{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:35:32Z","timestamp":1767864932253,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6605,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.micinf.2005.05.008","type":"journal-article","created":{"date-parts":[[2005,7,2]],"date-time":"2005-07-02T11:29:25Z","timestamp":1120303765000},"page":"1501-1511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bacterial cell wall-expressed protein A triggers supraclonal B-cell responses upon in vivo infection with Staphylococcus aureus"],"prefix":"10.1016","volume":"7","author":[{"given":"Niklas","family":"Palmqvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg J.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Josefsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Tarkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2005.05.008_bib1","series-title":"Gram-Positive Pathogens","first-page":"414","article-title":"The epidemiology of Staphylococcus aureus infections","author":"Tenover","year":"2000"},{"key":"10.1016\/j.micinf.2005.05.008_bib2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0966-842X(01)02175-8","article-title":"The emergence and evolution of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Hiramatsu","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib3","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1128\/AAC.47.10.3040-3045.2003","article-title":"Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods","volume":"47","author":"Liu","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micinf.2005.05.008_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0966-842X(98)01400-0","article-title":"Surface protein adhesins of Staphylococcus aureus","volume":"6","author":"Foster","year":"1998","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2005.05.008_bib6","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.4049\/jimmunol.155.4.2067","article-title":"Mice with the xid B-cell defects are less susceptible to developing Staphylococcus aureus-induced arthritis","volume":"155","author":"Zhao","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib7","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1128\/IAI.68.5.2431-2434.2000","article-title":"Are B lymphocytes of importance in severe Staphylococcus aureus infections?","volume":"68","author":"Gjertsson","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.05.008_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.171.2.455","article-title":"The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells","volume":"171","author":"Marrack","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.05.008_bib9","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1128\/iai.63.11.4463-4469.1995","article-title":"Overexpression of the T-cell receptor V beta 3 in transgenic mice increases mortality during infection by enterotoxin A-producing Staphylococcus aureus","volume":"63","author":"Zhao","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.05.008_bib10","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/eji.1830240523","article-title":"Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci","volume":"24","author":"Abdelnour","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib11","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1128\/iai.60.7.2976-2985.1992","article-title":"Histopathological and serological progression of experimental Staphylococcus aureus arthritis","volume":"60","author":"Bremell","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.05.008_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/CDLI.7.1.14-20.2000","article-title":"Antibody responses in patients with staphylococcal septicemia against two Staphylococcus aureus fibrinogen binding proteins: clumping factor and an extracellular fibrinogen binding protein","volume":"7","author":"Colque-Navarro","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib13","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1080\/00365540310016682","article-title":"Staphylococcus aureus bacteremia: compliance with standard treatment, long-term outcome and predictors of relapse","volume":"35","author":"Johnson","year":"2003","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.05.008_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01.md.0000091184.93122.09","article-title":"Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study","volume":"82","author":"Chang","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.micinf.2005.05.008_bib15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.4049\/jimmunol.97.6.822","article-title":"\u201cProtein A\u201d from S. aureus. I. Pseudo-immune reaction with human gamma-globulin","volume":"97","author":"Forsgren","year":"1966","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib16","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0021-9258(17)43463-6","article-title":"Complete sequence of the staphylococcal gene encoding protein A. A gene evolved through multiple duplications","author":"Uhlen","year":"1984","journal-title":"J. Biol. Chem. 259"},{"key":"10.1016\/j.micinf.2005.05.008_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1432-1033.1986.tb09625.x","article-title":"Staphylococcal protein A consists of five IgG-binding domains","volume":"156","author":"Moks","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.micinf.2005.05.008_bib18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1128\/iai.15.3.760-764.1977","article-title":"Effect of protein A on staphylococcal opsonization","volume":"15","author":"Peterson","year":"1977","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.05.008_bib19","series-title":"The Staphylococci, Proceedings of the VIth International Symposium on Staphylococci and Staphylococcal Infections, Zbl. Bakt. Suppl. 21. Gustav Fisher Verlag","first-page":"273","article-title":"Susceptibility to opsonophagocytosis of protein A, \u03b1-haemolysin and \u03b2-toxin deficient mutants of S. aureus isolated by allele-replacement","author":"Gemmell","year":"1991"},{"key":"10.1016\/j.micinf.2005.05.008_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0928-8244(97)00108-9","article-title":"All individual domains of staphylococcal protein A show Fab binding","volume":"20","author":"Jansson","year":"1998","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib21","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.4049\/jimmunol.142.8.2778","article-title":"Human IgM molecules that bind staphylococcal protein A contain VHIII H chains","volume":"142","author":"Sasso","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib22","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.4049\/jimmunol.145.9.2989","article-title":"Mouse Ig coded by VH families S107 or J606 bind to protein A","volume":"145","author":"Seppala","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0161-5890(99)00085-1","article-title":"The murine clan V(H) III related 7183, J606 and S107 and DNA4 families commonly encode for binding to a bacterial B-cell superantigen","volume":"36","author":"Cary","year":"1999","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib24","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1073\/pnas.97.10.5399","article-title":"Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity","volume":"97","author":"Graille","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.05.008_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(95)80166-9","article-title":"The human immunoglobulin VH repertoire","volume":"16","author":"Cook","year":"1995","journal-title":"Immunol. Today"},{"key":"10.1016\/j.micinf.2005.05.008_bib26","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.4049\/jimmunol.151.10.5840","article-title":"Age-associated changes in binding of human B lymphocytes to a VH3-restricted unconventional bacterial antigen","volume":"151","author":"Silverman","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/346471a0","article-title":"Residues of the variable region of the T-cell-receptor beta-chain that interact with S. aureus toxin superantigens","volume":"346","author":"Choi","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2005.05.008_bib28","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.4049\/jimmunol.153.7.2974","article-title":"Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes","volume":"153","author":"Kristiansen","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/eji.1830060312","article-title":"Lymphocyte stimulation by protein A of Staphylococcus aureus","volume":"6","author":"Forsgren","year":"1976","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib30","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.4049\/jimmunol.161.10.5720","article-title":"The dual phases of the response to neonatal exposure to a VH family-restricted staphylococcal B-cell superantigen","volume":"161","author":"Silverman","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1084\/jem.192.1.87","article-title":"A B-cell superantigen-induced persistent \u201cHole\u201d in the B-1 repertoire","volume":"192","author":"Silverman","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.05.008_bib32","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20020552","article-title":"Death by a B-cell superantigen: in vivo VH-targeted apoptotic supraclonal B-cell deletion by a staphylococcal toxin","volume":"197","author":"Goodyear","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.05.008_bib33","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.276.5313.718","article-title":"Exploitation of mammalian host cell functions by bacterial pathogens","volume":"276","author":"Finlay","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.micinf.2005.05.008_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/mpat.2002.0533","article-title":"Protein A is a virulence factor in Staphylococcus aureus arthritis and septic death","volume":"33","author":"Palmqvist","year":"2002","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micinf.2005.05.008_bib35","first-page":"95","article-title":"Staphylococcal coagulase: mode of action and antigenicity","volume":"6","author":"Duthie","year":"1952","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib36","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-2958.1995.tb02316.x","article-title":"Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of Staphylococcus aureus","volume":"16","author":"McDevitt","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2958.1994.tb00304.x","article-title":"Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus","volume":"11","author":"McDevitt","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2005.05.008_bib38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.micinf.2003.10.014","article-title":"Clumping factor A-mediated virulence during Staphylococcus aureus infection is retained despite fibrinogen depletion","volume":"6","author":"Palmqvist","year":"2004","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2005.05.008_bib39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.4049\/jimmunol.129.2.596","article-title":"Demonstration on protein A of two distinct immunoglobulin-binding sites and their role in the mitogenic activity of Staphylococcus aureus Cowan I on human B-cells","volume":"129","author":"Romagnani","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib40","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.4049\/jimmunol.164.9.4730","article-title":"Characterization of superantigen-induced clonal deletion with a novel clan III-restricted avian monoclonal antibody: exploiting evolutionary distance to create antibodies specific for a conserved VH region surface","volume":"164","author":"Cary","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib41","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1086\/324430","article-title":"Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant","volume":"184","author":"Josefsson","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.05.008_bib42","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1172\/JCI1823","article-title":"Vaccination with a recombinant fragment of collagen adhesin provides protection against Staphylococcus aureus-mediated septic death","volume":"101","author":"Nilsson","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2005.05.008_bib43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/08830189709116520","article-title":"B-cell superantigens: molecular and cellular implications","volume":"14","author":"Silverman","year":"1997","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib44","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.4049\/jimmunol.154.12.6437","article-title":"VH3 family antibodies bind domain D of staphylococcal protein A","volume":"154","author":"Roben","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.05.008_bib45","doi-asserted-by":"crossref","first-page":"11392","DOI":"10.1073\/pnas.0404382101","article-title":"Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes","volume":"101","author":"Goodyear","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.05.008_bib46","doi-asserted-by":"crossref","first-page":"6864","DOI":"10.1128\/IAI.71.12.6864-6870.2003","article-title":"Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A","volume":"71","author":"Hall","year":"2003","journal-title":"Infect. Immun."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905001954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905001954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:14:52Z","timestamp":1761142492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457905001954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":46,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1286457905001954"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2005.05.008","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacterial cell wall-expressed protein A triggers supraclonal B-cell responses upon in vivo infection with Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2005.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}