{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:24:51Z","timestamp":1793975091508,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K14616"],"award-info":[{"award-number":["25K14616"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism Open"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.metop.2026.100504","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:02:57Z","timestamp":1791270177000},"page":"100504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Long-term voluntary exercise partially reverses obesity-associated transcriptomic remodeling in brown adipose tissue"],"prefix":"10.1016","volume":"32","author":[{"given":"Takuya","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-9085","authenticated-orcid":false,"given":"Tetsuya","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7121","key":"10.1016\/j.metop.2026.100504_bib1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"issue":"7121","key":"10.1016\/j.metop.2026.100504_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nature05483","article-title":"Adipocytes as regulators of energy balance and glucose homeostasis","volume":"444","author":"Rosen","year":"2006","journal-title":"Nature"},{"issue":"Suppl 3","key":"10.1016\/j.metop.2026.100504_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases","author":"Pedersen","year":"2015","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"10.1016\/j.metop.2026.100504_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2000-8847","article-title":"Exercise and insulin sensitivity: a review","volume":"21","author":"Borghouts","year":"2000","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.metop.2026.100504_bib29","doi-asserted-by":"crossref","first-page":"R220","DOI":"10.1152\/ajpregu.00227.2024","article-title":"Effect of different intensity aerobic exercise on remodeling immune microenvironment of adipose tissue in obesity mouse","volume":"328","author":"Lu","year":"2025","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10.1016\/j.metop.2026.100504_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"issue":"15","key":"10.1016\/j.metop.2026.100504_bib6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.metop.2026.100504_bib7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.metop.2026.100504_bib8","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.metop.2026.100504_bib9","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1172\/JCI71643","article-title":"Vascular rarefaction mediates whitening of brown fat in obesity","volume":"124","author":"Shimizu","year":"2014","journal-title":"J Clin Investig"},{"key":"10.1016\/j.metop.2026.100504_bib10","doi-asserted-by":"crossref","first-page":"E820","DOI":"10.1152\/ajpendo.00123.2019","article-title":"A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice","volume":"317","author":"Kuipers","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.metop.2026.100504_bib11","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1194\/jlr.M079665","article-title":"Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation","volume":"59","author":"Kotzbeck","year":"2018","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.metop.2026.100504_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12986-021-00581-0","article-title":"Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway","volume":"18","author":"Fu","year":"2021","journal-title":"Nutr Metab"},{"key":"10.1016\/j.metop.2026.100504_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910391","article-title":"Physical activity attenuates the obesity-induced dysregulated expression of brown adipokines in murine interscapular brown adipose tissue","volume":"22","author":"Sakurai","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"W1","key":"10.1016\/j.metop.2026.100504_bib14","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.metop.2026.100504_bib15","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.metop.2026.100504_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.01.006","article-title":"TNNT1, TNNT2, and TNNT3: isoform genes, regulation, and structure-function relationships","volume":"582","author":"Wei","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.metop.2026.100504_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.gene.2015.10.052","article-title":"TNNI1, TNNI2 and TNNI3: evolution, regulation, and protein structure-function relationships","volume":"576","author":"Sheng","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.metop.2026.100504_bib18","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s12276-020-00535-1","article-title":"Calsequestrin: a well-known but curious protein in skeletal muscle","volume":"52","author":"Woo","year":"2020","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.metop.2026.100504_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/hmg\/ddg020","article-title":"Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly","volume":"12","author":"Salmikangas","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metop.2026.100504_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yexcr.2005.06.027","article-title":"Actin-organising properties of the muscular dystrophy protein myotilin","volume":"310","author":"von Nandelstadh","year":"2005","journal-title":"Exp Cell Res"},{"issue":"4","key":"10.1016\/j.metop.2026.100504_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001148","article-title":"Molecular basis of F-actin regulation and sarcomere assembly via myotilin","volume":"19","author":"Kostan","year":"2021","journal-title":"PLoS Biol"},{"key":"10.1016\/j.metop.2026.100504_bib22","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nm.4429","article-title":"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis","volume":"23","author":"Ikeda","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.metop.2026.100504_bib23","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1038\/s41467-020-16572-3","article-title":"NCLX prevents cell death during adrenergic activation of the brown adipose tissue","volume":"11","author":"Assali","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.metop.2026.100504_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2022.07.011","article-title":"The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis","volume":"34","author":"Xue","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.metop.2026.100504_bib25","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Investig"},{"key":"10.1016\/j.metop.2026.100504_bib26","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Investig"},{"key":"10.1016\/j.metop.2026.100504_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fnmol.2013.00004","article-title":"Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions","volume":"6","author":"Weiner","year":"2013","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.metop.2026.100504_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.semcdb.2017.07.023","article-title":"Structural origins of clustered protocadherin-mediated neuronal barcoding","volume":"69","author":"Rubinstein","year":"2017","journal-title":"Semin Cell Dev Biol"}],"updated-by":[{"DOI":"10.1016\/j.metop.2026.100519","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:00Z","timestamp":1793059200000}}],"container-title":["Metabolism Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936826000630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589936826000630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:28:11Z","timestamp":1793971691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589936826000630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":29,"alternative-id":["S2589936826000630"],"URL":"https:\/\/doi.org\/10.1016\/j.metop.2026.100504","relation":{},"ISSN":["2589-9368"],"issn-type":[{"value":"2589-9368","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term voluntary exercise partially reverses obesity-associated transcriptomic remodeling in brown adipose tissue","name":"articletitle","label":"Article Title"},{"value":"Metabolism Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metop.2026.100504","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100504"}}