{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:39:29Z","timestamp":1791337169408,"version":"4.3.1"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.mib.2019.12.001","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T02:21:35Z","timestamp":1581474095000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Dynamics of expression, secretion and translocation of type III effectors during enteropathogenic Escherichia coli infection"],"prefix":"10.1016","volume":"54","author":[{"given":"Antonio","family":"Serapio-Palacios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton Brett","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2019.12.001_bib0005","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-genet-120215-035138","article-title":"The Genetics of Enteropathogenic Escherichia coli Virulence","volume":"50","author":"Pearson","year":"2016","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.mib.2019.12.001_bib0010","article-title":"Molecular mechanisms of Escherichia coli pathogenicity","volume":"8","author":"Croxen","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.femsre.2004.07.002","article-title":"Enteropathogenic Escherichia coli: unravelling pathogenesis","volume":"29","author":"Deborah Chen","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.mib.2019.12.001_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/534738","article-title":"Locus of enterocyte effacement: a pathogenicity island involved in the virulence of enteropathogenic and enterohemorragic Escherichia coli subjected to a complex network of gene regulation","volume":"2015","author":"Franzin","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.mib.2019.12.001_bib0025","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1128\/JB.00069-14","article-title":"Dynamics of expression and maturation of the type III secretion system of enteropathogenic Escherichia coli","volume":"196","author":"Yerushalmi","year":"2014","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2958.1998.00783.x","article-title":"The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348\/69","volume":"28","author":"Elliott","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2958.1996.tb02619.x","article-title":"EspA, a protein secreted by enteropathogenic Escherichia coll, is required to induce signals in epithelial cells","volume":"20","author":"Kenny","year":"1996","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0040","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1462-5822.2001.00146.x","article-title":"Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli","volume":"3","author":"Ide","year":"2001","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1574-6968.1998.tb13185.x","article-title":"A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway","volume":"166","author":"McNamara","year":"1998","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.mib.2019.12.001_bib0050","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0092-8674(00)80437-7","article-title":"Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells","volume":"91","author":"Kenny","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mib.2019.12.001_bib0055","first-page":"961","article-title":"Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells","volume":"55","author":"DeVinney","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.mib.2019.12.001_bib0060","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1111\/j.1365-2958.2005.04802.x","article-title":"CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli","volume":"57","author":"Thomas","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006706","article-title":"Attaching and effacing (A\/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors","volume":"13","author":"Cepeda-Molero","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2019.12.001_bib0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/JB.01238-08","article-title":"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348\/69","volume":"91","author":"Iguchi","year":"2009","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0075","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/IAI.69.1.315-324.2001","article-title":"espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin","volume":"69","author":"Mellies","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0080","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00184-17","article-title":"A novel mechanism for protein delivery by the type 3 secretion system for extracellularly secreted proteins","volume":"8","author":"Tejeda-Dominguez","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0085","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1111\/j.1462-5822.2008.01181.x","article-title":"EspC translocation into epithelial cells by enteropathogenic Escherichia coli requires a concerted participation of type V and III secretion systems","volume":"10","author":"Vidal","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1574-6968.2006.00119.x","article-title":"A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis","volume":"255","author":"Spears","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.mib.2019.12.001_bib0095","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00228-18","article-title":"After the fact(or): posttranscriptional gene regulation in enterohemorrhagic Escherichia coli O157:H7","volume":"200","author":"Sauder","year":"2018","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0100","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1322033111","article-title":"DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC)","volume":"111","author":"Bhat","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.12.001_sbref0105","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3389\/fmicb.2018.01694","article-title":"Environment controls LEE regulation in enteropathogenic Escherichia coli","volume":"9","author":"Platenkamp","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/BST20180546","article-title":"Control freaks\u2014signals and cues governing the regulation of virulence in attaching and effacing pathogens","volume":"47","author":"Turner","year":"2018","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.mib.2019.12.001_bib0115","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1099\/00221287-148-9-2735","article-title":"Thermoregulated expression of virulence genes in enteropathogenic Escherichia coli","volume":"148","author":"Umanski","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2019.12.001_bib0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/JB.187.1.349-357.2005","article-title":"Ler is a negative autoregulator of the LEE1 operon in enteropathogenic Escherichia coli","volume":"187","author":"Berdichevsky","year":"2005","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0125","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1046\/j.1365-2958.1999.01655.x","article-title":"Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli","volume":"34","author":"Friedberg","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0130","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1365-2958.2011.07956.x","article-title":"An unusual feature associated with LEE1 P1 promoters in enteropathogenic Escherichia coli (EPEC)","volume":"83","author":"Jeong","year":"2012","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1006\/jmbi.1996.0669","article-title":"Variable structures of Fis-DNA complexes determined by flanking DNA-protein contacts","volume":"264","author":"Pan","year":"1996","journal-title":"J Mol Biol"},{"key":"10.1016\/j.mib.2019.12.001_bib0140","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1365-2958.2001.02526.x","article-title":"Role of the nucleoid-associated protein fis in the regulation of virulence properties of enteropathogenic Escherichia coli","volume":"41","author":"Goldberg","year":"2001","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0145","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3546","article-title":"Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes","volume":"4","author":"Padavannil","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2019.12.001_bib0150","doi-asserted-by":"crossref","DOI":"10.1128\/JB.187.23.7918-7930.2005","article-title":"A positive regulatory loop controls expression of the locus of enterocyte effacement-encoded regulators Ler and GrlA","author":"Barba","year":"2005","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_sbref0155","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw113","article-title":"Hfq and three Hfq-dependent small regulatory RNAs\u2014MgrR, RyhB and McaS\u2014coregulate the locus of enterocyte effacement in enteropathogenic Escherichia coli","volume":"75","author":"Bhatt","year":"2017","journal-title":"Pathog Dis"},{"key":"10.1016\/j.mib.2019.12.001_bib0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1574-6968.2009.01664.x","article-title":"An overview of atypical enteropathogenic Escherichia coli","volume":"297","author":"Hernandes","year":"2009","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.mib.2019.12.001_bib0165","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2015.14","article-title":"Genomic diversity of EPEC associated with clinical presentations of differing severity","volume":"1","author":"Hazen","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0170","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1128\/iai.63.5.1767-1776.1995","article-title":"A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli","volume":"63","author":"Gomez-Duarte","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijmm.2019.01.003","article-title":"Virulence-related genes are associated with clinical and nutritional outcomes of Shigella\/Enteroinvasive Escherichia coli pathotype infection in children from Brazilian semiarid region: a community case-control study","volume":"309","author":"Bona","year":"2019","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0180","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1365-2958.1999.01473.x","article-title":"The Per regulon of enteropathogenic Escherichia coli: identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler)","volume":"33","author":"Mellies","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0185","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2958.2011.07819.x","article-title":"PerC and GrlA independently regulate Ler expression in enteropathogenic Escherichia coli","volume":"82","author":"Bustamante","year":"2011","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0190","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1099\/mic.0.27100-0","article-title":"Positive effects of multiple pch genes on expression of the locus of enterocyte effacement genes and adherence of enterohaemorrhagic Escherichia coli O157:H7 to HEp-2 cells","volume":"150","author":"Iyoda","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2019.12.001_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080160","article-title":"Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains","volume":"9","author":"Bingle","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mib.2019.12.001_bib0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2017.00032","article-title":"PerC manipulates metabolism and surface antigens in enteropathogenic Escherichia coli","volume":"7","author":"Mellies","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0205","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1365-2958.2010.07145.x","article-title":"The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus","volume":"76","author":"Vogt","year":"2010","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0210","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/IAI.01265-07","article-title":"Activation of the Cpx envelope stress response down-regulates expression of several locus of enterocyte effacement-encoded genes in enteropathogenic Escherichia coli","volume":"76","author":"MacRitchie","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0215","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/IAI.05679-11","article-title":"DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli","volume":"80","author":"MacRitchie","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0220","series-title":"Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion","first-page":"1","author":"Volk","year":"2019"},{"key":"10.1016\/j.mib.2019.12.001_bib0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fcimb.2016.00105","article-title":"The tip of the iceberg: on the roles of regulatory small RNAs in the virulence of enterohemorrhagic and enteropathogenic Escherichia coli","volume":"6","author":"Bhatt","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0230","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2958.2009.06781.x","article-title":"Hfq affects the expression of the LEE pathogenicity island in enterohaemorrhagic Escherichia coli","volume":"73","author":"Hansen","year":"2009","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0235","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2958.2009.06856.x","article-title":"Hfq negatively regulates type III secretion in EHEC and several other pathogens","volume":"74","author":"Shakhnovich","year":"2009","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0240","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrmicro.2017.20","article-title":"Assembly, structure, function and regulation of type III secretion systems","volume":"15","author":"Deng","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_sbref0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007224","article-title":"Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli","volume":"14","author":"Little","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2019.12.001_bib0250","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1128\/JB.00406-12","article-title":"Expanded roles for multicargo and class 1B effector chaperones in type III secretion","volume":"194","author":"Thomas","year":"2012","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0255","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.str.2011.03.015","article-title":"Biogenesis, regulation, and targeting of the type III secretion system","volume":"19","author":"Izor\u00e9","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.mib.2019.12.001_bib0260","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1046\/j.1365-2958.1999.01558.x","article-title":"Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion","volume":"33","author":"Abe","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0265","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/JB.01967-12","article-title":"A novel C-terminal region within the multicargo type III secretion chaperone CesT contributes to effector secretion","volume":"195","author":"Ramu","year":"2013","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_sbref0270","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/mmi.13948","article-title":"Tandem tyrosine phosphosites in the enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence","volume":"108","author":"Runte","year":"2018","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_sbref0275","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.aah4886","article-title":"Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria","volume":"355","author":"Katsowich","year":"2017","journal-title":"Science (80-)"},{"key":"10.1016\/j.mib.2019.12.001_bib0280","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1128\/IAI.72.6.3218-3227.2004","article-title":"Comparative analysis of EspF from enteropathogenic and enterohemorrhagic Escherichia coli in alteration of epithelial barrier function","volume":"72","author":"Viswanathan","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0285","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1128\/IAI.70.5.2271-2277.2002","article-title":"A gene from the locus of enterocyte effacement that is required for enteropathogenic Escherichia coli to increase tight-junction permeability encodes a chaperone for EspF","volume":"70","author":"Elliott","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0290","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1099\/mic.0.26735-0","article-title":"CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB","volume":"149","author":"Creasey","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2019.12.001_bib0295","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1046\/j.1365-2958.1998.00771.x","article-title":"EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coil","volume":"27","author":"Wainwright","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0300","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1128\/IAI.71.4.2130-2141.2003","article-title":"CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD","volume":"71","author":"Neves","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_sbref0305","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01050-18","article-title":"High-throughput screening of type III secretion determinants reveals a major chaperone-independent pathway","volume":"9","author":"Ernst","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0310","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/1574-6976.12061","article-title":"Assembly of the bacterial type III secretion machinery","volume":"38","author":"Diepold","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.mib.2019.12.001_bib0315","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1128\/JB.00760-10","article-title":"SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal","volume":"192","author":"Younis","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2019.12.001_bib0320","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1128\/IAI.73.4.2135-2146.2005","article-title":"Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens","volume":"73","author":"Deng","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0325","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.571","article-title":"Novel insights into the mechanism of SepL-mediated control of effector secretion in enteropathogenic Escherichia coli","volume":"7","author":"Gayt\u00e1n","year":"2018","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.mib.2019.12.001_bib0330","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.15252\/embj.201797515","article-title":"Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic Escherichia coli","volume":"36","author":"Portaliou","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.mib.2019.12.001_sbref0335","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01733-16","article-title":"The ruler protein EscP of the enteropathogenic Escherichia coli type III secretion system is involved in calcium sensing and secretion hierarchy regulation by interacting with the gatekeeper protein SepL","volume":"8","author":"Shaulov","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0340","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tim.2018.01.010","article-title":"Host cell targeting by enteropathogenic bacteria T3SS effectors","volume":"26","author":"Pinaud","year":"2018","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0345","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00303-13","article-title":"Dynamics of the type III secretion system activity of enteropathogenic Escherichia coli","volume":"4","author":"Mills","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0350","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.molmed.2017.10.003","article-title":"Post-translational mechanisms of host subversion by bacterial effectors","volume":"23","author":"Scott","year":"2017","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.mib.2019.12.001_bib0355","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00317-12","article-title":"EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation","volume":"3","author":"Berger","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005013","article-title":"The serine protease EspC from enteropathogenic Escherichia coli regulates pore formation and cytotoxicity mediated by the type III secretion system","volume":"11","author":"Guignot","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2019.12.001_bib0365","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/AEM.02635-12","article-title":"Autotransporter protein-encoding genes of diarrheagenic Escherichia coli are found in both typical and atypical enteropathogenic E. coli strains","volume":"79","author":"Abreu","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_sbref0370","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02204-18","article-title":"Microbiota and pathogen proteases modulate type iii secretion activity in enterohemorrhagic Escherichia coli","volume":"9","author":"Cameron","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0375","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.01386-13","article-title":"EspC promotes epithelial cell detachment by enteropathogenic Escherichia coli via sequential cleavages of a cytoskeletal protein and then focal adhesion proteins","volume":"82","author":"Navarro-Garcia","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00479-16","article-title":"EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli, causes apoptosis and necrosis through caspase and calpain activation, including direct procaspase-3 cleavage","volume":"7","author":"Serapio-Palacios","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.mib.2019.12.001_bib0385","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chom.2014.11.005","article-title":"The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape","volume":"16","author":"Curtis","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2019.12.001_bib0390","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature11623","article-title":"Fucose sensing regulates bacterial intestinal colonization","volume":"492","author":"Pacheco","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mib.2019.12.001_bib0395","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijmm.2018.03.005","article-title":"Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells","volume":"308","author":"Baumann","year":"2018","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0400","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1128\/IAI.05761-11","article-title":"The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b","volume":"79","author":"Shames","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0405","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1128\/IAI.73.7.4327-4337.2005","article-title":"SepZ\/EspZ is secreted and translocated into HeLa cells by the enteropathogenic Escherichia coli type III secretion system","volume":"73","author":"Kanack","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0410","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chom.2007.11.007","article-title":"Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli","volume":"3","author":"Mills","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2019.12.001_bib0415","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.01069-16","article-title":"Yersinia pestis YopK inhibits bacterial adhesion to host cells by binding to the extracellular matrix adaptor protein matrilin-2","volume":"85","author":"Tan","year":"2017","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0420","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/j.1365-2958.2011.07534.x","article-title":"YopK regulates the Yersinia pestis type III secretion system from within host cells","volume":"79","author":"Dewoody","year":"2011","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.mib.2019.12.001_bib0425","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1128\/iai.63.6.2269-2276.1995","article-title":"Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in mice","volume":"63","author":"Holmstrom","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2019.12.001_bib0430","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.0400326101","article-title":"Dissecting virulence: systematic and functional analyses of a pathogenicity island","volume":"101","author":"Deng","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mib.2019.12.001_bib0435","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1099\/mic.0.26355-0","article-title":"Yeast two-hybrid system survey of interactions between LEE-encoded proteins of enteropathogenic Escherichia coli","volume":"149","author":"Creasey","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.mib.2019.12.001_bib0440","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1462-5822.2010.01470.x","article-title":"The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling","volume":"12","author":"Shames","year":"2010","journal-title":"Cell Microbiol"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527420300011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527420300011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:50:04Z","timestamp":1761285004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527420300011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":88,"alternative-id":["S1369527420300011"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2019.12.001","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of expression, secretion and translocation of type III effectors during enteropathogenic Escherichia coli infection","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2019.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}