{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:33:49Z","timestamp":1791297229025,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6574,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.micinf.2005.06.014","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T07:12:58Z","timestamp":1124176378000},"page":"157-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":205,"title":["Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-\u03baB activation"],"prefix":"10.1016","volume":"8","author":[{"given":"Tsung-Hsien","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Len","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2005.06.014_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri888","article-title":"Viruses and interferon: a fight for supremacy","volume":"2","author":"Katze","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.micro.55.1.255","article-title":"Viruses and interferons","volume":"55","author":"Sen","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2005.06.014_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1359-6101(00)00027-7","article-title":"The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion","volume":"12","author":"Levy","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.micinf.2005.06.014_bib4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s000180050240","article-title":"Type I interferons: expression and signalization","volume":"54","author":"Doly","year":"1998","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.micinf.2005.06.014_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/smvy.1995.0021","article-title":"Molecular mechanisms of interferon beta gene induction","volume":"6","author":"Hiscott","year":"1995","journal-title":"Semin. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(92)90554-P","article-title":"The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene","volume":"71","author":"Thanos","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.micinf.2005.06.014_bib7","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1093\/emboj\/18.11.3074","article-title":"The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome","volume":"18","author":"Yie","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.micinf.2005.06.014_bib8","doi-asserted-by":"crossref","first-page":"9837","DOI":"10.1073\/pnas.95.17.9837","article-title":"Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3","volume":"95","author":"Juang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.014_bib9","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1128\/MCB.18.5.2986","article-title":"Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation","volume":"18","author":"Lin","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1097-2765(00)80051-9","article-title":"Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo","volume":"1","author":"Wathelet","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.micinf.2005.06.014_bib11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/emboj\/17.4.1087","article-title":"Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP\/p300","volume":"17","author":"Yoneyama","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.micinf.2005.06.014_bib12","doi-asserted-by":"crossref","first-page":"13108","DOI":"10.1073\/pnas.96.23.13108","article-title":"Mechanism by which the IFN-beta enhanceosome activates transcription","volume":"96","author":"Yie","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.014_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.micinf.2005.06.014_bib14","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/0022-1317-81-10-2341","article-title":"Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures","volume":"81","author":"Goodbourn","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib15","doi-asserted-by":"crossref","first-page":"31805","DOI":"10.1074\/jbc.M005288200","article-title":"Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation","volume":"275","author":"Lu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction","volume":"13","author":"Sato","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2005.06.014_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0952-7915(01)00305-3","article-title":"The interferon-alpha\/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors","volume":"14","author":"Taniguchi","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/107999002753452656","article-title":"Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function","volume":"22","author":"Servant","year":"2002","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.micinf.2005.06.014_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib20","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.1081315","article-title":"Triggering the interferon antiviral response through an IKK-related pathway","volume":"300","author":"Sharma","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.micinf.2005.06.014_bib21","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nsmb847","article-title":"Novel roles of TLR3 tyrosine phosphorylation and PI3Kinase in double-stranded RNA signaling","volume":"11","author":"Sarkar","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ni0704-699","article-title":"RIGging an antiviral defense\u2014it\u2019s in the CARDs","volume":"5","author":"Levy","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib23","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib24","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/JVI.79.5.2689-2699.2005","article-title":"Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I","volume":"79","author":"Sumpter","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib25","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1128\/jvi.71.4.3255-3258.1997","article-title":"Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis","volume":"71","author":"Adler","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib26","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1128\/JVI.75.10.4692-4698.2001","article-title":"Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis","volume":"75","author":"Schweizer","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/088282402317340215","article-title":"Activation of the interferon-beta promoter during hepatitis C virus RNA replication","volume":"15","author":"Fredericksen","year":"2002","journal-title":"Viral Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib28","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1128\/JVI.78.14.7737-7747.2004","article-title":"The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway","volume":"78","author":"Fredericksen","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4269\/ajtmh.1993.48.222","article-title":"High levels of interferon alpha in the sera of children with dengue virus infection","volume":"48","author":"Kurane","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2005.06.014_bib30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1084\/jem.166.4.999","article-title":"Induction of interferon alpha from human lymphocytes by autologous, dengue virus-infected monocytes","volume":"166","author":"Kurane","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.06.014_bib31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1099\/0022-1317-69-2-445","article-title":"Production of interferon alpha by dengue virus-infected human monocytes","volume":"69","author":"Kurane","year":"1988","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib32","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/infdis\/155.4.797","article-title":"Levels of interferon in the plasma and cerebrospinal fluid of patients with acute Japanese encephalitis","volume":"155","author":"Burke","year":"1987","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.06.014_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/viro.1996.0457","article-title":"Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro","volume":"223","author":"Chen","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2005.06.014_bib34","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1128\/JVI.72.12.9729-9737.1998","article-title":"Study of Dengue virus infection in SCID mice engrafted with human K562 cells","volume":"72","author":"Lin","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1099\/vir.0.19496-0","article-title":"Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system","volume":"85","author":"Lin","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2443.2001.00426.x","article-title":"Induction of IRF-3\/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways","volume":"6","author":"Iwamura","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/j.micinf.2005.06.014_bib37","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1073\/pnas.92.25.11657","article-title":"Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes","volume":"92","author":"Au","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.014_bib38","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2144\/00295bm08","article-title":"Generation of deletion and point mutations with one primer in a single cloning step","volume":"29","author":"Makarova","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.micinf.2005.06.014_bib39","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib40","doi-asserted-by":"crossref","first-page":"7989","DOI":"10.1128\/JVI.74.17.7989-7996.2000","article-title":"Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein","volume":"74","author":"Talon","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/viro.1996.0109","article-title":"Persistence of Japanese encephalitis virus is associated with abnormal expression of the nonstructural protein NS1 in host cells","volume":"217","author":"Chen","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2005.06.014_bib42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/oxfordjournals.jbchem.a021379","article-title":"Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3)","volume":"120","author":"Yoneyama","year":"1996","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.micinf.2005.06.014_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/107999002753452665","article-title":"On the role of IRF in host defense","volume":"22","author":"Barnes","year":"2002","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.micinf.2005.06.014_bib44","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1128\/JVI.75.17.7828-7839.2001","article-title":"Salicylates inhibit flavivirus replication independently of blocking nuclear factor kappa b activation","volume":"75","author":"Liao","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib45","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1073\/pnas.052713899","article-title":"Interferon regulatory factor-3 is an in vivo target of DNA-PK","volume":"99","author":"Karpova","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.014_bib46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1074\/jbc.M007790200","article-title":"Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3","volume":"276","author":"Servant","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0006-2952(02)01165-6","article-title":"Multiple signaling pathways leading to the activation of interferon regulatory factor 3","volume":"64","author":"Servant","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.micinf.2005.06.014_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/107999002753452674","article-title":"Control of IRF-3 activation by phosphorylation","volume":"22","author":"Yoneyama","year":"2002","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.micinf.2005.06.014_bib49","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/MCB.19.4.2465","article-title":"Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains","volume":"19","author":"Lin","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib50","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","article-title":"A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)","volume":"269","author":"Vlahos","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib51","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1128\/JVI.78.17.9285-9294.2004","article-title":"Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection","volume":"78","author":"Lin","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib52","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micinf.2005.06.014_bib53","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2005.06.014_bib54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2004.01.033","article-title":"Does Toll-like receptor 3 play a biological role in virus infections?","volume":"322","author":"Edelmann","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2005.06.014_bib55","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2005.06.014_bib56","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1128\/MCB.19.7.4798","article-title":"Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65\/RelA subunit","volume":"19","author":"Sizemore","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib57","doi-asserted-by":"crossref","first-page":"29167","DOI":"10.1074\/jbc.272.46.29167","article-title":"Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation","volume":"272","author":"Reddy","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib58","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.1128\/JVI.75.13.6022-6032.2001","article-title":"Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling","volume":"75","author":"Johnson","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.micinf.2005.06.014_bib59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1074\/jbc.M108107200","article-title":"Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway","volume":"277","author":"Thomas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib60","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1096\/fj.03-1429fje","article-title":"Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3\u00a0K\/AKT pathways: involvement of invasive potential","volume":"18","author":"Chung","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.micinf.2005.06.014_bib61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1073\/pnas.2237236100","article-title":"IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts","volume":"101","author":"McWhirter","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.014_bib62","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.20040520","article-title":"The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection","volume":"199","author":"Hemmi","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.06.014_bib63","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1084\/jem.20040528","article-title":"Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection","volume":"199","author":"Perry","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2005.06.014_bib64","doi-asserted-by":"crossref","first-page":"9698","DOI":"10.1074\/jbc.M310616200","article-title":"Identification of ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation","volume":"279","author":"Mori","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib65","doi-asserted-by":"crossref","first-page":"9441","DOI":"10.1074\/jbc.M209851200","article-title":"Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA","volume":"278","author":"Servant","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2005.06.014_bib66","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nsb1002","article-title":"Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation","volume":"10","author":"Qin","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib67","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/nsb1001","article-title":"X-ray crystal structure of IRF-3 and its functional implications","volume":"10","author":"Takahasi","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib68","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nsb1103-874","article-title":"The nuts and bolts of IRF structure","volume":"10","author":"Moustakas","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.micinf.2005.06.014_bib69","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/oxfordjournals.jbchem.a022753","article-title":"Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP\/p300","volume":"128","author":"Suhara","year":"2000","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.micinf.2005.06.014_bib70","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","article-title":"Inhibition of interferon signaling by dengue virus","volume":"100","author":"Munoz-Jordan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905002418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905002418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:15:46Z","timestamp":1761142546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457905002418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1286457905002418"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2005.06.014","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-\u03baB activation","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2005.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}