{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:08:31Z","timestamp":1792159711790,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007941","name":"Addis Ababa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.metop.2021.100118","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T04:30:09Z","timestamp":1628829009000},"page":"100118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of Rubus Erlangeri Engl (Rosacea) in mice"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-1086","authenticated-orcid":false,"given":"Akeberegn Gorems","family":"Ayele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-6421","authenticated-orcid":false,"given":"Ephrem","family":"Engidawork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metop.2021.100118_bib1","first-page":"S1","article-title":"Standards of medical care in diabetes. , S1-S193. Standards of medical care in diabetes","volume":"42","author":"Riddle","year":"2019","journal-title":"American Diabetes Association. American Diabetes Association."},{"key":"10.1016\/j.metop.2021.100118_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3086167","article-title":"Complications of diabetes 2017","volume":"2018","author":"Papatheodorou","year":"2018","journal-title":"Journal of Diabetes Research"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S2213-8587(13)70112-8","article-title":"Diabetes: a 21st century challenge","volume":"2","author":"Zimmet","year":"2014","journal-title":"The lancet Diabetes endocrinology"},{"key":"10.1016\/j.metop.2021.100118_bib4","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1186\/s12889-018-6053-x","article-title":"Prevalence and factors associated with pre-diabetes and diabetes mellitus in Kenya: results from a national survey","author":"Mohamed","year":"2018","journal-title":"BMC Publ Health"},{"issue":"1084","key":"10.1016\/j.metop.2021.100118_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/postgradmedj-2015-133281","article-title":"Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective","volume":"92","author":"Zaccardi","year":"2016","journal-title":"Postgrad Med"},{"issue":"4","key":"10.1016\/j.metop.2021.100118_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.sjbs.2012.12.005","article-title":"Free radical scavenging activity from different extracts of leaves of Bauhinia vahlii Wight & Arn","volume":"20","author":"Sowndhararajan","year":"2013","journal-title":"Saudi J Biol Sci"},{"issue":"24","key":"10.1016\/j.metop.2021.100118_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s12906-016-1452-y","article-title":"In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina","volume":"16","author":"Wickramaratne","year":"2016","journal-title":"BMC Compl Alternative Med"},{"issue":"4","key":"10.1016\/j.metop.2021.100118_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S2221-1691(12)60020-3","article-title":"Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats","volume":"2","author":"Ramachandran","year":"2012","journal-title":"Asian Pac J Trop Biomed"},{"key":"10.1016\/j.metop.2021.100118_bib9","series-title":"Endemic plants of Ethiopia: preliminary working list to contribute to National plant conservation target","first-page":"14","author":"Awas","year":"2016"},{"key":"10.1016\/j.metop.2021.100118_bib10","series-title":"Rosaceae: taxonomy, economic importance, genomics. Genetics and genomics of Rosaceae","first-page":"1","author":"Hummer","year":"2009"},{"key":"10.1016\/j.metop.2021.100118_bib11","doi-asserted-by":"crossref","first-page":"S348","DOI":"10.1016\/S1995-7645(14)60257-1","article-title":"Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran","volume":"7","author":"Bahmani","year":"2014","journal-title":"Asian Pac J Trop Med"},{"issue":"10","key":"10.1016\/j.metop.2021.100118_bib12","first-page":"1431","article-title":"Ethnobotanical survey of medicinal plants used for the treatment of diabetes in Manisa, Turkey","volume":"42","author":"Durmuskahya","year":"2013","journal-title":"Sains Malays"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib13","doi-asserted-by":"crossref","DOI":"10.4172\/2472-0992.1000130","article-title":"Ethnobotanical survey of medicinal plants used for the treatment of diabetes in the Tizi n'Test region (Taroudant Province, Morocco)","volume":"3","author":"Katiri","year":"2017","journal-title":"J pharmacogn nat prod"},{"issue":"5","key":"10.1016\/j.metop.2021.100118_bib14","first-page":"5","article-title":"Ethno-botanical study of anti-diabetic medicinal plants used by the local people of Kokrajhar District of Bodoland Territorial Council, India","volume":"1","author":"Swargiary","year":"2013","journal-title":"Journal of Medicinal Plants Studies"},{"key":"10.1016\/j.metop.2021.100118_bib15","series-title":"Edible wild plants of Tanzania","author":"Ruffo","year":"2002"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib16","first-page":"40","article-title":"Herbal medicines for the management of diabetic mellitus in Ethiopia and Eretria including their phytochemical constituents","volume":"5","author":"Meresa","year":"2017","journal-title":"J American Journal of Advanced Drug Delivery"},{"issue":"5","key":"10.1016\/j.metop.2021.100118_bib17","first-page":"501","article-title":"Rubus caesius L. Leaves: pharmacognostic analysis and the study of hypoglycemic activity","volume":"7","author":"Sch\u00e4dler","year":"2017","journal-title":"NJPPP"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1099-1573(199903)13:2<91::AID-PTR350>3.0.CO;2-8","article-title":"Hypoglycaemic activity of four plants used in Chilean popular medicine","volume":"13","author":"Lemus","year":"1999","journal-title":"Phytother Res"},{"issue":"3\u20134","key":"10.1016\/j.metop.2021.100118_bib19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1515\/znc-2002-3-412","article-title":"Cytotoxic, hypoglycemic activity and phytochemical analysis of Rubus imperialis (Rosaceae)","volume":"57","author":"Kanegusuku","year":"2002","journal-title":"Z Naturforsch B Chem Sci"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/2078-7685.197962","article-title":"Anti-diabetic effect of Rubus ellipticus fruit extracts in alloxan induced diabetic rats","volume":"2","author":"Sharma","year":"2011","journal-title":"Journal of Diabetology"},{"issue":"S 1","key":"10.1016\/j.metop.2021.100118_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1055\/s-2008-1075012","article-title":"A preliminary study of hypoglycemic activity of Rubus fruticosus","volume":"40","author":"Alonso","year":"1980","journal-title":"PLANT MED"},{"key":"10.1016\/j.metop.2021.100118_bib22","series-title":"Pharmaceutical resource discovery from traditional medicinal plants: pharmacophylogeny and pharmacophylogenomics","author":"Hao","year":"2020"},{"key":"10.1016\/j.metop.2021.100118_bib23","series-title":"A N. Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.metop.2021.100118_bib24","series-title":"AVMA guidelines for the euthanasia of animals: 2013 edition","author":"Association","year":"2013"},{"key":"10.1016\/j.metop.2021.100118_bib25","volume":"vol. 3","author":"Hedberg","year":"1989"},{"key":"10.1016\/j.metop.2021.100118_bib26","series-title":"Remington: the science and practice of pharmacy","author":"Remington","year":"2006"},{"key":"10.1016\/j.metop.2021.100118_bib27","series-title":"Trease and evans pharmacognosy","author":"EVANS","year":"2009"},{"key":"10.1016\/j.metop.2021.100118_bib28","first-page":"38","article-title":"Preliminary screening techniques of secondary metabolites","author":"Debella","year":"2002","journal-title":"Manual for Phytochemical Screening of Medicinal Plants"},{"issue":"11","key":"10.1016\/j.metop.2021.100118_bib29","first-page":"228","article-title":"Phytochemical constituents of some selected medicinal plants","volume":"3","author":"Njoku","year":"2009","journal-title":"AJPAC"},{"issue":"9","key":"10.1016\/j.metop.2021.100118_bib30","first-page":"61","article-title":"Estimation of phenolic content, flavonoid content, antioxidant and alpha amylase inhibitory activity of marketed polyherbal formulation","volume":"4","author":"Kamtekar","year":"2014","journal-title":"J Appl Pharmaceut Sci"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib31","first-page":"66","article-title":"Estimation of flavonoid, polyphenolic content and in vitro antioxidant capacity of leaves of Tephrosia purpurea Linn.(Leguminosae)","volume":"1","author":"Patel","year":"2010","journal-title":"Int J Pharma Sci Res"},{"issue":"24","key":"10.1016\/j.metop.2021.100118_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s12906-016-1452-y","article-title":"In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina","volume":"16","author":"Wickramaratne","year":"2016","journal-title":"BMC Compl Alternative Med"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib33","first-page":"88","article-title":"In vitro antidiabetic activity of anthocyanin extract of Asystasia gangetica (Chinese violet) flower","volume":"3","author":"Sama","year":"2013","journal-title":"Asian J Plant Sci Res"},{"key":"10.1016\/j.metop.2021.100118_bib34","first-page":"103","article-title":"Antioxidant activities of three Rubus species growing in Ethiopia","volume":"25","author":"Tadesse","year":"2007","journal-title":"Ethiop Pharmaceut J"},{"key":"10.1016\/j.metop.2021.100118_bib35","series-title":"Guidelines for testing of chemicals: guideline 425 : acute oral toxicity","year":"2008"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib36","first-page":"4186","article-title":"Effect of fasting time on measuring mouse blood glucose level","volume":"9","author":"Sun","year":"2016","journal-title":"Int J, Clin Exp, mecl."},{"issue":"5","key":"10.1016\/j.metop.2021.100118_bib37","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jemt.20039","article-title":"Effect of streptozotocin on the ultrastructure of rat pancreatic islets","volume":"63","author":"Mythili","year":"2004","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.metop.2021.100118_bib38","series-title":"Animal models of diabetic complications consortium protocols","first-page":"1","article-title":"High-dose streptozotocin induction protocol (Mouse)\/Low-Dose streptozotocin induction protocol (mouse)","author":"Brosius","year":"2009"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin\u2010induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Current protocols in pharmacology"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib40","first-page":"67","article-title":"Effects of solvent fractions of Caylusea abyssinica (fresen.) fisch. And mey. On blood glucose levels of normoglycemic, glucose loaded and streptozotocin-induced diabetic rodents","volume":"14","author":"Gebreyohannis","year":"2013","journal-title":"J Nat Med"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib41","first-page":"110","article-title":"Hypoglycemic and antihyperglycemic activity of aqueous extract of Justicia Schimperiana leaves in normal and streptozotocin-induced diabetic mice","volume":"7","author":"Tesfaye","year":"2016","journal-title":"Int J Pharma Sci Res"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib42","first-page":"4186","article-title":"Effect of fasting time on measuring mouse blood glucose level","volume":"9","author":"Sun","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"issue":"11","key":"10.1016\/j.metop.2021.100118_bib43","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4014\/jmb.1503.03098","article-title":"Bioconversion of cyanidin-3-rutinoside to cyanidin-3-glucoside in Black raspberry by Crude \u03b1-L-rhamnosidase from Aspergillus species","volume":"25","author":"Lim","year":"2015","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3164\/jcbn.10-116","article-title":"Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal \u03b1-glucosidase","volume":"49","author":"Adisakwattana","year":"2011","journal-title":"J Clin Biochem Nutr"},{"issue":"4","key":"10.1016\/j.metop.2021.100118_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.sjbs.2012.12.005","article-title":"Free radical scavenging activity from different extracts of leaves of Bauhinia vahlii Wight & Arn","volume":"20","author":"Sowndhararajan","year":"2013","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib46","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s12906-016-1452-y","article-title":"In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina","volume":"16","author":"Wickramaratne","year":"2016","journal-title":"BMC Compl Alternative Med"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib47","first-page":"1","article-title":"Antidiabetic and antioxidant activity of Rubus apetalus poir. And Rubus steudneri schweinf. Leaf extract on alloxan induced diabetes mellitus","volume":"11","author":"Raghavendra","year":"2019","journal-title":"J Bioanal Biomed"},{"key":"10.1016\/j.metop.2021.100118_bib48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000497675","article-title":"Biochemical study on the hypoglycaemic effects of extract and fraction of Acacia catechu willd in alloxan-induced diabetic rats","volume":"17","author":"Jarald","year":"2009","journal-title":"Int J Diabetes Metabol"},{"issue":"3","key":"10.1016\/j.metop.2021.100118_bib49","doi-asserted-by":"crossref","first-page":"G13","DOI":"10.1530\/JOE-14-0182","article-title":"Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models","volume":"222","author":"Bowe","year":"2014","journal-title":"Internet J Endocrinol"},{"issue":"9\u201310","key":"10.1016\/j.metop.2021.100118_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice","volume":"3","author":"Ayala","year":"2010","journal-title":"DIS MODEL MECH"},{"key":"10.1016\/j.metop.2021.100118_bib51","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/cddiscovery.2016.9","article-title":"Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice","volume":"2","author":"Wilson","year":"2016","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib52","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1677\/joe.1.06596","article-title":"Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats","volume":"190","author":"Vital","year":"2006","journal-title":"Internet J Endocrinol"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib53","first-page":"60","article-title":"Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans","volume":"12","author":"Eleazu","year":"2013","journal-title":"JDMDC"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib54","first-page":"253","article-title":"Streptozotocin-a diabetogenic agent in animal models","volume":"3","author":"Goud","year":"2015","journal-title":"Int J Pharm Pharmaceut Res"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib55","first-page":"49","article-title":"The dual role of nitric oxide in islet \u03b2-cells","volume":"14","author":"Spinas","year":"1999","journal-title":"PHYSIOL INT"},{"issue":"3","key":"10.1016\/j.metop.2021.100118_bib56","first-page":"111","article-title":"Correlations between blood glucose level and diabetes signs in streptozotocin-induced diabetic mice","volume":"4","author":"Tian","year":"2010","journal-title":"Int J Pharmacol"},{"key":"10.1016\/j.metop.2021.100118_bib57","series-title":"Comprehensive medicinal chemistry II","article-title":"Therapeutic areas I: Central nervous system, pain, metabolic syndrome, urology, gastrointestinal and cardiovascular","author":"Schmeltz","year":"2007"},{"issue":"3","key":"10.1016\/j.metop.2021.100118_bib58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","article-title":"Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab Anim"},{"issue":"2","key":"10.1016\/j.metop.2021.100118_bib59","first-page":"82","article-title":"Ameliorative potentials of ginger (Z. officinale Roscoe) on relative organ weights in streptozotocin induced diabetic rats","volume":"9","author":"Eleazu","year":"2013","journal-title":"IJBS"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib60","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.19082\/1832","article-title":"The role of medicinal plants in the treatment of diabetes: a systematic review","volume":"8","author":"Kooti","year":"2016","journal-title":"Electron Physician"},{"key":"10.1016\/j.metop.2021.100118_bib61","doi-asserted-by":"crossref","first-page":"134","DOI":"10.14196\/mjiri.31.134","article-title":"Polyphenols and their effects on diabetes management: a review","volume":"31","author":"Aryaeian","year":"2017","journal-title":"MJIRI"},{"issue":"3","key":"10.1016\/j.metop.2021.100118_bib62","first-page":"5396","article-title":"Antihyperglycemic effect of tannic acid in streptozotocin induced diabetic rats","volume":"6","author":"Babby","year":"2014","journal-title":"Int J Curr Res"},{"issue":"1","key":"10.1016\/j.metop.2021.100118_bib63","first-page":"148","article-title":"Saponins and their potential role in diabetes mellitus","volume":"7","author":"El Barky","year":"2017","journal-title":"Diabetes Manag"}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936821000426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936821000426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:57:07Z","timestamp":1762905427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589936821000426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":63,"alternative-id":["S2589936821000426"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2021.100118","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of Rubus Erlangeri Engl (Rosacea) in mice","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2021.100118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100118"}}