{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:53:02Z","timestamp":1792446782660,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-119520"],"award-info":[{"award-number":["MOP-119520"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-86452"],"award-info":[{"award-number":["MOP-86452"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01"],"award-info":[{"award-number":["R01"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI127375-01"],"award-info":[{"award-number":["1R01AI127375-01"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["477598"],"award-info":[{"award-number":["477598"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["462167"],"award-info":[{"award-number":["462167"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["06261"],"award-info":[{"award-number":["06261"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006639","name":"Grant Foundation","doi-asserted-by":"publisher","award":["FDN-154288"],"award-info":[{"award-number":["FDN-154288"]}],"id":[{"id":"10.13039\/100006639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.mib.2018.02.005","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T18:02:19Z","timestamp":1520964139000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":497,"special_numbering":"C","title":["Antifungal drug resistance: evolution, mechanisms and impact"],"prefix":"10.1016","volume":"45","author":[{"given":"Nicole M","family":"Revie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali R","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah E","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2018.02.005_bib0270","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.mib.2018.02.005_bib0275","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.mib.2018.02.005_sbref0280","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd.2017.46","article-title":"The antifungal pipeline: a reality check","volume":"16","author":"Perfect","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.mib.2018.02.005_bib0285","doi-asserted-by":"crossref","first-page":"17258","DOI":"10.1073\/pnas.0402981101","article-title":"A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)","volume":"101","author":"Kidd","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2018.02.005_bib0290","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","article-title":"Emerging fungal threats to animal, plant and ecosystem health","volume":"484","author":"Fisher","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mib.2018.02.005_bib0295","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0027-2016","article-title":"Emerging fungal threats to plants and animals challenge agriculture and ecosystem resilience","volume":"5","author":"Fones","year":"2017","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.mib.2018.02.005_sbref0300","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev-micro-030117-020345","article-title":"Molecular evolution of antifungal drug resistance","volume":"71","author":"Robbins","year":"2017","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0305","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1128\/MMBR.00045-10","article-title":"Regulatory circuitry governing fungal development, drug resistance, and disease","volume":"75","author":"Shapiro","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.mib.2018.02.005_bib0310","doi-asserted-by":"crossref","first-page":"e1001692","DOI":"10.1371\/journal.pbio.1001692","article-title":"Fitness trade-offs restrict the evolution of resistance to amphotericin B","volume":"11","author":"Vincent","year":"2013","journal-title":"PLoS Biol"},{"key":"10.1016\/j.mib.2018.02.005_bib0315","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1099\/00221287-145-10-2701","article-title":"Contribution of mutations in the cytochrome P450 14\u03b1-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans","volume":"145","author":"Marichal","year":"1999","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2018.02.005_bib0320","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/JCM.43.1.214-222.2005","article-title":"Rapid, high-throughput, multiplex, real-time PCR for identification of mutations in the cyp51A gene of Aspergillus fumigatus that confer resistance to itraconazole","volume":"43","author":"Balashov","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0325","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/EC.3.6.1391-1397.2004","article-title":"Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism","volume":"3","author":"Silver","year":"2004","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.mib.2018.02.005_bib0330","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1365-2958.2007.05676.x","article-title":"Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans","volume":"64","author":"Chang","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0335","doi-asserted-by":"crossref","first-page":"e1000200","DOI":"10.1371\/journal.ppat.1000200","article-title":"A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus","volume":"4","author":"Willger","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0340","doi-asserted-by":"crossref","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.mib.2018.02.005_bib0345","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.1118370","article-title":"Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi","volume":"309","author":"Cowen","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mib.2018.02.005_bib0350","doi-asserted-by":"crossref","first-page":"e1001069","DOI":"10.1371\/journal.ppat.1001069","article-title":"PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90","volume":"6","author":"Lafayette","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0355","article-title":"Chemogenomic profiling of the fungal pathogen Candida albicans","volume":"62","author":"Chen","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_sbref0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12766","article-title":"Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans","volume":"7","author":"Lee","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2018.02.005_bib0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7757","article-title":"Systematic functional profiling of transcription factor networks in Cryptococcus neoformans","volume":"6","author":"Jung","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2018.02.005_bib0370","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1128\/AAC.39.11.2378","article-title":"Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters","volume":"39","author":"Sanglard","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_bib0375","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1099\/00221287-143-2-405","article-title":"Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene","volume":"143","author":"Sanglard","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2018.02.005_bib0380","doi-asserted-by":"crossref","first-page":"e1006655","DOI":"10.1371\/journal.ppat.1006655","article-title":"An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses","volume":"13","author":"Hampe","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0385","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/genetics.105.054767","article-title":"A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans","volume":"172","author":"Coste","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2018.02.005_bib0390","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1371\/journal.ppat.0030164","article-title":"The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans","volume":"3","author":"Morschh\u00e4user","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0395","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2958.2003.03281.x","article-title":"Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole","volume":"47","author":"Posteraro","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0400","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1087-1845(02)00016-6","article-title":"Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate","volume":"36","author":"Slaven","year":"2002","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.mib.2018.02.005_bib0405","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1126\/science.1128242","article-title":"Aneuploidy and isochromosome formation in drug-resistant Candida albicans","volume":"313","author":"Selmecki","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mib.2018.02.005_bib0410","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2958.2008.06176.x","article-title":"An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1","volume":"68","author":"Selmecki","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0415","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1534\/genetics.117.300295","article-title":"Parasex generates phenotypic diversity de novo and impacts drug resistance and virulence in Candida albicans","volume":"207","author":"Hirakawa","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2018.02.005_bib0420","doi-asserted-by":"crossref","first-page":"e1000848","DOI":"10.1371\/journal.ppat.1000848","article-title":"Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes","volume":"6","author":"Sionov","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0425","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1128\/AEM.00231-09","article-title":"Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles","volume":"75","author":"Snelders","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_sbref0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.01024","article-title":"Azole resistance in Aspergillus fumigatus: a consequence of antifungal use in agriculture?","volume":"8","author":"Berger","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0435","article-title":"Environmental triazole induces cross-resistance to clinical drugs and affects morphophysiology and virulence of Cryptococcus gattii and C. neoformans","volume":"62","author":"Bastos","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_bib0440","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1128\/AAC.49.8.3264-3273.2005","article-title":"Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates","volume":"49","author":"Park","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_bib0445","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1128\/AAC.00813-12","article-title":"Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance","volume":"56","author":"Katiyar","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_bib0450","doi-asserted-by":"crossref","first-page":"e1002718","DOI":"10.1371\/journal.ppat.1002718","article-title":"Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata","volume":"8","author":"Singh-Babak","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0455","doi-asserted-by":"crossref","first-page":"e1000532","DOI":"10.1371\/journal.ppat.1000532","article-title":"Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin","volume":"5","author":"Singh","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_sbref0460","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00547-y","article-title":"The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation","volume":"8","author":"Xie","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2018.02.005_bib0465","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/IDR.S124918","article-title":"Antifungal resistance: current trends and future strategies to combat","volume":"10","author":"Wiederhold","year":"2017","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.mib.2018.02.005_sbref0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11128","article-title":"Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance","volume":"7","author":"Healey","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2018.02.005_sbref0475","doi-asserted-by":"crossref","first-page":"e28802","DOI":"10.7554\/eLife.28802","article-title":"Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii","volume":"6","author":"Billmyre","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.mib.2018.02.005_bib0480","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1128\/AAC.49.7.2851-2856.2005","article-title":"Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins","volume":"49","author":"Maligie","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2018.02.005_bib0485","doi-asserted-by":"crossref","first-page":"e00478","DOI":"10.1128\/mBio.00478-16","article-title":"Lipid flippase subunit Cdc50 mediates drug resistance and virulence in Cryptococcus neoformans","volume":"7","author":"Huang","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.mib.2018.02.005_bib0490","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2174\/138945006776359458","article-title":"Biofilms and their role in the resistance of pathogenic Candida to antifungal agents","volume":"7","author":"d\u2019Enfert","year":"2006","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.mib.2018.02.005_bib0495","doi-asserted-by":"crossref","first-page":"e1006290","DOI":"10.1371\/journal.ppat.1006290","article-title":"Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally","volume":"13","author":"Chowdhary","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2018.02.005_bib0500","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2018.02.005_bib0505","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1186\/s12864-015-1863-z","article-title":"Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris","volume":"16","author":"Chatterjee","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mib.2018.02.005_sbref0510","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature16963","article-title":"Inhibiting fungal multidrug resistance by disrupting an activator\u2013mediator interaction","volume":"530","author":"Nishikawa","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mib.2018.02.005_bib0515","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1073\/pnas.0813394106","article-title":"Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease","volume":"106","author":"Cowen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2018.02.005_bib0520","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nchembio.2436","article-title":"Functional annotation of chemical libraries across diverse biological processes","volume":"13","author":"Piotrowski","year":"2017","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.mib.2018.02.005_bib0525","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2958.2003.03697.x","article-title":"Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery","volume":"50","author":"Roemer","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2018.02.005_bib0530","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.cell.2014.10.044","article-title":"Unraveling the biology of a fungal meningitis pathogen using chemical genetics","volume":"159","author":"Brown","year":"2014","journal-title":"Cell"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527417300875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527417300875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:50:21Z","timestamp":1761285021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527417300875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":53,"alternative-id":["S1369527417300875"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2018.02.005","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifungal drug resistance: evolution, mechanisms and impact","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2018.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}