{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:19:54Z","timestamp":1783545594089,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":4932,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbes and Infection"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.micinf.2010.03.010","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T14:01:36Z","timestamp":1269957696000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Experimental antibacterial therapy with puroindolines, lactoferrin and lysozyme in Listeria monocytogenes-infected mice"],"prefix":"10.1016","volume":"12","author":[{"given":"Daniela","family":"Palumbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Iannaccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Capparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micinf.2010.03.010_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1128\/mr.55.3.476-511.1991","article-title":"Listeria monocytogenes, a food-borne pathogen","volume":"55","author":"Faber","year":"1991","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.micinf.2010.03.010_bib2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.micinf.2008.07.043","article-title":"Listeria monocytogenes, a unique model in infection biology: an overview","volume":"10","author":"Cossart","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.micinf.2010.03.010_bib3","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/AAC.43.9.2103","article-title":"Antibiotic resistance in Listeria spp.","volume":"43","author":"Charpentier","year":"1999","journal-title":"Antimicrobial. Agents Chemother."},{"key":"10.1016\/j.micinf.2010.03.010_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jaci.2006.04.033","article-title":"Innate immune defects in atopic dermatitis","volume":"118","author":"McGirt","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micinf.2010.03.010_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.imbio.2005.10.016","article-title":"Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity","volume":"211","author":"Kurata","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.micinf.2010.03.010_bib6","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/1381612023395475","article-title":"Molecular diversity in gene-encoded, cationic antimicrobial polypeptides","volume":"8","author":"Tossi","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.micinf.2010.03.010_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1574-695X.2006.00132.x","article-title":"Antimicrobial peptides and proteins, exercise and innate mucosal immunity","volume":"48","author":"West","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.micinf.2010.03.010_bib8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2010.03.010_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/jcp.55.4.298","article-title":"Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa","volume":"55","author":"Cunliffe","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.micinf.2010.03.010_bib10","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/jn\/135.5.1289","article-title":"Antimicrobial peptides in mucosal secretions: the importance of local secretions in mitigating infection","volume":"135","author":"Phadke","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.micinf.2010.03.010_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/jez.b.21102","article-title":"The evolution of immune mechanisms","volume":"306","author":"Danilova","year":"2006","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.micinf.2010.03.010_bib12","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1128\/AAC.01513-06","article-title":"Experimental phage therapy against Staphylococcus aureus in mice","volume":"51","author":"Capparelli","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micinf.2010.03.010_bib13","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0006-3495(03)75046-2","article-title":"Puroindolines form ion channels in biological membranes","volume":"84","author":"Charnet","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.micinf.2010.03.010_bib14","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1111\/j.1742-4658.2006.05185.x","article-title":"Puroindoline-a and alpha1-purothionin form ion channels in giant liposomes but exert different toxic actions on murine cells","volume":"273","author":"Llanos","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.micinf.2010.03.010_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.327545","article-title":"A bactericidal effect for human lactoferrin","volume":"197","author":"Arnold","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.micinf.2010.03.010_bib16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/iai.35.3.792-799.1982","article-title":"Bactericidal activity of lactoferrin: differentiation from the stasis of iron deprivation","volume":"35","author":"Arnold","year":"1982","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.03.010_bib17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/B:BIOM.0000027696.48707.42","article-title":"Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties","volume":"17","author":"Legrand","year":"2004","journal-title":"Biometals"},{"key":"10.1016\/j.micinf.2010.03.010_bib18","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1007\/s00018-005-5369-8","article-title":"Multifunctional roles of lactoferrin: a critical overview","volume":"62","author":"Ward","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.micinf.2010.03.010_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/14786410701650253","article-title":"Fungistatic activity of iron free bovine lactoferrin against several fungal plant pathogens and antagonists","volume":"22","author":"Lahoz","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.micinf.2010.03.010_bib20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jbiotec.2006.11.004","article-title":"Expression of recombinant puroindolines for the treatment of staphylococcal skin infections (Acne vulgaris)","volume":"128","author":"Capparelli","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.micinf.2010.03.010_bib21","doi-asserted-by":"crossref","first-page":"28565","DOI":"10.1074\/jbc.M606031200","article-title":"A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer","volume":"281","author":"Rosenfeld","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micinf.2010.03.010_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature04263","article-title":"An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection","volume":"439","author":"Palliser","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.micinf.2010.03.010_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/EDE.0b013e3181761f6f","article-title":"Listeriosis: a model for the fine balance between immunity and morbidity","volume":"19","author":"Lavi","year":"2008","journal-title":"Epidemiology"},{"key":"10.1016\/j.micinf.2010.03.010_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1473-3099(01)00092-5","article-title":"Cationic peptides: effectors in innate immunity and novel antimicrobials","volume":"1","author":"Hancock","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micinf.2010.03.010_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0014-5793(93)80249-T","article-title":"Complete amino acid sequence of puroindoline, a new basic and cystine-rich protein with a unique tryptophan-rich domain, isolated from wheat endosperm by Triton X-114 phase partitioning","volume":"329","author":"Blochet","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.micinf.2010.03.010_bib26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s11103-005-8270-9","article-title":"Two plant puroindolines colocalize in wheat seed and in vitro synergistically fight against pathogens","volume":"58","author":"Capparelli","year":"2005","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.micinf.2010.03.010_bib27","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1097\/00001756-199812010-00007","article-title":"The wheat proteins puroindoline-a and alpha 1-purothionin induce nodal swelling in myelinated axons","volume":"9","author":"Mattei","year":"1998","journal-title":"NeuroReport"},{"key":"10.1016\/j.micinf.2010.03.010_bib28","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1128\/JB.185.16.4938-4947.2003","article-title":"Conformation of a bactericidal domain of puroindoline a: structure and mechanism of action of a 13-residue antimicrobial peptide","volume":"185","author":"Jing","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micinf.2010.03.010_bib29","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1094\/MPMI.2001.14.10.1255","article-title":"Wheat puroindolines enhance fungal disease resistance in transgenic rice","volume":"14","author":"Krishnamurthy","year":"2001","journal-title":"Mol. Plant Microbe Interact."},{"key":"10.1016\/j.micinf.2010.03.010_bib30","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/iai.61.2.719-728.1993","article-title":"Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment","volume":"61","author":"Yamauchi","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micinf.2010.03.010_bib31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2672.1992.tb05007.x","article-title":"Antibacterial spectrum of lactoferricin-B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin","volume":"73","author":"Bellamy","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.micinf.2010.03.010_bib32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1472-765X.1994.tb00854.x","article-title":"Antifungal properties of lactoferricin-B, a peptide derived from the N-terminal region of bovine lactoferrin","volume":"18","author":"Bellamy","year":"1994","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micinf.2010.03.010_bib33","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.3168\/jds.S0022-0302(91)78608-6","article-title":"Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin","volume":"74","author":"Tomita","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micinf.2010.03.010_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.peptides.2003.12.006","article-title":"Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin","volume":"25","author":"van der Kraan","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.micinf.2010.03.010_bib35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1365-2672.1997.00372.x","article-title":"Identification and isolation of a bactericidal domain in chicken egg white lysozyme","volume":"82","author":"Pellegrini","year":"1997","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.micinf.2010.03.010_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0167-4838(92)90346-F","article-title":"Identification of the bactericidal domain of lactoferrin","volume":"1121","author":"Bellamy","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micinf.2010.03.010_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0944-5013(00)80040-3","article-title":"Effect of lysozyme or modified lysozyme fragments on DNA and RNA synthesis and membrane permeability of Escherichia coli","volume":"155","author":"Pellegrini","year":"2000","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micinf.2010.03.010_bib38","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s00134-002-1330-6","article-title":"Clinical implications of antibiotic-induced endotoxin release in septic shock","volume":"28","author":"Lepper","year":"2002","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.micinf.2010.03.010_bib39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.me.38.020187.002221","article-title":"Endotoxin and disease mechanisms","volume":"38","author":"Morrison","year":"1987","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.micinf.2010.03.010_bib40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00024382-200206000-00004","article-title":"Six at six: interleukin-6 measured 6h after the initiation of sepsis predicts mortality over 3 days","volume":"17","author":"Remick","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.micinf.2010.03.010_bib41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/00365549609037921","article-title":"Listeriosis in non-pregnant patients in 1992: clinical aspects and outcome in relation to predisposing conditions","volume":"28","author":"Goulet","year":"1996","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.micinf.2010.03.010_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1128\/CMR.10.2.345","article-title":"Management of listeriosis","volume":"10","author":"Hof","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micinf.2010.03.010_bib43","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1345\/aph.19315","article-title":"Treatment of listeriosis","volume":"34","author":"Temple","year":"2000","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.micinf.2010.03.010_bib44","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10529-006-9031-9","article-title":"Cloning and expression of two plant proteins: similar antimicrobial activity of native and recombinant form","volume":"28","author":"Capparelli","year":"2006","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.micinf.2010.03.010_bib45","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0167-7799(03)00145-8","article-title":"Gone gene fishing: how to catch novel marine antimicrobials","volume":"21","author":"Petrzykat","year":"2003","journal-title":"Trends Biotechnol."}],"container-title":["Microbes and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286457910000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:26:15Z","timestamp":1761143175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286457910000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1286457910000791"],"URL":"https:\/\/doi.org\/10.1016\/j.micinf.2010.03.010","relation":{},"ISSN":["1286-4579"],"issn-type":[{"value":"1286-4579","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental antibacterial therapy with puroindolines, lactoferrin and lysozyme in Listeria monocytogenes-infected mice","name":"articletitle","label":"Article Title"},{"value":"Microbes and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micinf.2010.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}