{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:58:56Z","timestamp":1770479936522,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6393,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.micinf.2006.03.008","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T17:11:45Z","timestamp":1149181905000},"page":"2044-2051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Persistent joint swelling and borrelia-specific antibodies in Borrelia garinii-infected mice after eradication of vegetative spirochetes with antibiotic treatment"],"prefix":"10.1016","volume":"8","author":[{"given":"Heta","family":"Yrj\u00e4n\u00e4inen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ove","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmo","family":"Oksi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaija","family":"Hartiala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti K.","family":"Viljanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2006.03.008_bib1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM198908313210906","article-title":"Lyme disease","volume":"321","author":"Steere","year":"1989","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.micinf.2006.03.008_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1099\/00207713-42-3-378","article-title":"Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis","volume":"42","author":"Baranton","year":"1992","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.micinf.2006.03.008_bib3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.en.36.010191.003103","article-title":"Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe","volume":"36","author":"Lane","year":"1991","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.micinf.2006.03.008_bib4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.7326\/0003-4819-91-5-730","article-title":"Cases of Lyme disease in the United States: locations correlated with distribution of Ixodes dammini","volume":"91","author":"Steere","year":"1979","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micinf.2006.03.008_bib5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","author":"Steere","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micinf.2006.03.008_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0923-2508(96)81056-4","article-title":"Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato","volume":"146","author":"Balmelli","year":"1995","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micinf.2006.03.008_bib7","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/clinids\/17.4.708","article-title":"Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis","volume":"17","author":"van Dam","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7326\/0003-4819-99-1-22","article-title":"Treatment of the early manifestations of Lyme disease","volume":"99","author":"Steere","year":"1983","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.micinf.2006.03.008_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.micinf.2006.03.008_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00002281-200207000-00008","article-title":"Lyme arthritis and post-Lyme disease syndrome","volume":"14","author":"Weinstein","year":"2002","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.micinf.2006.03.008_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/infdis\/162.1.133","article-title":"Lyme borreliosis in selected strains and ages of laboratory mice","volume":"162","author":"Barthold","year":"1990","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib12","first-page":"959","article-title":"Chronic Lyme borreliosis in the laboratory mouse","volume":"143","author":"Barthold","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micinf.2006.03.008_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/AAC.31.2.164","article-title":"In vitro and in vivo susceptibility of the Lyme disease spirochete, Borrelia burgdorferi, to four antimicrobial agents","volume":"31","author":"Johnson","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micinf.2006.03.008_bib14","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1128\/AAC.38.7.1567","article-title":"Effectiveness of antimicrobial treatment against Borrelia burgdorferi infection in mice","volume":"38","author":"Moody","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micinf.2006.03.008_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0923-2508(97)83622-4","article-title":"Use of the C3H\/He Lyme disease mouse model for the recovery of a Spanish isolate of Borrelia garinii from erythema migrans lesions","volume":"149","author":"Oteo","year":"1998","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micinf.2006.03.008_bib16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/ana.20192","article-title":"Genotype determines phenotype in experimental Lyme borreliosis","volume":"56","author":"Pachner","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.micinf.2006.03.008_bib17","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.71.8.4432-4440.2003","article-title":"Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice","volume":"71","author":"Lawrenz","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.03.008_bib18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1365-3083.2002.01171.x","article-title":"Sublethal concentrations of complement can effectively opsonize Borrelia burgdorferi","volume":"56","author":"Suhonen","year":"2002","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.micinf.2006.03.008_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-1759(89)90195-6","article-title":"The effect of storage of antigen-coated polystyrene microwells on the detection of antibodies against Borrelia burgdorferi by enzyme immunoassay (EIA)","volume":"124","author":"Viljanen","year":"1989","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.micinf.2006.03.008_bib20","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1128\/iai.62.7.2825-2833.1994","article-title":"Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi","volume":"62","author":"Lim","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.03.008_bib21","first-page":"44","article-title":"Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi: modulation by tumor necrosis factor alpha","volume":"10","author":"Christopherson","year":"2003","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.micinf.2006.03.008_bib22","first-page":"811","article-title":"Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver","volume":"137","author":"Schaible","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.micinf.2006.03.008_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00365549850160918","article-title":"Characterization of Borrelia burgdorferi strains in Lyme arthritis","volume":"30","author":"Eiffert","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/ard.60.3.284","article-title":"Treatment resistant Lyme arthritis caused by Borrelia garinii","volume":"60","author":"Limbach","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/IAI.66.1.161-168.1998","article-title":"Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL\/6N mice","volume":"66","author":"Ma","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.03.008_bib26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00002281-200207000-00010","article-title":"Borrelia burgdorferi and its tropisms for adhesion molecules in the joint","volume":"14","author":"Coburn","year":"2002","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.micinf.2006.03.008_bib27","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1086\/322669","article-title":"Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10\u201320 years after active Lyme disease","volume":"33","author":"Kalish","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9343(03)00308-5","article-title":"Long-term follow-up of patients with culture-confirmed Lyme disease","volume":"115","author":"Nowakowski","year":"2003","journal-title":"Am. J. Med."},{"key":"10.1016\/j.micinf.2006.03.008_bib29","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1086\/345284","article-title":"Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment","volume":"186","author":"Bockenstedt","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.03.008_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nri1267","article-title":"Elucidation of Lyme arthritis","volume":"4","author":"Steere","year":"2004","journal-title":"Nat. Rev. Immunol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906001602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906001602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:17:31Z","timestamp":1761142651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457906001602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1286457906001602"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2006.03.008","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent joint swelling and borrelia-specific antibodies in Borrelia garinii-infected mice after eradication of vegetative spirochetes with antibiotic treatment","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2006.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}