{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:00:32Z","timestamp":1793653232135,"version":"4.5.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.metop.2025.100441","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:27:57Z","timestamp":1767860877000},"page":"100441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Gene and non-coding RNA expression in human cumulus cells in polycystic ovary syndrome: A systematic review"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9981-4861","authenticated-orcid":false,"given":"Faezeh","family":"Soheili Azad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metop.2025.100441_bib1","article-title":"Multi-omics approach to reveal follicular metabolic changes and their effects on oocyte competence in PCOS patients","volume":"15","author":"Chen","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.metop.2025.100441_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.843867","article-title":"PCOS and role of cumulus gene expression in assessing oocytes quality","volume":"13","author":"Sayutti","year":"2022","journal-title":"Front Endocrinol"},{"issue":"8","key":"10.1016\/j.metop.2025.100441_bib3","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1093\/humrep\/des172","article-title":"Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo and in vitro oocyte maturation","volume":"27","author":"Ouandaogo","year":"2012","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13048-020-00696-7","article-title":"Transcriptomics of cumulus Cells\u2013a window into oocyte maturation in humans","volume":"13","author":"Wyse","year":"2020","journal-title":"J Ovarian Res"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1477-7827-11-109","article-title":"RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte\/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients","volume":"11","author":"Huang","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/srep39638","article-title":"Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.metop.2025.100441_bib7","article-title":"Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.metop.2025.100441_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/molehr\/gan082","article-title":"Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients","volume":"15","author":"Kenigsberg","year":"2009","journal-title":"Mol Hum Reprod"},{"issue":"12","key":"10.1016\/j.metop.2025.100441_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168875","article-title":"Identification of polycystic ovary syndrome (PCOS) specific genes in cumulus and mural granulosa cells","volume":"11","author":"Aydos","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.metop.2025.100441_bib10","first-page":"235","article-title":"Upregulation of oxidative phosphorylation genes in cumulus cells of the polycystic ovary syndrome patients with or without insulin resistance","volume":"26","author":"Motiee","year":"2024","journal-title":"Cell J (Yakhteh)"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib11","first-page":"35","article-title":"Downregulation of extracellular matrix and cell adhesion molecules in cumulus cells of infertile polycystic ovary syndrome women with and without insulin resistance","volume":"21","author":"Hassani","year":"2018","journal-title":"Cell J (Yakhteh)"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13048-014-0110-6","article-title":"The transcriptome of corona radiata cells from individual M\u0406\u0406 oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women","volume":"7","author":"Wissing","year":"2014","journal-title":"J Ovarian Res"},{"issue":"3","key":"10.1016\/j.metop.2025.100441_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2014.07.103","article-title":"Endoplasmic reticulum stress pathway gene expression is altered in the cumulus cells of PCOS patients undergoing IVF","volume":"102","author":"Collins","year":"2014","journal-title":"Fertil Steril"},{"issue":"10","key":"10.1016\/j.metop.2025.100441_bib14","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10815-012-9827-6","article-title":"Overexpression of ribosomal RNA in cumulus cells of patients with polycystic ovary syndrome","volume":"29","author":"Polzikov","year":"2012","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib15","article-title":"Transcriptome profiling reveals dysregulation of inflammatory and protein synthesis genes in PCOS","volume":"14","author":"Li","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12967-015-0605-y","article-title":"Altered microRNAs expression profiling in cumulus cells from patients with polycystic ovary syndrome","volume":"13","author":"Liu","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.metop.2025.100441_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mce.2015.01.030","article-title":"Characterization of microRNA profile in human cumulus granulosa cells: identification of microRNAs that regulate notch signaling and are associated with PCOS","volume":"404","author":"Xu","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10815-015-0630-z","article-title":"Aberrant expression of long noncoding RNAs in cumulus cells isolated from PCOS patients","volume":"33","author":"Huang","year":"2016","journal-title":"J Assist Reprod Genet"},{"issue":"10","key":"10.1016\/j.metop.2025.100441_bib19","first-page":"1144","article-title":"Evaluation of the expression profile of mRNAs and lncRNAs in cumulus cells associated with polycystic ovary syndrome and pregnancy","volume":"26","author":"Hammami","year":"2023","journal-title":"Iranian J Basic Med Sci"},{"issue":"17","key":"10.1016\/j.metop.2025.100441_bib20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1071\/RD22082","article-title":"Target gene repression mediated by miR-144 and miR-224 in cumulus cells is related to the success of oocyte in vitro maturation and fertilisation in patients with polycystic ovary syndrome (PCOS)","volume":"34","author":"Shafienia","year":"2022","journal-title":"Reprod Fertil Dev"},{"issue":"6","key":"10.1016\/j.metop.2025.100441_bib21","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1530\/REP-13-0005","article-title":"Differences in the transcriptional profiles of human cumulus cells isolated from MI and MII oocytes of patients with polycystic ovary syndrome","volume":"145","author":"Huang","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.metop.2025.100441_bib22","article-title":"The insulin signaling pathway is dysregulated in cumulus cells from obese, infertile women with polycystic ovarian syndrome with an absence of clinical insulin resistance","volume":"14","author":"Chehin","year":"2020","journal-title":"Therapeut Adv Reproduct Health"},{"issue":"3","key":"10.1016\/j.metop.2025.100441_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/10799893.2020.1806320","article-title":"Expression of ADR-\u03b11, 2 and ADR-\u03b22 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression","volume":"41","author":"Zangeneh","year":"2021","journal-title":"J Recept Signal Transduction"},{"issue":"2","key":"10.1016\/j.metop.2025.100441_bib24","first-page":"111","article-title":"Assessment of gene expression on the gap junction connexin of cumulus cells on infertile women with polycystic ovary syndrome and poor ovarian response: the novel role of propranolol","volume":"19","author":"Zangeneh","year":"2025","journal-title":"J Fam Reprod Health"},{"issue":"3","key":"10.1016\/j.metop.2025.100441_bib25","first-page":"265","article-title":"Evaluation of frizzled class receptor 3 and miR-378 expression levels in cumulus cells of polycystic ovary syndrome women: a case-control study","volume":"23","author":"Bagheri","year":"2025","journal-title":"Int J Reproduct Biomed"},{"key":"10.1016\/j.metop.2025.100441_bib26","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"bmj"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib27","first-page":"58","article-title":"The updated Joanna Briggs Institute model of evidence-based healthcare","volume":"17","author":"Jordan","year":"2019","journal-title":"JBI Evid Implement"},{"issue":"4","key":"10.1016\/j.metop.2025.100441_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","article-title":"Assessing the quality of studies in meta-analyses: advantages and limitations of the Newcastle Ottawa scale","volume":"5","author":"Luchini","year":"2017","journal-title":"World J Meta-Anal"},{"key":"10.1016\/j.metop.2025.100441_bib29","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"bmj"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4103\/abr.abr_111_21","article-title":"Differential gene expressions of CALM1, PSMD6, and AK124742 long noncoding RNA in cumulus cells from polycystic ovary syndrome patients versus normal control women","volume":"12","author":"Akbari","year":"2023","journal-title":"Adv Biomed Res"},{"issue":"7","key":"10.1016\/j.metop.2025.100441_bib31","first-page":"410","article-title":"TGF\u00df gene members and their regulatory factors in granulosa compared to cumulus cells in PCOS: a case-control study","volume":"24","author":"Alvandian","year":"2022","journal-title":"Cell J (Yakhteh)"},{"issue":"10","key":"10.1016\/j.metop.2025.100441_bib32","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s10815-012-9825-8","article-title":"Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation","volume":"29","author":"de Resende","year":"2012","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"10.1016\/j.metop.2025.100441_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12958-023-01176-5","article-title":"Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation","volume":"22","author":"Ersahin","year":"2024","journal-title":"Reprod Biol Endocrinol"},{"issue":"12","key":"10.1016\/j.metop.2025.100441_bib34","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1093\/humrep\/des325","article-title":"Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome","volume":"27","author":"Haouzi","year":"2012","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.metop.2025.100441_bib35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.5114\/aoms.2019.86060","article-title":"Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome","volume":"15","author":"Hosseini","year":"2019","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.metop.2025.100441_bib36","series-title":"Human reproduction","article-title":"LncRNAs expression signatures of cumulus cells isolated from PCOS patients revealed by microarray","year":"2015"},{"issue":"6","key":"10.1016\/j.metop.2025.100441_bib37","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1530\/REP-16-0071","article-title":"Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8","volume":"151","author":"Huang","year":"2016","journal-title":"Reproduction"}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936825000970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936825000970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:04:18Z","timestamp":1775757858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589936825000970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"alternative-id":["S2589936825000970"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2025.100441","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene and non-coding RNA expression in human cumulus cells in polycystic ovary syndrome: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2025.100441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100441"}}