{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:46:35Z","timestamp":1793119595122,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470948"],"award-info":[{"award-number":["82470948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.metabol.2025.156159","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T02:55:06Z","timestamp":1739501706000},"page":"156159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli"],"prefix":"10.1016","volume":"166","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2025.156159_bb0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13287-020-1581-6","article-title":"Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice","volume":"11","author":"Hu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.metabol.2025.156159_bb0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/036354659402200605","article-title":"Stimulation of bone growth through sports. A radiologic investigation of the upper extremities in professional tennis players","volume":"22","author":"Krahl","year":"1994","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.metabol.2025.156159_bb0015","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1359\/JBMR.040307","article-title":"Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight","volume":"19","author":"Lang","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11154-015-9313-4","article-title":"Physiological mechanisms and therapeutic potential of bone mechanosensing","volume":"16","author":"Xiao","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.metabol.2025.156159_bb0025","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/jbmr.3677","article-title":"Sirt1 promotes osteogenic differentiation and increases alveolar bone mass via Bmi1 activation in mice","volume":"34","author":"Wang","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41413-023-00269-6","article-title":"Premature aging of skeletal stem\/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation","volume":"11","author":"Yang","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0035","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3094154","article-title":"Prx1-expressing progenitor primary cilia mediate bone formation in response to mechanical loading in mice","volume":"2019","author":"Moore","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.metabol.2025.156159_bb0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jbmr.3668","article-title":"Mechanical loading promotes the expansion of primitive osteoprogenitors and organizes matrix and vascular morphology in long bone defects","volume":"34","author":"Liu","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0045","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/00220345211046606","article-title":"Role of primary cilia in bone and cartilage","volume":"101","author":"Chinipardaz","year":"2022","journal-title":"J Dent Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12195-010-0127-x","article-title":"The role of primary cilia in mesenchymal stem cell differentiation: a pivotal switch in guiding lineage commitment","volume":"3","author":"Tummala","year":"2010","journal-title":"Cell Mol Bioeng"},{"key":"10.1016\/j.metabol.2025.156159_bb0055","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/stem.1235","article-title":"Primary cilia-mediated mechanotransduction in human mesenchymal stem cells","volume":"30","author":"Hoey","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.metabol.2025.156159_bb0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/ajmg.c.31336","article-title":"Ciliary disorder of the skeleton","volume":"160c","author":"Huber","year":"2012","journal-title":"Am J Med Genet C: Semin Med Genet"},{"key":"10.1016\/j.metabol.2025.156159_bb0065","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/hmg\/ddr013","article-title":"An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia","volume":"20","author":"Rix","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metabol.2025.156159_bb0070","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.1038\/ncomms11024","article-title":"Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation","volume":"7","author":"Yuan","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2025.156159_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/scrt318","article-title":"Mechanically induced osteogenic lineage commitment of stem cells","volume":"4","author":"Chen","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.metabol.2025.156159_bb0080","first-page":"11","article-title":"Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1(+) cells via ciliary TGF-beta signaling","author":"Xiao","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.metabol.2025.156159_bb0085","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13287-018-0930-1","article-title":"Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation","volume":"9","author":"Moore","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.metabol.2025.156159_bb0090","doi-asserted-by":"crossref","first-page":"F693","DOI":"10.1152\/ajprenal.00545.2020","article-title":"Role of the polycystins as mechanosensors of extracellular stiffness","volume":"320","author":"Nigro","year":"2021","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.metabol.2025.156159_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109877","article-title":"The functions of mechanosensitive ion channels in tooth and bone tissues","volume":"78","author":"Pei","year":"2021","journal-title":"Cell Signal"},{"key":"10.1016\/j.metabol.2025.156159_bb0100","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/0022034518781509","article-title":"Overexpressed Sirt1 in MSCs promotes dentin formation in Bmi1-deficient mice","volume":"97","author":"Wang","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0105","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1038\/s41467-022-35010-0","article-title":"Creb5 coordinates synovial joint formation with the genesis of articular cartilage","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2025.156159_bb0110","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13440","article-title":"Piezo1-mediated M2 macrophage mechanotransduction enhances bone formation through secretion and activation of transforming growth factor-beta1","volume":"56","author":"Cai","year":"2023","journal-title":"Cell Prolif"},{"key":"10.1016\/j.metabol.2025.156159_bb0115","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149828","article-title":"Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms","volume":"132","author":"Salamone","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2025.156159_bb0120","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1097\/00005768-200010000-00007","article-title":"Exercise and tumor development in a mouse predisposed to multiple intestinal adenomas","volume":"32","author":"Colbert","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.metabol.2025.156159_bb0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jbmr.3889","article-title":"Targeting bortezomib to bone increases its bone anabolic activity and reduces systemic adverse effects in mice","volume":"35","author":"Wang","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0130","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41467-018-07626-8","article-title":"B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation","volume":"9","author":"Sun","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2025.156159_bb0135","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI11653","article-title":"Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol","volume":"107","author":"Di Gregorio","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2025.156159_bb0140","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/jbmr.1630","article-title":"Repression of osteocyte Wnt\/beta-catenin signaling is an early event in the progression of renal osteodystrophy","volume":"27","author":"Sabbagh","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0145","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/s41467-019-10809-6","article-title":"Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"issue":"1168\u201382","key":"10.1016\/j.metabol.2025.156159_bb0150","article-title":"A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis","volume":"34","author":"Peng","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2025.156159_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115846","article-title":"Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling","volume":"145","author":"Johnson","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.metabol.2025.156159_bb0160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/nyas.12463","article-title":"Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton","volume":"1335","author":"Yuan","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.metabol.2025.156159_bb0165","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ecl.2021.07.005","article-title":"Physiology of calcium homeostasis: an overview","volume":"50","author":"Matikainen","year":"2021","journal-title":"Endocrinol Metab Clin N Am"},{"key":"10.1016\/j.metabol.2025.156159_bb0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fendo.2012.00099","article-title":"The involvement of TRP channels in bone homeostasis","volume":"3","author":"Lieben","year":"2012","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.metabol.2025.156159_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-5793(03)00055-3","article-title":"Calcium regulates the PI3K-Akt pathway in stretched osteoblasts","volume":"536","author":"Danciu","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.metabol.2025.156159_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111916","article-title":"Role of TRPV1 and TRPA1 in TSLP production in nasal epithelial cells","volume":"131","author":"Li","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.metabol.2025.156159_bb0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jmg.2009.069468","article-title":"Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum","volume":"48","author":"Cavalcanti","year":"2011","journal-title":"J Med Genet"},{"key":"10.1016\/j.metabol.2025.156159_bb0190","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.yexcr.2012.12.028","article-title":"IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways","volume":"319","author":"Wang","year":"2013","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.metabol.2025.156159_bb0195","doi-asserted-by":"crossref","first-page":"773","DOI":"10.15252\/embj.201593164","article-title":"Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex","volume":"35","author":"Taschner","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.metabol.2025.156159_bb0200","article-title":"The intraflagellar transport cycle","author":"Lacey","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.metabol.2025.156159_bb0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2007.02.003","article-title":"Development of the post-natal growth plate requires intraflagellar transport proteins","volume":"305","author":"Song","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.metabol.2025.156159_bb0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.02732","article-title":"Intraflagellar transport is essential for endochondral bone formation","volume":"134","author":"Haycraft","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.metabol.2025.156159_bb0215","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/s41467-022-30618-8","article-title":"Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth","volume":"13","author":"Dzamukova","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2025.156159_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218230","article-title":"Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones","volume":"14","author":"Schroeder","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2025.156159_bb0225","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/bdrc.21060","article-title":"The chondrocytic journey in endochondral bone growth and skeletal dysplasia","volume":"102","author":"Tsang","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.metabol.2025.156159_bb0230","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/s41588-022-01227-4","article-title":"Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice","volume":"54","author":"Liu","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2025.156159_bb0235","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2021.12.004","article-title":"Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice","volume":"482","author":"Yamaguchi","year":"2022","journal-title":"Dev Biol"},{"key":"10.1016\/j.metabol.2025.156159_bb0240","article-title":"Deletion of IFT80 impairs epiphyseal and articular cartilage formation due to disruption of chondrocyte differentiation","volume":"10","author":"Yuan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2025.156159_bb0245","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jemt.1070280606","article-title":"Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes","volume":"28","author":"Hunziker","year":"1994","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.metabol.2025.156159_bb0250","doi-asserted-by":"crossref","DOI":"10.1177\/1947603519900800","article-title":"Analysis of association between morphometric parameters of growth plate and bone growth of tibia in mice and humans","volume":"13","author":"Wilson","year":"2021","journal-title":"Cartilage"},{"issue":"2122\u201336","key":"10.1016\/j.metabol.2025.156159_bb0255","article-title":"Tracing the skeletal progenitor transition during postnatal bone formation","volume":"28","author":"Shu","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.metabol.2025.156159_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10199","article-title":"Site-specific load-induced expansion of Sca-1(+)Prrx1(+) and Sca-1(\u2212)Prrx1(+) cells in adult mouse long bone is attenuated with age","volume":"3","author":"Cabahug-Zuckerman","year":"2019","journal-title":"JBMR Plus"},{"key":"10.1016\/j.metabol.2025.156159_bb0265","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.metabol.2025.156159_bb0270","first-page":"9","article-title":"Osteoblast-osteoclast communication and bone homeostasis","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.metabol.2025.156159_bb0275","article-title":"FSH exacerbates bone loss by promoting osteoclast energy metabolism through the CREB-MDH2-NAD(+) axis","volume":"156147","author":"Chen","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2025.156159_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155746","article-title":"Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss","volume":"151","author":"Park","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2025.156159_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910459","article-title":"Role of K(+) and Ca(2+)-permeable channels in osteoblast functions","volume":"22","author":"Kito","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.metabol.2025.156159_bb0290","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13440","article-title":"Piezo1-mediated M2 macrophage mechanotransduction enhances bone formation through secretion and activation of transforming growth factor-\u03b21","volume":"56","author":"Cai","year":"2023","journal-title":"Cell Prolif"},{"key":"10.1016\/j.metabol.2025.156159_bb0295","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/JME-18-0051","article-title":"TRPM3\/TRPV4 regulates Ca2+-mediated RANKL\/NFATc1 expression in osteoblasts","volume":"61","author":"Son","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.metabol.2025.156159_bb0300","article-title":"Transient receptor potential vanilloid 1 and 4 double knockout leads to increased bone mass in mice","volume":"12","author":"Nishimura","year":"2020","journal-title":"Bone Rep"},{"key":"10.1016\/j.metabol.2025.156159_bb0305","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fbioe.2019.00422","article-title":"Human osteoblast migration in DC electrical fields depends on store operated Ca(2+)-release and is correlated to upregulation of stretch-activated TRPM7 channels","volume":"7","author":"Rohde","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.metabol.2025.156159_bb0310","doi-asserted-by":"crossref","first-page":"42385","DOI":"10.1038\/srep42385","article-title":"TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2025.156159_bb0315","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41419-018-0951-9","article-title":"IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development","volume":"10","author":"Yuan","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.metabol.2025.156159_bb0320","article-title":"Extracellular calcium-induced calcium transient regulating the proliferation of osteoblasts through glycolysis metabolism pathways","volume":"24","author":"Gao","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.metabol.2025.156159_bb0325","first-page":"9","article-title":"Piezo1\/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-\u00df-catenin","author":"Zhou","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.metabol.2025.156159_bb0330","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1038\/s41388-022-02421-8","article-title":"Correction: hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca(2+)\/PI3K\/AKT pathway","volume":"41","author":"Dou","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.metabol.2025.156159_bb0335","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","article-title":"Mechanisms of mechanotransduction and physiological roles of PIEZO channels","volume":"25","author":"Xiao","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.metabol.2025.156159_bb0340","article-title":"The effects on type 2 diabetes mellitus mouse femoral bone achieved by anti-osteoporosis exercise interventions","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.metabol.2025.156159_bb0345","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41418-022-01053-5","article-title":"Sirt3 mediates the benefits of exercise on bone in aged mice","volume":"30","author":"Li","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.metabol.2025.156159_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116870","article-title":"Interleukin-6 signaling in osteoblasts regulates bone remodeling during exercise","volume":"176","author":"Palmisano","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.metabol.2025.156159_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156057","article-title":"The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation","volume":"161","author":"Stefanakis","year":"2024","journal-title":"Metabolism"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049525000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049525000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:07:29Z","timestamp":1777453649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049525000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":71,"alternative-id":["S0026049525000289"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2025.156159","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2025.156159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"156159"}}