{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:59:25Z","timestamp":1784649565891,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"French National Agency for Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Parasitology Consortium \u2018LabexParaFrap\u2019","award":["ANR-11-LABX0024"],"award-info":[{"award-number":["ANR-11-LABX0024"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACyT)-M\u00e9xico","doi-asserted-by":"publisher","award":["265955"],"award-info":[{"award-number":["265955"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.mib.2016.07.016","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T10:02:17Z","timestamp":1470304937000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["The motility of Entamoeba histolytica: finding ways to understand intestinal amoebiasis"],"prefix":"10.1016","volume":"34","author":[{"given":"Arturo","family":"Aguilar-Rojas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Olivo-Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Guillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2016.07.016_bib0225","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/mmi.13131","article-title":"Molecular biology research to benefit patients with Entamoeba histolytica infection","volume":"98","author":"Watanabe","year":"2015","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0230","doi-asserted-by":"crossref","first-page":"e1643","DOI":"10.1371\/journal.pntd.0001643","article-title":"Proteomic analysis of the cyst stage of Entamoeba histolytica","volume":"6","author":"Ali","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.mib.2016.07.016_bib0235","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ceb.2016.03.025","article-title":"Multiple mechanisms of 3D migration: the origins of plasticity","volume":"42","author":"Petrie","year":"2016","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0240","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.201201124","article-title":"Nonpolarized signaling reveals two distinct modes of 3D cell migration","volume":"197","author":"Petrie","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0245","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nrm2453","article-title":"Blebs lead the way: how to migrate without lamellipodia","volume":"9","author":"Charras","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0250","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10555-008-9174-3","article-title":"Proteolytic interstitial cell migration: a five-step process","volume":"28","author":"Friedl","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.mib.2016.07.016_bib0255","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tcb.2015.07.013","article-title":"Fibroblasts lead the way: a unified view of 3D cell motility","volume":"25","author":"Petrie","year":"2015","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0260","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200209006","article-title":"Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis","volume":"160","author":"Wolf","year":"2003","journal-title":"J Cell Biol"},{"issue":"Pt 24","key":"10.1016\/j.mib.2016.07.016_bib0265","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1242\/jcs.093732","article-title":"At the leading edge of three-dimensional cell migration","volume":"125","author":"Petrie","year":"2012","journal-title":"J Cell Sci"},{"issue":"Pt 22","key":"10.1016\/j.mib.2016.07.016_bib0270","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1242\/jcs.065672","article-title":"Dynamic instability of the intracellular pressure drives bleb-based motility","volume":"123","author":"Maugis","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mib.2016.07.016_bib0275","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1462-5822.2004.00426.x","article-title":"Myosin II and the Gal-GalNAc lectin play a crucial role in tissue invasion by Entamoeba histolytica","volume":"7","author":"Coudrier","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0280","series-title":"Molecular and Cell biology of Anaerobic Protists","first-page":"81","article-title":"Dissecting the actin cytoskeleton of Entamoeba histolytica from a genomic perspective","author":"Hon","year":"2009"},{"key":"10.1016\/j.mib.2016.07.016_bib0285","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jprot.2014.03.041","article-title":"Proteomic profiling reveals that EhPC4 transcription factor induces cell migration through up-regulation of the 16-kDa actin-binding protein EhABP16 in Entamoeba histolytica","volume":"111","author":"de la Cruz","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.mib.2016.07.016_bib0290","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/j.1462-5822.2008.01158.x","article-title":"Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the galactose\/N-acetylgalactosamine lectin activity","volume":"10","author":"Blazquez","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0295","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1128\/EC.00329-13","article-title":"A genomewide overexpression screen identifies genes involved in the phosphatidylinositol 3-kinase pathway in the human protozoan parasite Entamoeba histolytica","volume":"13","author":"Koushik","year":"2014","journal-title":"Eukaryot Cell"},{"issue":"Pt 1","key":"10.1016\/j.mib.2016.07.016_bib0300","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/jcs.00190","article-title":"EhPAK, a member of the p21-activated kinase family, is involved in the control of Entamoeba histolytica migration and phagocytosis","volume":"116","author":"Labruy\u00e8re","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mib.2016.07.016_bib0305","doi-asserted-by":"crossref","first-page":"e28003","DOI":"10.4161\/sgtp.28003","article-title":"P21 activated kinases: structure, regulation, and functions","volume":"5","author":"Rane","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.mib.2016.07.016_bib0310","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1021\/bi501226f","article-title":"Entamoeba histolytica RacC selectively engages p21-activated kinase effectors","volume":"54","author":"Bosch","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.mib.2016.07.016_bib0315","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molbiopara.2006.04.001","article-title":"EhPAK2, a novel p21-activated kinase, is required for collagen invasion and capping in Entamoeba histolytica","volume":"149","author":"Arias-Romero","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.mib.2016.07.016_bib0320","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12603","article-title":"A new nucleocytoplasmic RhoGAP protein contributes to control the pathogenicity of Entamoeba histolytica by regulating EhRacC and EhRacD activity","author":"Hernandez-Flores","year":"2016","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0325","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature03291","article-title":"The genome of the protist parasite Entamoeba histolytica","volume":"433","author":"Loftus","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mib.2016.07.016_bib0330","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1462-5822.2012.01752.x","article-title":"Newly visualized fibrillar collagen scaffolds dictate Entamoeba histolytica invasion route in the human colon","volume":"14","author":"Thibeaux","year":"2012","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0335","doi-asserted-by":"crossref","first-page":"e551","DOI":"10.1371\/journal.pntd.0000551","article-title":"An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis","volume":"3","author":"Bansal","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.mib.2016.07.016_bib0340","doi-asserted-by":"crossref","first-page":"e1003824","DOI":"10.1371\/journal.ppat.1003824","article-title":"Identification of the virulence landscape essential for Entamoeba histolytica invasion of the human colon","volume":"9","author":"Thibeaux","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2016.07.016_sbref0345","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1038\/ncomms6142","article-title":"The parasite Entamoeba histolytica exploits the activities of human matrix metalloproteinases to invade colonic tissue","volume":"5","author":"Thibeaux","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2016.07.016_bib0350","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.semcdb.2015.10.010","article-title":"Amoeboid movement in protozoan pathogens","volume":"46","author":"Dufour","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0355","series-title":"Principles of Tissue Engineering","first-page":"1","article-title":"The history and scope of tissue engineering","author":"Vacanti","year":"2011"},{"key":"10.1016\/j.mib.2016.07.016_bib0360","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1039\/b314469k","article-title":"Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities","volume":"4","author":"Andersson","year":"2004","journal-title":"Lab Chip"},{"key":"10.1016\/j.mib.2016.07.016_bib0365","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2011.09.005","article-title":"From 3D cell culture to organs-on-chips","volume":"21","author":"Huh","year":"2011","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0370","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1039\/b717091b","article-title":"An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models","volume":"8","author":"Kimura","year":"2008","journal-title":"Lab Chip"},{"key":"10.1016\/j.mib.2016.07.016_bib0375","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1016\/j.biomaterials.2009.08.046","article-title":"Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype","volume":"30","author":"Wang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.mib.2016.07.016_bib0380","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1021\/ac802351w","article-title":"Drug permeability assay using microhole-trapped cells in a microfluidic device","volume":"81","author":"Yeon","year":"2009","journal-title":"Anal Chem"},{"key":"10.1016\/j.mib.2016.07.016_bib0385","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2116\/analsci.25.1403","article-title":"A microfluidic system to evaluate intestinal absorption","volume":"25","author":"Imura","year":"2009","journal-title":"Anal Sci"},{"key":"10.1016\/j.mib.2016.07.016_sbref0390","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1039\/c2lc40074j","article-title":"Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow","volume":"12","author":"Kim","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.mib.2016.07.016_bib0395","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1039\/c3ib40126j","article-title":"Gut-on-a-chip microenvironment induces human intestinal cells to undergo villus differentiation","volume":"5","author":"Kim","year":"2013","journal-title":"Integr Biol"},{"key":"10.1016\/j.mib.2016.07.016_bib0400","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/bit.25180","article-title":"Synthetic small intestinal scaffolds for improved studies of intestinal differentiation","volume":"111","author":"Costello","year":"2014","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.mib.2016.07.016_bib0405","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1039\/C0LC00273A","article-title":"Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model","volume":"11","author":"Sung","year":"2011","journal-title":"Lab Chip"},{"key":"10.1016\/j.mib.2016.07.016_bib0410","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1039\/c4ib00157e","article-title":"Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression","volume":"6","author":"Kim","year":"2014","journal-title":"Integr Biol (Camb)"},{"key":"10.1016\/j.mib.2016.07.016_sbref0415","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1073\/pnas.1522193112","article-title":"Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip","volume":"113","author":"Kim","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2016.07.016_bib0420","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-micro-091313-103550","article-title":"Regulation of virulence of Entamoeba histolytica","volume":"68","author":"Marie","year":"2014","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.mib.2016.07.016_bib0425","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nature13242","article-title":"Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion","volume":"508","author":"Ralston","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mib.2016.07.016_bib0430","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13223","article-title":"Infection biology: nibbled to death","volume":"508","author":"Guill\u00e9n","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mib.2016.07.016_bib0435","doi-asserted-by":"crossref","first-page":"e1005310","DOI":"10.1371\/journal.ppat.1005310","article-title":"The Entamoeba histolytica, Arp2\/3 complex is recruited to phagocytic cups through an atypical kinase EhAK1","volume":"11","author":"Babuta","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2016.07.016_sbref0440","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1038\/srep13613","article-title":"A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica","volume":"5","author":"Marie","year":"2015","journal-title":"Sci Rep"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527416301047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527416301047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T04:34:13Z","timestamp":1572755653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527416301047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":44,"alternative-id":["S1369527416301047"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2016.07.016","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The motility of Entamoeba histolytica: finding ways to understand intestinal amoebiasis","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2016.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}