{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:02:45Z","timestamp":1761897765760,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P200A210024"],"award-info":[{"award-number":["P200A210024"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI120846"],"award-info":[{"award-number":["R01AI120846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008227","name":"Achievement Rewards for College Scientists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.mib.2023.102264","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T17:52:13Z","timestamp":1676310733000},"page":"102264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Capers with caspases: Toxoplasma gondii tales of inflammation and survival"],"prefix":"10.1016","volume":"72","author":[{"given":"Stephanie Y","family":"Matsuno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Pandori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa B","family":"Lodoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2023.102264_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41579-021-00518-7","article-title":"Toxoplasma gondii infection and its implications within the central nervous system","volume":"19","author":"Matta","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.mib.2023.102264_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev-immunol-112019-072301","article-title":"The antisocial network: cross talk between cell death programs in host defense","volume":"39","author":"Snyder","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107959","article-title":"An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages","volume":"32","author":"de Vasconcelos","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.mib.2023.102264_bib4","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.4049\/jimmunol.1101620","article-title":"Caspase-4 is required for activation of inflammasomes","volume":"188","author":"Sollberger","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms9761","article-title":"Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes","volume":"6","author":"Vigan\u00f2","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2023.102264_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41422-020-0295-8","article-title":"Toward targeting inflammasomes: insights into their regulation and activation","volume":"30","author":"Christgen","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.mib.2023.102264_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-immunol-101220-030653","article-title":"Inflammatory caspases: toward a unified model for caspase activation by inflammasomes","volume":"40","author":"Ross","year":"2022","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cdd.2014.216","article-title":"Old, new and emerging functions of caspases","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.mib.2023.102264_bib9","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib10","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201314","article-title":"Lessons from Toxoplasma: host responses that mediate parasite control and the microbial effectors that subvert them","volume":"218","author":"Frickel","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.mib.2023.102264_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.mib.2023.102264_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev-immunol-101320-011235","article-title":"Innate sensors trigger regulated cell death to combat intracellular infection","volume":"40","author":"Nozaki","year":"2022","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mib.2023.102264_bib14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-immunol-073119-095439","article-title":"Caspases in cell death, inflammation, and pyroptosis","volume":"38","author":"Kesavardhana","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib15","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1073\/pnas.0506643103","article-title":"The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms","volume":"103","author":"Cavaill\u00e8s","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mib.2023.102264_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004005","article-title":"A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage","volume":"10","author":"Cavailles","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2023.102264_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02388-18","article-title":"Three Toxoplasma gondii dense granule proteins are required for induction of lewis rat macrophage pyroptosis","volume":"10","author":"Wang","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_bib18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1462-5822.2005.00517.x","article-title":"Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll\/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging","volume":"7","author":"Hitziger","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2023.102264_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/IAI.01170-13","article-title":"NLRP1 is an inflammasome sensor for Toxoplasma gondii","volume":"82","author":"Ewald","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2023.102264_sbref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-17491-z","article-title":"Gasdermin-D-dependent IL-1\u03b1 release from microglia promotes protective immunity during chronic Toxoplasma gondii infection","volume":"11","author":"Batista","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2023.102264_sbref21","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02361-22","article-title":"Inflammasome activation dampens Type I IFN signaling to strengthen anti-Toxoplasma immunity","volume":"13","author":"Hu","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_sbref22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007872","article-title":"TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-\u03b3 production and host resistance to Toxoplasma gondii","volume":"15","author":"L\u00f3pez-Yglesias","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2023.102264_bib23","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/IAI.00898-10","article-title":"NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells","volume":"79","author":"Witola","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2023.102264_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00255-13","article-title":"Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15","volume":"4","author":"Gov","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_bib25","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.4049\/jimmunol.1700245","article-title":"NLRP3 and potassium efflux drive rapid IL-1\u03b2 release from primary human monocytes during Toxoplasma gondii infection","volume":"199","author":"Gov","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007923","article-title":"Toxoplasma gondii activates a Syk-CARD9-NF-\u03baB signaling axis and gasdermin D-independent release of IL-1\u03b2 during infection of primary human monocytes","volume":"15","author":"Pandori","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2023.102264_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41590-018-0250-8","article-title":"Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii","volume":"20","author":"Safronova","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.mib.2023.102264_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02027-17","article-title":"Evasion of human neutrophil-mediated host defense during Toxoplasma gondii infection","volume":"9","author":"Lima","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mib.2023.102264_sbref30","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1073\/pnas.1820529116","article-title":"Caspase-8 promotes c-Rel\u2013dependent inflammatory cytokine expression and resistance against Toxoplasma gondii","volume":"116","author":"DeLaney","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mib.2023.102264_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100926","article-title":"Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis","volume":"38","author":"Fisch","year":"2019","journal-title":"EMBO J"},{"key":"10.1016\/j.mib.2023.102264_bib32","article-title":"Unique role for caspase-8 in the release of IL-1\u03b2 and active caspase-1 from viable human monocytes during Toxoplasma gondii infection","author":"Pandori","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.mib.2023.102264_sbref33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-020-2796-5","article-title":"Integration of innate immune signalling by caspase-8 cleavage of N4BP1","volume":"587","author":"Gitlin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mib.2023.102264_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008586","article-title":"Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11","volume":"16","author":"Mukhopadhyay","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2023.102264_bib35","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41564-019-0431-8","article-title":"The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-\u03baB signalling via EZH2","volume":"4","author":"Braun","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2023.102264_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00603-21","article-title":"Toxoplasma gondii matrix antigen 1 is a secreted immunomodulatory effector","volume":"12","author":"Tomita","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_bib37","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1242\/jcs.114.19.3495","article-title":"Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression","volume":"114","author":"Goebel","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mib.2023.102264_bib38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1462-5822.2005.00622.x","article-title":"Toxoplasma gondii inhibits ultraviolet light-induced apoptosis through multiple interactions with the mitochondrion-dependent programmed cell death pathway","volume":"8","author":"Carmen","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2023.102264_bib39","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1242\/jcs.050963","article-title":"Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax","volume":"122","author":"Hippe","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mib.2023.102264_bib40","doi-asserted-by":"crossref","DOI":"10.15698\/mic2015.05.201","article-title":"Toxoplasma gondii inhibits cytochrome c-induced caspase activation in its host cell by interference with holo-apoptosome assembly","volume":"2","author":"Graumann","year":"2015","journal-title":"Microb Cell"},{"key":"10.1016\/j.mib.2023.102264_bib41","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1242\/jcs.00756","article-title":"Inhibition of caspase activation and a requirement for NF-\u03baB function in the Toxoplasma gondii-mediated blockade of host apoptosis","volume":"116","author":"Payne","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mib.2023.102264_bib42","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/IAI.01546-07","article-title":"Fas\/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop","volume":"76","author":"Hippe","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2023.102264_bib43","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1462-5822.2007.00893.x","article-title":"Toxoplasma gondii inhibits Fas\/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8","volume":"9","author":"Vutova","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2023.102264_sbref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.02031-20","article-title":"Toxoplasma gondii extends the life span of infected human neutrophils by inducing cytosolic PCNA and blocking activation of apoptotic caspases","volume":"12","author":"Lima","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.mib.2023.102264_sbref45","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.chom.2021.04.016","article-title":"Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis","volume":"29","author":"Rosenberg","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2023.102264_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00021-21","article-title":"RIPK3 facilitates host resistance to oral Toxoplasma gondii infection","volume":"89","author":"Cervantes","year":"2021","journal-title":"Infect Immun"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527423000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527423000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:57:46Z","timestamp":1761285466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527423000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":46,"alternative-id":["S1369527423000012"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2023.102264","relation":{},"ISSN":["1369-5274"],"issn-type":[{"type":"print","value":"1369-5274"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capers with caspases: Toxoplasma gondii tales of inflammation and survival","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2023.102264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102264"}}