{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:24:43Z","timestamp":1792031083035,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["S10RR029119"],"award-info":[{"award-number":["S10RR029119"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL170039"],"award-info":[{"award-number":["R01HL170039"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB015908"],"award-info":[{"award-number":["P41EB015908"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS107409"],"award-info":[{"award-number":["R01NS107409"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK127984"],"award-info":[{"award-number":["P30DK127984"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014055","name":"United States Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","award":["W81XWH2210485"],"award-info":[{"award-number":["W81XWH2210485"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"National Institutes of Health Office of the Director","doi-asserted-by":"publisher","award":["S10OD018468"],"award-info":[{"award-number":["S10OD018468"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.metabol.2025.156151","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:11:33Z","timestamp":1738174293000},"page":"156151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver"],"prefix":"10.1016","volume":"165","author":[{"given":"Jae Mo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Han","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie D.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal E.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennine","family":"Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Mozingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Liticker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsook S.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.metabol.2025.156151_bb0005","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4093\/dmj.2017.41.6.430","article-title":"Non-alcoholic fatty liver disease: the emerging burden in cardiometabolic and renal diseases","volume":"41","author":"Han","year":"2017","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.metabol.2025.156151_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.biochi.2017.10.019","article-title":"Steatosis and NASH in type 2 diabetes","volume":"143","author":"Hu","year":"2017","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.metabol.2025.156151_bb0015","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"41","key":"10.1016\/j.metabol.2025.156151_bb0020","doi-asserted-by":"crossref","first-page":"27565","DOI":"10.1074\/jbc.M804393200","article-title":"Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat","volume":"283","author":"Nye","year":"2008","journal-title":"J Biol Chem"},{"issue":"51","key":"10.1016\/j.metabol.2025.156151_bb0025","doi-asserted-by":"crossref","first-page":"34422","DOI":"10.1074\/jbc.273.51.34422","article-title":"Regulation of rat pyruvate carboxylase gene expression by alternate promoters during development, in genetically obese rats and in insulin-secreting cells. Multiple transcripts with 5\u2032-end heterogeneity modulate translation","volume":"273","author":"Jitrapakdee","year":"1998","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.metabol.2025.156151_bb0030","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2337\/db12-1311","article-title":"Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance","volume":"62","author":"Kumashiro","year":"2013","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.metabol.2025.156151_bb0035","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.cmet.2019.03.014","article-title":"Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver","volume":"29","author":"Cappel","year":"2019","journal-title":"Cell Metab"},{"issue":"47","key":"10.1016\/j.metabol.2025.156151_bb0040","doi-asserted-by":"crossref","first-page":"19084","DOI":"10.1073\/pnas.1111247108","article-title":"Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance","volume":"108","author":"Merritt","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.metabol.2025.156151_bb0045","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s11306-014-0768-1","article-title":"Production of hyperpolarized (13)CO(2) from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production","volume":"11","author":"Moreno","year":"2015","journal-title":"Metabolomics"},{"issue":"4","key":"10.1016\/j.metabol.2025.156151_bb0050","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/nbm.3479","article-title":"Metabolism of hyperpolarized [1-(13)C]pyruvate through alternate pathways in rat liver","volume":"29","author":"Jin","year":"2016","journal-title":"NMR Biomed"},{"key":"10.1016\/j.metabol.2025.156151_bb0055","article-title":"[(13)C]bicarbonate labelled from hyperpolarized [1-(13)C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state","volume":"5(1):10","author":"Can","year":"2022","journal-title":"Commun Biol"},{"issue":"12","key":"10.1016\/j.metabol.2025.156151_bb0060","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/nbm.3656","article-title":"Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS","volume":"29","author":"Le Page","year":"2016","journal-title":"NMR Biomed"},{"issue":"2","key":"10.1016\/j.metabol.2025.156151_bb0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.26028","article-title":"In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model","volume":"57","author":"Lee","year":"2013","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.metabol.2025.156151_bb0070","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/nbm.3431","article-title":"Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-(13)C]pyruvate","volume":"28","author":"Josan","year":"2015","journal-title":"NMR Biomed"},{"issue":"5","key":"10.1016\/j.metabol.2025.156151_bb0075","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/nbm.1616","article-title":"In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma","volume":"24","author":"Darpolor","year":"2011","journal-title":"NMR Biomed"},{"issue":"4","key":"10.1016\/j.metabol.2025.156151_bb0080","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/mrm.29954","article-title":"Hyperpolarized [1-(13) C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease","volume":"91","author":"Piraquive Agudelo","year":"2024","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.metabol.2025.156151_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/srep46014","article-title":"Hyperpolarized (13)C spectroscopic evaluation of oxidative stress in a rodent model of steatohepatitis","volume":"7","author":"Wilson","year":"2017","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.metabol.2025.156151_bb0090","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/jmri.28196","article-title":"Whole-abdomen metabolic imaging of healthy volunteers using hyperpolarized [1-(13) C]pyruvate MRI","volume":"56","author":"Lee","year":"2022","journal-title":"J Magn Reson Imaging"},{"issue":"5","key":"10.1016\/j.metabol.2025.156151_bb0095","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/liv.15222","article-title":"Hyperpolarized carbon 13 MRI in liver diseases: recent advances and future opportunities","volume":"42","author":"Ye","year":"2022","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.metabol.2025.156151_bb0100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cmet.2022.11.011","article-title":"Q-Flux: a method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo","volume":"35","author":"Hubbard","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2025.156151_bb0105","article-title":"Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)","volume":"8(1):798","author":"Perry","year":"2017","journal-title":"Nat Commun"},{"issue":"36","key":"10.1016\/j.metabol.2025.156151_bb0110","doi-asserted-by":"crossref","first-page":"19031","DOI":"10.1074\/jbc.M116.742262","article-title":"An Oral load of [13C3]glycerol and blood NMR analysis detect fatty acid esterification, pentose phosphate pathway, and glycerol metabolism through the tricarboxylic acid cycle in human liver","volume":"291","author":"Jin","year":"2016","journal-title":"J Biol Chem"},{"issue":"47","key":"10.1016\/j.metabol.2025.156151_bb0115","doi-asserted-by":"crossref","first-page":"32593","DOI":"10.1074\/jbc.M114.577692","article-title":"Interaction between the pentose phosphate pathway and gluconeogenesis from glycerol in the liver","volume":"289","author":"Jin","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2025.156151_bb0120","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.metabol.2016.11.008","article-title":"Effects of visceral adiposity on glycerol pathways in gluconeogenesis","volume":"67","author":"Neeland","year":"2017","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.metabol.2025.156151_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17050633","article-title":"Definitions of normal liver fat and the association of insulin sensitivity with acquired and genetic NAFLD-a systematic review","volume":"17","author":"Petaja","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.metabol.2025.156151_bb0130","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1148\/radiol.12120896","article-title":"Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis","volume":"267","author":"Tang","year":"2013","journal-title":"Radiology"},{"issue":"11","key":"10.1016\/j.metabol.2025.156151_bb0135","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1016\/S0021-9258(20)89598-2","article-title":"Noninvasive tracing of Krebs cycle metabolism in liver","volume":"266","author":"Magnusson","year":"1991","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.metabol.2025.156151_bb0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrendo.2011.138","article-title":"The role of mitochondria in insulin resistance and type 2 diabetes mellitus","volume":"8","author":"Szendroedi","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.metabol.2025.156151_bb0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.00024.2006","article-title":"Disordered lipid metabolism and the pathogenesis of insulin resistance","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol Rev"},{"issue":"43","key":"10.1016\/j.metabol.2025.156151_bb0150","doi-asserted-by":"crossref","first-page":"17075","DOI":"10.1073\/pnas.0707060104","article-title":"Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"31","key":"10.1016\/j.metabol.2025.156151_bb0155","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.metabol.2025.156151_bb0160","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.cmet.2011.11.004","article-title":"Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease","volume":"14","author":"Sunny","year":"2011","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.metabol.2025.156151_bb0165","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.2337\/diabetes.54.7.1942","article-title":"Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis","volume":"54","author":"Basu","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.metabol.2025.156151_bb0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1210\/jc.2014-2404","article-title":"Influence of liver triglycerides on suppression of glucose production by insulin in men","volume":"100","author":"Jin","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.metabol.2025.156151_bb0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2016.06.005","article-title":"Assessment of hepatic mitochondrial oxidation and pyruvate cycling in NAFLD by (13)C magnetic resonance spectroscopy","volume":"24","author":"Petersen","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2025.156151_bb0180","series-title":"Encyclopedia of toxicology","first-page":"754","article-title":"Glycerol","author":"Wernke","year":"2014"},{"key":"10.1016\/j.metabol.2025.156151_bb0185","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1146\/annurev.bi.46.070177.004001","article-title":"Glycerol utilization and its regulation in mammals","volume":"46","author":"Lin","year":"1977","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.metabol.2025.156151_bb0190","doi-asserted-by":"crossref","DOI":"10.1177\/17562848211031394","article-title":"Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation","volume":"14","author":"Middleton","year":"2021","journal-title":"Therap Adv Gastroenterol"},{"issue":"3","key":"10.1016\/j.metabol.2025.156151_bb0195","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/mrm.28489","article-title":"Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1-(13) C]-l-lactate","volume":"85","author":"Chen","year":"2021","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.metabol.2025.156151_bb0200","doi-asserted-by":"crossref","unstructured":"Huynh MT, Erfani Z, Kovacs Z, Park JM. Hyperpolarized [2-(13)C, 3-(2)H(3)]pyruvate detects hepatic gluconeogenesis in vivo. ACS Sens. Jun 28 2024;9(6):2801\u20132805. doi:https:\/\/doi.org\/10.1021\/acssensors.4c00734.","DOI":"10.1021\/acssensors.4c00734"},{"issue":"3","key":"10.1016\/j.metabol.2025.156151_bb0205","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/mrm.28796","article-title":"Cardiac T2 * measurement of hyperpolarized (13) C metabolites using metabolite-selective multi-echo spiral imaging","volume":"86","author":"Ma","year":"2021","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.metabol.2025.156151_bb0210","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/mrm.29042","article-title":"Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate","volume":"87","author":"Ma","year":"2022","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.metabol.2025.156151_bb0215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mrm.28691","article-title":"Characterization and compensation of f0 inhomogeneity artifact in spiral hyperpolarized (13) C imaging of the human heart","volume":"86","author":"Reed","year":"2021","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.metabol.2025.156151_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102749","article-title":"Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver","volume":"63","author":"Jin","year":"2023","journal-title":"Redox Biol"},{"issue":"198","key":"10.1016\/j.metabol.2025.156151_bb0225","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006070","article-title":"Metabolic imaging of patients with prostate cancer using hyperpolarized [1-(1)(3)C]pyruvate","volume":"5","author":"Nelson","year":"2013","journal-title":"Sci Transl Med"},{"issue":"11","key":"10.1016\/j.metabol.2025.156151_bb0230","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/CIRCRESAHA.116.309769","article-title":"Hyperpolarized 13C metabolic MRI of the human heart: initial experience","volume":"119","author":"Cunningham","year":"2016","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.metabol.2025.156151_bb0235","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/nbm.2935","article-title":"Measuring mitochondrial metabolism in rat brain in vivo using MR spectroscopy of hyperpolarized [2-(1)(3)C]pyruvate","volume":"26","author":"Park","year":"2013","journal-title":"NMR Biomed"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049525000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049525000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:46:53Z","timestamp":1782481613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049525000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":47,"alternative-id":["S0026049525000204"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2025.156151","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2025.156151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"156151"}}