometabolic diseases: a two-sample mendelian randomization study","volume":"288","author":"Larsson","year":"2020","journal-title":"J Intern Med"},{"issue":"5","key":"10.1016\/j.metabol.2022.155329_bb0185","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1212\/WNL.0000000000004173","article-title":"Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: mendelian randomization study","volume":"89","author":"Larsson","year":"2017","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.metabol.2022.155329_bb0190","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.2337\/db21-0905","article-title":"Differentiating associations of glycemic traits with atherosclerotic and thrombotic outcomes: mendelian randomization investigation","volume":"71","author":"Yuan","year":"2022","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.metabol.2022.155329_bb0195","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00125-020-05190-9","article-title":"IGF-1 and cardiometabolic diseases: a mendelian randomisation study","volume":"63","author":"Larsson","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2022.155329_bb0200","first-page":"193","article-title":"Insulin resistance: the clinical spectrum","volume":"6","author":"Mantzoros","year":"1995","journal-title":"Adv Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.metabol.2022.155329_bb0205","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1210\/jcem.83.9.5143","article-title":"Clinical review 97: syndromes of severe insulin resistance","volume":"83","author":"Tritos","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.metabol.2022.155329_bb0210","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1056\/NEJM197201272860407","article-title":"Alkaline phosphatase","volume":"286","author":"Kaplan","year":"1972","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1016\/j.metabol.2022.155329_bb0215","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1128\/MCB.23.21.7525-7530.2003","article-title":"Accelerated fat absorption in intestinal alkaline phosphatase knockout mice","volume":"23","author":"Narisawa","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.metabol.2022.155329_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00897","article-title":"Alkaline phosphatase, an unconventional immune protein","volume":"8","author":"Rader","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.metabol.2022.155329_bb0225","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2147\/CEG.S345531","article-title":"Alkaline phosphatase pathophysiology with emphasis on the seldom-discussed role of defective elimination in unexplained elevations of serum ALP - a case report and literature review","volume":"15","author":"Levitt","year":"2022","journal-title":"Clin Exp Gastroenterol"},{"issue":"2","key":"10.1016\/j.metabol.2022.155329_bb0230","doi-asserted-by":"crossref","first-page":"92","DOI":"10.23736\/S0391-1977.16.02563-3","article-title":"Adipose tissue, obesity and non-alcoholic fatty liver disease","volume":"42","author":"Polyzos","year":"2017","journal-title":"Minerva Endocrinol"},{"issue":"1","key":"10.1016\/j.metabol.2022.155329_bb0235","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3803\/EnM.2018.33.1.33","article-title":"Association of adipokines with development and progression of nonalcoholic fatty liver disease","volume":"33","author":"Boutari","year":"2018","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.metabol.2022.155329_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.744518","article-title":"Role of galectins in the liver diseases: a systematic review and meta-analysis","volume":"8","author":"An","year":"2021","journal-title":"Front Med"},{"issue":"3","key":"10.1016\/j.metabol.2022.155329_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/genes13030491","article-title":"Pleiotropic effects of common and rare GCKR exonic mutations on cardiometabolic traits","volume":"13","author":"Yeh","year":"2022","journal-title":"Genes"},{"issue":"11","key":"10.1016\/j.metabol.2022.155329_bb0250","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.metabol.2022.155329_bb0255","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.2337\/db08-0516","article-title":"Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations","volume":"57","author":"Orho-Melander","year":"2008","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.metabol.2022.155329_bb0260","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.biopsych.2019.09.011","article-title":"Recent efforts to dissect the genetic basis of alcohol use and abuse","volume":"87","author":"Sanchez-Roige","year":"2020","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.metabol.2022.155329_bb0265","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1038\/s41380-020-0697-5","article-title":"Genomic analysis of diet composition finds novel loci and associations with health and lifestyle","volume":"26","author":"Meddens","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.metabol.2022.155329_bb0270","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.3390\/nu13051504","article-title":"Genetic evidence supporting fibroblast growth factor 21 signalling as a pharmacological target for cardiometabolic outcomes and Alzheimer's disease","volume":"13","author":"Larsson","year":"2021","journal-title":"Nutrients"}],"updated-by":[{"DOI":"10.1016\/j.metabol.2023.155555","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000}}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049522002074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049522002074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:02:00Z","timestamp":1778626920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049522002074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":54,"alternative-id":["S0026049522002074"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2022.155329","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2022.155329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155329"}}