{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:35:19Z","timestamp":1761179719518,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6543,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.micinf.2005.06.025","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T22:53:42Z","timestamp":1126738422000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Protection against Helicobacter pylori infection in the Mongolian gerbil after prophylactic vaccination"],"prefix":"10.1016","volume":"8","author":[{"given":"A.H.T.","family":"Jeremy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2005.06.025_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.micinf.2005.06.025_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tim.2003.11.005","article-title":"Helicobacter pylori-induced epithelial signalling in gastric carcinogenesis","volume":"12","author":"Naumann","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2005.06.025_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1703","article-title":"Gastrointestinal lymphoma: where morpology meets molecular biology","volume":"205","author":"Isaacson","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.micinf.2005.06.025_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.1998.tb11114.x","article-title":"Helicobacter pylori infection and the pathogenesis of duodenal ulceration","volume":"859","author":"Walker","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.micinf.2005.06.025_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2005.06.025_bib6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin-1\u03b2 and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1286-4579(03)00113-8","article-title":"Priming and expression of immune response in the gastric mucosa","volume":"5","author":"Svennerholm","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2005.06.025_bib8","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/eji.1830270723","article-title":"Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer disease","volume":"27","author":"D\u2019Elios","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/IAI.73.1.523-531.2005","article-title":"Mucosal FOXP3-expressing CD4+ CD25 high regulatory T cells in Helicobacter pylori-infected patients","volume":"73","author":"Lundgren","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.0300-9475.2004.01447.x","article-title":"Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4+CD25+ regulatory T cells","volume":"60","author":"Raghavan","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib11","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0016-5085(98)70100-3","article-title":"Antibiotic resistance in Helicobacter pylori: implications for therapy","volume":"115","author":"Graham","year":"1998","journal-title":"Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib12","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1086\/516083","article-title":"Rapid recurrence of Helicobacter pylori infection in Peruvian patients after successful eradication","volume":"25","author":"Ramirez-Ramos","year":"1997","journal-title":"Clin. Infec. Dis."},{"key":"10.1016\/j.micinf.2005.06.025_bib13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1086\/379046","article-title":"Gastrointestinal Physiology Working Group in Peru, Helicobacter pylori reinfection is common in Peruvian adults after antibiotic eradication therapy","volume":"188","author":"Soto","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.06.025_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.immunol.19.1.523","article-title":"The design of vaccines against Helicobacter pylori and their development","volume":"19","author":"Del Giudice","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S1286-4579(03)00125-4","article-title":"The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?","volume":"5","author":"Ruggiero","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2005.06.025_bib16","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.4049\/jimmunol.169.12.6977","article-title":"Protection against Helicobacter pylori infection following immunization is IL-12 dependent and mediated by Th1 cells","volume":"169","author":"Akhiani","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib17","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/IAI.71.2.910-921.2003","article-title":"Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent","volume":"71","author":"Garhart","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib18","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.4049\/jimmunol.173.5.3348","article-title":"N. Lycke, Vaccine-induced immunity against Helicobacter pylori infection is impaired in IL-18-deficient mice","volume":"173","author":"Akhiani","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib19","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1128\/IAI.70.7.3529-3538.2002","article-title":"Clearance of Helicobacter pylori infection and resolution of post-immunization gastritis in a kinetic study of prophylactically immunized mice","volume":"70","author":"Garhart","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib20","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1128\/IAI.67.5.2531-2539.1999","article-title":"Local secretory immunoglobulin A and postimmunization gastritis correlate with protection against Helicobacter pylori infection after oral vaccination of mice","volume":"67","author":"Goto","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/gut.49.4.467","article-title":"Post-iimnisation gastritis and Helicobacter infection in the mouse: a long term study","volume":"49","author":"Sutton","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.micinf.2005.06.025_bib22","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1086\/344321","article-title":"Gastric Helicobacter species infection in murine and gerbil models: comparative analysis of effects of H. pylori and H. felis on gastric epithelial cell proliferation","volume":"186","author":"Court","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.06.025_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/003655202317284165","article-title":"Differential susceptibility of inbred mouse strains to Helicobacter pylori infection","volume":"37","author":"Mahler","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib24","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1128\/IAI.67.6.3040-3046.1999","article-title":"Helicobacter pylori-associated gastritis in mice is host and strain specific","volume":"67","author":"van Doorn","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/gut.39.5.639","article-title":"Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependant and separate from antral gastritis","volume":"39","author":"Sakagami","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.micinf.2005.06.025_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/path.1498","article-title":"Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils","volume":"202","author":"Crabtree","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.micinf.2005.06.025_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI11450","article-title":"Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses","volume":"107","author":"Israel","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.micinf.2005.06.025_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0928-8244(02)00464-9","article-title":"Infection of Mongolian gerbils with Chinese Helicobacter pylori strains","volume":"36","author":"Wang","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2005.06.025_bib29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1462-5822.2002.00189.x","article-title":"Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates","volume":"4","author":"Philpott","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.micinf.2005.06.025_bib30","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1073\/pnas.95.21.12619","article-title":"Free recombination within Helicobacter pylori","volume":"95","author":"Suerbaum","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2005.06.025_bib31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0016-5085(99)70065-X","article-title":"Geographic distribution of vacA allelic types of Helicobacter pylori","volume":"116","author":"van Doorn","year":"1999","journal-title":"Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1574-6968.2002.tb11018.x","article-title":"Evolution of functional polymorphism in the gene coding for the Helicobacter pylori cytotoxin","volume":"206","author":"Ji","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micinf.2005.06.025_bib33","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.172.8.5024","article-title":"Helicobacter pylori specific antibodies impair the development of gastritis, facilitate bacterial colonisation, and counteract resistance against infection","volume":"172","author":"Akhiani","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2005.06.025_bib34","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1128\/IAI.66.9.4340-4346.1998","article-title":"Immunization against natural Helicobacter pylori infection in nonhuman primates","volume":"66","author":"Dubois","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2005.06.025_bib35","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0016-5085(98)70143-X","article-title":"Helicobacter pylori infection induces gastric cancer in Mongolian Gerbils","volume":"115","author":"Watanabe","year":"1998","journal-title":"Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib36","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1053\/j.gastro.2005.02.064","article-title":"Helicobacter pylori cag-Type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils","volume":"128","author":"Rieder","year":"2005","journal-title":"Gastroenterol."},{"key":"10.1016\/j.micinf.2005.06.025_bib37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1086\/427657","article-title":"Host adaptation and immune modulation are mediated by homologous recombination in Helicobacter pylori","volume":"191","author":"Robinson","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2005.06.025_bib38","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2005.06.025_bib39","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.vaccine.2003.11.056","article-title":"A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and upregulates the expression of beta defensins and IL-10 in stomachs of immunized mice","volume":"22","author":"Hatzifoti","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2005.06.025_bib40","doi-asserted-by":"crossref","unstructured":"D. Gaucher, K. Chadee, Molecular cloning of gerbil interleukin 12 and its expression as a bioactive single-chain protein, Cytokine14 (2001) 177\u2013183.","DOI":"10.1006\/cyto.2001.0866"},{"key":"10.1016\/j.micinf.2005.06.025_bib41","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1128\/JCM.41.5.1942-1945.2003","article-title":"Regional variation in vacA alleles of Helicobacter pylori in China","volume":"41","author":"Wang","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micinf.2005.06.025_bib42","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1096\/fj.04-2321fje","article-title":"Transcription profiling analysis of the mechanisms of vaccine-induced protection against H. pylori","volume":"18","author":"Walduck","year":"2004","journal-title":"FASEB J."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905002637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457905002637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:16:31Z","timestamp":1761142591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457905002637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S1286457905002637"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2005.06.025","relation":{},"ISSN":["1286-4579"],"issn-type":[{"type":"print","value":"1286-4579"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against Helicobacter pylori infection in the Mongolian gerbil after prophylactic vaccination","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2005.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}