{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:54:01Z","timestamp":1791060841036,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":7240,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.micinf.2003.10.013","type":"journal-article","created":{"date-parts":[[2004,1,2]],"date-time":"2004-01-02T05:29:21Z","timestamp":1073021361000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease"],"prefix":"10.1016","volume":"6","author":[{"given":"Abbas","family":"Jolodar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich W.","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert W.","family":"Brattig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2003.10.013_BIB1","first-page":"1","article-title":"Third report","volume":"752","author":"Expert Committee on Onchocerciasis","year":"1987","journal-title":"Wld. Hlth. Org. Tech. Rep. Ser."},{"key":"10.1016\/j.micinf.2003.10.013_BIB2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.micro.53.1.71","article-title":"Wolbachia pipientis: microbial manipulator of arthropod reproduction","volume":"53","author":"Stouthamer","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-4017(01)00432-0","article-title":"Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases","volume":"98","author":"Bandi","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB4","first-page":"25","article-title":"The Wolbachia endosymbionts of filarial nematodes","author":"Bandi","year":"2001"},{"key":"10.1016\/j.micinf.2003.10.013_BIB5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1286-4579(03)00026-1","article-title":"Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms","volume":"5","author":"Hoerauf","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2003.10.013_BIB6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00436-002-0813-2","article-title":"An aspartate aminotransferase of Wolbachia endobacteria from Onchocerca volvulus is recognized by IgG1 antibodies from residents of endemic areas","volume":"90","author":"Fischer","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micinf.2003.10.013_BIB7","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/JB.180.9.2373-2378.1998","article-title":"Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis","volume":"180","author":"Braig","year":"1998","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s002840010100","article-title":"wsp gene sequences from the Wolbachia of filarial nematodes","volume":"41","author":"Bazzocchi","year":"2000","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1365-2958.1997.5601928.x","article-title":"The HtrA family of serine proteases","volume":"26","author":"Pallen","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1097-2765(02)00658-5","article-title":"The HtrA family of proteases: implications for protein composition and cell fate","volume":"10","author":"Clausen","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.micinf.2003.10.013_BIB11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(03)00192-2","article-title":"A stress sensor for the bacterial periplasm","volume":"113","author":"Young","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2003.10.013_BIB12","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1128\/iai.64.11.4838-4841.1996","article-title":"The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes","volume":"64","author":"Elzer","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2003.10.013_BIB13","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1128\/IAI.68.10.5970-5978.2000","article-title":"Transcriptional activation of the HtrA (High-temperature requirement A) gene from Bartonella henselae","volume":"68","author":"Resto-Ruiz","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2003.10.013_BIB14","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1073\/pnas.85.5.1576","article-title":"An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins","volume":"85","author":"Strauch","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2003.10.013_BIB15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","article-title":"Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites","volume":"10","author":"Henrik","year":"1997","journal-title":"Protein Engineering"},{"key":"10.1016\/j.micinf.2003.10.013_BIB16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/30.1.235","article-title":"The PROSITE database, its status in 2002","volume":"30","author":"Falquet","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micinf.2003.10.013_BIB17","first-page":"390","article-title":"Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique","volume":"39","author":"B\u00fcttner","year":"1988","journal-title":"Trop. Med. Parasitol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB18","first-page":"311","article-title":"Parasitological and clinical characterization of Simulium neavei-transmitted onchocerciasis in western Uganda","volume":"44","author":"Fischer","year":"1993","journal-title":"Trop. Med. Parasitol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(00)04581-5","article-title":"Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment","volume":"357","author":"Hoerauf","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2003.10.013_BIB20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0169-4758(99)01533-1","article-title":"Wolbachia bacteria of filarial nematodes","volume":"15","author":"Taylor","year":"1999","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.micinf.2003.10.013_BIB21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF00932419","article-title":"Light and electron microscopy studies on Onchocerca jakutensis and O. flexuosa of red deer show different host-parasite interactions","volume":"81","author":"Plenge-B\u00f6nig","year":"1995","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micinf.2003.10.013_BIB22","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/infdis\/170.4.955","article-title":"Strong IgG isotypic antibody response in sowdah type onchocerciasis","volume":"170","author":"Brattig","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2003.10.013_BIB23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1365-3024.2000.00325.x","article-title":"Humoral responses to a secretory Onchocerca volvulus protein: differences in the pattern of antibody isotypes to recombinant Ov20\/OvS1 in generalized and hyperreactive onchocerciasis","volume":"22","author":"Mpagi","year":"2000","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB24","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1046\/j.1365-3156.1997.d01-384.x","article-title":"Characterization of the human immune responses to the cytosolic superoxide dismutase and glutathione S-transferase from Onchocerca volvulus","volume":"2","author":"Brattig","year":"1997","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.micinf.2003.10.013_BIB25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/334528a0","article-title":"The molecular evolution of genes and proteins: a tale of two serines","volume":"334","author":"Brenner","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2003.10.013_BIB26","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1093\/nar\/14.11.4683","article-title":"A new method for predicting signal sequence cleavage sites","volume":"14","author":"Von Heijne","year":"1986","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.micinf.2003.10.013_BIB27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-2883-2-10","article-title":"Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa","volume":"2","author":"B\u00fcttner","year":"2003","journal-title":"Filaria J."},{"key":"10.1016\/j.micinf.2003.10.013_BIB28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2567.2002.01375.x","article-title":"Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut","volume":"105","author":"Miller","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2003.10.013_BIB29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1098\/rspb.2000.1110","article-title":"Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship","volume":"267","author":"Langworthy","year":"2000","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.micinf.2003.10.013_BIB30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/MMBR.62.3.597-635.1998","article-title":"Molecular and biotechnological aspects of microbial proteases","volume":"62","author":"Rao","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micinf.2003.10.013_BIB31","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/sj.cdd.4400991","article-title":"Origin and evolution of eukaryotic apoptosis: the bacterial connection","volume":"9","author":"Koonin","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.micinf.2003.10.013_BIB32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1078\/1438-4221-00139","article-title":"Pathogenicity of Legionella pneumophila","volume":"291","author":"Cianciotto","year":"2001","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/416455a","article-title":"Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine","volume":"416","author":"Krojer","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2003.10.013_BIB34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0969-2126(02)00782-7","article-title":"HtrA\u2014a renaissance protein","volume":"10","author":"Day","year":"2002","journal-title":"Structure"},{"key":"10.1016\/j.micinf.2003.10.013_BIB35","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1242\/jcs.114.18.3219","article-title":"Mechanism and role of PDZ domains in signaling complex assembly","volume":"114","author":"Harris","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.micinf.2003.10.013_BIB36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1749-6632.1999.tb07925.x","article-title":"The molecular mechanism of programmed cell death in C. elegans","volume":"887","author":"Liu","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.micinf.2003.10.013_BIB37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(96)00620-5","article-title":"The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family","volume":"390","author":"Erttmann","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.micinf.2003.10.013_BIB38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-3024.2001.00397.x","article-title":"Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity","volume":"23","author":"Maizels","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2003.10.013_BIB39","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1182\/blood.V94.4.1418","article-title":"A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases","volume":"94","author":"Zang","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.micinf.2003.10.013_BIB40","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1021\/bi0271650","article-title":"BmSPN2, a serpin secreted by the filarial nematode Brugia malayi, does not inhibit human neutrophil proteinases but plays a noninhibitory role","volume":"42","author":"Stanley","year":"2003","journal-title":"Biochemistry"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457903003174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457903003174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:11:22Z","timestamp":1761142282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457903003174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S1286457903003174"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2003.10.013","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2003.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 \u00c9ditions scientifiques et m\u00e9dicales Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}