{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T02:19:40Z","timestamp":1794709180141,"version":"4.9.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HR21C0198"],"award-info":[{"award-number":["HR21C0198"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-00554046"],"award-info":[{"award-number":["RS-2025-00554046"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00223501"],"award-info":[{"award-number":["RS-2023-00223501"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25526181"],"award-info":[{"award-number":["RS-2026-25526181"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.metabol.2026.156789","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:25:31Z","timestamp":1790519131000},"page":"156789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hypothalamic microglial IL-4 signaling mediates cancer-associated cachexia via sympathetic activation"],"prefix":"10.1016","volume":"185","author":[{"given":"Saeha","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooyeon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subin","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Gyeong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hee","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keunwook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Seon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2026.156789_bb0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.smhs.2020.10.003","article-title":"Development and progression of cancer cachexia: Perspectives from bench to bedside","volume":"2","author":"Lim","year":"2020","journal-title":"Sports Med Health Sci"},{"key":"10.1016\/j.metabol.2026.156789_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-010-0002-6","article-title":"Cachexia as a major underestimated and unmet medical need: facts and numbers","volume":"1","author":"von Haehling","year":"2010","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.metabol.2026.156789_bb0015","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s12276-021-00582-2","article-title":"Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor","volume":"53","author":"Yoo","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.metabol.2026.156789_bb0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2026.156789_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13163990","article-title":"Neural mechanisms of cancer cachexia","volume":"13","author":"Olson","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.metabol.2026.156789_bb0030","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.metabol.2026.156789_bb0035","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1210\/jc.2002-021687","article-title":"Interleukin-6 stimulates lipolysis and fat oxidation in humans","volume":"88","author":"van Hall","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2026.156789_bb0040","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2337\/diabetes.51.10.2929","article-title":"Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP","volume":"51","author":"Zhang","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2026.156789_bb0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0050","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-024-48971-1","article-title":"Area postrema neurons mediate interleukin-6 function in cancer cachexia","volume":"15","author":"Sun","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0055","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jcsm.12033","article-title":"Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients","volume":"6","author":"Lerner","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.metabol.2026.156789_bb0060","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2026.156789_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111947","article-title":"GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia","volume":"42","author":"Kim-Muller","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.metabol.2026.156789_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062998","article-title":"Involvement of IL-4, IL-13 and their receptors in pancreatic cancer","volume":"22","author":"Shi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.metabol.2026.156789_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2022.100830","article-title":"Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype","volume":"32","author":"de Groot","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.metabol.2026.156789_bb0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41698-024-00522-z","article-title":"Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance","volume":"8","author":"Wang","year":"2024","journal-title":"npj Precis Oncol"},{"key":"10.1016\/j.metabol.2026.156789_bb0085","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00262-017-2043-6","article-title":"IL-4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model","volume":"66","author":"Ito","year":"2017","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.metabol.2026.156789_bb0090","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112840119","article-title":"An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia","volume":"119","author":"Xie","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.metabol.2026.156789_bb0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-06249-4","article-title":"GDF15 promotes weight loss by enhancing energy expenditure in muscle","volume":"619","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2026.156789_bb0100","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1172\/JCI138392","article-title":"Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia","volume":"130","author":"Zhu","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2026.156789_bb0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5483\/BMBRep.2024-0019","article-title":"The contribution of the nervous system in the cancer progression","volume":"57","author":"Park","year":"2024","journal-title":"BMB Rep"},{"key":"10.1016\/j.metabol.2026.156789_bb0110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.metabol.2026.156789_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5483\/BMBRep.2025-0066","article-title":"Differential regulation of type 2 immunity by glucocorticoids","volume":"59","author":"Song","year":"2026","journal-title":"BMB Rep"},{"key":"10.1016\/j.metabol.2026.156789_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5483\/BMBRep.2015.48.4.272","article-title":"Network of hypothalamic neurons that control appetite","volume":"48","author":"Sohn","year":"2015","journal-title":"BMB Rep"},{"key":"10.1016\/j.metabol.2026.156789_bb0125","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3803\/EnM.2016.31.4.519","article-title":"Brain regulation of energy metabolism","volume":"31","author":"Roh","year":"2016","journal-title":"Endocrinol Metab (Seoul)"},{"key":"10.1016\/j.metabol.2026.156789_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2021.01.003","article-title":"Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism","volume":"33","author":"Kang","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2026.156789_bb0135","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s12276-022-00741-z","article-title":"Hypothalamic control of energy expenditure and thermogenesis","volume":"54","author":"Tran","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.metabol.2026.156789_bb0140","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12974-024-03244-y","article-title":"Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice","volume":"21","author":"Moon","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.metabol.2026.156789_bb0145","article-title":"A psychological stressor conveyed by appetite-linked neurons","volume":"6","author":"Lee","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.metabol.2026.156789_bb0150","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20111020","article-title":"Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis","volume":"208","author":"Braun","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.metabol.2026.156789_bb0155","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-021-03417-2","article-title":"Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence","volume":"592","author":"Choi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2026.156789_bb0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7150\/thno.48206","article-title":"Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer","volume":"11","author":"Zhu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.metabol.2026.156789_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.869108","article-title":"Cell-free RNA as a novel biomarker for response to therapy in head & neck cancer","volume":"12","author":"Tosevska","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.metabol.2026.156789_bb0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75181","article-title":"Cancer type classification using plasma cell-free RNAs derived from human and microbes","volume":"11","author":"Chen","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.metabol.2026.156789_bb0175","article-title":"Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients\u2019 blood","volume":"4","author":"Tao","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.metabol.2026.156789_bb0180","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.immuni.2015.03.006","article-title":"The NLRP12 sensor negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells","volume":"42","author":"Lukens","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.metabol.2026.156789_bb0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41541-020-00247-7","article-title":"Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders","volume":"5","author":"Crouse","year":"2020","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.metabol.2026.156789_bb0190","doi-asserted-by":"crossref","first-page":"E487","DOI":"10.1152\/ajpendo.00443.2018","article-title":"Intact innervation is essential for diet-induced recruitment of brown adipose tissue","volume":"316","author":"Fischer","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2026.156789_bb0195","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1038\/s41467-020-19638-4","article-title":"Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus","volume":"11","author":"Lee","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0200","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1989","article-title":"Protocol for primary microglial culture preparation","volume":"6","author":"Lian","year":"2016","journal-title":"Bio Protoc"},{"key":"10.1016\/j.metabol.2026.156789_bb0205","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41392-025-02331-7","article-title":"Cancer cachexia: molecular basis and therapeutic advances","volume":"11","author":"Tan","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.metabol.2026.156789_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.906717","article-title":"Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice","volume":"13","author":"Suh","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.metabol.2026.156789_bb0215","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41592-022-01547-7","article-title":"Directed evolution of adeno-associated virus for efficient gene delivery to microglia","volume":"19","author":"Lin","year":"2022","journal-title":"Nat Methods"},{"key":"10.1016\/j.metabol.2026.156789_bb0220","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/dmm.026609","article-title":"Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity","volume":"10","author":"Timper","year":"2017","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.metabol.2026.156789_bb0225","article-title":"Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis","volume":"6","author":"Jin","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.metabol.2026.156789_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15143","article-title":"TNF\u03b1 drives mitochondrial stress in POMC neurons in obesity","volume":"8","author":"Yi","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0235","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jcsm.12294","article-title":"Dysregulation of metabolic-associated pathways in muscle of breast cancer patients: preclinical evaluation of interleukin-15 targeting fatigue","volume":"9","author":"Bohlen","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.metabol.2026.156789_bb0240","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argil\u00e9s","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.metabol.2026.156789_bb0245","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.metabol.2026.156789_bb0250","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1038\/s41467-023-40024-3","article-title":"Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer","volume":"14","author":"Babic","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0255","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1152\/physrev.00024.2017","article-title":"POMC: the physiological power of hormone processing","volume":"98","author":"Harno","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.metabol.2026.156789_bb0260","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1210\/en.2012-1166","article-title":"\u03b2-Endorphin antagonizes the effects of \u03b1-MSH on food intake and body weight","volume":"153","author":"Dutia","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2026.156789_bb0265","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/s41467-023-37912-z","article-title":"The melanocortin action is biased toward protection from weight loss in mice","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.metabol.2026.156789_bb0270","doi-asserted-by":"crossref","first-page":"223","DOI":"10.9738\/INTSURG-D-13-00259.1","article-title":"Low serum interleukin-13 levels correlate with poorer prognoses for colorectal cancer patients","volume":"99","author":"Saigusa","year":"2014","journal-title":"Int Surg"},{"key":"10.1016\/j.metabol.2026.156789_bb0275","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00262-011-1028-0","article-title":"Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13","volume":"60","author":"Gabitass","year":"2011","journal-title":"Cancer Immunol Immunother"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049526003021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049526003021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T01:33:59Z","timestamp":1794706439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049526003021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":55,"alternative-id":["S0026049526003021"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2026.156789","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothalamic microglial IL-4 signaling mediates cancer-associated cachexia via sympathetic activation","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2026.156789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"156789"}}