{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:57Z","timestamp":1790665557550,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":6089,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.micinf.2007.02.016","type":"journal-article","created":{"date-parts":[[2007,2,25]],"date-time":"2007-02-25T06:57:41Z","timestamp":1172386661000},"page":"729-734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain"],"prefix":"10.1016","volume":"9","author":[{"given":"George","family":"Aperis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Burgwyn Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Calderwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2007.02.016_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/clinids\/11.3.440","article-title":"Nature of protective immunity to Francisella tularensis","volume":"11","author":"Tarnvik","year":"1989","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.micinf.2007.02.016_bib2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1046\/j.1365-2672.2001.01499.x","article-title":"Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4","volume":"91","author":"Prior","year":"2001","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.micinf.2007.02.016_bib3","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1001\/jama.285.21.2763","article-title":"Tularemia as a biological weapon: medical and public health management","volume":"285","author":"Dennis","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.micinf.2007.02.016_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/CMR.15.4.631-646.2002","article-title":"Tularemia","volume":"15","author":"Ellis","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2007.02.016_bib5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/1615-9861(200104)1:4<508::AID-PROT508>3.0.CO;2-K","article-title":"Construction of a Francisella tularensis two-dimensional electrophoresis protein database","volume":"1","author":"Hernychova","year":"2001","journal-title":"Proteomics"},{"key":"10.1016\/j.micinf.2007.02.016_bib6","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1073\/pnas.0307690101","article-title":"MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival","volume":"101","author":"Lauriano","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micinf.2007.02.016_bib7","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1128\/IAI.73.9.5892-5902.2005","article-title":"Francisella tularensis enters macrophages via a novel process involving pseudopod loops","volume":"73","author":"Clemens","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2007.02.016_bib8","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1128\/IAI.71.10.5940-5950.2003","article-title":"An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells","volume":"71","author":"Golovliov","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2007.02.016_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/infdis\/135.1.55","article-title":"Immunization against tularemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemia","volume":"135","author":"Burke","year":"1977","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2007.02.016_bib10","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/IAI.73.7.3842-3850.2005","article-title":"Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis","volume":"73","author":"Mylonakis","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2007.02.016_bib11","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1128\/JB.182.13.3843-3845.2000","article-title":"Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects","volume":"182","author":"Jander","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2007.02.016_bib12","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/IAI.71.5.2404-2413.2003","article-title":"Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis","volume":"71","author":"Miyata","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2007.02.016_bib13","first-page":"177","article-title":"Structural alterations to Proteus mirabilis as a result of exposure to haemolymph from the larvae of Galleria mellonella","volume":"39","author":"Morton","year":"1984","journal-title":"Microbios"},{"key":"10.1016\/j.micinf.2007.02.016_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0145-305X(87)90007-3","article-title":"Reactions of hemocytes of immune and non-immune Galleria mellonella larvae to Proteus mirabilis","volume":"11","author":"Morton","year":"1987","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micinf.2007.02.016_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1574-6968.2002.tb11314.x","article-title":"Detection and characterisation of pr1 virulent gene deficiencies in the insect pathogenic fungus Metarhizium anisopliae","volume":"213","author":"Wang","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micinf.2007.02.016_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/AEM.66.1.320-324.2000","article-title":"Lack of host specialization in Aspergillus flavus","volume":"66","author":"St Leger","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micinf.2007.02.016_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/w04-124","article-title":"Serial passage of the opportunistic pathogen Aspergillus flavus through an insect host yields decreased saprobic capacity","volume":"51","author":"Scully","year":"2005","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.micinf.2007.02.016_bib18","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1128\/AEM.70.6.3733-3735.2004","article-title":"Methods for enhanced culture recovery of Francisella tularensis","volume":"70","author":"Petersen","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micinf.2007.02.016_bib19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-291X(02)02766-3","article-title":"Influence of fungal infection on the DOPA-semiquinone and DOPA-quinone production in haemolymph of Galleria mellonella larvae","volume":"300","author":"Slepneva","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micinf.2007.02.016_bib20","unstructured":"Anonymous. Tularemia: current, comprehensive information on pathogenesis, microbiology, epidemiology, diagnosis, treatment, and prophylaxis. http:\/\/www.cidrap.umn.edu\/idsa\/bt\/tularemia\/biofacts\/tularemiafactsheet.html access confirmed on August 18, 2005."},{"key":"10.1016\/j.micinf.2007.02.016_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.femsre.2003.09.002","article-title":"Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens","volume":"28","author":"Kavanagh","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.micinf.2007.02.016_bib22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/jac\/dki359","article-title":"In vivo efficacy of fluoroquinolones against systemic tularaemia infection in mice","volume":"56","author":"Piercy","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micinf.2007.02.016_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1086\/322601","article-title":"Tularemia epidemic in northwestern Spain: clinical description and therapeutic response","volume":"33","author":"Perez-Castrillon","year":"2001","journal-title":"Clin. Infect. Dis."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457907000974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457907000974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:19:23Z","timestamp":1761142763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457907000974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S1286457907000974"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2007.02.016","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2007.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}