{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:52:11Z","timestamp":1788922331213,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"am","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","award":["PS61669"],"award-info":[{"award-number":["PS61669"]}],"id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00004"],"award-info":[{"award-number":["75N92020D00004"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00003"],"award-info":[{"award-number":["75N92020D00003"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00007"],"award-info":[{"award-number":["75N92020D00007"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00006"],"award-info":[{"award-number":["75N92020D00006"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00001"],"award-info":[{"award-number":["75N92020D00001"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00002"],"award-info":[{"award-number":["75N92020D00002"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["75N92020D00005"],"award-info":[{"award-number":["75N92020D00005"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["HHSN268201500003I"],"award-info":[{"award-number":["HHSN268201500003I"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1122854"],"award-info":[{"award-number":["1122854"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["100715"],"award-info":[{"award-number":["100715"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["HHSN268201500003I"],"award-info":[{"award-number":["HHSN268201500003I"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR-001420"],"award-info":[{"award-number":["UL1-TR-001420"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR-001079"],"award-info":[{"award-number":["UL1-TR-001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.metabol.2023.155535","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T13:03:10Z","timestamp":1678885390000},"page":"155535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis"],"prefix":"10.1016","volume":"143","author":[{"given":"William","family":"Tucker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyses","family":"Szklo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry-Anne","family":"Rye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok Leung","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0005","first-page":"263","article-title":"Pathophysiology of heart failure","volume":"11","author":"Schwinger","year":"2021","journal-title":"CardiovascDiagnTher"},{"issue":"15","key":"10.1016\/j.metabol.2023.155535_bb0010","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1053\/euhj.2000.2533","article-title":"The prognosis of heart failure in the general population.The Rotterdam Study","volume":"22","author":"Mosterd","year":"2001","journal-title":"Eur Heart J"},{"issue":"17","key":"10.1016\/j.metabol.2023.155535_bb0015","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvu263","article-title":"Fibroblast growth factor 21 protects the heart from oxidative stress","volume":"106","author":"Planavila","year":"2015","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0025","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10741-022-10268-0","article-title":"Fibroblast growth factor 21 in heart failure","volume":"28","author":"Tucker","year":"2022","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.metabol.2023.155535_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.metabol.2018.01.017","article-title":"Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis","volume":"83","author":"Lakhani","year":"2018","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.metabol.2023.155535_bb0040","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.metabol.2023.155535_bb0045","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41574-020-0386-0","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"16","author":"Geng","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10741-022-10268-0","article-title":"Fibroblast growth factor 21 in heart failure","volume":"28","author":"Tucker","year":"2023","journal-title":"Heart Fail Rev"},{"issue":"9","key":"10.1016\/j.metabol.2023.155535_bb0055","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.metabol.2023.155535_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154738","article-title":"FGF21 and chronic kidney disease","volume":"118","author":"Salgado","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2023.155535_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.153994","article-title":"Fibroblast growth factor 21 in non-alcoholic fatty liver disease","volume":"101","author":"Tucker","year":"2019","journal-title":"Metabolism"},{"issue":"12","key":"10.1016\/j.metabol.2023.155535_bb0070","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1210\/jc.2012-2267","article-title":"Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes","volume":"97","author":"Ong","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiol.2341040439","article-title":"Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study","volume":"234","author":"Carr","year":"2005","journal-title":"Radiology"},{"issue":"6_supplement_2","key":"10.1016\/j.metabol.2023.155535_bb0080","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.2214\/AJR.04.1868","article-title":"Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity","volume":"186","author":"Natori","year":"2006","journal-title":"Am J Roentgenol"},{"issue":"25","key":"10.1016\/j.metabol.2023.155535_bb0085","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.jacc.2008.09.014","article-title":"The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study","volume":"52","author":"Bluemke","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2023.155535_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.atherosclerosis.2017.12.026","article-title":"The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis","volume":"269","author":"Hui","year":"2018","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.metabol.2023.155535_bb0095","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1053\/j.ajkd.2010.02.337","article-title":"Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions","volume":"55","author":"Levey","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.metabol.2023.155535_bb0100","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.metabol.2023.155535_bb0105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ijcard.2011.11.034","article-title":"Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: results from a multi-ethnic cohort","volume":"166","author":"Veeranna","year":"2013","journal-title":"Int J Cardiol"},{"issue":"6","key":"10.1016\/j.metabol.2023.155535_bb0110","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCHEARTFAILURE.112.968701","article-title":"N-terminal pro-B-type natriuretic peptide, left ventricular mass, and incident heart failure: Multi-Ethnic Study of Atherosclerosis","volume":"5","author":"Choi","year":"2012","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10.1016\/j.metabol.2023.155535_bb0115","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2217\/bmm.13.71","article-title":"Associations between total serum GGT activity and metabolic risk: MESA","volume":"7","author":"Bradley","year":"2013","journal-title":"Biomark Med"},{"issue":"5","key":"10.1016\/j.metabol.2023.155535_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007885","article-title":"Predictive value of collagen biomarkers for heart failure with and without preserved ejection fraction: MESA (Multi-Ethnic Study of Atherosclerosis)","volume":"7","author":"Duprez","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"14","key":"10.1016\/j.metabol.2023.155535_bb0125","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1113\/JP277117","article-title":"Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite","volume":"597","author":"von Holstein-Rathlou","year":"2019","journal-title":"J Physiol"},{"issue":"3","key":"10.1016\/j.metabol.2023.155535_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/1536867X1001000303","article-title":"Comparing the predictive powers of survival models using Harrell's C or Somers' D","volume":"10","author":"Newson","year":"2010","journal-title":"Stata J"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers","volume":"30","author":"Pencina","year":"2011","journal-title":"Stat Med"},{"issue":"2","key":"10.1016\/j.metabol.2023.155535_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1009612305785","article-title":"A simplified method of calculating an overall goodness-of-fit test for the Cox proportional hazards model","volume":"4","author":"May","year":"1998","journal-title":"Lifetime Data Anal"},{"issue":"11","key":"10.1016\/j.metabol.2023.155535_bb0145","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.2337\/db13-0645","article-title":"High glucose represses \u03b2-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator\u2013activated receptor \u03b3 signaling","volume":"62","author":"So","year":"2013","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.metabol.2023.155535_bb0150","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.celrep.2019.02.014","article-title":"Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues","volume":"26","author":"Geng","year":"2019","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.metabol.2023.155535_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087102","article-title":"Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts","volume":"9","author":"Patel","year":"2014","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.metabol.2023.155535_bb0160","doi-asserted-by":"crossref","first-page":"H1029","DOI":"10.1152\/ajpheart.00527.2015","article-title":"Fibroblast growth factors in cardiovascular disease: the emerging role of FGF21","volume":"309","author":"Domouzoglou","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.metabol.2023.155535_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038022","article-title":"Exercise increases serum fibroblast growth factor 21 (FGF21) levels","volume":"7","author":"Cuevas-Ramos","year":"2012","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.metabol.2023.155535_bb0170","first-page":"2958","article-title":"A high circulating FGF21 level as a prognostic marker in patients with acute myocardial infarction","volume":"10","author":"Chen","year":"2018","journal-title":"AmJTranslRes"},{"issue":"11","key":"10.1016\/j.metabol.2023.155535_bb0175","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.metabol.2010.03.018","article-title":"Serum fibroblast growth factor\u201321 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis","volume":"59","author":"Han","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2023.155535_bb0180","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h910","article-title":"The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting","volume":"350","author":"Roberts","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2023.155535_bb0185","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.008910","article-title":"FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure","volume":"15","author":"Sommakia","year":"2022","journal-title":"Circ Heart Fail"},{"issue":"11","key":"10.1016\/j.metabol.2023.155535_bb0190","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jacbts.2021.07.010","article-title":"Relationship of nonalcoholic fatty liver disease and heart failure with preserved ejection fraction","volume":"6","author":"Salah","year":"2021","journal-title":"<sb:contribution><sb:title>JACC Basic Transl <\/sb:title><\/sb:contribution><sb:host><sb:issue><sb:series><sb:title>Sci<\/sb:title><\/sb:series><\/sb:issue><\/sb:host>"},{"issue":"2","key":"10.1016\/j.metabol.2023.155535_bb0195","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/ehf2.13250","article-title":"Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT","volume":"8","author":"Peters","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"10","key":"10.1016\/j.metabol.2023.155535_bb0200","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/eurheartj\/ehs440","article-title":"What does the liver tell us about the failing heart?","volume":"34","author":"Auer","year":"2012","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.metabol.2023.155535_bb0205","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/cvr\/cvaa217","article-title":"Metabolic inflammation in heart failure with preserved ejection fraction","volume":"117","author":"Schiattarella","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.metabol.2023.155535_bb0210","first-page":"701","article-title":"The association of obesity and cardiometabolic traits with incident HFpEF and HFrEF. JACC","volume":"6","author":"Savji","year":"2018","journal-title":"Heart Fail"},{"issue":"10165","key":"10.1016\/j.metabol.2023.155535_bb0215","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/S0140-6736(18)31785-9","article-title":"Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial","volume":"392","author":"Sanyal","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2023.155535_bb0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cen.12134","article-title":"Serum FGF 21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status","volume":"80","author":"Lee","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.metabol.2023.155535_bb0225","doi-asserted-by":"crossref","first-page":"66","DOI":"10.7150\/ijbs.73936","article-title":"Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine","volume":"19","author":"Tan","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10.1016\/j.metabol.2023.155535_bb0230","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123130","article-title":"SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and-independent mechanisms","volume":"4","author":"Osataphan","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.metabol.2023.155535_bb0235","article-title":"SGLT-2 inhibitors on prognosis and health-related quality of life in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysis","volume":"9","author":"Yang","year":"2022","journal-title":"FrontCardiovascMed"},{"key":"10.1016\/j.metabol.2023.155535_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100933","article-title":"SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure: a systematic review and meta-analysis","volume":"36","author":"Cardoso","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.metabol.2023.155535_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155329","article-title":"Genome-wide association and mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH","volume":"137","author":"Larsson","year":"2022","journal-title":"Metabolism"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049523001385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049523001385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:20:18Z","timestamp":1777432818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049523001385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":49,"alternative-id":["S0026049523001385"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2023.155535","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2023.155535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155535"}}