{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:50:40Z","timestamp":1782175840119,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":5113,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.micinf.2009.09.013","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T04:19:26Z","timestamp":1254025166000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir"],"prefix":"10.1016","volume":"12","author":[{"given":"Thananya","family":"Thongtan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonlarp","family":"Cheepsunthorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voravasa","family":"Chaiworakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutima","family":"Rattanarungsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitwara","family":"Wikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2009.09.013_bib1","doi-asserted-by":"crossref","unstructured":"T.F. Tsai, New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO\/CVI meeting, Bangkok, Thailand, 13\u201315 October 1998, Vaccine 18 Suppl 2 (2000) 1-25.","DOI":"10.1016\/S0264-410X(00)00037-2"},{"key":"10.1016\/j.micinf.2009.09.013_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2009.09.013_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jns.2007.06.041","article-title":"Japanese encephalitis revisited","volume":"262","author":"Diagana","year":"2007","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.micinf.2009.09.013_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatr"},{"key":"10.1016\/j.micinf.2009.09.013_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1096-9071(199702)51:2<132::AID-JMV8>3.0.CO;2-8","article-title":"Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients","volume":"51","author":"Ravi","year":"1997","journal-title":"J. Med. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib6","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1086\/423328","article-title":"Proinflammatory cytokines and chemokines in humans with Japanese encephalitis","volume":"190","author":"Winter","year":"2004","journal-title":"J.\u00a0Infect. Dis"},{"key":"10.1016\/j.micinf.2009.09.013_bib7","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1128\/JVI.78.22.12107-12119.2004","article-title":"Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection","volume":"78","author":"Chen","year":"2004","journal-title":"J. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0301-0082(98)00083-5","article-title":"The role of microglia and macrophages in the pathophysiology of the CNS","volume":"58","author":"Stoll","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.micinf.2009.09.013_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as mediators of inflammatory and degenerative diseases","volume":"22","author":"Gonzalez-Scarano","year":"1999","journal-title":"Annu. Rev. Neurosci"},{"key":"10.1016\/j.micinf.2009.09.013_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/glia.20474","article-title":"Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis","volume":"55","author":"Ghoshal","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.micinf.2009.09.013_bib11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/icb.1994.30","article-title":"Regulation of vascular permeability by macrophage-derived chemotactic factor produced in Japanese encephalitis","volume":"72","author":"Khanna","year":"1994","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.micinf.2009.09.013_bib12","first-page":"603","article-title":"Breakdown of blood\u2013brain barrier by virus-induced cytokine during Japanese encephalitis virus infection","volume":"73","author":"Mathur","year":"1992","journal-title":"Int. J. Exp. Pathol"},{"key":"10.1016\/j.micinf.2009.09.013_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"Blasi","year":"1990","journal-title":"J.\u00a0Neuroimmunol"},{"key":"10.1016\/j.micinf.2009.09.013_bib14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/viro.1999.9633","article-title":"Analysis of the steps involved in Dengue virus entry into host cells","volume":"257","author":"Hung","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2009.09.013_bib15","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4269\/ajtmh.1982.31.830","article-title":"Dengue virus-specific and Flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence","volume":"31","author":"Henchal","year":"1982","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1016\/j.micinf.2009.09.013_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000097394","article-title":"Entry into and production of the Japanese encephalitis virus from C6\/36 cells","volume":"50","author":"Boonsanay","year":"2007","journal-title":"Intervirology"},{"key":"10.1016\/j.micinf.2009.09.013_bib17","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1128\/jvi.71.8.5963-5971.1997","article-title":"Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells","volume":"71","author":"Liao","year":"1997","journal-title":"J. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib18","doi-asserted-by":"crossref","first-page":"16547","DOI":"10.1074\/jbc.M110629200","article-title":"The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c","volume":"277","author":"Karpinich","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2009.09.013_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jnr.490180123","article-title":"Ameboid microglia as effectors of inflammation in the central nervous system","volume":"18","author":"Giulian","year":"1987","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.micinf.2009.09.013_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1099\/0022-1317-40-3-531","article-title":"Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses","volume":"40","author":"Igarashi","year":"1978","journal-title":"J. Gen. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1099\/vir.0.19426-0","article-title":"A model to study neurotropism and persistency of Japanese encephalitis virus infection in human neuroblastoma cells and leukocytes","volume":"85","author":"Yang","year":"2004","journal-title":"J. Gen. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib22","first-page":"143","article-title":"Growth and cytopathic effect of Japanese encephalitis virus in astrocyte-enriched cell cultures from neonatal mouse brains","volume":"39","author":"Suri","year":"1995","journal-title":"Acta Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/viro.1996.0109","article-title":"Persistence of Japanese encephalitis virus is associated with abnormal expression of the nonstructural protein NS1 in host cells","volume":"217","author":"Chen","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.micinf.2009.09.013_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF01309676","article-title":"Specific tropism of Japanese encephalitis virus for developing neurons in primary rat brain culture","volume":"130","author":"Kimura-Kuroda","year":"1993","journal-title":"Arch. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib25","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1471-4159.2008.05511.x","article-title":"Japanese encephalitis virus infects neural progenitor cells and decreases their proliferation","volume":"106","author":"Das","year":"2008","journal-title":"J. Neurochem"},{"key":"10.1016\/j.micinf.2009.09.013_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jneuroim.2008.01.009","article-title":"Japanese encephalitis virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death","volume":"195","author":"Das","year":"2008","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.micinf.2009.09.013_bib27","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.neuint.2008.01.014","article-title":"Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis","volume":"52","author":"Swarup","year":"2008","journal-title":"Neurochem. Int"},{"key":"10.1016\/j.micinf.2009.09.013_bib28","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jmv.1890400412","article-title":"Persistence of Japanese encephalitis virus in the human nervous system","volume":"40","author":"Ravi","year":"1993","journal-title":"J. Med. Virol"},{"key":"10.1016\/j.micinf.2009.09.013_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10753-008-9058-2","article-title":"Japanese encephalitis virus envelope protein mitigates TNF-alpha mRNA expression in RAW264.7 cells","volume":"31","author":"Hsu","year":"2008","journal-title":"Inflammation"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457909002184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457909002184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:25:04Z","timestamp":1761143104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457909002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S1286457909002184"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2009.09.013","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2009.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}