{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:25:12Z","timestamp":1790724312799,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"10-11","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":5597,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.micinf.2008.06.013","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T17:22:25Z","timestamp":1216315345000},"page":"1201-1209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice"],"prefix":"10.1016","volume":"10","author":[{"given":"Jian-Jun","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monisha","family":"Dhiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elbert B.","family":"Whorton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha Jain","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2008.06.013_bib1","article-title":"Control of Chagas\u2019 disease: second report of the WHO expert committee","volume":"905","author":"World Health Organization","year":"2002"},{"key":"10.1016\/j.micinf.2008.06.013_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00436-003-0937-z","article-title":"Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy","volume":"91","author":"Mukherjee","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.micinf.2008.06.013_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1042\/BJ20040356","article-title":"Gene expression analysis in mitochondria from chagasic mice: Alterations in specific metabolic pathways","volume":"381","author":"Garg","year":"2004","journal-title":"Biochemical. J."},{"key":"10.1016\/j.micinf.2008.06.013_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00229474","article-title":"Heart FoF1-ATPase changes during the acute phase of Trypanosoma cruzi infection in rats","volume":"165","author":"Uyemura","year":"1996","journal-title":"Mol. Cell. Biochem"},{"key":"10.1016\/j.micinf.2008.06.013_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbadis.2004.03.005","article-title":"Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development","volume":"1689","author":"Vyatkina","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micinf.2008.06.013_bib6","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2353\/ajpath.2006.060475","article-title":"Phenyl-alpha-tert-butyl nitrone reverses mitochondrial decay in acute Chagas disease","volume":"169","author":"Wen","year":"2006","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.micinf.2008.06.013_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.86.2.119","article-title":"Mitochondrial oxidative stress in heart failure: \u201coxygen wastage\u201d revisited","volume":"86","author":"Sawyer","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.micinf.2008.06.013_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1471-4922(02)02283-3","article-title":"Chemokines, inflammation and Trypanosoma cruzi infection","volume":"18","author":"Teixeira","year":"2002","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.micinf.2008.06.013_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0925-4439(03)00060-7","article-title":"Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development","volume":"1638","author":"Garg","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micinf.2008.06.013_bib10","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.freeradbiomed.2004.08.018","article-title":"Oxidative damage during chagasic cardiomyopathy development: Role of mitochondrial oxidant release and inefficient antioxidant defense","volume":"37","author":"Wen","year":"2004","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.micinf.2008.06.013_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.micinf.2008.06.013_bib12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2006.04.009","article-title":"Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients","volume":"41","author":"Wen","year":"2006","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.micinf.2008.06.013_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-5793(93)80394-A","article-title":"Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid","volume":"333","author":"Candeias","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.micinf.2008.06.013_bib14","first-page":"883","article-title":"Chagas\u2019 heart disease, Clin","volume":"23","author":"Rassi","year":"2000","journal-title":"Cardiol"},{"key":"10.1016\/j.micinf.2008.06.013_bib15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4269\/ajtmh.2001.65.435","article-title":"Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism","volume":"65","author":"Lages-Silva","year":"2001","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1016\/j.micinf.2008.06.013_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cardfail.2004.05.005","article-title":"Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy","volume":"11","author":"Nakamura","year":"2005","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.micinf.2008.06.013_bib17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1073\/pnas.95.2.510","article-title":"Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction","volume":"95","author":"Lucas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micinf.2008.06.013_bib18","first-page":"293","article-title":"Hemoproteins affect H(2)O(2) removal from rat tissues, Int J Biochem","volume":"33","author":"Venditti","year":"2001","journal-title":"Cell Biol."},{"key":"10.1016\/j.micinf.2008.06.013_bib19","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/BF01923990","article-title":"Tissue protection against oxidative stress","volume":"52","author":"Di Meo","year":"1996","journal-title":"Experientia"},{"key":"10.1016\/j.micinf.2008.06.013_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0008-6363(00)00078-X","article-title":"Status of myocardial antioxidants in ischemia-reperfusion injury","volume":"47","author":"Dhalla","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.micinf.2008.06.013_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.micinf.2008.06.013_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bj1560435","article-title":"Role of ubiquinone in the mitochondrial generation of hydrogen peroxide","volume":"156","author":"Boveris","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.micinf.2008.06.013_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0188-4409(03)00004-3","article-title":"Heart metabolic disturbances in cardiovascular diseases","volume":"34","author":"Carvajal","year":"2003","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.micinf.2008.06.013_bib24","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.freeradbiomed.2004.09.011","article-title":"Oxidative modifications of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection","volume":"37","author":"Wen","year":"2004","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.micinf.2008.06.013_bib25","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1124\/mol.64.5.1136","article-title":"Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria","volume":"64","author":"Han","year":"2003","journal-title":"Mol. Pharmacol"},{"key":"10.1016\/j.micinf.2008.06.013_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/abio.1994.1358","article-title":"Bioluminescent assay of bacterial intracellular AMP, ADP, and ATP with the use of a coimmobilized three-enzyme reagent (adenylate kinase, pyruvate kinase, and firefly luciferase)","volume":"220","author":"Brovko","year":"1994","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.micinf.2008.06.013_bib27","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1016\/S0021-9258(19)62677-3","article-title":"Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. Reactions with organic molecules and ferrocytochrome c","volume":"261","author":"Rush","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2008.06.013_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem. J."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457908002013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457908002013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:23:12Z","timestamp":1761142992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457908002013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":28,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1286457908002013"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2008.06.013","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2008.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}