{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:11:43Z","timestamp":1790820703811,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001738","name":"Ministry of Innovation, Science and Technology","doi-asserted-by":"publisher","award":["1001695377"],"award-info":[{"award-number":["1001695377"]}],"id":[{"id":"10.13039\/501100001738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004576","name":"Ministry of Agriculture and Rural Development","doi-asserted-by":"publisher","award":["12-12-0008"],"award-info":[{"award-number":["12-12-0008"]}],"id":[{"id":"10.13039\/501100004576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","award":["ZN4041"],"award-info":[{"award-number":["ZN4041"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1535\/20"],"award-info":[{"award-number":["1535\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["249\/25"],"award-info":[{"award-number":["249\/25"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Microbiology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mib.2026.102781","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T19:40:44Z","timestamp":1782330044000},"page":"102781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Discovery of novel antimicrobials within microbiomes"],"prefix":"10.1016","volume":"92","author":[{"given":"Erez","family":"Weisberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"de la Fuente-Nunez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mib.2026.102781_bib1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050","volume":"404","author":"GBD 2021 Antimicrobial Resistance Collaborators","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.mib.2026.102781_bib2","series-title":"Global Antibiotic Resistance Surveillance Report 2025: WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS)","author":"World Health Organization","year":"2025"},{"key":"10.1016\/j.mib.2026.102781_sbref3","series-title":"WHO Bacterial Priority Pathogens List, 2024: Bacterial Pathogens of Public Health Importance, to Guide Research, Development, and Strategies to Prevent and Control Antimicrobial Resistance","author":"World Health Organization","year":"2024"},{"key":"10.1016\/j.mib.2026.102781_sbref4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S2666-5247(24)00042-9","article-title":"The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation","volume":"5","author":"Casalini","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.mib.2026.102781_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114874","article-title":"New antifungal strategies: Drug combination and co-delivery","volume":"198","author":"Zhu","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.mib.2026.102781_sbref6","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gkaf334","article-title":"antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation","volume":"53","author":"Blin","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mib.2026.102781_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg4320","article-title":"Evolution-inspired engineering of nonribosomal peptide synthetases","volume":"383","author":"Bozh\u00fcy\u00fck","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib8","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.chom.2023.07.001","article-title":"Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning","volume":"31","author":"Maasch","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mib.2026.102781_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/acsinfecdis.0c00871","article-title":"Random peptide mixtures as safe and effective antimicrobials against and MRSA in mouse models of bacteremia and pneumonia","volume":"7","author":"Bennett","year":"2021","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.mib.2026.102781_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celbio.2025.100183","article-title":"Generative latent diffusion language modeling yields anti-infective synthetic peptides","volume":"1","author":"Torres","year":"2025","journal-title":"Cell Biomater"},{"key":"10.1016\/j.mib.2026.102781_sbref11","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1038\/s41564-024-01820-9","article-title":"Systematic discovery of antibacterial and antifungal bacterial toxins","volume":"9","author":"Nachmias","year":"2024","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3390\/microorganisms8050639","article-title":"Bacteriocins, antimicrobial peptides from bacterial origin: overview of their biology and their impact against multidrug-resistant bacteria","volume":"8","author":"Simons","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.mib.2026.102781_sbref13","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1016\/j.cell.2024.07.027","article-title":"Mining human microbiomes reveals an untapped source of peptide antibiotics","volume":"187","author":"Torres","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.mib.2026.102781_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01519-22","article-title":"PlyKp104, a novel phage lysin for the treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and other gram-negative ESKAPE pathogens","volume":"67","author":"Euler","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mib.2026.102781_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01813-23","article-title":"Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria","volume":"11","author":"Gerstmans","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.mib.2026.102781_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30729-7","article-title":"Colicin F inhibits pathogenic Yersinia enterocolitica in mice","volume":"8","author":"Bos\u00e1k","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.mib.2026.102781_bib17","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4315\/0362-028X-70.5.1256","article-title":"Inhibitory activity of colicin E1 against Listeria monocytogenes","volume":"70","author":"Patton","year":"2007","journal-title":"J Food Prot"},{"key":"10.1016\/j.mib.2026.102781_bib18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41586-022-05019-y","article-title":"Teixobactin kills bacteria by a two-pronged attack on the cell envelope","volume":"608","author":"Shukla","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1432-1327.1999.00085.x","article-title":"The cyclic structure of microcin J25, a 21-residue peptide antibiotic from Escherichia coli","volume":"259","author":"Blond","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.mib.2026.102781_bib21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molcel.2004.06.010","article-title":"Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel","volume":"14","author":"Mukhopadhyay","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.mib.2026.102781_bib22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.cell.2014.08.032","article-title":"A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics","volume":"158","author":"Donia","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mib.2026.102781_bib23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41586-025-08678-9","article-title":"A polyene macrolide targeting phospholipids in the fungal cell membrane","volume":"640","author":"Deng","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2022.2050224","article-title":"Echinocandins \u2013 structure, mechanism of action and use in antifungal therapy","volume":"37","author":"Szyma\u0144ski","year":"2022","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.mib.2026.102781_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd.2017.46","article-title":"The antifungal pipeline: a reality check","volume":"16","author":"Perfect","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.mib.2026.102781_bib26","doi-asserted-by":"crossref","first-page":"S604","DOI":"10.1093\/cid\/civ814","article-title":"Echinocandins: the expanding antifungal armamentarium","volume":"61","author":"Aguilar-Zapata","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102781_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00074-23","article-title":"Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease","volume":"37","author":"Hoenigl","year":"2024","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.mib.2026.102781_bib28","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1093\/cid\/ciaf185","article-title":"Fosmanogepix for the treatment of invasive mold diseases caused by Aspergillus species and rare molds: a phase 2, open-label study (AEGIS)","volume":"81","author":"Hodges","year":"2025","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mib.2026.102781_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax9176","article-title":"A metagenomic strategy for harnessing the chemical repertoire of the human microbiome","volume":"366","author":"Sugimoto","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib30","article-title":"Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41564-018-0110-1","article-title":"Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens","volume":"3","author":"Hover","year":"2018","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_sbref32","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1016\/j.cell.2024.05.013","article-title":"Discovery of antimicrobial peptides in the global microbiome with machine learning","volume":"187","author":"Santos-J\u00fanior","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.mib.2026.102781_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-08438-0","article-title":"The antimicrobial potential of Streptomyces from insect microbiomes","volume":"10","author":"Chevrette","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41586-020-1990-9","article-title":"Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling","volume":"578","author":"Culp","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib35","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/nbt.2685","article-title":"Identifying producers of antibacterial compounds by screening for antibiotic resistance","volume":"31","author":"Thaker","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.mib.2026.102781_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/acsinfecdis.7b00081","article-title":"Identification of the Colicin V bacteriocin gene cluster by functional screening of a human microbiome metagenomic library","volume":"4","author":"Cohen","year":"2018","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.mib.2026.102781_bib37","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1128\/AEM.02169-09","article-title":"Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria","volume":"76","author":"Craig","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib38","first-page":"410","article-title":"Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains","volume":"8","author":"Apjok","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib39","article-title":"Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body","author":"Chia","year":"2025","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.mib.2026.102781_bib40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41587-022-01226-0","article-title":"Identification of antimicrobial peptides from the human gut microbiome using deep learning","volume":"40","author":"Ma","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.mib.2026.102781_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/science.1254766","article-title":"HUMAN MICROBIOTA. Small molecules from the human microbiota","volume":"349","author":"Donia","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1126\/science.2781297","article-title":"Symbiotic marine bacteria chemically defend crustacean embryos from a pathogenic fungus","volume":"246","author":"Sofia Gil-Turnes","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41586-019-1501-z","article-title":"Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus","volume":"572","author":"Kim","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11494-1","article-title":"A family of anti-bacteroidales peptide toxins wide-spread in the human gut microbiota","volume":"10","author":"Coyne","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature18634","article-title":"Human commensals producing a novel antibiotic impair pathogen colonization","volume":"535","author":"Zipperer","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-019-1791-1","article-title":"A new antibiotic selectively kills Gram-negative pathogens","volume":"576","author":"Imai","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.1160423","article-title":"Bacterial protection of beetle-fungus mutualism","volume":"322","author":"Scott","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib48","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1613285113","article-title":"Selvamicin, an atypical antifungal polyene from two alternative genomic contexts","volume":"113","author":"Van Arnam","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mib.2026.102781_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04955-6","article-title":"An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles","volume":"9","author":"Fl\u00f3rez","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib50","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1128\/jb.170.8.3499-3508.1988","article-title":"Role of a phenazine antibiotic from Pseudomonas fluorescens in biological control of Gaeumannomyces graminis var. tritici","volume":"170","author":"Thomashow","year":"1988","journal-title":"J Bacteriol"},{"key":"10.1016\/j.mib.2026.102781_bib51","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nbt1325","article-title":"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42","volume":"25","author":"Chen","year":"2007","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.mib.2026.102781_sbref52","article-title":"Antifungal biosynthesis by root-associated Streptomyces and Pseudomonas is elicited upon plant colonization","author":"Tigani","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mib.2026.102781_bib53","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.aaw9285","article-title":"Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome","volume":"366","author":"Carri\u00f3n","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_sbref54","doi-asserted-by":"crossref","DOI":"10.1126\/science.ado0713","article-title":"A phage tail-like bacteriocin suppresses competitors in metapopulations of pathogenic bacteria","volume":"384","author":"Backman","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01018-21","article-title":"Metagenomic sequencing of multiple soil horizons and sites in close vicinity revealed novel secondary metabolite diversity","volume":"6","author":"Mantri","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.mib.2026.102781_bib56","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/antibiotics9010024","article-title":"Development and challenges of antimicrobial peptides for therapeutic applications","volume":"9","author":"Chen","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.mib.2026.102781_bib57","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41564-022-01110-2","article-title":"Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes","volume":"7","author":"Gavriilidou","year":"2022","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib58","doi-asserted-by":"crossref","first-page":"40554","DOI":"10.1021\/jacs.5c12501","article-title":"Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant gram-positive bacterial pathogens","volume":"147","author":"Corre","year":"2025","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.mib.2026.102781_sbref59","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41586-025-08723-7","article-title":"A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome","volume":"640","author":"Jangra","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib60","article-title":"Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib61","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1128\/am.14.4.649-653.1966","article-title":"Production of a pyrrole antibiotic by a marine bacterium","volume":"14","author":"Burkholder","year":"1966","journal-title":"Appl Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib62","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41586-024-07891-2","article-title":"Global marine microbial diversity and its potential in bioprospecting","volume":"633","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib63","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.abd6919","article-title":"A marine microbiome antifungal targets urgent-threat drug-resistant fungi","volume":"370","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mib.2026.102781_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/JCI145123","article-title":"Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking","volume":"131","author":"Zhao","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mib.2026.102781_bib65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/acsinfecdis.7b00105","article-title":"Marine mammal microbiota yields novel antibiotic with potent activity against Clostridium difficile","volume":"4","author":"Ochoa","year":"2018","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.mib.2026.102781_bib66","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nchembio.2207","article-title":"Discovery of MRSA active antibiotics using primary sequence from the human microbiome","volume":"12","author":"Chu","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.mib.2026.102781_bib67","article-title":"Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery","volume":"12","author":"Behsaz","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.mib.2026.102781_bib68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04862-3","article-title":"Biosynthetic potential of the global ocean microbiome","volume":"607","author":"Paoli","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mib.2026.102781_bib69","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/s41564-023-01524-6","article-title":"Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra","volume":"8","author":"King","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib70","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41551-022-00991-2","article-title":"Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences","volume":"7","author":"Huang","year":"2023","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.mib.2026.102781_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-023-01573-3","article-title":"Global analysis of the biosynthetic chemical space of marine prokaryotes","volume":"11","author":"Wei","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.mib.2026.102781_sbref72","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/s41564-025-02061-0","article-title":"Deep learning reveals antibiotics in the archaeal proteome","volume":"10","author":"Torres","year":"2025","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib73","article-title":"Unveiling the evolution of antimicrobial peptides in gut microbes via foundation-model-powered framework","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.mib.2026.102781_sbref74","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1038\/s41564-025-02114-4","article-title":"A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria","volume":"10","author":"Wang","year":"2025","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.mib.2026.102781_bib75","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2020.01.021","article-title":"A deep learning approach to antibiotic discovery","volume":"180","author":"Stokes","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.mib.2026.102781_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-017-0042-1","article-title":"The rumen microbiome: an underexplored resource for novel antimicrobial discovery","volume":"3","author":"Oyama","year":"2017","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.mib.2026.102781_bib77","article-title":"Phocoenamicins B and C, new antibacterial Spirotetronates isolated from a marine Micromonospora sp.","volume":"16","author":"Molina","year":"2018","journal-title":"Mar Drugs"},{"key":"10.1016\/j.mib.2026.102781_bib78","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00201-17","article-title":"Microbial eukaryotes: a missing link in gut microbiome studies","volume":"3","author":"Laforest-Lapointe","year":"2018","journal-title":"mSystems"},{"key":"10.1016\/j.mib.2026.102781_bib79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coviro.2019.05.007","article-title":"Virome and bacteriome: two sides of the same coin","volume":"37","author":"Stern","year":"2019","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.mib.2026.102781_bib80","first-page":"1333","article-title":"Archaeal lineages within the human microbiome: absent, rare or elusive?","volume":"5","author":"Horz","year":"2015","journal-title":"Life (Basel)"}],"container-title":["Current Opinion in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527426000755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369527426000755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:38:49Z","timestamp":1790152729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369527426000755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":80,"alternative-id":["S1369527426000755"],"URL":"https:\/\/doi.org\/10.1016\/j.mib.2026.102781","relation":{},"ISSN":["1369-5274"],"issn-type":[{"value":"1369-5274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel antimicrobials within microbiomes","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mib.2026.102781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102781"}}