{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:28Z","timestamp":1791174688327,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":5447,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.micinf.2008.11.017","type":"journal-article","created":{"date-parts":[[2008,12,28]],"date-time":"2008-12-28T04:59:29Z","timestamp":1230440369000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma"],"prefix":"10.1016","volume":"11","author":[{"given":"Ricardo R.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Gollob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanemile P.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eada M.","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana S.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline S.B.","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis A.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cec\u00edlia","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ilma","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2008.11.017_bib1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(97)01468-2","article-title":"Epidemiology of childhood asthma","volume":"350","author":"Sears","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.micinf.2008.11.017_bib2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.micinf.2008.11.017_bib3","first-page":"1","article-title":"Summary of notifiable diseases \u2013 United States, 2004","volume":"53","author":"Jajosky","year":"2006","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.micinf.2008.11.017_bib4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micinf.2008.11.017_bib5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0091-6749(93)90119-Z","article-title":"Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum","volume":"92","author":"Lynch","year":"1993","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0091-6749(98)70386-0","article-title":"Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment","volume":"101","author":"Lynch","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1067\/mai.2003.1348","article-title":"Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics","volume":"111","author":"Cooper","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000024433","article-title":"Inverse association between skin response to aeroallergens and Schistosoma mansoni infection","volume":"123","author":"Araujo","year":"2000","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1067\/mai.2003.1381","article-title":"Schistosoma mansoni infection is associated with a reduced course of asthma","volume":"111","author":"Medeiros","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib10","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1086\/425017","article-title":"Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma","volume":"190","author":"Araujo","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micinf.2008.11.017_bib11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.4049\/jimmunol.151.3.1280","article-title":"IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes","volume":"151","author":"Punnonen","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1286-4579(01)01449-6","article-title":"Role of IL-10 in allergen-specific immunotherapy and normal response to allergens","volume":"3","author":"Akdis","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2008.11.017_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1084\/jem.180.2.631","article-title":"Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function","volume":"180","author":"Hathcock","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2008.11.017_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/328267a0","article-title":"A new member of the immunoglobulin superfamily \u2013 CTLA-4","volume":"328","author":"Brunet","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2008.11.017_bib15","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.4049\/jimmunol.168.9.4643","article-title":"Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40\/CD154 interaction","volume":"168","author":"MacDonald","year":"2002","journal-title":"J. Immunol."},{"issue":"Suppl. 5","key":"10.1016\/j.micinf.2008.11.017_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1365-2222.1998.028s5052.x","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee","volume":"28","author":"Asher","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.micinf.2008.11.017_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/eji.1830260633","article-title":"Evidence of a T helper type 2 activation in human schistosomiasis","volume":"26","author":"Araujo","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0100-879X1998000100024","article-title":"Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection","volume":"31","author":"Correa-Oliveira","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.micinf.2008.11.017_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1365-2222.2000.00097.x","article-title":"The role of co-stimulation in airway inflammation","volume":"30","author":"Djukanovic","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.micinf.2008.11.017_bib20","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1084\/jem.185.9.1671","article-title":"Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness","volume":"185","author":"Tsuyuki","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micinf.2008.11.017_bib21","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.micinf.2006.08.013","article-title":"Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis","volume":"8","author":"Furze","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2008.11.017_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0091-6749(98)70199-X","article-title":"Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma","volume":"101","author":"Hofer","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1365-2222.2001.01068.x","article-title":"Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma","volume":"31","author":"Balbo","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.micinf.2008.11.017_bib24","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1128\/IAI.70.7.3656-3664.2002","article-title":"Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability","volume":"70","author":"Rodriguez-Sosa","year":"2002","journal-title":"Infect Immun."},{"key":"10.1016\/j.micinf.2008.11.017_bib25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1165\/ajrcmb.23.5.3954","article-title":"CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice","volume":"23","author":"Mehlhop","year":"2000","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.micinf.2008.11.017_bib26","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jaci.2005.07.005","article-title":"T-cell costimulatory molecules: optimal targets for the treatment of allergic airway disease with monoclonal antibodies","volume":"116","author":"Kroczek","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/eji.1830270105","article-title":"Split activity of interleukin-10 on antigen capture and antigen presentation by human dendritic cells: definition of a maturative step","volume":"27","author":"Morel","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1074-7613(00)80014-X","article-title":"Other functions, other genes: alternative activation of antigen-presenting cells","volume":"10","author":"Goerdt","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.micinf.2008.11.017_bib29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/76957","article-title":"CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+dendritic cells","volume":"1","author":"Aliberti","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.micinf.2008.11.017_bib30","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/1521-4141(200009)30:9<2669::AID-IMMU2669>3.0.CO;2-1","article-title":"Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact","volume":"30","author":"Loke","year":"2000","journal-title":"Eur. J. Immunol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790800333X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790800333X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:24:13Z","timestamp":1761143053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645790800333X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S128645790800333X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2008.11.017","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2008.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}