{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:09:18Z","timestamp":1768475358866,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI90818"],"award-info":[{"award-number":["AI90818"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI104987"],"award-info":[{"award-number":["AI104987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.mib.2016.05.009","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T16:57:27Z","timestamp":1464368247000},"page":"13-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["The oxadiazole antibacterials"],"prefix":"10.1016","volume":"33","author":[{"given":"Jeshina","family":"Janardhanan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayland","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar","family":"Mobashery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2016.05.009_bib0150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/metabo2020303","article-title":"A historical overview of natural products in drug discovery","volume":"2","author":"Dias","year":"2012","journal-title":"Metabolites"},{"key":"10.1016\/j.mib.2016.05.009_bib0155","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mib.2003.08.003","article-title":"Why is big Pharma getting out of antibacterial drug discovery?","volume":"6","author":"Projan","year":"2003","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.mib.2016.05.009_bib0160","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.coph.2003.04.003","article-title":"The abandonment of antibacterials: why and wherefore?","volume":"3","author":"Shlaes","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.mib.2016.05.009_bib0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.mib.2016.05.009_bib0170","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrd3975","article-title":"Platforms for antibiotic discovery","volume":"12","author":"Lewis","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.mib.2016.05.009_bib0175","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.febslet.2011.04.029","article-title":"How to cope with the quest for new antibiotics","volume":"585","author":"Fabbretti","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.mib.2016.05.009_bib0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cbi.2006.12.006","article-title":"Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach","volume":"171","author":"Kapetanovic","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.mib.2016.05.009_bib0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-61779-012-6_2","article-title":"Computer-aided drug discovery and development","volume":"716","author":"Zhang","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.mib.2016.05.009_sbref0190","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1021\/ja500053x","article-title":"Discovery of a new class of non-beta-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity","volume":"136","author":"O\u2019Daniel","year":"2014","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.mib.2016.05.009_bib0195","doi-asserted-by":"crossref","first-page":"S344","DOI":"10.1086\/533590","article-title":"Epidemiology of methicillin-resistant Staphylococcus aureus","volume":"46Suppl5","author":"Boucher","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2016.05.009_bib0200","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0966-842X(01)02175-8","article-title":"The emergence and evolution of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Hiramatsu","year":"2001","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.mib.2016.05.009_bib0205","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1007\/s00018-005-5148-6","article-title":"Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome","volume":"62","author":"Fuda","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.mib.2016.05.009_bib0210","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1128\/AAC.00084-09","article-title":"Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge","volume":"53","author":"Llarrull","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2016.05.009_bib0215","doi-asserted-by":"crossref","first-page":"10630","DOI":"10.1073\/pnas.0601971103","article-title":"The discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of methicillin-resistant Staphylococcus aureus bacterium","volume":"103","author":"Thumanu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2016.05.009_bib0220","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1073\/pnas.191260798","article-title":"An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci","volume":"98","author":"Pinho","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2016.05.009_bib0225","series-title":"Antibiotic resistance threats in the United States, 2013","author":"Centers for Disease Control and Prevention (CDC)","year":"2013"},{"key":"10.1016\/j.mib.2016.05.009_bib0230","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.mib.2010.09.008","article-title":"The future of the beta-lactams","volume":"13","author":"Llarrull","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.mib.2016.05.009_bib0235","series-title":"Burger's Medicinal Chemistry","first-page":"259","article-title":"Beta-lactam Antibiotics","author":"Testero","year":"2010"},{"key":"10.1016\/j.mib.2016.05.009_bib0240","first-page":"1207","article-title":"The beta lactam antibiotics as an empirical therapy in a developing country: an update on their current status and recommendations to counter the resistance against them","volume":"7","author":"Thakuria","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.mib.2016.05.009_bib0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1586\/eri.13.12","article-title":"Clinical relevance of the ESKAPE pathogens","volume":"11","author":"Pendleton","year":"2013","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.mib.2016.05.009_bib0250","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE","volume":"197","author":"Rice","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.mib.2016.05.009_bib0255","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/j.bmcl.2015.06.044","article-title":"Exploration of the structure\u2013activity relationship of 1,2,4-oxadiazole antibiotics","volume":"25","author":"Ding","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.mib.2016.05.009_bib0260","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1128\/AAC.37.10.2045","article-title":"Penicillin-binding proteins and bacterial resistance to beta-lactams","volume":"37","author":"Georgopapadakou","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2016.05.009_sbref0265","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.bmcl.2015.12.041","article-title":"Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials","volume":"26","author":"Leemans","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.mib.2016.05.009_sbref0270","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1021\/jm501661f","article-title":"Structure\u2013activity relationship for the oxadiazole class of antibiotics","volume":"58","author":"Spink","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.mib.2016.05.009_bib0275","series-title":"Handbook of Animal Models of Infection: Experimental Models in Antimicrobial Chemotherapy","first-page":"127","article-title":"The mouse peritonitis\/sepsis model","author":"Frimodt-Moller","year":"1999"},{"key":"10.1016\/j.mib.2016.05.009_sbref0280","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1128\/AAC.03501-14","article-title":"Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus","volume":"58","author":"Xiao","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2016.05.009_bib0285","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.chembiol.2012.03.006","article-title":"MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria","volume":"19","author":"Varela","year":"2012","journal-title":"Chem Biol"},{"key":"10.1016\/j.mib.2016.05.009_bib0290","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1080\/00498250210158249","article-title":"Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog","volume":"32","author":"Slatter","year":"2002","journal-title":"Xenobiotica"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527416300649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527416300649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T19:07:46Z","timestamp":1572462466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527416300649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":29,"alternative-id":["S1369527416300649"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2016.05.009","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The oxadiazole antibacterials","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2016.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}