{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:51:21Z","timestamp":1791521481898,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-000271-00"],"award-info":[{"award-number":["MOH-000271-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.metabol.2026.156782","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:37:52Z","timestamp":1789627072000},"page":"156782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dose-response associations of whole-body and regional body fat with continuous glucose monitoring-derived glycemic level and glycemic variability: A cross-sectional study of Asian adults without diabetes"],"prefix":"10.1016","volume":"184","author":[{"given":"Jiali","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Shyong","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"M\u00fcller-Riemenschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M.","family":"van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2026.156782_bb0005","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.jacc.2018.07.081","article-title":"Blood sugar regulation for cardiovascular health promotion and disease prevention","volume":"72","author":"Schwarz","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2026.156782_bb0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S2213-8587(18)30136-0","article-title":"Glycaemic variability in diabetes: clinical and therapeutic implications","volume":"7","author":"Ceriello","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109940","article-title":"Impact of short-term glycemic variability on risk of all-cause mortality in type 2 diabetes patients with well-controlled glucose profile by continuous glucose monitoring: a prospective cohort study","volume":"189","author":"Mo","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.metabol.2026.156782_bb0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S2213-8587(21)00245-X","article-title":"Glycaemic management in diabetes: old and new approaches","volume":"10","author":"Ceriello","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41574-023-00832-5","article-title":"A new Article Series for adipose tissue","volume":"19","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0030","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.2337\/dc25-S008","article-title":"8. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes\u20132025","volume":"48","author":"ElSayed","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2026.156782_bb0035","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2023.04.002","article-title":"CGMap: characterizing continuous glucose monitor data in thousands of non-diabetic individuals","volume":"35","author":"Keshet","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2026.156782_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00238","article-title":"High adiposity is associated with higher nocturnal and diurnal glycaemia, but not with glycemic variability in older individuals without diabetes","volume":"9","author":"Noordam","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.metabol.2026.156782_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/s24030744","article-title":"Real world interstitial glucose profiles of a large cohort of physically active men and women","volume":"24","author":"Skroce","year":"2024","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.metabol.2026.156782_bb0050","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.clnu.2024.02.014","article-title":"Glycemic variability assessed using continuous glucose monitoring in individuals without diabetes and associations with cardiometabolic risk markers: a systematic review and meta-analysis","volume":"43","author":"Hjort","year":"2024","journal-title":"Clin Nutr"},{"key":"10.1016\/j.metabol.2026.156782_bb0055","article-title":"Continuous glucose monitoring-derived glycemic profiles and correlates in young adults ages 18 to 26 years","author":"Arce","year":"2025","journal-title":"J Diabetes Sci Technol"},{"key":"10.1016\/j.metabol.2026.156782_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0291923","article-title":"Assessment of glycemic variability and lifestyle behaviors in healthy nondiabetic individuals according to the categories of body mass index","volume":"18","author":"Kashiwagi","year":"2023","journal-title":"PloS One"},{"key":"10.1016\/j.metabol.2026.156782_bb0065","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-082440","article-title":"Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide","volume":"390","author":"Lopez-Ayala","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2026.156782_bb0070","article-title":"Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study","volume":"362","author":"Lee","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2026.156782_bb0075","article-title":"Advancing understanding of dietary and movement behaviours in an Asian population through real-time monitoring: protocol of the Continuous Observations of Behavioural Risk Factors in Asia study (COBRA)","volume":"8","author":"Edney","year":"2022","journal-title":"Digit Health"},{"key":"10.1016\/j.metabol.2026.156782_bb0080","series-title":"Practical and technical advantages of DXA visceral fat assessment compared with computed tomography","author":"Kelly","year":"2012"},{"key":"10.1016\/j.metabol.2026.156782_bb0085","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1038\/nutd.2016.28","article-title":"Comparison of visceral fat mass measurement by dual-X-ray absorptiometry and magnetic resonance imaging in a multiethnic cohort: the Dallas Heart Study","volume":"6","author":"Neeland","year":"2016","journal-title":"Nutr Diabetes"},{"key":"10.1016\/j.metabol.2026.156782_bb0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S2213-8587(22)00319-9","article-title":"Continuous glucose monitoring and metrics for clinical trials: an international consensus statement","volume":"11","author":"Battelino","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12966-024-01693-5","article-title":"Diet, physical activity, and sleep in relation to postprandial glucose responses under free-living conditions: an intensive longitudinal observational study","volume":"21","author":"Yao","year":"2024","journal-title":"Int J Behav Nutr Phys Act"},{"key":"10.1016\/j.metabol.2026.156782_bb0100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41569-023-00847-5","article-title":"Obesity and the risk of cardiometabolic diseases","volume":"20","author":"Valenzuela","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.metabol.2026.156782_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/nu14020366","article-title":"Diet and physical activity as determinants of continuously measured glucose levels in persons at high risk of type 2 diabetes","volume":"14","author":"Park","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.metabol.2026.156782_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2022.102387","article-title":"Glucose variability in subjects with normal glucose tolerance: relations with body composition, insulin secretion and sensitivity","volume":"16","author":"Klimontov","year":"2022","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.metabol.2026.156782_bb0115","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S2213-8587(20)30110-8","article-title":"Causes, consequences, and treatment of metabolically unhealthy fat distribution","volume":"8","author":"Stefan","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/diacare.27.2.372","article-title":"Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study","volume":"27","author":"Snijder","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2026.156782_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/ije\/dyi253","article-title":"What aspects of body fat are particularly hazardous and how do we measure them?","volume":"35","author":"Snijder","year":"2006","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.metabol.2026.156782_bb0130","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/eurheartj\/ehz391","article-title":"Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index","volume":"40","author":"Chen","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.metabol.2026.156782_bb0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng.3714","article-title":"Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance","volume":"49","author":"Lotta","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2026.156782_bb0140","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2026.156782_bb0145","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.56067","article-title":"Baseline fasting glucose level, age, sex, and body mass index and the development of diabetes in US adults","volume":"8","author":"Egan","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.metabol.2026.156782_bb0150","first-page":"0","article-title":"Undernutrition-associated diabetes mellitus: pathophysiology of a global problem","volume":"40","author":"Wadivkar","year":"2025","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.metabol.2026.156782_bb0155","doi-asserted-by":"crossref","first-page":"e2053","DOI":"10.1210\/clinem\/dgab052","article-title":"Prevalence and features of impaired glucose tolerance in young underweight Japanese women","volume":"106","author":"Sato","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2026.156782_bb0160","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/dom.15049","article-title":"Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: a prospective observational study","volume":"25","author":"Miya","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.metabol.2026.156782_bb0165","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-024-07019-6","article-title":"Genetic drivers of heterogeneity in type 2 diabetes pathophysiology","volume":"627","author":"Suzuki","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2026.156782_bb0170","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2026.156782_bb0175","author":"Jain"},{"key":"10.1016\/j.metabol.2026.156782_bb0180","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.metabol.2026.156782_bb0185","article-title":"Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms","author":"Chiriac\u00f2","year":"2025","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2026.156782_bb0190","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154068","article-title":"\u03b2 cell function and plasma insulin clearance in people with obesity and different glycemic status","volume":"132","author":"Mittendorfer","year":"2022","journal-title":"J Clin Invest"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049526002957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049526002957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:44:20Z","timestamp":1791521060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049526002957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0026049526002957"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2026.156782","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-response associations of whole-body and regional body fat with continuous glucose monitoring-derived glycemic level and glycemic variability: A cross-sectional study of Asian adults without diabetes","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2026.156782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"156782"}}