{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:43:01Z","timestamp":1790649781918,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIAMD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Meta Gene"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.mgene.2021.100877","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T12:38:31Z","timestamp":1615120711000},"page":"100877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Elevated expression of plasminogen activator inhibitor (PAI-1\/SERPINE1) is independent from rs1799889 genotypes in arthrofibrosis"],"prefix":"10.1016","volume":"28","author":[{"given":"Banu","family":"Bayram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Dudakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob W.","family":"Bettencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afton K.","family":"Limberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Morrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Sanchez-Sotelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre A.","family":"Kocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre J.","family":"van Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Abdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mgene.2021.100877_bb0005","doi-asserted-by":"crossref","first-page":"16469","DOI":"10.1038\/srep16469","article-title":"Fibrosis is a common outcome following total knee arthroplasty","volume":"5","author":"Abdul","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mgene.2021.100877_bb0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5455\/aim.2018.26.156-159","article-title":"Association between - 675 ID, 4G\/5G PAI-1 gene polymorphism and pregnancy loss: a systematic review","volume":"26","author":"Adler","year":"2018","journal-title":"Acta Inform. Med."},{"key":"10.1016\/j.mgene.2021.100877_bb0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jstrokecerebrovasdis.2007.03.002","article-title":"The PAI-1 4G\/5G gene polymorphism and ischemic stroke: an association study and meta-analysis","volume":"16","author":"Attia","year":"2007","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"4","key":"10.1016\/j.mgene.2021.100877_bb0020","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1016\/j.ygeno.2020.03.004","article-title":"Molecular pathology of human knee arthrofibrosis defined by RNA sequencing","volume":"112","author":"Bayram","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.mgene.2021.100877_bb0025","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mgene.2021.100877_bb0030","doi-asserted-by":"crossref","first-page":"16992","DOI":"10.1038\/s41598-019-53490-x","article-title":"Integration of TGF-\u03b2-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells","volume":"9","author":"Budi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mgene.2021.100877_bb0035","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1101\/gad.242842.114","article-title":"An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors","volume":"29","author":"Chang","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.mgene.2021.100877_bb0040","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1016\/j.arth.2017.02.005","article-title":"Arthrofibrosis associated with Total knee arthroplasty","volume":"32","author":"Cheuy","year":"2017","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.mgene.2021.100877_bb0045","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.arth.2020.05.070","article-title":"Human fibrosis: is there evidence for a genetic predisposition in musculoskeletal tissues?","volume":"35","author":"Dagneaux","year":"2020","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.mgene.2021.100877_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mgene.2021.100877_bb0055","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.chest.2020.03.009","article-title":"A practical overview of case-control studies in clinical practice","volume":"158","author":"Dey","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.mgene.2021.100877_bb0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tranon.2015.05.002","article-title":"Circulating levels of PAI-1 and SERPINE1 4G\/4G polymorphism are predictive of poor prognosis in HCC patients undergoing TACE","volume":"8","author":"Divella","year":"2015","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.mgene.2021.100877_bb0065","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1665-2681(19)31518-2","article-title":"Plasminogen activator inhibitor type 1 serum levels and 4G\/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease","volume":"10","author":"Espino","year":"2011","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.mgene.2021.100877_bb0070","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCULATIONAHA.117.028145","article-title":"Plasminogen activator inhibitor type I controls cardiomyocyte transforming growth factor-\u03b2 and cardiac fibrosis","volume":"136","author":"Flevaris","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.mgene.2021.100877_bb0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s40139-016-0099-1","article-title":"Fibroblast-extracellular matrix interactions in tissue fibrosis","volume":"4","author":"Frangogiannis","year":"2016","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.mgene.2021.100877_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/mutage\/ger039","article-title":"STrengthening the reporting of OBservational studies in epidemiology--molecular epidemiology (STROBE-ME): an extension of the STROBE statement","volume":"27","author":"Gallo","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mgene.2021.100877_bb0085","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","article-title":"PAI-1 in tissue fibrosis","volume":"227","author":"Ghosh","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mgene.2021.100877_bb0090","doi-asserted-by":"crossref","first-page":"c315","DOI":"10.1159\/000323136","article-title":"Matching, an appealing method to avoid confounding?","volume":"118","author":"de Graaf","year":"2011","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.mgene.2021.100877_bb0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mgene.2021.100877_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jcp.22109","article-title":"Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene","volume":"228","author":"Hovhannisyan","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mgene.2021.100877_bb0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5217\/ir.2019.00037","article-title":"Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice","volume":"18","author":"Imai","year":"2020","journal-title":"Intest. Res."},{"key":"10.1016\/j.mgene.2021.100877_bb0110","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.joca.2017.07.022","article-title":"Projected increase in total knee arthroplasty in the United States - an alternative projection model","volume":"25","author":"Inacio","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mgene.2021.100877_bb0115","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1056\/NEJM200006153422406","article-title":"Plasminogen-activator inhibitor type 1 and coronary artery disease","volume":"342","author":"Kohler","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mgene.2021.100877_bb0120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/art.39443","article-title":"Resolution of skin fibrosis by neutralization of the Antifibrinolytic function of plasminogen activator inhibitor 1","volume":"68","author":"Lemaire","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.mgene.2021.100877_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbm058","article-title":"Three lectures on case-control genetic association analysis","volume":"9","author":"Li","year":"2008","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.mgene.2021.100877_bb0130","first-page":"1923","article-title":"Idiopathic pulmonary fibrosis in relation to gene polymorphisms of transforming growth factor-\u03b21 and plasminogen activator inhibitor 1","volume":"124","author":"Li","year":"2011","journal-title":"Chin. Med. J."},{"issue":"11","key":"10.1016\/j.mgene.2021.100877_bb0240","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1002\/jor.24647","article-title":"Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen","volume":"38","author":"Limberg","year":"2020","journal-title":"J Orthop Res."},{"key":"10.1016\/j.mgene.2021.100877_bb0135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s12276-020-0397-x","article-title":"Therapeutics targeting the fibrinolytic system","volume":"52","author":"Lin","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mgene.2021.100877_bb0140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/ars.2007.1903","article-title":"Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis","volume":"10","author":"Liu","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mgene.2021.100877_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129565","article-title":"The 4G\/4G genotype of PAI-1 polymorphism is associated with higher plasma PAI-1 concentrations and mortality in patients with severe sepsis","volume":"10","author":"Lorente","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mgene.2021.100877_bb0150","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3892\/mmr.2014.1903","article-title":"Impact of the 4G\/5G polymorphism in the plasminogen activator inhibitor-1 gene on primary nephrotic syndrome","volume":"9","author":"Luo","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mgene.2021.100877_bb0155","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2741\/3361","article-title":"PAI-1 and kidney fibrosis","volume":"14","author":"Ma","year":"2009","journal-title":"Front Biosci. (Landmark Ed)"},{"key":"10.1016\/j.mgene.2021.100877_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2007.11.015","article-title":"Binding of upstream stimulatory factor 1 to the E-box regulates the 4G\/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells","volume":"121","author":"Ma","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mgene.2021.100877_bb0165","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fonc.2018.00024","article-title":"Multifaceted role of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR): diagnostic, prognostic, and therapeutic applications","volume":"8","author":"Mahmood","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mgene.2021.100877_bb0170","article-title":"The \u2212675 4G\/5G polymorphism in plasminogen activator inhibitor-1 gene is associated with risk of asthma: a meta-analysis","volume":"7","author":"Nie","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mgene.2021.100877_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124334","article-title":"Association between five common plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms and colorectal cancer susceptibility","volume":"21","author":"Oh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mgene.2021.100877_bb0180","doi-asserted-by":"crossref","first-page":"260101","DOI":"10.1155\/2015\/260101","article-title":"The effect of PAI-1 4G\/5G polymorphism and clinical factors on coronary artery occlusion in myocardial infarction","volume":"2015","author":"Parpugga","year":"2015","journal-title":"Dis. Markers"},{"key":"10.1016\/j.mgene.2021.100877_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcb.26146","article-title":"Plasminogen activator inhibitor Type-1 as a regulator of fibrosis","volume":"119","author":"Rabieian","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mgene.2021.100877_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197066","article-title":"PAI-1, the plasminogen system, and skeletal muscle","volume":"21","author":"Rahman","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mgene.2021.100877_bb0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cellsig.2012.10.003","article-title":"TGF-\u03b2 signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities","volume":"25","author":"Samarakoon","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mgene.2021.100877_bb0200","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.2106\/JBJS.18.01217","article-title":"Acquired idiopathic stiffness after total knee arthroplasty: a systematic review and meta-analysis","volume":"101","author":"Tibbo","year":"2019","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.mgene.2021.100877_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-019-0047-x","article-title":"Pathological mechanisms and therapeutic outlooks for arthrofibrosis","volume":"7","author":"Usher","year":"2019","journal-title":"Bone Res."},{"key":"10.1016\/j.mgene.2021.100877_bb0210","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.12659\/MSM.892397","article-title":"Association of the plasminogen activator inhibitor-1 (PAI-1) Gene -675 4G\/5G and \u2212844 A\/G promoter polymorphism with risk of keloid in a Chinese Han population","volume":"20","author":"Wang","year":"2014","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.mgene.2021.100877_bb0215","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mgene.2021.100877_bb0220","article-title":"PAI-1 -675 4G\/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mgene.2021.100877_bb0225","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1177\/0300060516664270","article-title":"SERPINE1 -844 and \u2212675 polymorphisms and chronic obstructive pulmonary disease in a Chinese Han population","volume":"44","author":"Xu","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.mgene.2021.100877_bb0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-017-0005-4","article-title":"Transforming growth factor-\u03b2 in stem cells and tissue homeostasis","volume":"6","author":"Xu","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.mgene.2021.100877_bb0235","first-page":"3777","article-title":"Plasminogen activator inhibitor-1 4G\/5G polymorphism is associated with coronary artery disease risk: a meta-analysis","volume":"7","author":"Zhang","year":"2014","journal-title":"Int. J. Clin. Exp. Med."}],"container-title":["Meta Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214540021000281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214540021000281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:16:55Z","timestamp":1762003015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214540021000281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":48,"alternative-id":["S2214540021000281"],"URL":"https:\/\/doi.org\/10.1016\/j.mgene.2021.100877","relation":{},"ISSN":["2214-5400"],"issn-type":[{"value":"2214-5400","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated expression of plasminogen activator inhibitor (PAI-1\/SERPINE1) is independent from rs1799889 genotypes in arthrofibrosis","name":"articletitle","label":"Article Title"},{"value":"Meta Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mgene.2021.100877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100877"}}