{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:20:33Z","timestamp":1790518833086,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.mib.2019.05.001","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T23:53:57Z","timestamp":1559778837000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Mechanisms of genome evolution in Candida albicans"],"prefix":"10.1016","volume":"52","author":[{"given":"Iuliana V","family":"Ene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Z","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2019.05.001_bib0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ympev.2014.04.024","article-title":"Estimating the Phanerozoic history of the Ascomycota lineages: combining fossil and molecular data","volume":"78","author":"Beimforde","year":"2014","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.mib.2019.05.001_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065576","article-title":"Dating the diversification of the major lineages of Ascomycota (Fungi)","volume":"8","author":"Prieto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mib.2019.05.001_bib0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3732\/ajb.1000298","article-title":"The fungi: 1, 2, 3\u2026 5.1 million species?","volume":"98","author":"Blackwell","year":"2011","journal-title":"Am J Bot"},{"key":"10.1016\/j.mib.2019.05.001_bib0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/pmj.78.922.455","article-title":"Oral candidiasis","volume":"78","author":"Akpan","year":"2002","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.mib.2019.05.001_bib0025","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/01.AOG.0000140687.51048.73","article-title":"Vaginal yeast colonization in nonpregnant women: a longitudinal study","volume":"104","author":"Beigi","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.mib.2019.05.001_bib0030","first-page":"837","article-title":"Yeasts in the gut: from commensals to infectious agents","volume":"106","author":"Schulze","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.mib.2019.05.001_bib0035","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/599039","article-title":"Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry","volume":"48","author":"Horn","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2019.05.001_bib0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","article-title":"Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options","volume":"62","author":"Sardi","year":"2013","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0045","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2019.05.001_bib0050","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/yea.1595","article-title":"A history of research on yeasts 12: medical yeasts part 1, Candida albicans","volume":"25","author":"Barnett","year":"2008","journal-title":"Yeast"},{"key":"10.1016\/j.mib.2019.05.001_bib0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1534\/genetics.118.301482","article-title":"Diverse lineages of Candida albicans live on old oaks","volume":"211","author":"Bensasson","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0060","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.1073\/pnas.0401648101","article-title":"The diploid genome sequence of Candida albicans","volume":"101","author":"Jones","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_sbref0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature08064","article-title":"Evolution of pathogenicity and sexual reproduction in eight Candida genomes","volume":"459","author":"Butler","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mib.2019.05.001_bib0070","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1128\/EC.00041-07","article-title":"Molecular phylogenetics of Candida albicans","volume":"6","author":"Odds","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.mib.2019.05.001_bib0075","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1128\/JCM.43.11.5601-5613.2005","article-title":"Population structure and properties of Candida albicans, as determined by multilocus sequence typing","volume":"43","author":"Tavanti","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0080","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1073\/pnas.0511328103","article-title":"Clonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Cote d\u2019Ivoire)","volume":"103","author":"Nebavi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_bib0085","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1128\/JCM.40.3.826-836.2002","article-title":"Ca3 fingerprinting of Candida albicans isolates from human immunodeficiency virus-positive and healthy individuals reveals a new clade in South Africa","volume":"40","author":"Blignaut","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0090","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1128\/JCM.40.8.2729-2740.2002","article-title":"Ca3 fingerprinting of Candida albicans bloodstream isolates from the United States, Canada, South America, and Europe reveals a European clade","volume":"40","author":"Pujol","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0928-8244(03)00242-6","article-title":"Candida albicans clades","volume":"39","author":"Soll","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_sbref0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04787-4","article-title":"Gene flow contributes to diversification of the major fungal pathogen Candida albicans","volume":"9","author":"Ropars","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2019.05.001_sbref0105","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1101\/gr.174623.114","article-title":"Genetic and phenotypic intra-species variation in Candida albicans","volume":"25","author":"Hirakawa","year":"2015","journal-title":"Genome Res"},{"key":"10.1016\/j.mib.2019.05.001_sbref0110","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01205-18","article-title":"The genome of the human pathogen Candida albicans is shaped by mutation and cryptic sexual recombination","volume":"9","author":"Wang","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.mib.2019.05.001_bib0115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1439-0507.2001.00707.x","article-title":"Candida africana sp. nov., a new human pathogen or a variant of Candida albicans?","volume":"44","author":"Tietz","year":"2001","journal-title":"Mycoses"},{"key":"10.1016\/j.mib.2019.05.001_bib0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/13693780701633101","article-title":"Isolation of Candida africana, probable atypical strains of Candida albicans, from a patient with vaginitis","volume":"46","author":"Alonso-Vargas","year":"2008","journal-title":"Med Mycol"},{"key":"10.1016\/j.mib.2019.05.001_bib0125","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/myc.12193","article-title":"Multilocus sequence typing of Candida africana from patients with vulvovaginal candidiasis in New Delhi, India","volume":"57","author":"Sharma","year":"2014","journal-title":"Mycoses"},{"key":"10.1016\/j.mib.2019.05.001_bib0130","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.cell.2018.10.023","article-title":"Tempo and mode of genome evolution in the budding yeast subphylum","volume":"175","author":"Shen","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.mib.2019.05.001_sbref0135","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/evo.13205","article-title":"Ploidy tug-of-war: evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen","volume":"71","author":"Gerstein","year":"2017","journal-title":"Evolution"},{"key":"10.1016\/j.mib.2019.05.001_bib0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11865","article-title":"The \u2018obligate diploid\u2019 Candida albicans forms mating-competent haploids","volume":"494","author":"Hickman","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mib.2019.05.001_sbref0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1126\/science.1128242","article-title":"Aneuploidy and isochromosome formation in drug-resistant Candida albicans","volume":"313","author":"Selmecki","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mib.2019.05.001_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000705","article-title":"Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance","volume":"5","author":"Selmecki","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mib.2019.05.001_bib0155","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/1567-1364.12155","article-title":"Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization","volume":"14","author":"Kravets","year":"2014","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.mib.2019.05.001_bib0160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1567-1364.2006.00150.x","article-title":"Chromosome instability in Candida albicans","volume":"7","author":"Rustchenko","year":"2007","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.mib.2019.05.001_bib0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006144","article-title":"A feast for Candida: metabolic plasticity confers an edge for virulence","volume":"13","author":"Miramon","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2019.05.001_bib0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrmicro.2016.157","article-title":"Candida albicans cell-type switching and functional plasticity in the mammalian host","volume":"15","author":"Noble","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0175","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2958.2008.06309.x","article-title":"Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains","volume":"69","author":"Dunkel","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0180","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00662","article-title":"The evolution of drug resistance in clinical isolates of Candida albicans","volume":"4","author":"Ford","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.mib.2019.05.001_sbref0185","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00129-11","article-title":"Stress alters rates and types of loss of heterozygosity in Candida albicans","volume":"2","author":"Forche","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.mib.2019.05.001_sbref0190","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1534\/genetics.118.301019","article-title":"Rapid phenotypic and genotypic diversification after exposure to the oral host niche in Candida albicans","volume":"209","author":"Forche","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0195","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1534\/genetics.109.103325","article-title":"Evolution in Candida albicans populations during a single passage through a mouse host","volume":"182","author":"Forche","year":"2009","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_sbref0200","doi-asserted-by":"crossref","first-page":"E8688","DOI":"10.1073\/pnas.1806002115","article-title":"Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen","volume":"115","author":"Ene","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_bib0205","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1186\/gb-2013-14-9-r97","article-title":"Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure","volume":"14","author":"Muzzey","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0210","doi-asserted-by":"crossref","first-page":"E2310","DOI":"10.1073\/pnas.1323011111","article-title":"Precise estimates of mutation rate and spectrum in yeast","volume":"111","author":"Zhu","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_bib0215","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1534\/genetics.115.177329","article-title":"The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombe","volume":"201","author":"Farlow","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0220","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1073\/pnas.0803466105","article-title":"A genome-wide view of the spectrum of spontaneous mutations in yeast","volume":"105","author":"Lynch","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_bib0225","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/molbev\/msp063","article-title":"Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria","volume":"26","author":"Chen","year":"2009","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.mib.2019.05.001_bib0230","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mib.2019.05.001_bib0235","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.fgb.2007.05.004","article-title":"Analysis of ALS5 and ALS6 allelic variability in a geographically diverse collection of Candida albicans isolates","volume":"44","author":"Zhao","year":"2007","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0240","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1099\/mic.0.26495-0","article-title":"Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9","volume":"149","author":"Zhao","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2019.05.001_sbref0245","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.aat0537","article-title":"Experimental evolution of a fungal pathogen into a gut symbiont","volume":"362","author":"Tso","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.mib.2019.05.001_bib0250","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1091\/mbc.e05-06-0502","article-title":"The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans","volume":"17","author":"Cao","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.mib.2019.05.001_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micres.2015.05.007","article-title":"Mutations in the Flo8 transcription factor contribute to virulence and phenotypic traits in Candida albicans strains","volume":"178","author":"Liu","year":"2015","journal-title":"Microbiol Res"},{"key":"10.1016\/j.mib.2019.05.001_bib0260","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00117-12","article-title":"Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations","volume":"3","author":"Pierce","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.mib.2019.05.001_bib0265","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01109-16","article-title":"Analysis of repair mechanisms following an induced double-strand break uncovers recessive deleterious alleles in the Candida albicans diploid genome","volume":"7","author":"Feri","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.mib.2019.05.001_bib0270","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/EC.4.1.156-165.2005","article-title":"Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection","volume":"4","author":"Forche","year":"2005","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.mib.2019.05.001_bib0275","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019604","article-title":"Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity","volume":"4","author":"Bennett","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.mib.2019.05.001_bib0280","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.fgb.2008.11.005","article-title":"Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans","volume":"46","author":"Diogo","year":"2009","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0285","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1567-1364.2009.00542.x","article-title":"Efficient and rapid identification of Candida albicans allelic status using SNP-RFLP","volume":"9","author":"Forche","year":"2009","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.mib.2019.05.001_bib0290","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00200-11","article-title":"Stress-induced loss of heterozygosity in Candida: a possible missing link in the ability to evolve","volume":"2","author":"Rosenberg","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.mib.2019.05.001_bib0295","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/genetics\/140.3.965","article-title":"DNA synthesis errors associated with double-strand-break repair","volume":"140","author":"Strathern","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000594","article-title":"Break-induced replication is highly inaccurate","volume":"9","author":"Deem","year":"2011","journal-title":"PLoS Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002659","article-title":"Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila","volume":"8","author":"Kane","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mib.2019.05.001_bib0310","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1073\/pnas.1416622112","article-title":"Crossovers are associated with mutation and biased gene conversion at recombination hotspots","volume":"112","author":"Arbeithuber","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.05.001_bib0315","doi-asserted-by":"crossref","first-page":"25639","DOI":"10.1074\/jbc.R100019200","article-title":"DNA damage control by novel DNA polymerases: translesion replication and mutagenesis","volume":"276","author":"Livneh","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mib.2019.05.001_bib0320","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1128\/MCB.00422-09","article-title":"The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast","volume":"29","author":"Mudrak","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0325","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/genetics.105.054767","article-title":"A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans","volume":"172","author":"Coste","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0330","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1128\/AAC.41.7.1488","article-title":"The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans","volume":"41","author":"White","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2019.05.001_bib0335","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1534\/genetics.116.189274","article-title":"Phenotypic consequences of a spontaneous loss of heterozygosity in a common laboratory strain of Candida albicans","volume":"203","author":"Ciudad","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0340","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.chom.2019.01.005","article-title":"Hemizygosity enables a mutational transition governing fungal virulence and commensalism","volume":"25","author":"Liang","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2019.05.001_bib0345","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1534\/genetics.115.178020","article-title":"Parasexual ploidy reduction drives population heterogeneity through random and transient aneuploidy in Candida albicans","volume":"200","author":"Hickman","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0350","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(02)00837-1","article-title":"White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating","volume":"110","author":"Miller","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mib.2019.05.001_bib0355","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/emboj\/cdg235","article-title":"Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains","volume":"22","author":"Bennett","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.mib.2019.05.001_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060110","article-title":"The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains","volume":"6","author":"Forche","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0365","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1534\/genetics.117.300295","article-title":"Parasex generates phenotypic diversity de novo and impacts drug resistance and virulence in Candida albicans","volume":"207","author":"Hirakawa","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.mib.2019.05.001_bib0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001815","article-title":"A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole","volume":"12","author":"Harrison","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.mib.2019.05.001_bib0375","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1567-1364.2009.00563.x","article-title":"Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants","volume":"9","author":"Arbour","year":"2009","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.mib.2019.05.001_bib0380","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1128\/JB.183.10.2971-2978.2001","article-title":"Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans","volume":"183","author":"Cowen","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.05.001_bib0385","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2958.2008.06176.x","article-title":"An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1","volume":"68","author":"Selmecki","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.05.001_bib0390","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/13693780801986631","article-title":"Mitochondrial haplotypes and recombination in Candida albicans","volume":"46","author":"Jacobsen","year":"2008","journal-title":"Med Mycol"},{"key":"10.1016\/j.mib.2019.05.001_bib0395","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/JB.183.3.865-872.2001","article-title":"Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans","volume":"183","author":"Anderson","year":"2001","journal-title":"J Bacteriol"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527418300924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527418300924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:52:15Z","timestamp":1761285135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527418300924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":79,"alternative-id":["S1369527418300924"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2019.05.001","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of genome evolution in Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2019.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}