{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:47:38Z","timestamp":1790930858007,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6209,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.micinf.2006.10.008","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T07:24:59Z","timestamp":1165994699000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain"],"prefix":"10.1016","volume":"9","author":[{"given":"Michelle A.","family":"Parent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Goenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"LeVier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Carreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Golding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"R. Martin","family":"Roop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2006.10.008_bib1","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1128\/jb.172.7.3569-3576.1990","article-title":"Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the alpha-2 subdivision of the class proteobacteria","volume":"172","author":"Moreno","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2006.10.008_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1615\/CritRevImmunol.v26.i5.30","article-title":"Host immune responses to the intracellular bacteria Brucella: Does the bacteria instruct the host to facilitate chronic infection?","volume":"26","author":"Baldwin","year":"2006","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.micinf.2006.10.008_bib3","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/IAI.69.6.3995-4006.2001","article-title":"Intracellular survival of Brucella spp. in human monocytes involves conventional uptake but special phagosomes","volume":"69","author":"Rittig","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","article-title":"Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide","volume":"151","author":"Jiang","year":"1993","journal-title":"Cell Immunol."},{"key":"10.1016\/j.micinf.2006.10.008_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0378-1135(02)00220-1","article-title":"Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home","volume":"90","author":"Roop","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib6","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1128\/iai.60.4.1385-1389.1992","article-title":"Lipopolysaccharide (LPS) from Brucella abortus is less toxic than that from Escherichia coli, suggesting the possible use of B. abortus or LPS from B. abortus as a carrier in vaccines","volume":"60","author":"Goldstein","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib7","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1126\/science.287.5462.2492","article-title":"Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival","volume":"287","author":"LeVier","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.micinf.2006.10.008_bib8","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1101\/gad.7.8.1485","article-title":"A Rhizobium meliloti homolog of the Escherichia coli peptide-antibiotic transport protein SbmA is essential for bacteroid development","volume":"7","author":"Glazebrook","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.micinf.2006.10.008_bib9","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1073\/pnas.0307137101","article-title":"Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids","volume":"101","author":"Ferguson","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micinf.2006.10.008_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1574-695X.1996.tb00136.x","article-title":"Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308","volume":"16","author":"Fernandes","year":"1996","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.2001.01258.x","article-title":"Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL\/6 and susceptible BALB\/c mice","volume":"103","author":"Murphy","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.micinf.2006.10.008_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/iai.61.1.124-134.1993","article-title":"Effects of cytokines on intracellular growth of Brucella abortus","volume":"61","author":"Jiang","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0966-842X(93)90115-8","article-title":"Macrophage control of Brucella abortus: influence of cytokines and iron","volume":"1","author":"Baldwin","year":"1993","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1046\/j.1365-2958.1999.01629.x","article-title":"The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice","volume":"34","author":"Robertson","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib15","series-title":"Color Atlas and Textbook of Diagnostic Microbiology","year":"1997"},{"key":"10.1016\/j.micinf.2006.10.008_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1472-765X.1989.tb00262.x","article-title":"Rapid extraction of bacterial genomic DNA with guanidium thiocyanate","volume":"8","author":"Pitcher","year":"1989","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib17","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1128\/jcm.32.11.2660-2666.1994","article-title":"Differentiation of Brucella abortus bv. 1, 2, and 4, Brucella melitensis, Brucella ovis, and Brucella suis bv. 1 by PCR","volume":"32","author":"Bricker","year":"1994","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib18","series-title":"Short Protocols in Molecular Biology","year":"1999"},{"key":"10.1016\/j.micinf.2006.10.008_bib19","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/iai.56.12.3251-3261.1988","article-title":"Killing of Brucella abortus by bovine serum","volume":"56","author":"Corbeil","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/abio.1998.2961","article-title":"Quantification of bacterial lipopolysaccharides by\u00a0the purpald assay: measuring formaldehyde generated from 2-keto-3-deoxyoctonate and heptose at the inner core by periodate oxidation","volume":"267","author":"Lee","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.micinf.2006.10.008_bib21","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.4049\/jimmunol.171.3.1441","article-title":"Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent","volume":"171","author":"Huang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.008_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1128\/iai.53.2.245-251.1986","article-title":"Comparison of living and nonliving vaccines for Brucella abortus in BALB\/c mice","volume":"53","author":"Montaraz","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib23","first-page":"85","article-title":"Immune control of Brucella abortus 2308 infections in BALB\/c mice, FEMS Immunol","volume":"32","author":"Murphy","year":"2001","journal-title":"Med. Microbiol."},{"key":"10.1016\/j.micinf.2006.10.008_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1471-4906(01)02169-X","article-title":"Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?","volume":"23","author":"Netea","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.micinf.2006.10.008_bib25","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1128\/IAI.70.12.6638-6645.2002","article-title":"Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB\/c and C57BL\/6 mice","volume":"70","author":"Liu","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/IAI.72.1.176-186.2004","article-title":"Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice","volume":"72","author":"Campos","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib27","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.008_bib28","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1128\/IAI.73.8.5137-5143.2005","article-title":"MyD88, but\u00a0not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus","volume":"73","author":"Weiss","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2006.10.008_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1574-6976.1993.tb00026.x","article-title":"Iron uptake mechanisms of pathogenic bacteria","volume":"12","author":"Wooldridge","year":"1993","journal-title":"FEMS Microbiol. Rev."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906003716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906003716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:18:34Z","timestamp":1761142714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457906003716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S1286457906003716"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.008","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}