{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:15:25Z","timestamp":1792592125528,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.metop.2025.100350","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T12:25:57Z","timestamp":1738326357000},"page":"100350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The role of vitamin D deficiency in placental dysfunction: A systematic review"],"prefix":"10.1016","volume":"25","author":[{"given":"Eleni","family":"Gerovasili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigoni","family":"Sarantaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Bothou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Deltsidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Dimitrakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-3318","authenticated-orcid":false,"given":"Athina","family":"Diamanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metop.2025.100350_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1298181","article-title":"Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases","volume":"15","author":"Yao","year":"2024","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.metop.2025.100350_bib2","article-title":"Correlation between serum levels of 25-hydroxyvitamin D and severity of community-acquired pneumonia in hospitalized patients assessed by pneumonia severity Index: an observational descriptive study","volume":"12","author":"Georgakopoulou","year":"2020","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.metop.2025.100350_bib3","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/nu12051432","article-title":"Vitamin D effects on the immune system from periconception through pregnancy","volume":"12","author":"Schr\u00f6der-Heurich","year":"2020","journal-title":"Nutrients"},{"issue":"1663","key":"10.1016\/j.metop.2025.100350_bib4","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.metop.2025.100350_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1200330","article-title":"Establishment of the fetal-maternal interface: developmental events in human implantation and placentation","volume":"11","author":"Huang","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"1 Suppl","key":"10.1016\/j.metop.2025.100350_bib6","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ajog.2016.03.001","article-title":"Placental origins of adverse pregnancy outcomes: potential molecular targets: an executive workshop summary of the eunice kennedy shriver national Institute of child health and human development","volume":"215","author":"Ilekis","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.metop.2025.100350_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12653","article-title":"Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes","volume":"77","author":"Sultana","year":"2017","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.metop.2025.100350_bib8","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/REP-16-0647","article-title":"Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?","volume":"153","author":"Yates","year":"2017","journal-title":"Reproduction"},{"issue":"6","key":"10.1016\/j.metop.2025.100350_bib9","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/advances\/nmab070","article-title":"Placental angiogenesis in mammals: a review of the regulatory effects of signaling pathways and functional nutrients","volume":"12","author":"Huang","year":"2021","journal-title":"Adv Nutr"},{"issue":"1\u20132","key":"10.1016\/j.metop.2025.100350_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/19336918.2015.1120397","article-title":"Intrauterine trophoblast migration: a comparative view of humans and rodents","volume":"10","author":"Silva","year":"2016","journal-title":"Cell Adhes Migrat"},{"issue":"1","key":"10.1016\/j.metop.2025.100350_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.13077","article-title":"Mechanisms of immune regulation by the placenta: role of type I interferon and interferon-stimulated genes signaling during pregnancy","volume":"308","author":"Ding","year":"2022","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.metop.2025.100350_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2217\/WHE.12.17","article-title":"The role of vitamin D in pregnancy and lactation: emerging concepts","volume":"8","author":"Wagner","year":"2012","journal-title":"Womens Health (Lond)"},{"issue":"1","key":"10.1016\/j.metop.2025.100350_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41387-024-00296-0","article-title":"Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: an umbrella review of systematic review and meta-analyses","volume":"14","author":"Chien","year":"2024","journal-title":"Nutr Diabetes"},{"issue":"20","key":"10.1016\/j.metop.2025.100350_bib14","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.3390\/nu14204230","article-title":"Relationship between maternal vitamin D levels and adverse outcomes","volume":"14","author":"Zhang","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.metop.2025.100350_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/nu10070867","article-title":"The association of vitamin D levels with common pregnancy complications","volume":"10","author":"Dovnik","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.metop.2025.100350_bib16","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.metop.2025.100350_bib17","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.metop.2025.100350_bib18","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses."},{"issue":"10","key":"10.1016\/j.metop.2025.100350_bib19","first-page":"2127","article-title":"Methodological quality of case series studies: an introduction to the JBI critical appraisal tool","volume":"18","author":"Munn","year":"2020","journal-title":"JBI Evid Synth"},{"key":"10.1016\/j.metop.2025.100350_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.preghy.2020.09.004","article-title":"Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency","volume":"22","author":"Awe","year":"2020","journal-title":"Pregnancy Hypertens"},{"issue":"6","key":"10.1016\/j.metop.2025.100350_bib21","doi-asserted-by":"crossref","first-page":"560.e1","DOI":"10.1016\/j.ajog.2013.08.015","article-title":"Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta","volume":"209","author":"Cho","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.metop.2025.100350_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3945\/ajcn.112.055426","article-title":"Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort","volume":"98","author":"Gernand","year":"2013","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.metop.2025.100350_bib23","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa057","article-title":"Vitamin D sufficiency has a limited effect on placental structure and pathology: placental phenotypes in the VDAART trial","volume":"161","author":"He","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.metop.2025.100350_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106358","article-title":"Does maternal vitamin D status influence placental weight or vascular and inflammatory pathology? Secondary analysis from the Kellogg Pregnancy Study","volume":"233","author":"Mead","year":"2023","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.metop.2025.100350_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.893848","article-title":"Vitamin D supplementation improves mitochondrial function and reduces inflammation in placentae of obese women","volume":"13","author":"Phillips","year":"2022","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.metop.2025.100350_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00250-5","article-title":"Vitamin D deficiency during late pregnancy mediates placenta-associated complications","volume":"11","author":"Raia-Barjat","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.metop.2025.100350_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jsbmb.2017.02.003","article-title":"Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy","volume":"173","author":"Schulz","year":"2017","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.metop.2025.100350_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12884-023-05484-x","article-title":"Vitamin D in pregnancy (GRAVITD) - a randomised controlled trial identifying associations and mechanisms linking maternal Vitamin D deficiency to placental dysfunction and adverse pregnancy outcomes - study protocol","volume":"23","author":"Vestergaard","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.metop.2025.100350_bib29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1210\/jc.2012-3275","article-title":"Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study","volume":"98","author":"Gernand","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.metop.2025.100350_bib30","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/REP-16-0647","article-title":"Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?","volume":"153","author":"Yates","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.metop.2025.100350_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105733","article-title":"Gestational vitamin D deficiency causes placental insufficiency and fetal intrauterine growth restriction partially through inducing placental inflammation","volume":"203","author":"Chen","year":"2020","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936825000064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936825000064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T03:11:47Z","timestamp":1741835507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589936825000064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":31,"alternative-id":["S2589936825000064"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2025.100350","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of vitamin D deficiency in placental dysfunction: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2025.100350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100350"}}