{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:48:27Z","timestamp":1792540107871,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:00:00Z","timestamp":1292889600000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.micinf.2009.12.004","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T04:08:26Z","timestamp":1261454906000},"page":"207-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["LipL53, a temperature regulated protein from Leptospira interrogans that binds to extracellular matrix molecules"],"prefix":"10.1016","volume":"12","author":[{"given":"Tatiane R.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana T.","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amane P.","family":"Gon\u00e7ales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenaide M.","family":"de Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio A.","family":"Vasconcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.T.O.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2009.12.004_bib1","series-title":"Leptospira and Leptospirosis","author":"Faine","year":"1999"},{"key":"10.1016\/j.micinf.2009.12.004_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jb.174.1.1-7.1992","article-title":"Environmental signals controlling expression of virulence determinants in bacteria","volume":"174","author":"Mekalanos","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2009.12.004_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/IAI.69.1.400-404.2001","article-title":"Temperature-regulated protein synthesis by Leptospira interrogans","volume":"69","author":"Nally","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib4","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1128\/IAI.00755-06","article-title":"Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays","volume":"74","author":"Lo","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2180-6-51","article-title":"Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601","volume":"6","author":"Qin","year":"2006","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micinf.2009.12.004_bib6","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1128\/IAI.01619-06","article-title":"Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition","volume":"75","author":"Matsunaga","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1574-6968.1998.tb13304.x","article-title":"In vivo apoptosis of hepatocytes in guinea pigs infected with Leptospira interrogans serovar Icterohaemorrhagiae","volume":"169","author":"Merien","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micinf.2009.12.004_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev.mi.48.100194.003101","article-title":"MSCRAMM-mediated adherence of microorganisms to host tissues","volume":"48","author":"Patti","year":"1994","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micinf.2009.12.004_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6968.2000.tb09034.x","article-title":"Identification of a 36-kDa fibronectin-binding protein expressed by a virulent variant of Leptospira interrogans serovar Icterohaemorrhagiae","volume":"185","author":"Merien","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micinf.2009.12.004_bib10","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1128\/IAI.00460-06","article-title":"A newly identified leptospiral adhesin mediates attachment to laminin","volume":"74","author":"Barbosa","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib11","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1128\/IAI.01635-06","article-title":"Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen","volume":"75","author":"Choy","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib12","doi-asserted-by":"crossref","first-page":"e1188","DOI":"10.1371\/journal.pone.0001188","article-title":"Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement","volume":"2","author":"Stevenson","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.micinf.2009.12.004_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2180-8-70","article-title":"Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection","volume":"8","author":"Atzingen","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micinf.2009.12.004_bib14","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1128\/IAI.01643-07","article-title":"LipL32 is an extracellular matrix-interacting protein of Leptospira spp. and Pseudoalteromonas tunicata","volume":"76","author":"Hoke","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib15","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1128\/IAI.01639-07","article-title":"In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectin","volume":"76","author":"Hauk","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib16","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.febslet.2009.03.050","article-title":"Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activity","volume":"583","author":"Carvalho","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.micinf.2009.12.004_bib17","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1099\/jmm.0.011916-0","article-title":"A novel identified protein of Leptospira interrogans mediates binding to laminin","volume":"58","author":"Longhi","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.micinf.2009.12.004_bib18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jinf.2009.07.010","article-title":"Lp95, a novel leptospiral protein that binds extracellular matrix components and activates e-selectin on endothelial cells","volume":"59","author":"Atzingen","year":"2009","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2009.12.004_bib19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2958.2003.03619.x","article-title":"Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily","volume":"49","author":"Matsunaga","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micinf.2009.12.004_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.femsle.2005.02.004","article-title":"Whole-genome analysis of Leptospira interrogans to identify potential vaccine candidates against leptospirosis","volume":"244","author":"Gamberini","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micinf.2009.12.004_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpara.2004.11.003","article-title":"Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1","volume":"35","author":"Rodrigues","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micinf.2009.12.004_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/abio.1993.1079","article-title":"A self-consistent method for the analysis of protein secondary structure from circular dichroism","volume":"209","author":"Sreerama","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.micinf.2009.12.004_bib23","first-page":"197","article-title":"An interactive graphic program for calculating the secondary structure content of proteins from circular dichroism spectrum","volume":"9","author":"Deleage","year":"1993","journal-title":"Comput. Appl. Biosci."},{"key":"10.1016\/j.micinf.2009.12.004_bib24","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1128\/CVI.00214-08","article-title":"Evaluation of leptospiral recombinant antigens MPL17 and MPL21 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays","volume":"15","author":"Oliveira","year":"2008","journal-title":"Clin. Vaccine. Immunol."},{"key":"10.1016\/j.micinf.2009.12.004_bib25","doi-asserted-by":"crossref","first-page":"e6071","DOI":"10.1371\/journal.pone.0006071","article-title":"A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans","volume":"4","author":"Pinne","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.micinf.2009.12.004_bib26","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1016\/j.vaccine.2007.05.053","article-title":"The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis","volume":"25","author":"Silva","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2009.12.004_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/prot.340110203","article-title":"Expert system for predicting protein localization sites in gram-negative bacteria","volume":"11","author":"Nakai","year":"1991","journal-title":"Proteins"},{"key":"10.1016\/j.micinf.2009.12.004_bib28","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/JB.186.7.2164-2172.2004","article-title":"Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis","volume":"186","author":"Nascimento","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2009.12.004_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1590\/S0100-879X2004000400003","article-title":"Genome features of Leptospira interrogans serovar Copenhageni","volume":"37","author":"Nascimento","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.micinf.2009.12.004_bib30","doi-asserted-by":"crossref","first-page":"19380","DOI":"10.1074\/jbc.M109.004531","article-title":"Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin","volume":"284","author":"Lin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2009.12.004_bib31","doi-asserted-by":"crossref","first-page":"23547","DOI":"10.1074\/jbc.M109.031369","article-title":"Fibronectin binds to and induces conformational change in a disordered region of leptospiral immunoglobulin-like protein B","volume":"284","author":"Lin","year":"2009","journal-title":"J.Biol. Chem."},{"key":"10.1016\/j.micinf.2009.12.004_bib32","doi-asserted-by":"crossref","first-page":"25140","DOI":"10.1074\/jbc.M801350200","article-title":"Calcium binds to leptospiral immunoglobulin-like protein, LigB, and modulates fibronectin binding","volume":"283","author":"Lin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2009.12.004_bib33","article-title":"Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV","author":"Vieira","year":"2009","journal-title":"J. Infect."},{"key":"10.1016\/j.micinf.2009.12.004_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/bj2520453","article-title":"Structure and distribution of N-linked oligosaccharide chains on various domains of mouse tumour laminin","volume":"252","author":"Fujiwara","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.micinf.2009.12.004_bib35","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1128\/JB.01537-07","article-title":"Heterologous expression of the Treponema pallidum laminin-binding adhesin Tp0751 in the culturable spirochete Treponema phagedenis","volume":"190","author":"Cameron","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2009.12.004_bib36","first-page":"689","article-title":"Participation of glycosylation sites in the binding of Staphylococcus aureus to laminin","volume":"26","author":"Carneiro","year":"1993","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.micinf.2009.12.004_bib37","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1099\/00221287-145-10-2835","article-title":"Trichomonas vaginalis interactions with fibronectin and laminin","volume":"145","author":"Crouch","year":"1999","journal-title":"Microbiology"},{"key":"10.1016\/j.micinf.2009.12.004_bib38","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/iai.65.3.916-923.1997","article-title":"Identification of the N-acetylneuraminyllactose-specific laminin-binding protein of Helicobacter pylori","volume":"65","author":"Valkonen","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib39","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature08184","article-title":"Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans","volume":"460","author":"Malmstrom","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2009.12.004_bib40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vaccine.2007.10.029","article-title":"Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters","volume":"26","author":"Faisal","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.micinf.2009.12.004_bib41","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1128\/IAI.70.11.5924-5930.2002","article-title":"Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans","volume":"70","author":"Palaniappan","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib42","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1128\/IAI.74.3.1745-1750.2006","article-title":"Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infection","volume":"74","author":"Palaniappan","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib43","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1128\/IAI.73.7.4062-4069.2005","article-title":"Protection against Leptospira interrogans sensu lato challenge by DNA immunization with the gene encoding hemolysin-associated protein 1","volume":"73","author":"Branger","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2009.12.004_bib44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.vaccine.2007.10.052","article-title":"Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge","volume":"26","author":"Seixas","year":"2007","journal-title":"Vaccine"}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790900272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S128645790900272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:25:37Z","timestamp":1761143137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S128645790900272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S128645790900272X"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2009.12.004","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LipL53, a temperature regulated protein from Leptospira interrogans that binds to extracellular matrix molecules","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2009.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}