{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:03:09Z","timestamp":1781211789098,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.metop.2026.100480","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:37:33Z","timestamp":1780357053000},"page":"100480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ensemble learning uncovers novel metabolomic biomarkers for early osteoporosis prediction in Tibetan plateau populations"],"prefix":"10.1016","volume":"30","author":[{"given":"Jiawei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lening","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Labasangzhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dunyou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Danbalangjie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metop.2026.100480_bib1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/joim.12369","article-title":"Osteoporosis: the evolution of a diagnosis","volume":"277","author":"Lorentzon","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.metop.2026.100480_bib2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1177\/1060028020970518","article-title":"Economic burden of osteoporosis-related fractures in the US medicare population","volume":"55","author":"Williams","year":"2021","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.metop.2026.100480_bib3","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/jbmr.3757","article-title":"The prevalence of osteoporosis in China, a Nationwide, multicenter DXA survey","volume":"34","author":"Zeng","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metop.2026.100480_bib4","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1186\/s12889-023-17015-6","article-title":"Influencing factors of bone mass abnormalities among postmenopausal women in Tibet, China","volume":"23","author":"Zhong","year":"2023","journal-title":"BMC Public Health"},{"key":"10.1016\/j.metop.2026.100480_bib5","first-page":"65","article-title":"The clinical epidemiology of male osteoporosis: a review of the recent literature","volume":"7","author":"Willson","year":"2015","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.metop.2026.100480_bib6","first-page":"37","article-title":"Development and validation of a simple questionnaire to facilitate identification of women likely to have low bone density","volume":"4","author":"Lydick","year":"1998","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.metop.2026.100480_bib7","first-page":"1289","article-title":"Development and validation of the osteoporosis risk assessment instrument to facilitate selection of women for bone densitometry","volume":"162","author":"Cadarette","year":"2000","journal-title":"Cmaj"},{"key":"10.1016\/j.metop.2026.100480_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/gye.16.3.245.250","article-title":"Development and assessment of the osteoporosis index of risk (OSIRIS) to facilitate selection of women for bone densitometry","volume":"16","author":"Sedrine","year":"2002","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.metop.2026.100480_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/qjmed\/hch002","article-title":"Validation and comparative evaluation of the osteoporosis self-assessment tool (OST) in a Caucasian population from Belgium","volume":"97","author":"Richy","year":"2004","journal-title":"Qjm"},{"key":"10.1016\/j.metop.2026.100480_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s41747-025-00572-3","article-title":"Artificial intelligence for predicting the risk of bone fragility fractures in osteoporosis","volume":"9","author":"Ulivieri","year":"2025","journal-title":"Eur Radiol Exp"},{"key":"10.1016\/j.metop.2026.100480_bib11","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1359\/JBMR.050609","article-title":"Identification of osteopenic women at high risk of fracture: the OFELY study","volume":"20","author":"Sornay-Rendu","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metop.2026.100480_bib12","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1007\/s00198-021-06037-8","article-title":"Metabolomic biomarkers of low BMD: a systematic review","volume":"32","author":"Panahi","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.metop.2026.100480_bib13","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1038\/s41591-022-01980-3","article-title":"Metabolomic profiles predict individual multidisease outcomes","volume":"28","author":"Buergel","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.metop.2026.100480_bib14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/bonekey.2016.58","article-title":"Protein\/amino-acid modulation of bone cell function","volume":"5","author":"MacDonell","year":"2016","journal-title":"BoneKEy Rep"},{"key":"10.1016\/j.metop.2026.100480_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jbmr.2053","article-title":"Dietary acid load is associated with lower bone mineral density in men with low intake of dietary calcium","volume":"29","author":"Mangano","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metop.2026.100480_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1515449","article-title":"Metabolomic insights into amino acid signatures and pathways associated with osteoporosis in Iranian elderly population","volume":"12","author":"Dehghanbanadaki","year":"2025","journal-title":"Front Med"},{"key":"10.1016\/j.metop.2026.100480_bib17","series-title":"Metabolites","author":"Wang","year":"2025"},{"key":"10.1016\/j.metop.2026.100480_bib18","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s00198-017-3930-6","article-title":"Bone mass loss is associated with systolic blood pressure in postmenopausal women with type 2 diabetes in Tibet: a retrospective cross-sectional study","volume":"28","author":"Zhou","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.metop.2026.100480_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12890-019-1008-2","article-title":"Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study","volume":"19","author":"Zeng","year":"2019","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.metop.2026.100480_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1024\/1661-8157\/a001991","article-title":"Update arterial hypertension 2015","volume":"104","author":"Rickenbacher","year":"2015","journal-title":"Praxis (Bern 1994)"},{"key":"10.1016\/j.metop.2026.100480_bib21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2318-14-118","article-title":"Association between difficulty initiating sleep in older adults and the combination of leisure-time physical activity and consumption of milk and milk products: a cross-sectional study","volume":"14","author":"Kitano","year":"2014","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.metop.2026.100480_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bone.2006.02.063","article-title":"Osteoblast responses to nucleotides increase during differentiation","volume":"39","author":"Orriss","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.metop.2026.100480_bib23","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1359\/jbmr.2001.16.5.846","article-title":"Expression of a P2X7 receptor by a subpopulation of human osteoblasts","volume":"16","author":"Gartland","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.metop.2026.100480_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5152\/eurjrheum.2018.18116","article-title":"Musculoskeletal manifestations of alkaptonuria: a case report and literature review","volume":"6","author":"Wu","year":"2019","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.metop.2026.100480_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s41927-025-00525-8","article-title":"The impact of lifestyle modification on metabolic pathways in older adults with overweight\/obesity and rheumatoid arthritis: a secondary exploratory analysis of the SWET-RA study","volume":"9","author":"Kim","year":"2025","journal-title":"BMC Rheumatol"},{"key":"10.1016\/j.metop.2026.100480_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s12891-024-07512-z","article-title":"Integration of bioinformatics and machine learning approaches for the validation of pyrimidine metabolism-related genes and their implications in immunotherapy for osteoporosis","volume":"25","author":"Feng","year":"2024","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.metop.2026.100480_bib27","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.metop.2026.100480_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116751","article-title":"Pym-18a, a novel pyrimidine derivative ameliorates glucocorticoid induced osteoblast apoptosis and promotes osteogenesis via autophagy and PINK 1\/Parkin mediated mitophagy induction","volume":"233","author":"Khanka","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.metop.2026.100480_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.11622\/smedj.2021036","article-title":"Menopausal osteoporosis: screening, prevention and treatment","volume":"62","author":"Yong","year":"2021","journal-title":"Singapore Med J"},{"key":"10.1016\/j.metop.2026.100480_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101551","article-title":"Menopausal hormone therapy for the management of osteoporosis","volume":"35","author":"Gosset","year":"2021","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.metop.2026.100480_bib31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00198-018-4414-z","article-title":"Estrogen therapy for osteoporosis in the modern era","volume":"29","author":"Levin","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.metop.2026.100480_bib32","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/jc.2019-00221","article-title":"Pharmacological management of osteoporosis in postmenopausal women: an Endocrine society\u2217 clinical practice guideline","volume":"104","author":"Eastell","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metop.2026.100480_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrendo.2015.89","article-title":"Skeletal changes through the lifespan--from growth to senescence","volume":"11","author":"Farr","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.metop.2026.100480_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00223-024-01319-9","article-title":"Association between sleep duration and low bone mineral density and osteoporosis: a systematic review and meta-analysis","volume":"116","author":"Tian","year":"2024","journal-title":"Calcif Tissue Int"}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936826000393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936826000393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:17:22Z","timestamp":1781209042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589936826000393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"alternative-id":["S2589936826000393"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2026.100480","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ensemble learning uncovers novel metabolomic biomarkers for early osteoporosis prediction in Tibetan plateau populations","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2026.100480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100480"}}