{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:57:41Z","timestamp":1773662261764,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6178,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.micinf.2006.10.017","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T13:04:38Z","timestamp":1165496678000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals"],"prefix":"10.1016","volume":"9","author":[{"given":"Silvia","family":"Guglietta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Beghetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Spadoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma","family":"Buffolano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Del Porto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Gargano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2006.10.017_bib1","series-title":"Infectious Diseases of the Foetus and Newborn Infant","first-page":"205","article-title":"Toxoplasmosis","author":"Remington","year":"2001"},{"key":"10.1016\/j.micinf.2006.10.017_bib2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(98)08220-8","article-title":"Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counseling","volume":"353","author":"Dunn","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2006.10.017_bib3","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1542\/peds.113.6.1567","article-title":"Long-term ocular prognosis in 327 children with congenital toxoplasmosis","volume":"113","author":"Wallon","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.micinf.2006.10.017_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and function of T-cell mediated immunity during Toxoplasma gondii infection","volume":"11","author":"Denkers","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2006.10.017_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S1286-4579(99)80071-9","article-title":"T lymphocyte-dependent effector mechanisms of immunity to Toxoplasma gondii","volume":"1","author":"Denkers","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2006.10.017_bib6","first-page":"113","article-title":"Cells and cytokines in resistance to Toxoplasma gondii","volume":"219","author":"Hunter","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4049\/jimmunol.154.1.290","article-title":"Enhanced cytotoxicity of interferon-gamma-producing CD4 cytotoxic T lymphocytes specific for T. gondii-infected human melanoma cells","volume":"154","author":"Yang","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib8","first-page":"704","article-title":"Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma","volume":"9","author":"Fatoohi","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.micinf.2003.11.009","article-title":"The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection","volume":"6","author":"Di Cristina","year":"2004","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2006.10.017_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1086\/427660","article-title":"A combination of antigenic regions of Toxoplasma gondii microneme proteins induces protective immunity against oral infection with parasite cysts","volume":"191","author":"Beghetto","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.10.017_bib11","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1086\/315494","article-title":"Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens","volume":"181","author":"Yamamoto","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.10.017_bib12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1365-3083.2002.01052.x","article-title":"Ocular toxoplasmosis: more than just what meets the eye","volume":"55","author":"Vallochi","year":"2002","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0923-2494(05)80096-3","article-title":"Excreted\/secreted antigens of Toxoplasma gondii, their origin and role in the host\u2013parasite interaction","volume":"1","author":"Cesbron-Delauw","year":"1993","journal-title":"Res. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib14","first-page":"376","article-title":"Recognition of Toxoplasma gondii excreted and secreted antigens by human sera from acquired and congenital toxoplasmosis: identification of markers of acute and chronic infection","volume":"3","author":"Decoster","year":"1988","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib15","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.4049\/jimmunol.164.7.3741","volume":"164","author":"Prigione","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0020-7519(01)00288-0","article-title":"Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries","volume":"31","author":"Beghetto","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micinf.2006.10.017_bib17","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0022-3476(89)80660-2","article-title":"Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment","volume":"115","author":"Hohlfeld","year":"1989","journal-title":"J. Pediatr."},{"key":"10.1016\/j.micinf.2006.10.017_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0020-7519(02)00256-4","article-title":"Molecular dissection of the human B-cell response against Toxoplasma gondii infection by lambda display of cDNA libraries","volume":"33","author":"Beghetto","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micinf.2006.10.017_bib19","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1073\/pnas.86.19.7537","article-title":"Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii","volume":"86","author":"Cesbron-Delauw","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micinf.2006.10.017_bib20","first-page":"254","article-title":"Results of 20 years follow-up of congenital toxoplasmosis","volume":"101","author":"Koppe","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2006.10.017_bib21","first-page":"149","article-title":"Lymphocyte anergy specific to Toxoplasma gondii antigens in a baby with congenital toxoplasmosis","volume":"17","author":"McLeod","year":"1985","journal-title":"J. Clin. Lab. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib22","first-page":"623","article-title":"Phenotypes and functions of lymphocytes in congenital toxoplasmosis","volume":"116","author":"McLeod","year":"1990","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.micinf.2006.10.017_bib23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/infdis\/148.6.953","article-title":"Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirus","volume":"148","author":"Pass","year":"1983","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.10.017_bib24","first-page":"453","article-title":"Congenital varicella-zoster virus infection and the failure to establish virus-specific cell-mediated immunity","volume":"6","author":"Grose","year":"1989","journal-title":"Mol. Biol. Med."},{"key":"10.1016\/j.micinf.2006.10.017_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jmv.10477","article-title":"Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection","volume":"71","author":"Hayashi","year":"2003","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.micinf.2006.10.017_bib26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/infdis\/157.5.979","article-title":"Production of gamma interferon by cultured human lymphocytes stimulated with a purified membrane protein (p30) from Toxoplasma gondii","volume":"157","author":"Khan","year":"1988","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2006.10.017_bib27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.micinf.2005.08.008","article-title":"T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis","volume":"8","author":"Prigione","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2006.10.017_bib28","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1046\/j.1365-2249.1999.01019.x","article-title":"A switch towards Th2 serological rebound in children with congenital toxoplasmosis","volume":"117","author":"Kahi","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib29","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/eji.1830250525","article-title":"Toxoplasma gondii-specific CD4+ T cell clones from healthy, latently infected humans display a Th0 profile of cytokine secretion","volume":"25","author":"Prigione","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2006.10.017_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10384-005-0295-8","article-title":"Systemic T cell response to Toxoplasma gondii antigen in patients with ocular toxoplasmosis","volume":"50","author":"Fatoohi","year":"2006","journal-title":"Jpn. J. Ophthalmol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906003807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457906003807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:18:17Z","timestamp":1761142697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457906003807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1286457906003807"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.017","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2006.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}