{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:54:55Z","timestamp":1776228895900,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6209,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.micinf.2006.10.003","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T13:04:38Z","timestamp":1165496678000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice"],"prefix":"10.1016","volume":"9","author":[{"given":"Laura A.","family":"Kerepesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofra","family":"Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard A.","family":"Schad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2006.10.003_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0065-308X(08)60036-6","article-title":"Human strongyloidiasis","volume":"38","author":"Grove","year":"1996","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.micinf.2006.10.003_bib2","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1086\/314507","article-title":"Interferon-gamma and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis","volume":"178","author":"Neva","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.10.003_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-3024.2001.00407.x","article-title":"HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis","volume":"23","author":"Porto","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib4","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.4049\/jimmunol.165.8.4544","article-title":"Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice","volume":"165","author":"Herbert","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-3024.1997.d01-142.x","article-title":"IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis","volume":"19","author":"Rotman","year":"1997","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib6","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.4049\/jimmunol.176.7.4315","article-title":"Complement component C3 is required for protective innate and adaptive immunity to larval Strongyloides stercoralis in mice","volume":"176","author":"Kerepesi","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/expr.1996.0035","article-title":"Strongyloides stercoralis: role of antibody and complement in immunity to the third stage of larvae in BALB\/cByJ mice","volume":"82","author":"Brigandi","year":"1996","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micinf.2006.10.003_bib8","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1128\/IAI.71.12.6835-6843.2003","article-title":"Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice","volume":"71","author":"Ligas","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.003_bib9","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1128\/IAI.01958-05","article-title":"Role of eosinophils and neutrophils in innate and adaptive protective immunity to\u00a0larval Strongyloides stercoralisin mice","volume":"74","author":"Galioto","year":"2006","journal-title":"Infect. Immun"},{"key":"10.1016\/j.micinf.2006.10.003_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1084\/jem.192.1.23","article-title":"The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells","volume":"192","author":"Ogata","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2006.10.003_bib13","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.4049\/jimmunol.168.9.4524","article-title":"Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells","volume":"168","author":"Dabbagh","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib14","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.4049\/jimmunol.171.11.5837","article-title":"Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism","volume":"171","author":"Thomas","year":"2003","journal-title":"J.\u2009Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nm832","article-title":"Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors","volume":"9","author":"Fan","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.micinf.2006.10.003_bib16","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.4049\/jimmunol.175.11.7504","article-title":"The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4","volume":"175","author":"Kirimanjeswara","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib17","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4269\/ajtmh.1989.41.650","article-title":"Protective immunity against Brugia malayi infective larvae in mice. I. Parameters of active and passive immunity","volume":"41","author":"Hayashi","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.micinf.2006.10.003_bib18","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1128\/IAI.73.12.8291-8297.2005","article-title":"Protective immunity to the larval stages of Onchocerca volvulus is dependent on Toll-like receptor 4","volume":"73","author":"Kerepesi","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.003_bib19","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1002\/eji.200324264","article-title":"Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection","volume":"33","author":"Helmby","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib20","first-page":"70","article-title":"Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata","volume":"53","author":"Stewart","year":"2003","journal-title":"Comp Med."},{"key":"10.1016\/j.micinf.2006.10.003_bib21","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.micinf.2006.10.003_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/expr.1995.1036","article-title":"Strongyloides stercoralis: protective immunity to third-stage larvae in BALB\/cByJ mice","volume":"80","author":"Abraham","year":"1995","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micinf.2006.10.003_bib23","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.immuni.2004.07.006","article-title":"Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus","volume":"21","author":"Tsuda","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2006.10.003_bib25","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.4049\/jimmunol.172.5.3059","article-title":"The contribution of the toll-like\/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo","volume":"172","author":"Bellocchio","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-2478(02)00210-9","article-title":"Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils","volume":"85","author":"Remer","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.micinf.2006.10.003_bib27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.164.2.558","article-title":"Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex","volume":"164","author":"Ohashi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib28","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.4049\/jimmunol.167.5.2887","article-title":"Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4","volume":"167","author":"Smiley","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.003_bib29","doi-asserted-by":"crossref","first-page":"10229","DOI":"10.1074\/jbc.M100099200","article-title":"The extra domain A of fibronectin activates toll-like receptor 4","volume":"276","author":"Okamura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2006.10.003_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s004360050218","article-title":"Expression of a 70-kDa heat-shock-related protein during transformation from free-living infective larvae to the parasitic stage in Strongyloides venezuelensis","volume":"83","author":"Tsuji","year":"1997","journal-title":"Parasitol. Res."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790600356X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790600356X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:18:19Z","timestamp":1761142699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645790600356X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S128645790600356X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.003","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}