{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:49:59Z","timestamp":1791564599211,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["CSRP23032186690"],"award-info":[{"award-number":["CSRP23032186690"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["TTK200408511634"],"award-info":[{"award-number":["TTK200408511634"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["MethodsX"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mex.2026.103867","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:07:10Z","timestamp":1773968830000},"page":"103867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Detecting neurobiological markers in treatment response to prolonged exposure therapy for PTSD: An RCT using functional near-infrared spectroscopy"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-3178","authenticated-orcid":false,"given":"Duane D.","family":"Booysen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizwe","family":"Zondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mex.2026.103867_bib0001","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2022.10.044","article-title":"The mental health of university students in South Africa: results of the national student survey","volume":"321","author":"Bantjes","year":"2023","journal-title":"J. Affect. Disord."},{"issue":"13","key":"10.1016\/j.mex.2026.103867_bib0002","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1017\/S0033291717000708","article-title":"Posttraumatic stress disorder in the world mental health surveys","author":"Koenen","year":"2017","journal-title":"Psychol. Med."},{"issue":"6","key":"10.1016\/j.mex.2026.103867_bib0003","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/07448481.2016.1178120","article-title":"Symptoms of posttraumatic stress, depression and anxiety as predictors of suicidal ideation among South African university students","volume":"64","author":"Bantjes","year":"2016","journal-title":"J. Am. Coll. Health"},{"key":"10.1016\/j.mex.2026.103867_bib0004","doi-asserted-by":"crossref","unstructured":"Hamblen, J.L., Norman, S.B., Sonis, J.H., Phelps, A.J., Bisson, J.I., Nunes, V.D., Schnurr, P.P. (2019). A guide to guidelines for the treatment of posttraumatic stress disorder in adults: an update. Psychotherapy. Advance online publication. https:\/\/doi.org\/10.1037\/pst0000231.","DOI":"10.1037\/pst0000231"},{"key":"10.1016\/j.mex.2026.103867_bib0005","series-title":"Prolonged Exposure Therapy for PTSD: Emotional Processing of Traumatic Experiences: Therapist Guide (2nd ed.)","author":"Foa","year":"2019"},{"issue":"1","key":"10.1016\/j.mex.2026.103867_bib0006","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1037\/int0000109","article-title":"Mechanisms of change in prolonged exposure therapy for PTSD: implications for clinical practice","volume":"29","author":"Brown","year":"2019","journal-title":"J. PsychOther Integr."},{"key":"10.1016\/j.mex.2026.103867_bib0007","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jpsychires.2021.10.020","article-title":"Functional near-infrared spectroscopy brain imaging predicts symptom severity in youth exposed to traumatic stress","volume":"144","author":"Balters","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"7","key":"10.1016\/j.mex.2026.103867_bib0008","first-page":"688","article-title":"Diagnostic and predictive neuroimaging biomarkers for posttraumatic stress disorder","volume":"5","author":"Zilcha-Mano","year":"2020","journal-title":"Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.mex.2026.103867_bib0009","doi-asserted-by":"crossref","unstructured":"Bovin M.J., Marx B.P., Weathers F.W., Gallagher M.W., Rodriguez P., Schnurr P.P., & Keane, T.M., Psychometric properties of the PTSD checklist for diagnostic and statistical manual of mental disorders\u2013fifth edition (PCL-5) in veterans. Psychol. Assess. Adv. (2016) .10.1037\/pas0000254.","DOI":"10.1037\/pas0000254"},{"key":"10.1016\/j.mex.2026.103867_bib0010","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jts.22239","article-title":"A functional near-infrared spectroscopy study of trauma-related auditory and olfactory cues: posttraumatic stress disorder or combat experience?","volume":"30","author":"Gramlich","year":"2017","journal-title":"J. Trauma Stress."},{"key":"10.1016\/j.mex.2026.103867_bib0011","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1017\/S0033291716000374","article-title":"Neurobiological correlates of distinct post-traumatic stress disorder symptom profiles during threat anticipation in combat veterans","volume":"46","author":"Grupe","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.mex.2026.103867_bib27","first-page":"2026","article-title":"Global disparities in neuroimaging research for mental health conditions","author":"Connell","year":"2026","journal-title":"medRxiv"},{"key":"10.1016\/j.mex.2026.103867_bib0012","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuroimage.2013.05.004","article-title":"A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology","volume":"85","author":"Scholkmann","year":"2014","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.mex.2026.103867_bib0013","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13948","article-title":"The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience","author":"Pinti","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.mex.2026.103867_bib0014","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10278-020-00387-1","article-title":"A narrative review on clinical applications of fNIRS","volume":"33","author":"Rahman","year":"2020","journal-title":"J. Digit. Imaging"},{"issue":"4","key":"10.1016\/j.mex.2026.103867_bib0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1037\/fsh0000315","article-title":"Moving effective treatment for posttraumatic stress disorder to primary care: a randomized controlled trial with active-duty military","volume":"35","author":"Cigrang","year":"2017","journal-title":"Fam. Syst. Health"},{"issue":"4","key":"10.1016\/j.mex.2026.103867_bib0016","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0033291707002231","article-title":"Amygdala and ventral anterior cingulate activation predicts treatment response to cognitive behaviourtherapy for post-traumatic stress disorder","volume":"38","author":"Bryant","year":"2008","journal-title":"Psychol. Med."},{"issue":"1","key":"10.1016\/j.mex.2026.103867_bib0017","article-title":"fNIRS Optodes\u2019 Location decider (fOLD): a toolbox for probe arrangement guided by brain regions-of-interest","volume":"8","author":"Morais","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mex.2026.103867_bib0018","author":"Weathers"},{"issue":"9","key":"10.1016\/j.mex.2026.103867_bib0019","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"issue":"10","key":"10.1016\/j.mex.2026.103867_bib0020","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"6","key":"10.1016\/j.mex.2026.103867_bib0021","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","article-title":"Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II","volume":"88","author":"Saunders","year":"1993","journal-title":"Addiction"},{"issue":"6","key":"10.1016\/j.mex.2026.103867_bib0022","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/1073191114561254","article-title":"Perceived characteristics of intervention scale:development and psychometric properties","volume":"22","author":"Cook","year":"2015","journal-title":"Assessment"},{"key":"10.1016\/j.mex.2026.103867_bib0023","doi-asserted-by":"crossref","unstructured":"Turner, H.M.I., & Bernard, R.M. (2006). Calculating and synthesizing effect sizes. Contemp. Issues. Commun. Sci. Disord., 33(Spring), 42\u201355.","DOI":"10.1044\/cicsd_33_S_42"}],"container-title":["MethodsX"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2215016126000853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2215016126000853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:53:16Z","timestamp":1791561196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2215016126000853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":24,"alternative-id":["S2215016126000853"],"URL":"https:\/\/doi.org\/10.1016\/j.mex.2026.103867","relation":{},"ISSN":["2215-0161"],"issn-type":[{"value":"2215-0161","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detecting neurobiological markers in treatment response to prolonged exposure therapy for PTSD: An RCT using functional near-infrared spectroscopy","name":"articletitle","label":"Article Title"},{"value":"MethodsX","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mex.2026.103867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103867"}}