{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:28:57Z","timestamp":1793600937189,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI185119"],"award-info":[{"award-number":["R01AI185119"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024339","name":"Monash Addiction Research Centre, Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mib.2026.102754","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:36:09Z","timestamp":1776371769000},"page":"102754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Innate immune responses to Rickettsia: emerging themes and contrasts between species"],"prefix":"10.1016","volume":"91","author":[{"given":"Nghi","family":"Ly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-8757","authenticated-orcid":false,"given":"Thomas P","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2026.102754_bib1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4269\/ajtmh.2010.09-0752","article-title":"Rocky mountain spotted fever in the United States, 2000\u20132007: interpreting contemporary increases in incidence","volume":"83","author":"Openshaw","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.mib.2026.102754_bib2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/clinids\/20.5.1118","article-title":"Therapeutic delay and mortality in cases of Rocky Mountain spotted fever","volume":"20","author":"Kirkland","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13080661","article-title":"Rickettsia species: genetic variability, vectors, and rickettsiosis\u2014a review","volume":"13","author":"Rymaszewska","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.mib.2026.102754_bib4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/CMR.18.4.719-756.2005","article-title":"Tick-borne rickettsioses around the world: emerging diseases challenging old concepts","volume":"18","author":"Parola","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.mib.2026.102754_bib5","first-page":"1","article-title":"Centers for Disease Control & Prevention (CDC) Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis-United States","volume":"65","author":"Biggs","year":"2016","journal-title":"Mortal Wkly Rep Recomm Rep"},{"key":"10.1016\/j.mib.2026.102754_bib6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1086\/592254","article-title":"Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever","volume":"47","author":"Paddock","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1086\/381894","article-title":"Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States","volume":"38","author":"Paddock","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-ento-052720-094533","article-title":"The impacts of climate change on ticks and tick-borne disease risk","volume":"66","author":"Gilbert","year":"2021","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.mib.2026.102754_bib9","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13279","article-title":"Climate change influences on the geographic distributional potential of the spotted fever vectors Amblyomma maculatum and Dermacentor andersoni","volume":"10","author":"Alkishe","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.mib.2026.102754_bib10","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1086\/518147","article-title":"Pathogenic rickettsiae as bioterrorism agents","volume":"45","author":"Azad","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftab019","article-title":"The enigmatic biology of rickettsiae: recent advances, open questions and outlook","volume":"79","author":"McGinn","year":"2021","journal-title":"Pathog Dis"},{"key":"10.1016\/j.mib.2026.102754_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/imm.12787","article-title":"Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses","volume":"152","author":"Yi","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.mib.2026.102754_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.chom.2010.04.004","article-title":"Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol","volume":"7","author":"Sauer","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2026.102754_bib14","first-page":"229","article-title":"Francisella inflammasomes: integrated responses to a cytosolic stealth bacterium","volume":"397","author":"Wallet","year":"2016","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.mib.2026.102754_sbref15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41564-020-0673-5","article-title":"Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis","author":"Burke","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102754_sbref16","article-title":"Pathogenic, but not nonpathogenic, Rickettsia spp. evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche","volume":"13","author":"Voss","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.mib.2026.102754_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00814-21","article-title":"Spotted fever group Rickettsia trigger species-specific alterations in macrophage proteome signatures with different impacts in host innate inflammatory responses","volume":"9","author":"Curto","year":"2021","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.mib.2026.102754_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157231","article-title":"Rickettsia australis activates inflammasome in human and murine macrophages","volume":"11","author":"Smalley","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mib.2026.102754_sbref19","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00886-19","article-title":"Activation of ASC inflammasome driven by toll-like receptor 4 contributes to host immunity against rickettsial infection","volume":"88","author":"Rumfield","year":"2020","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib20","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"R\u00fchl","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.mib.2026.102754_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/imr.13186","article-title":"Pyroptosis in neutrophils: multimodal integration of inflammasome and regulated cell death signaling pathways","volume":"314","author":"Dubyak","year":"2023","journal-title":"Immunol Rev"},{"key":"10.1016\/j.mib.2026.102754_sbref22","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00468-24","article-title":"Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation","volume":"93","author":"Velatooru","year":"2025","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152864","article-title":"The ubiquitin ligation machinery in the defense against bacterial pathogens","volume":"22","author":"Tripathi-Giesgen","year":"2021","journal-title":"EMBO Rep"},{"key":"10.1016\/j.mib.2026.102754_bib24","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4161\/auto.5.8.10177","article-title":"Listeria monocytogenes ActA is a key player in evading autophagic recognition","volume":"5","author":"Yoshikawa","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.mib.2026.102754_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12854","article-title":"Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol","volume":"20","author":"Cheng","year":"2018","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mib.2026.102754_bib26","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1128\/IAI.00110-15","article-title":"Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages","volume":"83","author":"Mitchell","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg2517","article-title":"Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy","volume":"7","author":"Engstr\u00f6m","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.mib.2026.102754_bib28","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41564-019-0583-6","article-title":"Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence","volume":"4","author":"Engstr\u00f6m","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102754_sbref29","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02791-23","article-title":"Autophagy facilitates intracellular survival of pathogenic rickettsiae in macrophages via evasion of autophagosomal maturation and reduction of microbicidal pro-inflammatory IL-1 cytokine responses","volume":"11","author":"Voss","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.mib.2026.102754_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00651-18","article-title":"Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo","volume":"87","author":"Bechelli","year":"2019","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib31","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1128\/JB.01379-12","article-title":"Two protein lysine methyltransferases methylate outer membrane protein B from Rickettsia","volume":"194","author":"Abeykoon","year":"2012","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2026.102754_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.638469","article-title":"Subversion of host innate immunity by Rickettsia australis via a modified autophagic response in macrophages","volume":"12","author":"Bechelli","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.mib.2026.102754_sbref33","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02284-25","article-title":"An effector of phosphatidylinositol 3-kinase activity promotes Rickettsia rickettsii virulence by enhancing autophagy","volume":"16","author":"Huang","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.mib.2026.102754_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12020296","article-title":"Endothelial mechanistic target of rapamycin activation with different strains of R. rickettsii: possible role in rickettsial pathogenesis","volume":"12","author":"Sahni","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.mib.2026.102754_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2020.11.003","article-title":"Characteristics of in vitro infection of human monocytes, by Rickettsia helvetica","volume":"23","author":"P\u00e5hlson","year":"2021","journal-title":"Microbes Infect"},{"key":"10.1016\/j.mib.2026.102754_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molimm.2017.02.013","article-title":"Autophagy and inflammasomes","volume":"86","author":"Harris","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.mib.2026.102754_sbref37","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00820-20","article-title":"Risk1, a phosphatidylinositol 3-kinase effector, promotes Rickettsia typhi intracellular survival","volume":"11","author":"Voss","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.mib.2026.102754_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-50493-9","article-title":"Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen","volume":"15","author":"Sanderlin","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102754_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003399","article-title":"Rickettsia typhi possesses phospholipase A2 enzymes that are involved in infection of host cells","volume":"9","author":"Rahman","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mib.2026.102754_bib40","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1128\/JB.00155-10","article-title":"Functional characterization of a phospholipase A(2) homolog from Rickettsia typhi","volume":"192","author":"Rahman","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2026.102754_sbref41","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31351-y","article-title":"A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes","volume":"13","author":"Borgo","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102754_sbref42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332810","article-title":"Pathogenic rickettsiae encode a secreted lipase that facilitates intracytosolic colonization in host cells","volume":"20","author":"Sadik","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.mib.2026.102754_sbref43","article-title":"Host glutathione is required for Rickettsia parkeri cell division and intracellular survival","volume":"16","author":"Sun","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102754_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mib.2016.11.007","article-title":"Actin-based motility and cell-to-cell spread of bacterial pathogens","volume":"35","author":"Lamason","year":"2017","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.mib.2026.102754_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00353-22","article-title":"Regulator of Actin-Based Motility (RoaM) downregulates actin tail formation by Rickettsia rickettsii and is negatively selected in mammalian cell culture","volume":"13","author":"Nock","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.mib.2026.102754_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cub.2013.11.025","article-title":"Rickettsia actin-based motility occurs in distinct phases mediated by different actin nucleators","volume":"24","author":"Reed","year":"2014","journal-title":"Curr Biol"},{"key":"10.1016\/j.mib.2026.102754_sbref47","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202406122","article-title":"Rickettsia parkeri forms extensive, stable contacts with the rough endoplasmic reticulum","volume":"224","author":"Acevedo-S\u00e1nchez","year":"2025","journal-title":"J Cell Biol"},{"key":"10.1016\/j.mib.2026.102754_bib48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-pathmechdis-012418-012800","article-title":"Pathogenesis of rickettsial diseases: pathogenic and immune mechanisms of an endotheliotropic infection","volume":"14","author":"Sahni","year":"2019","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.mib.2026.102754_bib49","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3201\/eid1209.051540","article-title":"Histologic features and immunodetection of African tick-bite fever eschar","volume":"12","author":"Lepidi","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_sbref50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67029","article-title":"Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis","volume":"10","author":"Burke","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.mib.2026.102754_bib51","first-page":"529","article-title":"Monoclonal antibody-based immunohistochemical diagnosis of rickettsialpox: the macrophage is the principal target","volume":"12","author":"Walker","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1016\/j.mib.2026.102754_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00686-19","article-title":"Cutaneous immunoprofiles of three spotted fever group Rickettsia cases","volume":"88","author":"Jia","year":"2020","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib53","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1128\/iai.8.4.519-527.1973","article-title":"Mechanisms of immunity in typhus infections. I. Multiplication of typhus rickettsiae in human macrophage cell cultures in the nonimmune system: influence of virulence of rickettsial strains and of chloramphenicol","volume":"8","author":"Gambrill","year":"1973","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib54","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/iai.7.6.1003-1005.1973","article-title":"Isolation of Rickettsia rickettsi in primary bone marrow cell and circulating monocyte cultures derived from experimentally infected guinea pigs","volume":"7","author":"Buhles","year":"1973","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib55","article-title":"Strategies used by bacteria to grow in macrophages","volume":"4","author":"Mitchell","year":"2016","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.mib.2026.102754_bib56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcimb.2016.00080","article-title":"Differences in intracellular fate of two spotted fever group Rickettsia in macrophage-like cells","volume":"6","author":"Curto","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.mib.2026.102754_sbref57","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10020228","article-title":"Significant growth by Rickettsia species within human macrophage-like cells is a phenotype correlated with the ability to cause disease in mammals","volume":"10","author":"Kristof","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.mib.2026.102754_bib58","article-title":"Differences between human and rodent nitric oxide production dictate susceptibility to tick-borne Rickettsia [Internet]","author":"Luu","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mib.2026.102754_bib59","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archdermatol.2010.48","article-title":"The expanding spectrum of eschar-associated rickettsioses in the United States","volume":"146","author":"Cragun","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.mib.2026.102754_bib60","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3201\/eid2205.151824","article-title":"Rickettsia parkeri rickettsiosis, Arizona, USA","volume":"22","author":"Herrick","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.mib.2026.102754_bib61","first-page":"1","article-title":"Amblyomma maculatum feeding augments Rickettsia parkeri infection in a rhesus macaque model: a pilot study","volume":"10","author":"Banajee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mib.2026.102754_bib62","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.03463-16","article-title":"Unique strain of Rickettsia parkeri associated with the hard tick Dermacentor parumapertus Neumann in the western United States","volume":"83","author":"Paddock","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.mib.2026.102754_sbref63","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02563-24","article-title":"The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity","volume":"16","author":"Tran","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.mib.2026.102754_bib64","first-page":"358","article-title":"Rickettsia conorii infection of C3H\/HeN mice: a model of endothelial- target rickettsiosis","volume":"70","author":"Walker","year":"1994","journal-title":"Lab Investig"},{"key":"10.1016\/j.mib.2026.102754_bib65","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/labinvest.3780144","article-title":"Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes","volume":"80","author":"Walker","year":"2000","journal-title":"Lab Investig"},{"key":"10.1016\/j.mib.2026.102754_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00156-17","article-title":"GFPuv-expressing recombinant Rickettsia typhi: a useful tool for the study of pathogenesis and CD8+ T cell immunology in R. typhi infection","volume":"85","author":"Hauptmann","year":"2017","journal-title":"Infect Immun"},{"key":"10.1016\/j.mib.2026.102754_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004935","article-title":"Liver necrosis and lethal systemic inflammation in a murine model of Rickettsia typhi infection: role of neutrophils, macrophages and NK cells","volume":"10","author":"Papp","year":"2016","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527426000482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527426000482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:56:59Z","timestamp":1793599019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527426000482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":67,"alternative-id":["S1369527426000482"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2026.102754","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innate immune responses to Rickettsia: emerging themes and contrasts between species","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2026.102754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102754"}}