{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:12:33Z","timestamp":1788628353883,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81925007"],"award-info":[{"award-number":["81925007"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014869","name":"The Second Affiliated Hospital of Army Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230025"],"award-info":[{"award-number":["82230025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["609"],"award-info":[{"award-number":["609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20673"],"award-info":[{"award-number":["U24A20673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024YQB027"],"award-info":[{"award-number":["2024YQB027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.metop.2026.100481","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T14:38:21Z","timestamp":1780843101000},"page":"100481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China"],"prefix":"10.1016","volume":"31","author":[{"given":"Ying","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilian","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-1039","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metop.2026.100481_bib1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S2213-8587(24)00157-8","article-title":"Understanding the cause of type 2 diabetes","volume":"12","author":"Taylor","year":"2024","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.metop.2026.100481_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094827","article-title":"Links among obesity, type 2 diabetes mellitus, and osteoporosis: bone as a target","volume":"25","author":"Martiniakova","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.metop.2026.100481_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413640","article-title":"Management of osteoporosis in men: a narrative review","volume":"22","author":"Vescini","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.metop.2026.100481_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000019762","article-title":"Prevalence of osteoporosis in patients with type 2 diabetes mellitus in the Chinese mainland: a protocol of systematic review and meta-analysis","volume":"99","author":"Si","year":"2020","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.metop.2026.100481_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.21037\/atm-20-2478","article-title":"Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults","volume":"9","author":"Ji","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.metop.2026.100481_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-022-01260-8","article-title":"Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.metop.2026.100481_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115323","article-title":"Increased prevalence of self-reported fractures in Asian Indians with diabetes: results from the ICMR-INDIAB population based cross-sectional study","volume":"135","author":"Kaur","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.metop.2026.100481_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s43465-023-01049-4","article-title":"Diabetes and osteoporosis","volume":"57","author":"Prasad","year":"2023","journal-title":"Indian J Orthop"},{"key":"10.1016\/j.metop.2026.100481_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116880","article-title":"Advanced glycation and glycoxidation end products in bone","volume":"176","author":"Wang","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.metop.2026.100481_bib10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.5114\/reum\/170048","article-title":"Osteoporosis and diabetes - possible links and diagnostic difficulties","volume":"61","author":"Tomasiuk","year":"2023","journal-title":"Reumatologia"},{"key":"10.1016\/j.metop.2026.100481_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2021.101705","article-title":"The obesity indices mediate the relationships of blood lipids and bone mineral density in Chinese elders","volume":"56","author":"Ge","year":"2021","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.metop.2026.100481_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19052999","article-title":"Prevalence and predictors of osteoporosis and osteopenia in postmenopausal women of Punjab, India","volume":"19","author":"Khinda","year":"2022","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.metop.2026.100481_bib13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1186\/s12891-021-04643-5","article-title":"Association between lipid biomarkers and osteoporosis: a cross-sectional study","volume":"22","author":"Kan","year":"2021","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.metop.2026.100481_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.17116\/terarkh201688182-88","article-title":"Associations of lipoproteins with bone mass in postmenopausal women","volume":"88","author":"Skripnikova","year":"2016","journal-title":"Ter Arkh"},{"key":"10.1016\/j.metop.2026.100481_bib15","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/jcsm.13611","article-title":"Associations of serum lipid traits with fracture and osteoporosis: a prospective cohort study from the UK biobank","volume":"15","author":"Xiong","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.metop.2026.100481_bib16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10654-004-1706-8","article-title":"Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women","volume":"19","author":"Orozco","year":"2004","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.metop.2026.100481_bib17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2018.06.055","article-title":"Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1\/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-kappaB pathway","volume":"503","author":"Noguchi","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metop.2026.100481_bib18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13018-022-02986-w","article-title":"Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018","volume":"17","author":"Xie","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.metop.2026.100481_bib19","doi-asserted-by":"crossref","first-page":"8863","DOI":"10.2147\/IJGM.S334972","article-title":"Association between HDL-C and bone mineral density: an cross-sectional analysis","volume":"14","author":"Niu","year":"2021","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.metop.2026.100481_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.maturitas.2021.03.001","article-title":"Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women","volume":"147","author":"Zolfaroli","year":"2021","journal-title":"Maturitas"},{"key":"10.1016\/j.metop.2026.100481_bib21","article-title":"The association between glycemic indicators and bone mineral density and osteoporosis: a cross-sectional study","volume":"15","author":"Hou","year":"2025","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.metop.2026.100481_bib22","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s00125-023-05891-x","article-title":"Sex differences in type 2 diabetes","volume":"66","author":"Kautzky-Willer","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.metop.2026.100481_bib23","article-title":"Correlation between blood glucose fluctuations and osteoporosis in type 2 diabetes mellitus","volume":"2025","author":"Chen","year":"2025","journal-title":"Internet J Endocrinol"},{"key":"10.1016\/j.metop.2026.100481_bib24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/jbmr\/zjaf077","article-title":"Cross-sectional and longitudinal associations between statin use and bone density: the Manitoba BMD registry","volume":"40","author":"Leslie","year":"2025","journal-title":"J Bone Miner Res : Off J Am Soc Bone Mineral Res"}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258993682600040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258993682600040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T16:43:34Z","timestamp":1788626614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258993682600040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":24,"alternative-id":["S258993682600040X"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2026.100481","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2026.100481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100481"}}