{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:27:06Z","timestamp":1783024026756,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172500"],"award-info":[{"award-number":["82172500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ30971"],"award-info":[{"award-number":["2021JJ30971"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"China Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["S2021SFYLJS0102"],"award-info":[{"award-number":["S2021SFYLJS0102"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.metabol.2024.156109","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T02:51:16Z","timestamp":1734490276000},"page":"156109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle"],"prefix":"10.1016","volume":"164","author":[{"given":"Mei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2024.156109_bb0005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2014.12.021","article-title":"Muscle as a \u201cmediator\u201d of systemic metabolism","volume":"21","author":"Baskin","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2024.156109_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101778","article-title":"Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: a systematic review with dose-response meta-analysis","volume":"82","author":"Lopez-Bueno","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.metabol.2024.156109_bb0015","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jhep.2021.11.006","article-title":"Effect of sarcopenia on survival in patients with cirrhosis: a meta-analysis","volume":"76","author":"Tantai","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.metabol.2024.156109_bb0020","series-title":"Seidel\u2019s guide to physical examination","author":"Ball","year":"2023"},{"key":"10.1016\/j.metabol.2024.156109_bb0025","series-title":"Goldman-Cecil medicine","author":"Selcen","year":"2024"},{"key":"10.1016\/j.metabol.2024.156109_bb0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41556-020-00630-5","article-title":"Functional mechanisms and abnormalities of the nuclear lamina","volume":"23","author":"Karoutas","year":"2021","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.metabol.2024.156109_bb0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.celrep.2013.09.024","article-title":"The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit","volume":"5","author":"Poleshko","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.metabol.2024.156109_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.103","article-title":"A novel role of PRR14 in the regulation of skeletal myogenesis","volume":"6","author":"Yang","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.metabol.2024.156109_bb0045","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1038\/onc.2016.93","article-title":"PRR14 is a novel activator of the PI3K pathway promoting lung carcinogenesis","volume":"35","author":"Yang","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.metabol.2024.156109_bb0050","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-020-2640-8","article-title":"Oncogene PRR14 promotes breast cancer through activation of PI3K signal pathway and inhibition of CHEK2 pathway","volume":"11","author":"Ren","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.metabol.2024.156109_bb0055","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.cell.2015.10.066","article-title":"Perinuclear anchoring of H3K9-methylated chromatin stabilizes induced cell fate in C. elegans embryos","volume":"163","author":"Gonzalez-Sandoval","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.metabol.2024.156109_bb0060","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1101\/gad.332213.119","article-title":"Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model","volume":"34","author":"Harr","year":"2020","journal-title":"Genes Dev"},{"key":"10.1016\/j.metabol.2024.156109_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2044-5040-2-8","article-title":"Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting","volume":"2","author":"McCarthy","year":"2012","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.metabol.2024.156109_bb0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.nmd.2011.07.008","article-title":"A single 30 min treadmill exercise session is suitable for \u2018proof-of concept studies\u2019 in adult mdx mice: a comparison of the early consequences of two different treadmill protocols","volume":"22","author":"Radley-Crabb","year":"2012","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.metabol.2024.156109_bb0075","first-page":"2467","article-title":"An alternant method to the traditional NASA hindlimb unloading model in mice","volume":"49","author":"Ferreira","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1016\/j.metabol.2024.156109_bb0080","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s11064-007-9485-8","article-title":"The effect of n-acetylcysteine and deferoxamine on exercise-induced oxidative damage in striatum and hippocampus of mice","volume":"33","author":"Aguiar","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.metabol.2024.156109_bb0085","first-page":"144","article-title":"Empowering multi-cohort gene expression analysis to increase reproducibility","volume":"22","author":"Haynes","year":"2017","journal-title":"Pac Symp Biocomput"},{"key":"10.1016\/j.metabol.2024.156109_bb0090","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2024.156109_bb0095","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.metabol.2024.156109_bb0100","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.metabol.2024.156109_bb0105","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.metabol.2024.156109_bb0110","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky822","article-title":"AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors","volume":"47","author":"Hu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.metabol.2024.156109_bb0115","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.240416","article-title":"The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting","volume":"133","author":"Dunlevy","year":"2020","journal-title":"J Cell Sci"},{"key":"10.1016\/j.metabol.2024.156109_bb0120","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1074\/jbc.M114.606277","article-title":"Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells","volume":"290","author":"Zhang","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2024.156109_bb0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/stem.2495","article-title":"Dynamic phosphorylation of the myocyte enhancer factor 2Calpha1 splice variant promotes skeletal muscle regeneration and hypertrophy","volume":"35","author":"Baruffaldi","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.metabol.2024.156109_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.032","article-title":"MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure","volume":"51","author":"Pereira","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.metabol.2024.156109_bb0135","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00401-008-0371-5","article-title":"Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice","volume":"115","author":"Sakuma","year":"2008","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.metabol.2024.156109_bb0140","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1128\/MCB.01187-07","article-title":"Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c","volume":"27","author":"Potthoff","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.metabol.2024.156109_bb0145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00401-017-1731-9","article-title":"IFN-beta-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis","volume":"134","author":"Meyer","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.metabol.2024.156109_bb0150","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41467-019-13869-w","article-title":"Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity","volume":"11","author":"Pillon","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2024.156109_bb0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-021-03933-1","article-title":"Genetic and epigenetic coordination of cortical interneuron development","volume":"597","author":"Allaway","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2024.156109_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd7695","article-title":"MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration","volume":"13","author":"Barker","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.metabol.2024.156109_bb0165","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41423-022-00841-w","article-title":"MEF2C promotes M1 macrophage polarization and Th1 responses","volume":"19","author":"Zhao","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.metabol.2024.156109_bb0170","doi-asserted-by":"crossref","first-page":"12376","DOI":"10.1038\/ncomms12376","article-title":"MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis","volume":"7","author":"Wang","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2024.156109_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ni.1694","article-title":"Regulation of lymphoid versus myeloid fate \u2018choice\u2019 by the transcription factor Mef2c","volume":"10","author":"Stehling-Sun","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.metabol.2024.156109_bb0180","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41413-020-00120-2","article-title":"MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS","volume":"9","author":"Fujii","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.metabol.2024.156109_bb0185","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.metabol.2024.156109_bb0190","doi-asserted-by":"crossref","first-page":"R799","DOI":"10.1152\/ajpregu.00452.2017","article-title":"MEF2 as upstream regulator of the transcriptome signature in human skeletal muscle during unloading","volume":"315","author":"Rullman","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.metabol.2024.156109_bb0195","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/mus.21789","article-title":"Altered MEF2 isoforms in myotonic dystrophy and other neuromuscular disorders","volume":"42","author":"Bachinski","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.metabol.2024.156109_bb0200","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/CIRCULATIONAHA.117.028561","article-title":"Histone methyltransferase G9a is required for cardiomyocyte homeostasis and hypertrophy","volume":"136","author":"Papait","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2024.156109_bb0205","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.celrep.2014.10.001","article-title":"Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons","volume":"9","author":"Lyons","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.metabol.2024.156109_bb0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molcel.2008.08.022","article-title":"Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation","volume":"32","author":"Pandey","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2024.156109_bb0215","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2013.12.005","article-title":"The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing","volume":"53","author":"Mozzetta","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2024.156109_bb0220","first-page":"4","article-title":"Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development","author":"Zylicz","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.metabol.2024.156109_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2007.09.011","article-title":"Facultative heterochromatin: is there a distinctive molecular signature?","volume":"28","author":"Trojer","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.metabol.2024.156109_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tig.2015.11.001","article-title":"H3K9me3-dependent heterochromatin: barrier to cell fate changes","volume":"32","author":"Becker","year":"2016","journal-title":"Trends Genet"}],"updated-by":[{"DOI":"10.1016\/j.metabol.2026.156674","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049524003378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049524003378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:08:14Z","timestamp":1783022894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049524003378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":46,"alternative-id":["S0026049524003378"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2024.156109","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2024.156109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"156109"}}